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Gene Expression

Glucose Limitation Induces GCN4 Translation by Activation of Gcn2 Protein Kinase

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Pages 2706-2717 | Received 07 Sep 1999, Accepted 07 Jan 2000, Published online: 27 Mar 2023

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Zih-Jie Shen, Spike Postnikoff & Jessica K. Tyler. (2019) Is Gcn4-induced autophagy the ultimate downstream mechanism by which hormesis extends yeast replicative lifespan?. Current Genetics 65:3, pages 717-720.
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Robert A. Crawford & Graham D. Pavitt. (2019) Translational regulation in response to stress in Saccharomyces cerevisiae . Yeast 36:1, pages 5-21.
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P. Mara, G. S. Fragiadakis, F. Gkountromichos & D. Alexandraki. (2018) The pleiotropic effects of the glutamate dehydrogenase (GDH) pathway in Saccharomyces cerevisiae. Microbial Cell Factories 17:1.
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Youjin Jung, Ki Moon Seong, Je-Hyun Baek & Joon Kim. (2018) Ssb2 is a novel factor in regulating synthesis and degradation of Gcn4 in Saccharomyces cerevisiae . Molecular Microbiology 110:5, pages 728-740.
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Zheng Hu, Bo Xia, Spike DL Postnikoff, Zih-Jie Shen, Alin S Tomoiaga, Troy A Harkness, Ja Hwan Seol, Wei Li, Kaifu Chen & Jessica K Tyler. (2018) Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan. eLife 7.
Crossref
Ronald C. Wek. (2018) Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress. Cold Spring Harbor Perspectives in Biology 10:7, pages a032870.
Crossref
Christine Müller, Laura M Zidek, Tobias Ackermann, Tristan de Jong, Peng Liu, Verena Kliche, Mohamad Amr Zaini, Gertrud Kortman, Liesbeth Harkema, Dineke S Verbeek, Jan P Tuckermann, Julia von Maltzahn, Alain de Bruin, Victor Guryev, Zhao-Qi Wang & Cornelis F Calkhoven. (2018) Reduced expression of C/EBPβ-LIP extends health and lifespan in mice. eLife 7.
Crossref
I. Faus, R. Niñoles, V. Kesari, P. Llabata, E. Tam, S.G. Nebauer, J. Santiago, M.T. Hauser & J. Gadea. (2018) Arabidopsis ILITHYIA protein is necessary for proper chloroplast biogenesis and root development independent of eIF2α phosphorylation. Journal of Plant Physiology 224-225, pages 173-182.
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Nitish Mittal, Joao C. Guimaraes, Thomas Gross, Alexander Schmidt, Arnau Vina-Vilaseca, Danny D. Nedialkova, Florian Aeschimann, Sebastian A. Leidel, Anne Spang & Mihaela Zavolan. (2017) The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan. Nature Communications 8:1.
Crossref
Kyle Mohler & Michael Ibba. (2017) Translational fidelity and mistranslation in the cellular response to stress. Nature Microbiology 2:9.
Crossref
Kyle Mohler, Rebecca Mann, Tammy J. Bullwinkle, Kyle Hopkins, Lin Hwang, Noah M. Reynolds, Brandon Gassaway, Hans-Rudolf Aerni, Jesse Rinehart, Michael Polymenis, Kym Faull & Michael Ibba. (2017) Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae. Nucleic Acids Research 45:7, pages 3985-3996.
Crossref
Linjuan Wang, Houhua Li, Chunzhao Zhao, Shengfei Li, Lingyao Kong, Wenwu Wu, Weisheng Kong, Yan Liu, Yuanyuan Wei, Jian-Kang Zhu & Hairong Zhang. (2017) The inhibition of protein translation mediated by AtGCN1 is essential for cold tolerance in Arabidopsis thaliana . Plant, Cell & Environment 40:1, pages 56-68.
Crossref
Kamlesh Kumar Yadav & Ram Rajasekharan. (2016) The transcription factor GCN4 regulates PHM8 and alters triacylglycerol metabolism in Saccharomyces cerevisiae. Current Genetics 62:4, pages 841-851.
