Advanced search
Publication Cover
Molecular and Cellular Biology Volume 21, 2001 - Issue 16
Submit an article Journal homepage
59
Views
203
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Negative Regulation of Protein Translation by Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2

Ursula KnaufArthritis and Bone Metabolism, Novartis Pharma AG, CH-4002Basel, Switzerland
,
Claude TschoppArthritis and Bone Metabolism, Novartis Pharma AG, CH-4002Basel, Switzerland
&
Hermann GramArthritis and Bone Metabolism, Novartis Pharma AG, CH-4002Basel, SwitzerlandCorrespondence[email protected]
Pages 5500-5511 | Received 15 Feb 2001, Accepted 24 May 2001, Published online: 28 Mar 2023

Citations (203)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (13)

Candice Mazewski & Leonidas C Platanias. (2023) MNK Proteins as Therapeutic Targets in Leukemia. OncoTargets and Therapy 16, pages 283-295.
Read now
Philippe P. Roux & Ivan Topisirovic. (2018) Signaling Pathways Involved in the Regulation of mRNA Translation. Molecular and Cellular Biology 38:12.
Read now
Neethi Nandagopal & Philippe P Roux. (2015) Regulation of global and specific mRNA translation by the mTOR signaling pathway. Translation 3:1.
Read now
Filippa Pettersson, Sonia V del Rincon & Wilson H Miller$suffix/text()$suffix/text(). (2014) Eukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond. Expert Opinion on Therapeutic Targets 18:9, pages 1035-1048.
Read now
Mayya Shveygert, Constanze Kaiser, Shelton S. Bradrick & Matthias Gromeier. (2010) Regulation of Eukaryotic Initiation Factor 4E (eIF4E) Phosphorylation by Mitogen-Activated Protein Kinase Occurs through Modulation of Mnk1-eIF4G Interaction. Molecular and Cellular Biology 30:21, pages 5160-5167.
Read now
Min Zhang, Wuxia Fu, Sharmila Prabhu, James C. Moore, Je Ko, Jung Woo Kim, Brian J. Druker, Valerie Trapp, John Fruehauf, Hermann Gram, Hung Y. Fan & S. Tiong Ong. (2008) Inhibition of Polysome Assembly Enhances Imatinib Activity against Chronic Myelogenous Leukemia and Overcomes Imatinib Resistance. Molecular and Cellular Biology 28:20, pages 6496-6509.
Read now
Derek Walsh, Carolina Arias, Cesar Perez, David Halladin, Martin Escandon, Takeshi Ueda, Rie Watanabe-Fukunaga, Rikiro Fukunaga & Ian Mohr. (2008) Eukaryotic Translation Initiation Factor 4F Architectural Alterations Accompany Translation Initiation Factor Redistribution in Poxvirus-Infected Cells. Molecular and Cellular Biology 28:8, pages 2648-2658.
Read now
Gabriel Mbalaviele & Joseph B Monahan. (2008) Mechanisms of the joint-protective effects of p38 MAPK inhibitors in rodent arthritis. Expert Opinion on Drug Discovery 3:2, pages 163-172.
Read now
Xuerong Wang, Ping Yue, Chi-Bun Chan, Keqiang Ye, Takeshi Ueda, Rie Watanabe-Fukunaga, Rikiro Fukunaga, Haian Fu, Fadlo R. Khuri & Shi-Yong Sun. (2007) Inhibition of Mammalian Target of Rapamycin Induces Phosphatidylinositol 3-Kinase-Dependent and Mnk-Mediated Eukaryotic Translation Initiation Factor 4E Phosphorylation. Molecular and Cellular Biology 27:21, pages 7405-7413.
Read now
Matthew Brook, Carmen R. Tchen, Tomas Santalucia, Joanne McIlrath, J. Simon C. Arthur, Jeremy Saklatvala & Andrew R. Clark. (2006) Posttranslational Regulation of Tristetraprolin Subcellular Localization and Protein Stability by p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Kinase Pathways. Molecular and Cellular Biology 26:6, pages 2408-2418.
Read now
John DaSilva, Lizhong Xu, Hong Joo Kim, W. Todd Miller & Dafna Bar-Sagi. (2006) Regulation of Sprouty Stability by Mnk1-Dependent Phosphorylation. Molecular and Cellular Biology 26:5, pages 1898-1907.
Read now
Takeshi Ueda, Rie Watanabe-Fukunaga, Hidehiro Fukuyama, Shigekazu Nagata & Rikiro Fukunaga. (2004) Mnk2 and Mnk1 Are Essential for Constitutive and Inducible Phosphorylation of Eukaryotic Initiation Factor 4E but Not for Cell Growth or Development. Molecular and Cellular Biology 24:15, pages 6539-6549.
Read now
Paul Shapiro. (2002) Ras-MAP Kinase Signaling Pathways and Control of Cell Proliferation: Relevance to Cancer Therapy. Critical Reviews in Clinical Laboratory Sciences 39:4-5, pages 285-330.
Read now

Articles from other publishers (190)

Xin Jin, Tingting Qiu, Li Li, Rilei Yu, Xiguang Chen, Changgui Li, Christopher G. Proud & Tao Jiang. (2023) Pathophysiology of obesity and its associated diseases. Acta Pharmaceutica Sinica B 13:6, pages 2403-2424.
Crossref
Elaiyaraja Subramanian, Ahmed Elewa, Gonçalo Brito, Anoop Kumar, Åsa Segerstolpe, Christos Karampelias, Åsa Björklund, Rickard Sandberg, Karen Echeverri, Weng-Onn Lui, Olov Andersson & András Simon. (2023) A small noncoding RNA links ribosome recovery and translation control to dedifferentiation during salamander limb regeneration. Developmental Cell 58:6, pages 450-460.e6.
Crossref
Bhanu Kanth Manne, Robert A. Campbell, Seema Bhatlekar, Abigail Ajanel, Frederik Denorme, Irina Portier, Elizabeth A. Middleton, Neal D. Tolley, Yasuhiro Kosaka, Emilie Montenont, Li Guo, Jesse W. Rowley, Paul F. Bray, Shancy Jacob, Rikiro Fukanaga, Christopher Proud, Andrew S. Weyrich & Matthew T. Rondina. (2022) MAPK-interacting kinase 1 regulates platelet production, activation, and thrombosis. Blood 140:23, pages 2477-2489.
Crossref
Samuel E.J. Preston, Margarita Bartish, Vincent R. Richard, Arash Aghigh, Christophe Gonçalves, Julian Smith-Voudouris, Fan Huang, Paméla Thébault, Aurélie Cleret-Buhot, Réjean Lapointe, François Légaré, Lynne-Marie Postovit, René P. Zahedi, Christoph H. Borchers, Wilson H. Miller Jr.Sonia V. del Rincón. (2022) Phosphorylation of eIF4E in the stroma drives the production and spatial organisation of collagen type I in the mammary gland. Matrix Biology 111, pages 264-288.
Crossref
Xin Jin, Maowei Li, Tingting Qiu, Rilei Yu & Tao Jiang. (2022) Design, Synthesis and Evaluation of Novel Phorbazole C Derivatives as MNK Inhibitors through Virtual High-Throughput Screening. Marine Drugs 20:7, pages 429.
Crossref
Thao N.D. Pham, Christina Spaulding, Mario A. Shields, Anastasia E. Metropulos, Dhavan N. Shah, Mahmoud G. Khalafalla, Daniel R. Principe, David J. Bentrem & Hidayatullah G. Munshi. (2022) Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8+ T cell antitumor immunity. JCI Insight 7:9.
