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Molecular and Cellular Biology Volume 21, 2001 - Issue 16
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Mammalian Genetic Models with Minimal or Complex Phenotypes

Functional Analysis of Mouse Kinesin Motor Kif3C

Zhaohuai YangHoward Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California92093
,
Elizabeth A. RobertsHoward Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California92093
&
Lawrence S. B. GoldsteinHoward Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California92093Correspondence[email protected]
Pages 5306-5311 | Received 26 Feb 2001, Accepted 30 May 2001, Published online: 28 Mar 2023

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Gabrielle Wheway, David A Parry & Colin A Johnson. (2014) The role of primary cilia in the development and disease of the retina. Organogenesis 10:1, pages 69-85.
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Jarema Malicki. (2012) Who drives the ciliary highway?. BioArchitecture 2:4, pages 111-117.
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Chen Du, Danli Mu, Xinming Gao, Shengyu Luo, Jianping Wang, Shan Jin & Junquan Zhu. (2022) Expression Characteristics and Putative Functions of KIF3A/KIF3B During Spermiogenesis of Phascolosoma esculenta. Journal of Ocean University of China 21:4, pages 998-1016.
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Mingxia Yao, Haoyang Qu, Yating Han, C. Yan Cheng & Xiang Xiao. (2022) Kinesins in Mammalian Spermatogenesis and Germ Cell Transport. Frontiers in Cell and Developmental Biology 10.
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Honggui Ma, Facai Zhang, Quliang Zhong & Jianquan Hou. (2021) METTL3-mediated m6A modification of KIF3C-mRNA promotes prostate cancer progression and is negatively regulated by miR-320d. Aging 13:18, pages 22332-22344.
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Donovan A. Christman, Haley N. Curry & Labib Rouhana. (2021) Heterotrimeric Kinesin II is required for flagellar assembly and elongation of nuclear morphology during spermiogenesis in Schmidtea mediterranea. Developmental Biology 477, pages 191-204.
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Yang Gao, Hui Zheng, Liangdong Li, Changshuai Zhou, Xin Chen, Xiaoyan Zhou & Yiqun Cao. (2020) KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT. BioMed Research International 2020, pages 1-10.
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Yang Gao, Liangdong Li, Hui Zheng, Changshuai Zhou, Xin Chen, Bin Hao & Yiqun Cao. (2020) KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway. Journal of Neuro-Oncology 146:3, pages 513-521.
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Stephanie K. Deeb, Stephanie Guzik-Lendrum, Jasper D. Jeffrey & Susan P. Gilbert. (2019) The ability of the kinesin-2 heterodimer KIF3AC to navigate microtubule networks is provided by the KIF3A motor domain. Journal of Biological Chemistry 294:52, pages 20070-20083.
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Martin F. Engelke, Bridget Waas, Sarah E. Kearns, Ayana Suber, Allison Boss, Benjamin L. Allen & Kristen J. Verhey. (2019) Acute Inhibition of Heterotrimeric Kinesin-2 Function Reveals Mechanisms of Intraflagellar Transport in Mammalian Cilia. Current Biology 29:7, pages 1137-1148.e4.
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Susan P. Gilbert, Stephanie Guzik-Lendrum & Ivan Rayment. (2018) Kinesin-2 motors: Kinetics and biophysics. Journal of Biological Chemistry 293:12, pages 4510-4518.
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Stephanie Guzik-Lendrum, Ivan Rayment & Susan P. Gilbert. (2017) Homodimeric Kinesin-2 KIF3CC Promotes Microtubule Dynamics. Biophysical Journal 113:8, pages 1845-1857.
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Nicole J. Camlin, Eileen A. McLaughlin & Janet E. Holt. (2017) Motoring through: the role of kinesin superfamily proteins in female meiosis. Human Reproduction Update 23:4, pages 409-420.
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Nele Schwarz, Amelia Lane, Katarina Jovanovic, David A. Parfitt, Monica Aguila, Clare L. ThompsonLyndon da Cruz, Peter J. Coffey, J. Paul Chapple, Alison J. Hardcastle & Michael E. Cheetham. (2017) Arl3 and RP2 regulate the trafficking of ciliary tip kinesins. Human Molecular Genetics 26:13, pages 2480-2492.
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V. Gache, E. R. Gomes & B. Cadot. (2017) Microtubule motors involved in nuclear movement during skeletal muscle differentiation. Molecular Biology of the Cell 28:7, pages 865-874.
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Mu He, Stephanie Agbu & Kathryn V. Anderson. (2017) Microtubule Motors Drive Hedgehog Signaling in Primary Cilia. Trends in Cell Biology 27:2, pages 110-125.
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Rakesh K. Raghupathy, Xun Zhang, Reem H. Alhasani, Xinzhi Zhou, Margaret Mullin, James Reilly, Wenchang Li, Mugen Liu & Xinhua Shu. (2016) Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish . Cell Biochemistry and Function 34:6, pages 429-440.
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Pengwei Zhang, Ivan Rayment & Susan P. Gilbert. (2016) Fast or Slow, Either Head Can Start the Processive Run of Kinesin-2 KIF3AC. Journal of Biological Chemistry 291:9, pages 4407-4416.
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Chengqin Wang, Chenggang Wang, Zhimin Wei, Yujun Li, Wenhong Wang, Xia Li, Jing Zhao, Xuan Zhou, Xun Qu & Fenggang Xiang. (2015) Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-β signaling. Cancer Letters 368:1, pages 105-114.
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Stephanie Guzik-Lendrum, Katherine C. Rank, Brandon M. Bensel, Keenan C. Taylor, Ivan Rayment & Susan P. Gilbert. (2015) Kinesin-2 KIF3AC and KIF3AB Can Drive Long-Range Transport along Microtubules. Biophysical Journal 109:7, pages 1472-1482.
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Brandon S. Carpenter, Renee L. Barry, Kristen J. Verhey & Benjamin L. Allen. (2015) The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function. Journal of Cell Science.
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Joost R. Broekhuis, Weng Y. Leong & Gert Jansen. 2013. 101 138 .
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Maria Pantelidou, Spyros E. Zographos, Carsten W. Lederer, Theodore Kyriakides, Michael W. Pfaffl & Niovi Santama. (2007) Differential expression of molecular motors in the motor cortex of sporadic ALS. Neurobiology of Disease 26:3, pages 577-589.
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Mark S. Miller, Jessica M. Esparza, Andrew M. Lippa, Fordyce G. LuxIIIIII, Douglas G. Cole & Susan K. Dutcher. (2005) Mutant Kinesin-2 Motor Subunits Increase Chromosome Loss. Molecular Biology of the Cell 16:8, pages 3810-3820.
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Joshua J. Snow, Guangshuo Ou, Amy L. Gunnarson, M. Regina S. Walker, H. Mimi Zhou, Ingrid Brust-Mascher & Jonathan M. Scholey. (2004) Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons. Nature Cell Biology 6:11, pages 1109-1113.
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Bhupinder Bhullar, Ying Zhang, Albert Junco, Richard Oko & Frans A. van der Hoorn. (2003) Association of Kinesin Light Chain with Outer Dense Fibers in a Microtubule-independent Fashion. Journal of Biological Chemistry 278:18, pages 16159-16168.
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