Crossref
Francis Doyle, Andrea Leonardi, Lauren Endres, Scott A. Tenenbaum, Peter C. Dedon & Thomas J. Begley. (2016) Gene- and genome-based analysis of significant codon patterns in yeast, rat and mice genomes with the CUT Codon UTilization tool. Methods 107, pages 98-109.
Crossref
Ryuta Ishimura, Gabor Nagy, Ivan Dotu, Jeffrey H Chuang & Susan L Ackerman. (2016) Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation. eLife 5.
Crossref
Richard C. Silva, Evelyn Sattlegger & Beatriz A. Castilho. (2016) Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response. Journal of Cell Science.
Crossref
Stefan Rothenburg, Millie M. Georgiadis & Ronald C. Wek. 2016. Evolution of the Protein Synthesis Machinery and Its Regulation. Evolution of the Protein Synthesis Machinery and Its Regulation 235 260 .
Weiquan Li & Richard A. Miller. (2015) Elevated ATF4 Function in Fibroblasts and Liver of Slow-Aging Mutant Mice. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 70:3, pages 263-272.
Crossref
Ira Bavli-Kertselli, Daniel Melamed, Lavi Bar-Ziv, Hila Volf & Yoav Arava. (2015) Overexpression of eukaryotic initiation factor 5 rescues the translational defect of tpk1 w in a manner that necessitates a novel phosphorylation site . FEBS Journal 282:3, pages 504-520.
Crossref
Beatriz A. Castilho, Renuka Shanmugam, Richard C. Silva, Rashmi Ramesh, Benjamin M. Himme & Evelyn Sattlegger. (2014) Keeping the eIF2 alpha kinase Gcn2 in check. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:9, pages 1948-1968.
Crossref
Arunkumar Sundaram & Chris M. Grant. (2014) Oxidant-specific regulation of protein synthesis in Candida albicans. Fungal Genetics and Biology 67, pages 15-23.
Crossref
Margarito RojasAnne-Claude Gingras & Thomas E. Dever. (2014) Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2γ bypasses targeting subunit requirement for eIF2α dephosphorylation. Proceedings of the National Academy of Sciences 111:14.
Crossref
Sarah K. Hewitt, Ian J. Donaldson, Simon C. Lovell & Daniela Delneri. (2014) Sequencing and Characterisation of Rearrangements in Three S. pastorianus Strains Reveals the Presence of Chimeric Genes and Gives Evidence of Breakpoint Reuse. PLoS ONE 9:3, pages e92203.
Crossref
Bertal H. Aktas & Ting Chen. 2014. Translation and Its Regulation in Cancer Biology and Medicine. Translation and Its Regulation in Cancer Biology and Medicine 195 221 .
Antonio Jiménez-Díaz, Miguel Remacha, Juan P. G. Ballesta & Juan José Berlanga. (2013) Phosphorylation of Initiation Factor eIF2 in Response to Stress Conditions Is Mediated by Acidic Ribosomal P1/P2 Proteins in Saccharomyces cerevisiae. PLoS ONE 8:12, pages e84219.
Crossref
Beáta Grallert & Erik Boye. (2013) GCN2, an old dog with new tricks. Biochemical Society Transactions 41:6, pages 1687-1691.
Crossref
Manali Joshi, Abhijeet Kulkarni & Jayanta K. Pal. (2013) Small molecule modulators of eukaryotic initiation factor 2α kinases, the key regulators of protein synthesis. Biochimie 95:11, pages 1980-1990.
Crossref
Neysan Donnelly, Adrienne M. Gorman, Sanjeev Gupta & Afshin Samali. (2013) The eIF2α kinases: their structures and functions. Cellular and Molecular Life Sciences 70:19, pages 3493-3511.
Crossref
Ali Kazemi Seresht, Ana Luisa Cruz, Erik de Hulster, Marit Hebly, Eva Akke Palmqvist, Walter van Gulik, Jean-Marc Daran, Jack Pronk & Lisbeth Olsson. (2013) Long-term adaptation of Saccharomyces cerevisiae to the burden of recombinant insulin production . Biotechnology and Bioengineering 110:10, pages 2749-2763.