Crossref
Bing-Rui Chen, Tian-Wen Wei, Chun-Ping Tang, Jia-Teng Sun, Tian-Kai Shan, Yi Fan, Tong-Tong Yang, Ya-Fei Li, Yao Ma, Si-Bo Wang, Zi-Mu Wang, Hao Wang, Jian-Zhou Shi, Liu Liu, Jia-Wen Chen, Liu-Hua Zhou, Chong Du, Rui Sun, Qi-Ming Wang & Lian-Sheng Wang. (2022) MNK2-eIF4E axis promotes cardiac repair in the infarcted mouse heart by activating cyclin D1. Journal of Molecular and Cellular Cardiology 166, pages 91-106.
Crossref
Jordan B. Metz, Nicholas J. Hornstein, Sohani Das Sharma, Jeremy Worley, Christian Gonzalez & Peter A. Sims. (2022) High-throughput translational profiling with riboPLATE-seq. Scientific Reports 12:1.
Crossref
Alice Romagnoli, Mattia D’Agostino, Chiara Ardiccioni, Cristina Maracci, Stefano Motta, Anna La Teana & Daniele Di Marino. (2021) Control of the eIF4E activity: structural insights and pharmacological implications. Cellular and Molecular Life Sciences 78:21-22, pages 6869-6885.
Crossref
Kleanthi Chalkiadaki, Elpida Statoulla, Maria Markou, Sofia Bellou, Eleni Bagli, Theodore Fotsis, Carol Murphy & Christos G. Gkogkas. (2021) Translational control in neurovascular brain development. Royal Society Open Science 8:10.
Crossref
Su Wu & Gerhard Wagner. (2021) Deep computational analysis details dysregulation of eukaryotic translation initiation complex eIF4F in human cancers. Cell Systems 12:9, pages 907-923.e6.
Crossref
Xin Jin, Rilei Yu, Xuemin Wang, Christopher G. Proud & Tao Jiang. (2021) Progress in developing MNK inhibitors. European Journal of Medicinal Chemistry 219, pages 113420.
Crossref
Xin-Yu Ke, Ye Chen, Valarie Yu-Yan Tham, Ruby Yu-Tong Lin, Pushkar Dakle, Kassoum Nacro, Mark Edward Puhaindran, Peter Houghton, Angela Pang, Victor Kwanmin Lee, Ling-Wen Ding, Sigal Gery, Jeffrey Hill, Leilei Chen, Liang Xu & H. Phillip Koeffler. (2021) MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma. Oncogene 40:10, pages 1851-1867.
Crossref
Agnieszka Dreas, Katarzyna Kucwaj-Brysz, Karolina Pyziak, Urszula Kulesza, Ewelina Wincza, Charles-Henry Fabritius, Kinga Michalik, Ewelina Gabor-Worwa, Aniela Gołas, Mariusz Milik, Magdalena Masiejczyk, Eliza Majewska, Kazimiera Pyśniak, Urszula Wójcik-Trechcińska, Zuzanna Sandowska-Markiewicz, Krzysztof Brzózka, Jerzy Ostrowski, Tomasz Rzymski & Michal Mikula. (2021) Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock. European Journal of Medicinal Chemistry 213, pages 113057.
Crossref
Cuiqing FanChuntao Zhao, Feng ZhangMeenu Kesarwani, Zhaowei Tu, Xiongwei CaiAshley Kuenzi Davis, Lingli XuCindy L. HochstetlerXiaoyi ChenFukun GuoGang Huang, Mohammad Azam, Weidong TianQ. Richard Lu & Yi Zheng. (2020) Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition . Proceedings of the National Academy of Sciences 118:1.
Crossref
Jaebeom Cho, Hye-Young Min, Ho Jin Lee, Seung Yeob Hyun, Jeong Yeon Sim, Myungkyung Noh, Su Jung Hwang, Shin-Hyung Park, Hye-Jin Boo, Hyo-Jong Lee, Sungyoul Hong, Rang-Woon Park, Young Kee Shin, Mien-Chie Hung & Ho-Young Lee. (2021) RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse. Journal of Clinical Investigation 131:1.
Crossref
Muhammad Saad Yousuf, Stephanie I. Shiers, James J. Sahn & Theodore J. Price. (2020) Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain. Pharmacological Reviews 73:1, pages 59-88.
Crossref
Tarjani Shukla, June Bryan de la Peña, John M. Perish, Jonathan E. Ploski, Craig R. Stumpf, Kevin R. Webster, Catherine A. Thorn & Zachary T. Campbell. (2020) A Highly Selective MNK Inhibitor Rescues Deficits Associated with Fragile X Syndrome in Mice. Neurotherapeutics 18:1, pages 624-639.
Crossref
Sylvain de Breyne, Caroline Vindry, Olivia Guillin, Lionel Condé, Fabrice Mure, Henri Gruffat, Laurent Chavatte & Théophile Ohlmann. (2020) Translational control of coronaviruses. Nucleic Acids Research 48:22, pages 12502-12522.
Crossref
Xiaotong Yang, Wu Zhong & Ruifeng Cao. (2020) Phosphorylation of the mRNA cap-binding protein eIF4E and cancer. Cellular Signalling 73, pages 109689.
Crossref
Celia Pinto-Díez, Raquel Ferreras-Martín, Rebeca Carrión-Marchante, Víctor M. González & María Elena Martín. (2020) Deeping in the Role of the MAP-Kinases Interacting Kinases (MNKs) in Cancer. International Journal of Molecular Sciences 21:8, pages 2967.
Crossref
Oro Uchenunu, Michael Pollak, Ivan Topisirovic & Laura Hulea. (2019) Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia. Journal of Molecular Endocrinology 62:2, pages R83-R103.
Crossref
Thao N.D. Pham, Krishan Kumar, Brian T. DeCant, Meng Shang, Samad Z. Munshi, Maria Matsangou, Kazumi Ebine & Hidayatullah G. Munshi. (2019) Induction of MNK Kinase–dependent eIF4E Phosphorylation by Inhibitors Targeting BET Proteins Limits Efficacy of BET Inhibitors. Molecular Cancer Therapeutics 18:2, pages 235-244.
Crossref
Xinrui Yuan, Hanshu Wu, Hong Bu, Jinpei Zhou & Huibin Zhang. (2019) Targeting the immunity protein kinases for immuno-oncology. European Journal of Medicinal Chemistry 163, pages 413-427.
Crossref
Ram Kumar, Nitin Khandelwal, Yogesh Chander, Thachamvally Riyesh, Bhupendra N. Tripathi, Sudhir Kumar Kashyap, Sanjay Barua, Sunil Maherchandani & Naveen Kumar. (2018) MNK1 inhibitor as an antiviral agent suppresses buffalopox virus protein synthesis. Antiviral Research 160, pages 126-136.
Crossref
Inês S. Amorim, Gilliard Lach & Christos G. Gkogkas. (2018) The Role of the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Neuropsychiatric Disorders. Frontiers in Genetics 9.
Crossref
Ashwin Sriram, Jonathan Bohlen & Aurelio A Teleman. (2018) Translation acrobatics: how cancer cells exploit alternate modes of translational initiation. EMBO reports 19:10.
Crossref
Huy-Dung Hoang, Tyson E. Graber & Tommy Alain. (2018) Battling for Ribosomes: Translational Control at the Forefront of the Antiviral Response. Journal of Molecular Biology 430:14, pages 1965-1992.
Crossref
Haiyan Yang, Lohitha Rao Chennamaneni, Melvyn Wai Tuck Ho, Shi Hua Ang, Eldwin Sum Wai Tan, Duraiswamy Athisayamani Jeyaraj, Yoon Sheng Yeap, Boping Liu, Esther Hq Ong, Joma Kanikadu Joy, John Liang Kuan Wee, Perlyn Kwek, Priya Retna, Nurul Dinie, Thuy Thi Hanh Nguyen, Shi Jing Tai, Vithya Manoharan, Vishal Pendharkar, Choon Bing Low, Yun Shan Chew, Susmitha Vuddagiri, Kanda Sangthongpitag, Meng Ling Choong, May Ann Lee, Srinivasaraghavan Kannan, Chandra S. Verma, Anders Poulsen, Sharon Lim, Charles Chuah, Tiong Sin Ong, Jeffrey Hill, Alex Matter & Kassoum Nacro. (2018) Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia. Journal of Medicinal Chemistry 61:10, pages 4348-4369.
Crossref
Santiago Ramon y Cajal, Josep Castellvi, Stefan Hümmer, Vicente Peg, Jerry Pelletier & Nahum Sonenberg. (2018) Beyond molecular tumor heterogeneity: protein synthesis takes control. Oncogene 37:19, pages 2490-2501.
Crossref
Siegfried H. Reich, Paul A. Sprengeler, Gary G. Chiang, James R. Appleman, Joan Chen, Jeff Clarine, Boreth Eam, Justin T. Ernst, Qing Han, Vikas K. Goel, Edward Z. R. Han, Vera Huang, Ivy N. J. Hung, Adrianna Jemison, Katti A. Jessen, Jolene Molter, Douglas Murphy, Melissa Neal, Gregory S. Parker, Michael Shaghafi, Samuel Sperry, Jocelyn Staunton, Craig R. Stumpf, Peggy A. Thompson, Chinh Tran, Stephen E. Webber, Christopher J. Wegerski, Hong Zheng & Kevin R. Webster. (2018) Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. Journal of Medicinal Chemistry 61:8, pages 3516-3540.
Crossref
Todd Bell, Virginia Espina, Lindsay Lundberg, Chelsea Pinkham, Ashwini Brahms, Brian Carey, Shih-Chao Lin, Bibha Dahal, Caitlin Woodson, Cynthia de la Fuente, Lance Liotta, Charles Bailey & Kylene Kehn-Hall. (2018) Combination Kinase Inhibitor Treatment Suppresses Rift Valley Fever Virus Replication. Viruses 10:4, pages 191.
Crossref
Inês S. Amorim, Sonal Kedia, Stella Kouloulia, Konstanze Simbriger, Ilse Gantois, Seyed Mehdi Jafarnejad, Yupeng Li, Agniete Kampaite, Tine Pooters, Nicola Romanò & Christos G. Gkogkas. (2018) Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation. The Journal of Neuroscience 38:8, pages 2118-2133.
Crossref
Jennifer Chu, Santiago Ramon y Cajal, Nahum Sonenberg & Jerry Pelletier. (2018) Eukaryotic initiation factor 4F — sidestepping resistance mechanisms arising from expression heterogeneity. Current Opinion in Genetics & Development 48, pages 89-96.
Crossref
Srinivasaraghavan Kannan, Mohan R. Pradhan, Joseph Cherian, Thomas L. Joseph, Zhi Ying Poh, Yang Hai Yan, Ho Melvyn, Liu Boping, Hill Jeffrey, Kassoum Nacro & Chandra S. Verma. (2017) Small Molecules Targeting the Inactive Form of the Mnk1/2 Kinases. ACS Omega 2:11, pages 7881-7891.
Crossref
Phillip A. Geter, Amanda W. Ernlund, Sofia Bakogianni, Amandine Alard, Rezina Arju, Shah Giashuddin, Abhilash Gadi, Jacqueline Bromberg & Robert J. Schneider. (2017) Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming. Genes & Development 31:22, pages 2235-2249.
Crossref
Xi Ma, Meng Han, Defa Li, Shengdi Hu, Kyler R. Gilbreath, Fuller W. Bazer & Guoyao Wu. (2017) l-Arginine promotes protein synthesis and cell growth in brown adipocyte precursor cells via the mTOR signal pathway. Amino Acids 49:5, pages 957-964.
Crossref
Susann Santag, Franziska Siegel, Antje M. Wengner, Claudia Lange, Ulf Bömer, Knut Eis, Florian Pühler, Philip Lienau, Linda Bergemann, Martin Michels, Franz von Nussbaum, Dominik Mumberg & Kirstin Petersen. (2017) BAY 1143269, a novel MNK1 inhibitor, targets oncogenic protein expression and shows potent anti-tumor activity. Cancer Letters 390, pages 21-29.
Crossref
Kun Hu, Juan Zhang, Min Yu & Chang'e Xiong. (2017) Inhibition of Mnk–eIF4E pathway sensitizes the efficacy to chemotherapy in anaplastic thyroid cancer. Future Oncology 13:6, pages 489-498.
Crossref
Michael C. Brown & Matthias Gromeier. (2017) MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1. Cell Reports 18:6, pages 1444-1457.
Crossref
Zhiqiang Li, Yang Sun, Miao Qu, Hongxing Wan, Fang Cai & Peng Zhang. (2016) Inhibiting the MNK-eIF4E-β-catenin axis increases the responsiveness of aggressive breast cancer cells to chemotherapy. Oncotarget 8:2, pages 2906-2915.
Crossref
Qin Song, Qiheng Gou, Yuxin Xie, Zhen Zhang & Chaomei Fu. (2017) Periplaneta americana Extracts Promote Skin Wound Healing via Nuclear Factor Kappa B Canonical Pathway and Extracellular Signal-Regulated Kinase Signaling . Evidence-Based Complementary and Alternative Medicine 2017, pages 1-12.
Crossref
Mauro Costa-Mattioli & Eric Klann. 2017. Learning and Memory: A Comprehensive Reference. Learning and Memory: A Comprehensive Reference 311 328 .
Yeon-Ho Chung, Dong-Hyun Kim & Won-Woo Lee. (2016) Monosodium urate crystal-induced pro-interleukin-1β production is post-transcriptionally regulated via the p38 signaling pathway in human monocytes. Scientific Reports 6:1.
Crossref
Michal Grzmil, Jan Seebacher, Daniel Hess, Martin Behe, Roger Schibli, Gerald Moncayo, Stephan Frank & Brian A. Hemmings. (2016) Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy. Cellular Signalling 28:9, pages 1412-1421.
Crossref
Yumiko Komatsu, Leena Derwish & Kensuke Hirasawa. (2016) IRF1 Downregulation by Ras/MEK Is Independent of Translational Control of IRF1 mRNA. PLOS ONE 11:8, pages e0160529.
Crossref
Qiuyuan Wen, Weiyuan Wang, Jiadi Luo, Shuzhou Chu, Lingjiao Chen, Lina Xu, Hongjing Zang, Mohannad Ma Alnemah, Jian Ma & Songqing Fan. (2016) CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway. Oncotarget 7:19, pages 27787-27801.
Crossref
Rebecca Lock, Rachel Ingraham, Ophélia Maertens, Abigail L. Miller, Nelly Weledji, Eric Legius, Bruce M. Konicek, Sau-Chi B. Yan, Jeremy R. Graff & Karen Cichowski. (2016) Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers. Journal of Clinical Investigation 126:6, pages 2181-2190.
Crossref
Wooseok Han, Yu Ding, Yongjin Xu, Keith Pfister, Shejin Zhu, Bob Warne, Mike Doyle, Mina Aikawa, Payman Amiri, Brent Appleton, Darrin D. Stuart, Abdallah Fanidi & Cynthia M. Shafer. (2016) Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design. Journal of Medicinal Chemistry 59:7, pages 3034-3045.
Crossref
Sarah Diab, Peng Li, Sunita KC Basnet, Jingfeng Lu, Mingfeng Yu, Hugo Albrecht, Robert W Milne & Shudong Wang. (2016) Unveiling new chemical scaffolds as Mnk inhibitors. Future Medicinal Chemistry 8:3, pages 271-285.