Crossref
Britta Herzog, Blagovesta Popova, Antonia Jakobshagen, Hedieh Shahpasandzadeh & Gerhard H. Braus. (2013) Mutual Cross Talk between the Regulators Hac1 of the Unfolded Protein Response and Gcn4 of the General Amino Acid Control of Saccharomyces cerevisiae. Eukaryotic Cell 12:8, pages 1142-1154.
Crossref
Noelia Valbuena, Ana Elisa Rozalén & Sergio Moreno. (2012) Fission yeast TORC1 prevents eIF2α phosphorylation in response to nitrogen and amino acids via Gcn2 kinase. Journal of Cell Science 125:24, pages 5955-5959.
Crossref
Thomas D. Baird & Ronald C. Wek. (2012) Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism. Advances in Nutrition 3:3, pages 307-321.
Crossref
Kevin A Morano, Chris M Grant & W Scott Moye-Rowley. (2012) The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae . Genetics 190:4, pages 1157-1195.
Crossref
Edward H. Byrne, Ian Prosser, Nira Muttucumaru, Tanya Y. Curtis, Astrid Wingler, Stephen Powers & Nigel G. Halford. (2012) Overexpression of GCN2-type protein kinase in wheat has profound effects on free amino acid concentration and gene expression. Plant Biotechnology Journal 10:3, pages 328-340.
Crossref
C.J. Rodriguez-Hernandez, J.J. Guinovart & J.R. Murguia. (2012) Anti-diabetic and anti-obesity agent sodium tungstate enhances GCN pathway activation through Glc7p inhibition. FEBS Letters 586:3, pages 270-276.
Crossref
Rachel Elsby, Joshua F. Heiber, Peter Reid, Scot R. Kimball, Graham D. Pavitt & Glen N. Barber. (2011) The Alpha Subunit of Eukaryotic Initiation Factor 2B (eIF2B) Is Required for eIF2-Mediated Translational Suppression of Vesicular Stomatitis Virus. Journal of Virology 85:19, pages 9716-9725.
Crossref
Lydia M. Castelli, Jennifer Lui, Susan G. Campbell, William Rowe, Leo A. H. Zeef, Leah E. A. Holmes, Nathaniel P. Hoyle, Jonathon Bone, Julian N. Selley, Paul F. G. Sims & Mark P. Ashe. (2011) Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated. Molecular Biology of the Cell 22:18, pages 3379-3393.
Crossref
Chris M. Grant. (2011) Regulation of Translation by Hydrogen Peroxide. Antioxidants & Redox Signaling 15:1, pages 191-203.
Crossref
Zharain BawaCharlotte E. BlandNicklas BonanderNagamani BoraStephanie P. CartwrightMichelle ClareMatthew T. ConnerRichard A.J. DarbyMarvin V. DilworthWilliam J. HolmesMohammed JamshadSarah J. RoutledgeStephane R. GrossRoslyn M. Bill. (2011) Understanding the yeast host cell response to recombinant membrane protein production. Biochemical Society Transactions 39:3, pages 719-723.
Crossref
Mark A. McCormick, Shih-yin Tsai & Brian K. Kennedy. (2011) TOR and ageing: a complex pathway for a complex process. Philosophical Transactions of the Royal Society B: Biological Sciences 366:1561, pages 17-27.
Crossref
Aliz R Rao & Matteo Pellegrini. (2011) Regulation of the yeast metabolic cycle by transcription factors with periodic activities. BMC Systems Biology 5:1, pages 160.
Crossref
Britta Herzog, Katrin Streckfuss-Bömeke & Gerhard H. Braus. (2011) A Feedback Circuit between Transcriptional Activation and Self-Destruction of Gcn4 Separates Its Metabolic and Morphogenic Response in Diploid Yeasts. Journal of Molecular Biology 405:4, pages 909-925.