Crossref
K-S Hsu, B-J Guan, X Cheng, D Guan, M Lam, M Hatzoglou & H-Y Kao. (2015) Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs. Cell Death & Differentiation 23:3, pages 469-483.
Crossref
Nadejda L. Korneeva, Anren Song, Hermann Gram, Mary Ann Edens & Robert E. Rhoads. (2016) Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5′-Terminal Cap and Hairpin. Journal of Biological Chemistry 291:7, pages 3455-3467.
Crossref
Julia H Carter, James A Deddens, Nelson Reed Spaulding IV, Denise Lucas, Bruce M Colligan, Thomas Grant Lewis, Elyse Hawkins, Jordan Jones, Jackson O Pemberton, Larry E Douglass & Jeremy R Graff. (2016) Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma. British Journal of Cancer 114:4, pages 444-453.
Crossref
Nizar A. HusseinTaylor L. DelaneyBrittany L. TounselFaith L.W. Liebl. (2016) The Extracellular-Regulated Kinase Effector Lk6 is Required for Glutamate Receptor Localization at the Drosophila Neuromuscular Junction . Journal of Experimental Neuroscience 10, pages JEN.S32840.
Crossref
Eva M García-Recio, Celia Pinto-Díez, M Isabel Pérez-Morgado, Marta García-Hernández, Gerónimo Fernández, M Elena Martín & Víctor M González. (2016) Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells. Molecular Therapy - Nucleic Acids 5, pages e275.
Crossref
Chunwan Lu, Levi Makala, Daqing Wu & Yafei Cai. (2016) Targeting translation: eIF4E as an emerging anticancer drug target. Expert Reviews in Molecular Medicine 18.
Crossref
IJsbrand M. Kramer. 2016. Signal Transduction. Signal Transduction 589 654 .
Nadeem Siddiqui & Nahum Sonenberg. (2015) Signalling to eIF4E in cancer. Biochemical Society Transactions 43:5, pages 763-772.
Crossref
Beichen Gao & Philippe P. Roux. (2015) Translational control by oncogenic signaling pathways. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1849:7, pages 753-765.
Crossref
Ruifeng Cao, Christos G Gkogkas, Nuria de Zavalia, Ian D Blum, Akiko Yanagiya, Yoshinori Tsukumo, Haiyan Xu, Choogon Lee, Kai-Florian Storch, Andrew C Liu, Shimon Amir & Nahum Sonenberg. (2015) Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nature Neuroscience 18:6, pages 855-862.
Crossref
Mingfeng Yu, Peng Li, Sunita K.C. Basnet, Malika Kumarasiri, Sarah Diab, Theodosia Teo, Hugo Albrecht & Shudong Wang. (2015) Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure–activity relationship analysis and biological evaluation. European Journal of Medicinal Chemistry 95, pages 116-126.
Crossref
N Robichaud, S V del Rincon, B Huor, T Alain, L A Petruccelli, J Hearnden, C Goncalves, S Grotegut, C H Spruck, L Furic, O Larsson, W J Muller, W H Miller & N Sonenberg. (2014) Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3. Oncogene 34:16, pages 2032-2042.
Crossref
Mamatha Bhat, Nathaniel Robichaud, Laura Hulea, Nahum Sonenberg, Jerry Pelletier & Ivan Topisirovic. (2015) Targeting the translation machinery in cancer. Nature Reviews Drug Discovery 14:4, pages 261-278.
Crossref
Malika Kumarasiri, Theodosia Teo & Shudong Wang. (2015) Dynamical insights of Mnk2 kinase activation by phosphorylation to facilitate inhibitor discovery. Future Medicinal Chemistry 7:2, pages 91-102.
Crossref
Michelle C. Dumoulin, Sara J. Aton, Adam J. Watson, Leslie Renouard, Tammi Coleman & Marcos G. Frank. (2015) Extracellular Signal-Regulated Kinase (ERK) Activity During Sleep Consolidates Cortical Plasticity In Vivo. Cerebral Cortex 25:2, pages 507-515.
Crossref
Jerry Pelletier, Jeremy Graff, Davide Ruggero & Nahum Sonenberg. (2015) Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development. Cancer Research 75:2, pages 250-263.
Crossref
Srinivasaraghavan Kannan, Anders Poulsen, Hai Yan Yang, Melvyn Ho, Shi Hua Ang, Tan Sum Wai Eldwin, Duraiswamy Athisayamani Jeyaraj, Lohitha Rao Chennamaneni, Boping Liu, Jeffrey Hill, Chandra S. Verma & Kassoum Nacro. (2014) Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations. Biochemistry 54:1, pages 32-46.
Crossref
Ari L. Landon, Parameswary A. Muniandy, Amol C. Shetty, Elin Lehrmann, Laurent Volpon, Simone Houng, Yongqing Zhang, Bojie Dai, Raymond Peroutka, Krystyna Mazan-Mamczarz, James Steinhardt, Anup Mahurkar, Kevin G. Becker, Katherine L. Borden & Ronald B. Gartenhaus. (2014) MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL. Nature Communications 5:1.
Crossref
Weiwei Wang, Zhenlong Wu, Gang Lin, Shengdi Hu, Bin Wang, Zhaolai Dai & Guoyao Wu. (2014) Glycine Stimulates Protein Synthesis and Inhibits Oxidative Stress in Pig Small Intestinal Epithelial Cells. The Journal of Nutrition 144:10, pages 1540-1548.
Crossref
Yu Miyagaki, Yoshinori Kanemori, Fumi Tanaka & Tadashi Baba. (2014) Possible Role of p38 MAPK-MNK1-EMI2 Cascade in Metaphase-II Arrest of Mouse Oocytes1. Biology of Reproduction 91:2.
Crossref
Yijiang Shi, Patrick Frost, Bao Hoang, Yonghui Yang, Carolyne Bardeleben, Joseph Gera & Alan Lichtenstein. (2014) MNK1-Induced eIF-4E Phosphorylation in Myeloma Cells: A Pathway Mediating IL-6-Induced Expansion and Expression of Genes Involved in Metabolic and Proteotoxic Responses. PLoS ONE 9:4, pages e94011.
Crossref
Sarah Diab, Malika Kumarasiri, Mingfeng Yu, Theodosia Teo, Christopher Proud, Robert Milne & Shudong Wang. (2014) MAP Kinase-Interacting Kinases—Emerging Targets against Cancer. Chemistry & Biology 21:4, pages 441-452.
Crossref
Avraham Maimon, Maxim Mogilevsky, Asaf Shilo, Regina Golan-Gerstl, Akram Obiedat, Vered Ben-Hur, Ilana Lebenthal-Loinger, Ilan Stein, Reuven Reich, Jonah Beenstock, Eldar Zehorai, Claus L. Andersen, Kasper Thorsen, Torben F. Ørntoft, Roger J. Davis, Ben Davidson, David Mu & Rotem Karni. (2014) Mnk2 Alternative Splicing Modulates the p38-MAPK Pathway and Impacts Ras-Induced Transformation. Cell Reports 7:2, pages 501-513.
Crossref
Michal Grzmil, Roland M. Huber, Daniel Hess, Stephan Frank, Debby Hynx, Gerald Moncayo, Dominique Klein, Adrian Merlo & Brian A. Hemmings. (2014) MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas. Journal of Clinical Investigation 124:2, pages 742-754.
Crossref
David A. Fruman & Christian Rommel. (2014) PI3K and cancer: lessons, challenges and opportunities. Nature Reviews Drug Discovery 13:2, pages 140-156.
Crossref
Senthilmurugan Ramalingam, Lalji Gediya, Andrew K. Kwegyir-Afful, Vidya P. Ramamurthy, Puranik Purushottamachar, Hannah Mbatia & Vincent C. O. Njar. (2014) First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines. Oncotarget 5:2, pages 530-543.
Crossref
Gabriela Galicia-Vázquez & Jerry Pelletier. 2014. Translation and Its Regulation in Cancer Biology and Medicine. Translation and Its Regulation in Cancer Biology and Medicine 279 304 .
Samira Ziaei & Naoko Shimada. 2014. Tumor Dormancy, Quiescence, and Senescence, Volume 2. Tumor Dormancy, Quiescence, and Senescence, Volume 2 111 119 .
Sharon LimTzuen Yih SawMin ZhangMatthew R. JanesKassoum NacroJeffrey HillAn Qi LimChia-Tien ChangDavid A. FrumanDavid A. RizzieriSoo Yong Tan, Hung FanCharles T. H. ChuahS. Tiong Ong. (2013) Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function. Proceedings of the National Academy of Sciences 110:25.
Crossref
Martin CarrollKatherine L.B. Borden. (2013) The Oncogene eIF4E: Using Biochemical Insights to Target Cancer. Journal of Interferon & Cytokine Research 33:5, pages 227-238.
Crossref
Yinghong GaoStephen P. DaviesMartin AugustinAnna WoodwardUmesh A. PatelRobert KovelmanKevin J. Harvey. (2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochemical Journal 451:2, pages 313-328.
Crossref
Ugo Moens, Sergiy Kostenko & Baldur Sveinbjørnsson. (2013) The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation. Genes 4:2, pages 101-133.
Crossref
Jamal-Eddine Bouameur, Yann Schneider, Nadja Begré, Ryan P. Hobbs, Prakash Lingasamy, Lionel Fontao, Kathleen J. Green, Bertrand Favre & Luca Borradori. (2013) Phosphorylation of serine 4642 in the COOH-extremity of plectin by MNK2 and PKA modulates its interaction with intermediate filaments. Journal of Cell Science.
Crossref
Michal Grzmil & Brian A. Hemmings. (2012) Translation Regulation as a Therapeutic Target in Cancer. Cancer Research 72:16, pages 3891-3900.
Crossref
Nicolas F. Schlecht, Margaret Brandwein-Gensler, Richard V. Smith, Nicole Kawachi, Darcy Broughel, Juan Lin, Christian E. Keller, Paul A. Reynolds, Frank J. Gunn-Moore, Thomas Harris, Geoffrey Childs, Thomas J. Belbin & Michael B. Prystowsky. (2012) Cytoplasmic Ezrin and Moesin Correlate with Poor Survival in Head and Neck Squamous Cell Carcinoma. Head and Neck Pathology 6:2, pages 232-243.
Crossref
Samira Ziaei, Naoko Shimada, Herman Kucharavy & Karen Hubbard. (2012) MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1. Experimental Cell Research 318:5, pages 500-508.
Crossref
Jinqiang Hou, Frankie Lam, Christopher Proud & Shudong Wang. (2012) Targeting Mnks for Cancer Therapy. Oncotarget 3:2, pages 118-131.
Crossref
Benjamin W. Jester, Alicia Gaj, Carolyn D. Shomin, Kurt J. Cox & Indraneel Ghosh. (2012) Testing the Promiscuity of Commercial Kinase Inhibitors Against the AGC Kinase Group Using a Split-luciferase Screen. Journal of Medicinal Chemistry 55:4, pages 1526-1537.
Crossref
Shou-Ih HuMark KatzSherry ChinXiaoqing QiJoseph CruzChikwendu IbebunjoShanchuan ZhaoAmy ChenDavid J. Glass. (2012) MNK2 Inhibits eIF4G Activation Through a Pathway Involving Serine-Arginine–Rich Protein Kinase in Skeletal Muscle. Science Signaling 5:211.
Crossref
Rajkumar NoubadeDimitry N. KrementsovRoxana del RioTina ThorntonViswas NagaleekarNaresha SaligramaAnthony SpitzackKaren SpachGuadalupe Sabio, Roger J. Davis, Mercedes RinconCory Teuscher. (2011) Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis. Blood 118:12, pages 3290-3300.
Crossref
Eric S. Wang, Elena Dobrikova, Christian Goetz, Andrew T. Dufresne & Matthias Gromeier. (2011) Adaptation of an ICAM-1-Tropic Enterovirus to the Mouse Respiratory Tract. Journal of Virology 85:11, pages 5606-5617.
Crossref
Radek Jorda, Libor Havlíček, Iain W. McNae, Malcolm D. Walkinshaw, Jiří Voller, Antonín Šturc, Jana Navrátilová, Marek Kuzma, Martin Mistrík, Jiří Bártek, Miroslav Strnad & Vladimír Kryštof. (2011) Pyrazolo[4,3- d ]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity . Journal of Medicinal Chemistry 54:8, pages 2980-2993.
Crossref
Viswas K. Nagaleekar, Guadalupe Sabio, Idil Aktan, Alan Chant, Isaac W. Howe, Tina M. Thornton, Patrick J. Benoit, Roger J. Davis, Mercedes Rincon & Jonathan E. Boyson. (2011) Translational Control of NKT Cell Cytokine Production by p38 MAPK. The Journal of Immunology 186:7, pages 4140-4146.
Crossref
Michal Grzmil, Pier MorinJrJr, Maria Maddalena Lino, Adrian Merlo, Stephan Frank, Yuhua Wang, Gerald Moncayo & Brian A. Hemmings. (2011) MAP Kinase-Interacting Kinase 1 Regulates SMAD2-Dependent TGF-β Signaling Pathway in Human Glioblastoma. Cancer Research 71:6, pages 2392-2402.
Crossref
Bruce W. Konicek, Jennifer R. Stephens, Ann M. McNulty, Nathaniel Robichaud, Robert B. Peery, Chad A. Dumstorf, Michele S. Dowless, Philip W. Iversen, Stephen Parsons, Karen E. Ellis, Denis J. McCann, Jerry Pelletier, Luc Furic, Jonathan M. Yingling, Louis F. Stancato, Nahum Sonenberg & Jeremy R. Graff. (2011) Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases. Cancer Research 71:5, pages 1849-1857.
Crossref
Marie Cargnello & Philippe P. Roux. (2011) Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases. Microbiology and Molecular Biology Reviews 75:1, pages 50-83.
Crossref
Ivan Topisirovic, Yuri V. Svitkin, Nahum Sonenberg & Aaron J. Shatkin. (2011) Cap and cap-binding proteins in the control of gene expression. Wiley Interdisciplinary Reviews: RNA 2:2, pages 277-298.
Crossref
Christian Goetz, Richard G Everson, Linda C Zhang & Matthias Gromeier. (2010) MAPK Signal-integrating Kinase Controls Cap-independent Translation and Cell Type-specific Cytotoxicity of an Oncolytic Poliovirus. Molecular Therapy 18:11, pages 1937-1946.
Crossref
Jessica K. Altman, Heather Glaser, Antonella Sassano, Sonali Joshi, Takeshi Ueda, Rie Watanabe-Fukunaga, Rikiro Fukunaga, Martin S. Tallman & Leonidas C. Platanias. (2010) Negative Regulatory Effects of Mnk Kinases in the Generation of Chemotherapy-Induced Antileukemic Responses. Molecular Pharmacology 78:4, pages 778-784.
Crossref
Julen Oyarzabal, Natasha Zarich, María Isabel Albarran, Irene Palacios, Manuel Urbano-Cuadrado, Genoveva Mateos, Isabel Reymundo, Obdulia Rabal, Antonio Salgado, Ana Corrionero, Jesús Fominaya, Joaquin Pastor & James R. Bischoff. (2010) Discovery of Mitogen-Activated Protein Kinase-Interacting Kinase 1 Inhibitors by a Comprehensive Fragment-Oriented Virtual Screening Approach. Journal of Medicinal Chemistry 53:18, pages 6618-6628.