Crossref
Hugo Hernández, Cristina Aranda, Lina Riego & Alicia González. (2011) Gln3–Gcn4 hybrid transcriptional activator determines catabolic and biosynthetic gene expression in the yeast Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications 404:3, pages 859-864.
Crossref
John M Zaborske, Xiaochen Wu, Ronald C Wek & Tao Pan. (2010) Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae. BMC Biochemistry 11:1.
Crossref
Jorge Pérez-Valle, Jessica Rothe, Cecilia Primo, Mar Martínez Pastor, Joaquin Ariño, Amparo Pascual-Ahuir, José Miguel Mulet, Ramón Serrano & Lynne Yenush. (2010) Hal4 and Hal5 Protein Kinases Are Required for General Control of Carbon and Nitrogen Uptake and Metabolism. Eukaryotic Cell 9:12, pages 1881-1890.
Crossref
Naoki Nemoto, Chingakham Ranjit Singh, Tsuyoshi Udagawa, Suzhi Wang, Elizabeth Thorson, Zachery Winter, Takahiro Ohira, Miki Ii, Leoš Valášek, Susan J. Brown & Katsura Asano. (2010) Yeast 18 S rRNA Is Directly Involved in the Ribosomal Response to Stringent AUG Selection during Translation Initiation. Journal of Biological Chemistry 285:42, pages 32200-32212.
Crossref
Lu Yu, Na Guo, Rizeng Meng, Bin Liu, Xudong Tang, Jing Jin, Yumei Cui & Xuming Deng. (2010) Allicin-induced global gene expression profile of Saccharomyces cerevisiae. Applied Microbiology and Biotechnology 88:1, pages 219-229.
Crossref
Jiangbin Ye, Monika Kumanova, Lori S Hart, Kelly Sloane, Haiyan Zhang, Diego N De Panis, Ekaterina Bobrovnikova-Marjon, J Alan Diehl, David Ron & Constantinos Koumenis. (2010) The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. The EMBO Journal 29:12, pages 2082-2096.
Crossref
Kirk A. Staschke, Souvik Dey, John M. Zaborske, Lakshmi Reddy Palam, Jeanette N. McClintick, Tao Pan, Howard J. Edenberg & Ronald C. Wek. (2010) Integration of General Amino Acid Control and Target of Rapamycin (TOR) Regulatory Pathways in Nitrogen Assimilation in Yeast. Journal of Biological Chemistry 285:22, pages 16893-16911.
Crossref
Wataru Nomura, Kazuhiro Maeta, Keiko Kita, Shingo Izawa & Yoshiharu Inoue. (2010) Methylglyoxal activates Gcn2 to phosphorylate eIF2α independently of the TOR pathway in Saccharomyces cerevisiae. Applied Microbiology and Biotechnology 86:6, pages 1887-1894.
Crossref
Chanelle A. Toerien, Donald R. Trout & John P. Cant. (2010) Nutritional Stimulation of Milk Protein Yield of Cows Is Associated with Changes in Phosphorylation of Mammary Eukaryotic Initiation Factor 2 and Ribosomal S6 Kinase 11–3. The Journal of Nutrition 140:2, pages 285-292.
Crossref
S. J. Hey, E. Byrne & N. G. Halford. (2009) The interface between metabolic and stress signalling. Annals of Botany 105:2, pages 197-203.
Crossref
Ranjana Mehta, Devon Chandler-Brown, Fresnida J. Ramos, Lara S. Shamieh & Matt Kaeberlein. 2010. Protein Metabolism and Homeostasis in Aging. Protein Metabolism and Homeostasis in Aging 14 29 .
Birgit Schönig, Sabine Vogel & Bettina Tudzynski. (2009) Cpc1 mediates cross-pathway control independently of Mbf1 in Fusarium fujikuroi. Fungal Genetics and Biology 46:12, pages 898-908.
Crossref
Monique N. Stanfel, Lara S. Shamieh, Matt Kaeberlein & Brian K. Kennedy. (2009) The TOR pathway comes of age. Biochimica et Biophysica Acta (BBA) - General Subjects 1790:10, pages 1067-1074.