Crossref
Ying Jiang, Shu Hong Zhang, Guo Qing Han & Cheng Yong Qin. (2010) Interaction of Pdcd4 with eIF4E inhibits the metastatic potential of hepatocellular carcinoma. Biomedicine & Pharmacotherapy 64:6, pages 424-429.
Crossref
Ryan J.O. Dowling & Nahum Sonenberg. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 2335 2341 .
Anand Selvaraj & George Thomas. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 2295 2300 .
Alexey Shiryaev, Marijke Van Ghelue & Ugo Moens. 2010. Signal Transduction in Cancer Metastasis. Signal Transduction in Cancer Metastasis 41 76 .
Caterina Millino, Marina Fanin, Andrea Vettori, Paolo Laveder, Maria Luisa Mostacciuolo, Corrado Angelini & Gerolamo Lanfranchi. (2009) Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy. BMC Medicine 7:1.
Crossref
Debabrata Panja, Girstaute Dagyte, Michael Bidinosti, Karin Wibrand, Åse-Marit Kristiansen, Nahum Sonenberg & Clive R. Bramham. (2009) Novel Translational Control in Arc-dependent Long Term Potentiation Consolidation in Vivo. Journal of Biological Chemistry 284:46, pages 31498-31511.
Crossref
Makoto Tsuda, Emika Toyomitsu, Miho Kometani, Hidetoshi Tozaki-Saitoh & Kazuhide Inoue. (2009) Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways. Journal of Cellular and Molecular Medicine 13:9b, pages 3251-3259.
Crossref
Sonali JoshiSurinder KaurAmanda J. RedigKaty GoldsboroughKevin DavidTakeshi UedaRie Watanabe-FukunagaDarren P. Baker, Eleanor N. Fish, Rikiro FukunagaLeonidas C. Platanias. (2009) Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses. Proceedings of the National Academy of Sciences 106:29, pages 12097-12102.
Crossref
Masatoshi HaraMasashi MoriTadashi WadaKazunori TachibanaTakeo Kishimoto. (2009) Start of the embryonic cell cycle is dually locked in unfertilized starfish eggs. Development 136:10, pages 1687-1696.
Crossref
Wuqiang ZhuMark H. SoonpaaHanying ChenWeihua ShenR. Mark PayneEdward A. LiechtyRandall L. CaldwellWeinian ShouLoren J. Field. (2009) Acute Doxorubicin Cardiotoxicity Is Associated With p53-Induced Inhibition of the Mammalian Target of Rapamycin Pathway. Circulation 119:1, pages 99-106.
Crossref
Thaer Khoury, Sadir Alrawi, Nithva Ramnath, Qiang Li, Melissa Grimm, Jennifer Black & Dongfeng Tan. (2009) Eukaryotic Initiation Factor-4E and Cyclin D1 Expression Associated with Patient Survival in Lung Cancer. Clinical Lung Cancer 10:1, pages 58-66.
Crossref
Jerry Pelletier & Jeremy R. Graff. 2010. mTOR Pathway and mTOR Inhibitors in Cancer Therapy. mTOR Pathway and mTOR Inhibitors in Cancer Therapy 257 285 .
Rasmus Boye Kjellerup, Knud Kragballe, Lars Iversen & Claus Johansen. (2008) Pro-inflammatory cytokine release in keratinocytes is mediated through the MAPK signal-integrating kinases. Experimental Dermatology 17:6, pages 498-504.
Crossref
Blazej Dolniak, Efstratios Katsoulidis, Nathalie Carayol, Jessica K. Altman, Amanda J. Redig, Martin S. Tallman, Takeshi Ueda, Rie Watanabe-Fukunaga, Rikiro Fukunaga & Leonidas C. Platanias. (2008) Regulation of Arsenic Trioxide-induced Cellular Responses by Mnk1 and Mnk2. Journal of Biological Chemistry 283:18, pages 12034-12042.
Crossref
Scott M. DeWire, Jihee Kim, Erin J. Whalen, Seungkirl Ahn, Minyong Chen & Robert J. Lefkowitz. (2008) β-Arrestin-mediated Signaling Regulates Protein Synthesis. Journal of Biological Chemistry 283:16, pages 10611-10620.
Crossref
A Phillips & J P Blaydes. (2007) MNK1 and EIF4E are downstream effectors of MEKs in the regulation of the nuclear export of HDM2 mRNA. Oncogene 27:11, pages 1645-1649.
Crossref
Robert M. Rowlett, Carol A. Chrestensen, Mark Nyce, Mary G. Harp, Jared W. Pelo, Fabio Cominelli, Peter B. Ernst, Theresa T. Pizarro, Thomas W. Sturgill & Mark T. Worthington. (2008) MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages. American Journal of Physiology-Gastrointestinal and Liver Physiology 294:2, pages G452-G459.
Crossref
Franklin C. Harwood, Lili Shu & Peter J. Houghton. (2008) mTORC1 Signaling Can Regulate Growth Factor Activation of p44/42 Mitogen-activated Protein Kinases through Protein Phosphatase 2A. Journal of Biological Chemistry 283:5, pages 2575-2585.
Crossref
Ying Zhang, Yan Li & Da-Qing Yang. (2008) Phosphorylation of eIF-4E positively regulates formation of the eIF-4F translation initiation complex following DNA damage. Biochemical and Biophysical Research Communications 367:1, pages 54-59.
Crossref
Maria Buxadé, Nick Morrice, Danielle L. Krebs & Christopher G. Proud. (2008) The PSF·p54nrb Complex Is a Novel Mnk Substrate That Binds the mRNA for Tumor Necrosis Factor α. Journal of Biological Chemistry 283:1, pages 57-65.
Crossref
Jessica L. Banko & Eric Klann. 2008. Essence of Memory. Essence of Memory 59 80 .
M. Costa-Mattioli, N. Sonenberg & E. Klann. 2008. Learning and Memory: A Comprehensive Reference. Learning and Memory: A Comprehensive Reference 675 694 .
Alexey Kotlyarov & Matthias Gaestel. 2008. Stress-Activated Protein Kinases. Stress-Activated Protein Kinases 243 260 .
Jenny BainLorna PlaterMatt ElliottNatalia ShpiroC. James HastieHilary MclauchlanIva KlevernicJ. Simon C. ArthurDario R. AlessiPhilip Cohen. (2007) The selectivity of protein kinase inhibitors: a further update. Biochemical Journal 408:3, pages 297-315.
Crossref
Ana O’Loghlen, Víctor M. González, Teresa Jurado, Matilde Salinas & M. Elena Martín. (2007) Characterization of the activity of human MAP kinase-interacting kinase Mnk1b. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:9, pages 1416-1427.
Crossref
Sofia Origanti & Lisa M. Shantz. (2007) Ras Transformation of RIE-1 Cells Activates Cap-Independent Translation of Ornithine Decarboxylase: Regulation by the Raf/MEK/ERK and Phosphatidylinositol 3-Kinase Pathways. Cancer Research 67:10, pages 4834-4842.
Crossref
Carol A. Chrestensen, Jacquelyn K. Shuman, Andrew Eschenroeder, Mark Worthington, Hermann Gram & Thomas W. Sturgill. (2007) MNK1 and MNK2 Regulation in HER2-overexpressing Breast Cancer Lines. Journal of Biological Chemistry 282:7, pages 4243-4252.
Crossref
Xuemin Wang & Christopher G. Proud. 2007. Translation Initiation: Cell Biology, High‐Throughput Methods, and Chemical‐Based Approaches. Translation Initiation: Cell Biology, High‐Throughput Methods, and Chemical‐Based Approaches 113 142 .
Alan R. Saltiel & Jeffrey E. PessinJoseph F. Christian & John C. LawrenceJr.Jr.. 2007. Mechanisms of Insulin Action. Mechanisms of Insulin Action 71 89 .
M. Salinas & J. Burda. 2007. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 1 33 .
María P.Pérez de Obanos, María J. López Zabalza, Jesús Prieto, María T. Herraiz & María J. Iraburu. (2006) Leucine stimulates procollagen α1(I) translation on hepatic stellate cells through ERK and PI3K/Akt/mTOR activation. Journal of Cellular Physiology 209:2, pages 580-586.
Crossref
Hania Wehbe & Tushar Patel. (2006) eIF4E. AfCS-Nature Molecule Pages.
Crossref
Malgorzata Milkiewicz, Cassandra Kelland, Stephen Colgan & Tara L. Haas. (2006) Nitric oxide and p38 MAP kinase mediate shear stress-dependent inhibition of MMP-2 production in microvascular endothelial cells. Journal of Cellular Physiology 208:1, pages 229-237.
Crossref
David L. Williamson, Neil Kubica, Scot R. Kimball & Leonard S. Jefferson. (2006) Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. The Journal of Physiology 573:2, pages 497-510.
Crossref
Sergey V. Slepenkov, Edward Darzynkiewicz & Robert E. Rhoads. (2006) Stopped-flow Kinetic Analysis of eIF4E and Phosphorylated eIF4E Binding to Cap Analogs and Capped Oligoribonucleotides. Journal of Biological Chemistry 281:21, pages 14927-14938.
Crossref
Gabriel Ross, John R. Dyer, Vincent F. Castellucci & Wayne S. Sossin. (2006) Mnk is a negative regulator of cap-dependent translation in Aplysia neurons. Journal of Neurochemistry 97:1, pages 79-91.
Crossref
Michael Schümann & Matthias Dobbelstein. (2006) Adenovirus-Induced Extracellular Signal-Regulated Kinase Phosphorylation during the Late Phase of Infection Enhances Viral Protein Levels and Virus Progeny. Cancer Research 66:3, pages 1282-1288.
Crossref
Zdenka Ellederova, Hana Kovarova, Fabiana Melo-Sterza, Mark Livingstone, Wolfgang Tomek & Michal Kubelka. (2006) Suppression of translation during in vitro maturation of pig oocytes despite enhanced formation of cap-binding protein complex eIF4F and 4E-BP1 hyperphosphorylation. Molecular Reproduction and Development 73:1, pages 68-76.
Crossref
Efstratios KatsoulidisYongzhong LiHeather MearsLeonidas C. Platanias. (2005) The p38 Mitogen-Activated Protein Kinase Pathway in Interferon Signal Transduction. Journal of Interferon & Cytokine Research 25:12, pages 749-756.
Crossref
Rama P Cherla, Sang-Yun Lee, Pieter L Mees & Vernon L Tesh. (2006) Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line. Journal of Leukocyte Biology 79:2, pages 397-407.
Crossref
Josep Lluis Parra, Maria Buxadé & Christopher G. Proud. (2005) Features of the Catalytic Domains and C Termini of the MAPK Signal-integrating Kinases Mnk1 and Mnk2 Determine Their Differing Activities and Regulatory Properties. Journal of Biological Chemistry 280:45, pages 37623-37633.
Crossref
Mohamed Rahmani, Eric Maynard Davis, Cheryl Bauer, Paul Dent & Steven Grant. (2005) Apoptosis Induced by the Kinase Inhibitor BAY 43-9006 in Human Leukemia Cells Involves Down-regulation of Mcl-1 through Inhibition of Translation. Journal of Biological Chemistry 280:42, pages 35217-35227.
Crossref
Ralf Jauch, Stefan Jäkel, Catharina Netter, Kay Schreiter, Babette Aicher, Herbert Jäckle & Markus C. Wahl. (2005) Crystal Structures of the Mnk2 Kinase Domain Reveal an Inhibitory Conformation and a Zinc Binding Site. Structure 13:10, pages 1559-1568.
Crossref
Takayuki Murata, Makoto Hijikata & Kunitada Shimotohno. (2005) Enhancement of internal ribosome entry site-mediated translation and replication of hepatitis C virus by PD98059. Virology 340:1, pages 105-115.
Crossref
Maria Buxadé, Josep L. Parra, Simon Rousseau, Natalia Shpiro, Rodolfo Marquez, Nick Morrice, Jenny Bain, Enric Espel & Christopher G. Proud. (2005) The Mnks Are Novel Components in the Control of TNFα Biosynthesis and Phosphorylate and Regulate hnRNP A1. Immunity 23:2, pages 177-189.
Crossref
Danna Hargett, Tim McLean & Steven L. Bachenheimer. (2005) Herpes Simplex Virus ICP27 Activation of Stress Kinases JNK and p38. Journal of Virology 79:13, pages 8348-8360.
Crossref
Derek Walsh, Cesar Perez, Joanna Notary & Ian Mohr. (2005) Regulation of the Translation Initiation Factor eIF4F by Multiple Mechanisms in Human Cytomegalovirus-Infected Cells. Journal of Virology 79:13, pages 8057-8064.
Crossref
W.E. Colpoys, B.H. Cochran, Tessa M. Carducci & C.M. Thorpe. (2005) Shiga toxins activate translational regulation pathways in intestinal epithelial cells. Cellular Signalling 17:7, pages 891-899.
Crossref
Mark ROLFELaura E. McLEODPhillip F. PRATTChristopher G. PROUD. (2005) Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2). Biochemical Journal 388:3, pages 973-984.
Crossref
Leonidas C. Platanias. (2005) Mechanisms of type-I- and type-II-interferon-mediated signalling. Nature Reviews Immunology 5:5, pages 375-386.
Crossref
Jeffrey S. Shenberger, Jennifer L. Myers, Stephen G. Zimmer, Richard J. Powell & Aaron Barchowsky. (2005) Hyperoxia alters the expression and phosphorylation of multiple factors regulating translation initiation. American Journal of Physiology-Lung Cellular and Molecular Physiology 288:3, pages L442-L449.
Crossref
Roger F. Duncan, Hazel Peterson & Alex Sevanian. (2005) Signal transduction pathways leading to increased eIF4E phosphorylation caused by oxidative stress. Free Radical Biology and Medicine 38:5, pages 631-643.
Crossref
Josep L. PARRA-PALAUGert C. SCHEPERDaniel E. HARPERChristopher G. PROUD. (2005) The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo . Biochemical Journal 385:3, pages 695-702.
Crossref
Nathalie Arquier, Marc Bourouis, Julien Colombani & Pierre Léopold. (2005) Drosophila Lk6 Kinase Controls Phosphorylation of Eukaryotic Translation Initiation Factor 4E and Promotes Normal Growth and Development. Current Biology 15:1, pages 19-23.
Crossref
Jan H. Reiling, Kathrin T. Doepfner, Ernst Hafen & Hugo Stocker. (2005) Diet-Dependent Effects of the Drosophila Mnk1/Mnk2 Homolog Lk6 on Growth via eIF4E. Current Biology 15:1, pages 24-30.
Crossref
Carolyn E. Patterson & Matthias Clauss. 2005. Perspectives on Lung Endothelial Barrier Function. Perspectives on Lung Endothelial Barrier Function 165 204 .
Jennifer Worch, Lara Tickenbrock, Joachim Schwäble, Björn Steffen, Thomas Cauvet, Barbara Mlody, Horst Buerger, H Phillip Koeffler, Wolfgang E Berdel, Hubert Serve & Carsten Müller-Tidow. (2004) The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARα and regulates differentiation of hematopoietic cells. Oncogene 23:57, pages 9162-9172.
Crossref
Ana O'Loghlen, Vı́ctor M. González, Matilde Salinas & M. Elena Martı́n. (2004) Suppression of human Mnk1 by small interfering RNA increases the eukaryotic initiation factor 4F activity in HEK293T cells. FEBS Letters 578:1-2, pages 31-35.