Crossref
John M. Zaborske, Jana Narasimhan, Li Jiang, Sheree A. Wek, Kimberly A. Dittmar, Florien Freimoser, Tao Pan & Ronald C. Wek. (2009) Genome-wide Analysis of tRNA Charging and Activation of the eIF2 Kinase Gcn2p. Journal of Biological Chemistry 284:37, pages 25254-25267.
Crossref
Francis Robert, Chris Williams, Yifei Yan, Elizabeth Donohue, Regina Cencic, Stephen K. Burley & Jerry Pelletier. (2009) Blocking UV-Induced eIF2α Phosphorylation with Small Molecule Inhibitors of GCN2. Chemical Biology & Drug Design 74:1, pages 57-67.
Crossref
Yan Li & Hui Zhou. (2009) tRNAs as regulators in gene expression. Science in China Series C: Life Sciences 52:3, pages 245-252.
Crossref
George L. Sutphin & Brian K. Kennedy. 2009. Evolutionary Biology. Evolutionary Biology 339 360 .
Ala TrusinaFeroz R. Papa & Chao Tang. (2008) Rationalizing translation attenuation in the network architecture of the unfolded protein response. Proceedings of the National Academy of Sciences 105:51, pages 20280-20285.
Crossref
Margaret K. Shirra, Rhonda R. McCartney, Chao Zhang, Kevan M. Shokat, Martin C. Schmidt & Karen M. Arndt. (2008) A Chemical Genomics Study Identifies Snf1 as a Repressor of GCN4 Translation. Journal of Biological Chemistry 283:51, pages 35889-35898.
Crossref
K.A. SteinkrausM. KaeberleinB.K. Kennedy. (2008) Replicative Aging in Yeast: The Means to the End. Annual Review of Cell and Developmental Biology 24:1, pages 29-54.
Crossref
Claire Mascarenhas, Laura C. Edwards-Ingram, Leo Zeef, Daniel Shenton, Mark P. Ashe & Chris M. Grant. (2008) Gcn4 Is Required for the Response to Peroxide Stress in the Yeast Saccharomyces cerevisiae . Molecular Biology of the Cell 19:7, pages 2995-3007.
Crossref
Simone Bittencourt, Catia M. Pereira, Marcelo Avedissian, Arthur Delamano, Luiz E. Mello & Beatriz A. Castilho. (2008) Distribution of the protein IMPACT, an inhibitor of GCN2, in the mouse, rat, and marmoset brain. The Journal of Comparative Neurology 507:5, pages 1811-1830.
Crossref
Kristan K. Steffen, Vivian L. MacKay, Emily O. Kerr, Mitsuhiro Tsuchiya, Di Hu, Lindsay A. Fox, Nick Dang, Elijah D. Johnston, Jonathan A. Oakes, Bie N. Tchao, Diana N. Pak, Stanley Fields, Brian K. Kennedy & Matt Kaeberlein. (2008) Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4. Cell 133:2, pages 292-302.
Crossref
Edith GomezMike L. PowellAlan BevingtonTerence P. Herbert. (2008) A decrease in cellular energy status stimulates PERK-dependent eIF2α phosphorylation and regulates protein synthesis in pancreatic β-cells. Biochemical Journal 410:3, pages 485-493.
Crossref
Daniel Shenton, Claire Mascarenhas & Chris M. Grant. 2008. Stress in Yeast and Filamentous Fungi. Stress in Yeast and Filamentous Fungi 221 233 .
Maria Carolina S. Moraes, Teresa C. L. Jesus, Nilce N. Hashimoto, Madhusudan Dey, Kevin J. Schwartz, Viviane S. Alves, Carla C. Avila, James D. Bangs, Thomas E. Dever, Sergio Schenkman & Beatriz A. Castilho. (2007) Novel Membrane-Bound eIF2α Kinase in the Flagellar Pocket of Trypanosoma brucei . Eukaryotic Cell 6:11, pages 1979-1991.
Crossref
Chaoguang Tian, Takao Kasuga, Matthew S. Sachs & N. Louise Glass. (2007) Transcriptional Profiling of Cross Pathway Control in Neurospora crassa and Comparative Analysis of the Gcn4 and CPC1 Regulons . Eukaryotic Cell 6:6, pages 1018-1029.