Crossref
Ivan Topisirovic, Melisa Ruiz-Gutierrez & Katherine L. B. Borden. (2004) Phosphorylation of the Eukaryotic Translation Initiation Factor eIF4E Contributes to Its Transformation and mRNA Transport Activities. Cancer Research 64:23, pages 8639-8642.
Crossref
Ana O'Loghlen, Vı́ctor M. González, David Piñeiro, M.Isabel Pérez-Morgado, Matilde Salinas & M.Elena Martı́n. (2004) Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1. Experimental Cell Research 299:2, pages 343-355.
Crossref
Stephen B. Pruett, Carlton Schwab, Qiang Zheng & Ruping Fan. (2004) Suppression of Innate Immunity by Acute Ethanol Administration: A Global Perspective and a New Mechanism Beginning with Inhibition of Signaling through TLR3. The Journal of Immunology 173:4, pages 2715-2724.
Crossref
Julie A. Fotheringham, Michael B. Mayne, Jeffrey A. Grant & Jonathan D. Geiger. (2004) Activation of adenosine receptors inhibits tumor necrosis factor-α release by decreasing TNF-α mRNA stability and p38 activity. European Journal of Pharmacology 497:1, pages 87-95.
Crossref
Rafael Cuesta, Qiaoran Xi & Robert J. Schneider. (2004) Structural Basis for Competitive Inhibition of eIF4G-Mnk1 Interaction by the Adenovirus 100-Kilodalton Protein. Journal of Virology 78:14, pages 7707-7716.
Crossref
Philippe P. Roux & John Blenis. (2004) ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions. Microbiology and Molecular Biology Reviews 68:2, pages 320-344.
Crossref
Derek Walsh & Ian Mohr. (2004) Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells. Genes & Development 18:6, pages 660-672.
Crossref
Kathleen Bradley, John C. Scatizzi, Stefano Fiore, Eli Shamiyeh, Alisa E. Koch, Gary S. Firestein, Laura L. Gorges, Kevin Kuntsman, Richard M. Pope, Terry L. Moore, Jiahuai Han & Harris Perlman. (2004) Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid arthritis synovial fibroblasts. Arthritis & Rheumatism 50:1, pages 78-87.
Crossref
Mari IshidaTakafumi IshidaHidekatsu NakashimaNarimasa MihoKiyoshi MiyagawaKazuaki ChayamaTetsuya OshimaMasayuki KambeMasao Yoshizumi. (2003) Mnk1 Is Required for Angiotensin II–Induced Protein Synthesis in Vascular Smooth Muscle Cells. Circulation Research 93:12, pages 1218-1224.
Crossref
Marilyn Kozak. (2003) Alternative ways to think about mRNA sequences and proteins that appear to promote internal initiation of translation. Gene 318, pages 1-23.
Crossref
Simon J. Morley & Susanne Naegele. (2003) Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated protein kinase 2a/p38. Cellular Signalling 15:8, pages 741-749.
Crossref
Malvyne Rolli-Derkinderen, François Machavoine, Jay M. Baraban, Annabelle Grolleau, Laura Beretta & Michel Dy. (2003) ERK and p38 Inhibit the Expression of 4E-BP1 Repressor of Translation through Induction of Egr-1. Journal of Biological Chemistry 278:21, pages 18859-18867.
Crossref
Ernesto Yagüe, Angel L. Armesilla, Georgina Harrison, James Elliott, Alessandro Sardini, Christopher F. Higgins & Selina Raguz. (2003) P-glycoprotein (MDR1) Expression in Leukemic Cells Is Regulated at Two Distinct Steps, mRNA Stabilization and Translational Initiation. Journal of Biological Chemistry 278:12, pages 10344-10352.
Crossref
Robert Newton & Neil Holden. (2003) Inhibitors of p38 Mitogen-Activated Protein Kinase. BioDrugs 17:2, pages 113-129.
Crossref
Marilyn Kozak. 2003. Gene Transfer and Expression in Mammalian Cells. Gene Transfer and Expression in Mammalian Cells 471 494 .
Freimut Schliess & Dieter Häussinger. 2003. 187 228 .
Thomas Radimerski & George Thomas. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling 305 309 .
Qiwei Han, Jay Leng, Dafang Bian, Chitladda Mahanivong, Kevin A. Carpenter, Zhixing K. Pan, Jiahuai Han & Shuang Huang. (2002) Rac1-MKK3-p38-MAPKAPK2 Pathway Promotes Urokinase Plasminogen Activator mRNA Stability in Invasive Breast Cancer Cells. Journal of Biological Chemistry 277:50, pages 48379-48385.
Crossref
Gert C. Scheper & Christopher G. Proud. (2002) Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?. European Journal of Biochemistry 269:22, pages 5350-5359.
Crossref
Hironobu Ihn & Kunihiko Tamaki. (2002) Mitogenic Activity of Dermatofibrosarcoma Protuberans is Mediated via an Extracellular Signal Related Kinase Dependent Pathway. Journal of Investigative Dermatology 119:4, pages 954-960.
Crossref
Weihua Shen, Daniel Mallon, David W. Boyle & Edward A. Liechty. (2002) IGF-I and insulin regulate eIF4F formation by different mechanisms in muscle and liver in the ovine fetus. American Journal of Physiology-Endocrinology and Metabolism 283:3, pages E593-E603.
Crossref
Simon J. Morley & Susanne Naegele. (2002) Phosphorylation of Eukaryotic Initiation Factor (eIF) 4E Is Not Required for de Novo Protein Synthesis following Recovery from Hypertonic Stress in Human Kidney Cells. Journal of Biological Chemistry 277:36, pages 32855-32859.
Crossref
Lynn E Horton, Martin Bushell, Diane Barth-Baus, Vivienne J Tilleray, Michael J Clemens & Jack O Hensold. (2002) p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation. Oncogene 21:34, pages 5325-5334.
Crossref
Tania Nikolcheva, Stephane Pyronnet, Szu-yi Chou, Nahum Sonenberg, An Song, Carol Clayberger & Alan M. Krensky. (2002) A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes. Journal of Clinical Investigation 110:1, pages 119-126.
Crossref
Tania Nikolcheva, Stephane Pyronnet, Szu-yi Chou, Nahum Sonenberg, An Song, Carol Clayberger & Alan M. Krensky. (2002) A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes. Journal of Clinical Investigation 110:1, pages 119-126.
Crossref
Tania Nikolcheva, Stephane Pyronnet, Szu-yi Chou, Nahum Sonenberg, An Song, Carol Clayberger & Alan M. Krensky. (2002) A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes. Journal of Clinical Investigation 110:1, pages 119-126.
Crossref
Sangeeta Banerjee, Krishna Narayanan, Tetsuya Mizutani & Shinji Makino. (2002) Murine Coronavirus Replication-Induced p38 Mitogen-Activated Protein Kinase Activation Promotes Interleukin-6 Production and Virus Replication in Cultured Cells. Journal of Virology 76:12, pages 5937-5948.
Crossref
Elke Schneider, Malvyne Rolli-Derkinderen, Michel Arock & Michel Dy. (2002) Trends in histamine research: new functions during immune responses and hematopoiesis. Trends in Immunology 23:5, pages 255-263.
Crossref
Gert C. Scheper, Barbara van Kollenburg, Jianzhong Hu, Yunjing Luo, Dixie J. Goss & Christopher G. Proud. (2002) Phosphorylation of Eukaryotic Initiation Factor 4E Markedly Reduces Its Affinity for Capped mRNA. Journal of Biological Chemistry 277:5, pages 3303-3309.
Crossref

Displaying 200 of 203 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.