Crossref
Seasson Phillips Vitiello, Devin M. Wolfe & David A. Pearce. (2007) Absence of Btn1p in the yeast model for juvenile Batten disease may cause arginine to become toxic to yeast cells. Human Molecular Genetics 16:9, pages 1007-1016.
Crossref
Sebastián BernalesFeroz R. PapaPeter Walter. (2006) Intracellular Signaling by the Unfolded Protein Response. Annual Review of Cell and Developmental Biology 22:1, pages 487-508.
Crossref
M Roccio, J L Bos & F J T Zwartkruis. (2005) Regulation of the small GTPase Rheb by amino acids. Oncogene 25:5, pages 657-664.
Crossref
Lotte Steffensen & Per Amstrup Pedersen. (2006) Heterologous Expression of Membrane and Soluble Proteins Derepresses GCN4 mRNA Translation in the Yeast Saccharomyces cerevisiae . Eukaryotic Cell 5:2, pages 248-261.
Crossref
Bärbel Hahn-Hägerdal, Kaisa Karhumaa, Christer U Larsson, Marie Gorwa-Grauslund, Johann Görgens & Willem H van Zyl. (2005) Role of cultivation media in the development of yeast strains for large scale industrial use. Microbial Cell Factories 4:1.
Crossref
Robert B. Hamanaka, Beth S. Bennett, Sara B. Cullinan & J. Alan Diehl. (2005) PERK and GCN2 Contribute to eIF2α Phosphorylation and Cell Cycle Arrest after Activation of the Unfolded Protein Response Pathway. Molecular Biology of the Cell 16:12, pages 5493-5501.
Crossref
Isabelle Dunand-Sauthier, Carol A. Walker, Jana Narasimhan, Amanda K. Pearce, Ronald C. Wek & Tim C. Humphrey. (2005) Stress-Activated Protein Kinase Pathway Functions To Support Protein Synthesis and Translational Adaptation in Response to Environmental Stress in Fission Yeast. Eukaryotic Cell 4:11, pages 1785-1793.
Crossref
Alan G. Hinnebusch. (2005) TRANSLATIONAL REGULATION OF GCN4 AND THE GENERAL AMINO ACID CONTROL OF YEAST . Annual Review of Microbiology 59:1, pages 407-450.
Crossref
Laura K. Palmer, Jessica L. Shoemaker, Beverly A. Baptiste, Darren Wolfe & Ralph L. Keil. (2005) Inhibition of Translation Initiation by Volatile Anesthetics Involves Nutrient-sensitive GCN-independent and -dependent Processes in Yeast. Molecular Biology of the Cell 16:8, pages 3727-3739.
Crossref
Cátia M. Pereira, Evelyn Sattlegger, Hao-Yuan Jiang, Beatriz M. Longo, Carolina B. Jaqueta, Alan G. Hinnebusch, Ronald C. Wek, Luiz E.A.M. Mello & Beatriz A. Castilho. (2005) IMPACT, a Protein Preferentially Expressed in the Mouse Brain, Binds GCN1 and Inhibits GCN2 Activation. Journal of Biological Chemistry 280:31, pages 28316-28323.
Crossref
Hao-Yuan Jiang & Ronald C. Wek. (2005) Phosphorylation of the α-Subunit of the Eukaryotic Initiation Factor-2 (eIF2α) Reduces Protein Synthesis and Enhances Apoptosis in Response to Proteasome Inhibition. Journal of Biological Chemistry 280:14, pages 14189-14202.
Crossref
Christopher G. Proud. (2005) eIF2 and the control of cell physiology. Seminars in Cell & Developmental Biology 16:1, pages 3-12.
Crossref
Nigel G. Halford. 2005. Incorporating Advances in Plant Pathology. Incorporating Advances in Plant Pathology 93 142 .
Ke Zhan, Jana Narasimhan & Ronald C Wek. (2004) Differential Activation of eIF2 Kinases in Response to Cellular Stresses in Schizosaccharomyces pombe. Genetics 168:4, pages 1867-1875.
Crossref
Edith Gomez, Michael L. Powell, Isabel C. Greenman & Terence P. Herbert. (2004) Glucose-stimulated Protein Synthesis in Pancreatic β-Cells Parallels an Increase in the Availability of the Translational Ternary Complex (eIF2-GTP·Met-tRNAi) and the Dephosphorylation of eIF2α. Journal of Biological Chemistry 279:52, pages 53937-53946.
Crossref
Christopher K Patil, Hao Li & Peter Walter. (2004) Gcn4p and Novel Upstream Activating Sequences Regulate Targets of the Unfolded Protein Response. PLoS Biology 2:8, pages e246.
Crossref
Tracy G. Anthony, Brent J. McDaniel, Rachel L. Byerley, Barbara C. McGrath, Douglas R. Cavener, Margaret A. McNurlan & Ronald C. Wek. (2004) Preservation of Liver Protein Synthesis during Dietary Leucine Deprivation Occurs at the Expense of Skeletal Muscle Mass in Mice Deleted for eIF2 Kinase GCN2. Journal of Biological Chemistry 279:35, pages 36553-36561.
Crossref
Jana Narasimhan, Kirk A. Staschke & Ronald C. Wek. (2004) Dimerization Is Required for Activation of eIF2 Kinase Gcn2 in Response to Diverse Environmental Stress Conditions. Journal of Biological Chemistry 279:22, pages 22820-22832.
Crossref
J Richard Dickinson. 2004. Metabolism and Molecular Physiology of Saccharomyces Cerevisiae, 2nd Edition. Metabolism and Molecular Physiology of Saccharomyces Cerevisiae, 2nd Edition 104 116 .
Arthur Kruckeberg & J Richard Dickinson. 2004. Metabolism and Molecular Physiology of Saccharomyces Cerevisiae, 2nd Edition. Metabolism and Molecular Physiology of Saccharomyces Cerevisiae, 2nd Edition 42 103 .
R. Pries, K. Bömeke, O. Draht, M. Künzler & G. H. Braus. (2003) Nuclear import of yeast Gcn4p requires karyopherins Srp1p and Kap95p. Molecular Genetics and Genomics 271:3, pages 257-266.
Crossref
Olivier Deloche, Jesús de la Cruz, Dieter Kressler, Monique Doère & Patrick Linder. (2004) A Membrane Transport Defect Leads to a Rapid Attenuation of Translation Initiation in Saccharomyces cerevisiae. Molecular Cell 13:3, pages 357-366.
Crossref
G. H. Braus, R. Pries, K. Düvel & O. Valerius. 2004. Genetics and Biotechnology. Genetics and Biotechnology 239 269 .
Nigel G. Halford & Matthew J. Paul. (2003) Carbon metabolite sensing and signalling. Plant Biotechnology Journal 1:6, pages 381-398.
Crossref
Carlos J. Rodriguez-Hernandez, Isabel Sanchez-Perez, Rosario Gil-Mascarell, Abigail Rodríguez-Afonso, Armando Torres, Rosario Perona & José R. Murguía. (2003) The Immunosuppressant FK506 Uncovers a Positive Regulatory Cross-talk between the Hog1p and Gcn2p Pathways. Journal of Biological Chemistry 278:36, pages 33887-33895.
Crossref
Ruojing Yang & Christopher B. Newgard. (2003) Hepatic Expression of a Targeting Subunit of Protein Phosphatase-1 in Streptozotocin-diabetic Rats Reverses Hyperglycemia and Hyperphagia Despite Depressed Glucokinase Expression. Journal of Biological Chemistry 278:26, pages 23418-23425.
Crossref
LOTTE STEFFENSEN & PER AMSTRUP PEDERSEN. (2003) Responses at the Translational Level to Heterologous Expression of the Na,K-ATPase. Annals of the New York Academy of Sciences 986:1, pages 539-540.
Crossref
Vera A. Cherkasova & Alan G. Hinnebusch. (2003) Translational control by TOR and TAP42 through dephosphorylation of eIF2α kinase GCN2. Genes & Development 17:7, pages 859-872.
Crossref
Minerva Garcia-Barrio, Jinsheng Dong, Vera A. Cherkasova, Xiaolong Zhang, Fan Zhang, Sandra Ufano, Ruby Lai, Jun Qin & Alan G. Hinnebusch. (2002) Serine 577 Is Phosphorylated and Negatively Affects the tRNA Binding and eIF2α Kinase Activities of GCN2. Journal of Biological Chemistry 277:34, pages 30675-30683.
Crossref
James Fernandez, Barry Bode, Antonis Koromilas, J. Alan Diehl, Irene Krukovets, Martin D. Snider & Maria Hatzoglou. (2002) Translation Mediated by the Internal Ribosome Entry Site of the cat-1 mRNA Is Regulated by Glucose Availability in a PERK Kinase-dependent Manner. Journal of Biological Chemistry 277:14, pages 11780-11787.
Crossref
Lina Riego, Amaranta Avendaño, Alexander DeLuna, Ekaterina Rodrı́guez & Alicia González. (2002) GDH1 expression is regulated by GLN3, GCN4, and HAP4 under respiratory growth. Biochemical and Biophysical Research Communications 293:1, pages 79-85.
Crossref
Alan G. Hinnebusch & Krishnamurthy Natarajan. (2002) Gcn4p, a Master Regulator of Gene Expression, Is Controlled at Multiple Levels by Diverse Signals of Starvation and Stress. Eukaryotic Cell 1:1, pages 22-32.
Crossref
Thomas E. Dever. (2002) Gene-Specific Regulation by General Translation Factors. Cell 108:4, pages 545-556.
Crossref
James Fernandez, Ibrahim Yaman, William C. Merrick, Antonis Koromilas, Ronald C. Wek, Rushira Sood, Jack Hensold & Maria Hatzoglou. (2002) Regulation of Internal Ribosome Entry Site-mediated Translation by Eukaryotic Initiation Factor-2α Phosphorylation and Translation of a Small Upstream Open Reading Frame. Journal of Biological Chemistry 277:3, pages 2050-2058.
Crossref
Ruojing Yang, Liwei Cao, Rosa Gasa, Matthew J. Brady, A. Dean Sherry & Christopher B. Newgard. (2002) Glycogen-targeting Subunits and Glucokinase Differentially Affect Pathways of Glycogen Metabolism and Their Regulation in Hepatocytes. Journal of Biological Chemistry 277:2, pages 1514-1523.
Crossref
Alain Goossens, Thomas E. Dever, Amparo Pascual-Ahuir & Ramon Serrano. (2001) The Protein Kinase Gcn2p Mediates Sodium Toxicity in Yeast. Journal of Biological Chemistry 276:33, pages 30753-30760.
Crossref
Olav Grundmann, Hans-Ulrich Mösch & Gerhard H. Braus. (2001) Repression of GCN4 mRNA Translation by Nitrogen Starvation in Saccharomyces cerevisiae. Journal of Biological Chemistry 276:28, pages 25661-25671.
Crossref
Irit Marbach, Ruth Licht, Hanns Frohnmeyer & David Engelberg. (2001) Gcn2 Mediates Gcn4 Activation in Response to Glucose Stimulation or UV Radiation Not via GCN4 Translation. Journal of Biological Chemistry 276:20, pages 16944-16951.
Crossref
Hiroyuki Kubota, Kazuhisa Ota, Yoshiyuki Sakaki & Takashi Ito. (2001) Budding Yeast GCN1 Binds the GI Domain to Activate the eIF2α Kinase GCN2. Journal of Biological Chemistry 276:20, pages 17591-17596.
Crossref
Krishna M. Vattem, Kirk A. Staschke, Shuhao Zhu & Ronald C. Wek. (2001) Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2α (eIF2α). European Journal of Biochemistry 268:4, pages 1143-1153.
Crossref
Christopher G. Proud. 2001. Signaling Pathways for Translation. Signaling Pathways for Translation 95 114 .

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