Negative Regulation of Protein Translation by Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2

REFERENCES

• Bu, X., D. W. Haas, and C. H. Hagedorn. 1993. Novel phosphorylation sites of eukaryotic initiation factor 4F and evidence that phosphorylation stabilizes interactions of the p25 and p220 subunits. J. Biol. Chem. 268:4975–4978.
   PubMed Web of Science ®Google Scholar
• Burnett, P. E., R. K. Barrow, N. A. Cohen, S. H. Snyder, and D. M. Sabatini. 1998. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. USA 95:1432–1437.
   PubMed Web of Science ®Google Scholar
• Cuesta, R., Q. Xi, and R. J. Schneider. 2000. Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F. EMBO J. 19:3465–3474.
   PubMedGoogle Scholar
• Dever, T.E.. 1999. Translation initiation: adept at adapting. Trends Biochem. Sci. 24:398–403.
   PubMedGoogle Scholar
• Dostie, J., F. Lejbkowicz, and N. Sonenberg. 2000. Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles. J. Cell Biol. 148:239–247.
   PubMed Web of Science ®Google Scholar
• Duncan, R., S. C. Milburn, and J. W. Hershey. 1987. Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F. J. Biol. Chem. 262:380–388.
   PubMed Web of Science ®Google Scholar
• Fraser, C. S., V. M. Pain, and S. J. Morley. 1999. Cellular stress in xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein. Biochem. J. 342:519–526.
   PubMedGoogle Scholar
• Fukunaga, R., and T. Hunter. 1997. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16:1921–1933.
   PubMed Web of Science ®Google Scholar
• Gingras, A. C., B. Raught, and N. Sonenberg. 1999. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68:913–963.
   PubMed Web of Science ®Google Scholar
• Haghighat, A., S. Mader, A. Pause, and N. Sonenberg. 1995. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J. 14:5701–5709.
   PubMed Web of Science ®Google Scholar
• Haghighat, A., and N. Sonenberg. 1997. eIF4G dramatically enhances the binding of eIF4E to the mRNA 5′-cap structure. J. Biol. Chem. 272:21677–21680.
   PubMedGoogle Scholar
• Herbert, T. P., G. R. Kilhams, I. H. Batty, and C. G. Proud. 2000. Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells. J. Biol. Chem. 275:11249–11256.
   PubMedGoogle Scholar
• Hiremath, L. S., N. R. Webb, and R. E. Rhoads. 1985. Immunological detection of the messenger RNA cap-binding protein. J. Biol. Chem. 260:7843–7849.
   PubMed Web of Science ®Google Scholar
• Khaleghpour, K., S. Pyronnet, A. C. Gingras, and N. Sonenberg. 1999. Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities. Mol. Cell. Biol. 19:4302–4310.
   PubMed Web of Science ®Google Scholar
• Koromilas, A. E., A. Lazaris-Karatzas, and N. Sonenberg. 1992. mRNAs containing extensive secondary structure in their 5′ non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E. EMBO J. 11:4153–4158.
   PubMed Web of Science ®Google Scholar
• Lamphear, B. J., and R. Panniers. 1990. Cap binding protein complex that restores protein synthesis in heat-shocked Ehrlich cell lysates contains highly phosphorylated eIF-4E. J. Biol. Chem. 265:5333–5336.
   PubMed Web of Science ®Google Scholar
• Mader, S., H. Lee, A. Pause, and N. Sonenberg. 1995. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol. Cell. Biol. 15:4990–4997.
   PubMed Web of Science ®Google Scholar
• Marcotrigiano, J., A. C. Gingras, N. Sonenberg, and S. K. Burley. 1997. Cocrystal structure of the messenger RNA 5′ cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell 89:951–961.
   PubMed Web of Science ®Google Scholar
• McKendrick, L., V. M. Pain, and S. J. Morley. 1999. Translation initiation factor 4E. Int. J. Biochem. Cell Biol. 31:31–35.
   PubMed Web of Science ®Google Scholar
• Minich, W. B., M. L. Balasta, D. J. Goss, and R. E. Rhoads. 1994. Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form. Proc. Natl. Acad. Sci. USA 91:7668–7672.
   PubMed Web of Science ®Google Scholar
• Morley, S. J., and L. McKendrick. 1997. Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells. J. Biol. Chem. 272:17887–17893.
   PubMed Web of Science ®Google Scholar
• New, L., Y. Jiang, M. Zhao, K. Liu, W. Zhu, L. J. Flood, Y. Kato, G. C. Parry, and J. Han. 1998. PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J. 17:3372–3384.
   PubMed Web of Science ®Google Scholar
• Pause, A., G. J. Belsham, A. C. Gingras, O. Donze, T. A. Lin, J. C. J. Lawrence, and N. Sonenberg. 1994. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371:762–767.
   PubMed Web of Science ®Google Scholar
• Pestova, T. V., and C. U. Hellen. 1999. Ribosome recruitment and scanning: what's new?. Trends Biochem. Sci. 24:85–87.
   PubMedGoogle Scholar
• Poulin, F., A. C. Gingras, H. Olsen, S. Chevalier, and N. Sonenberg. 1998. 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J. Biol. Chem. 273:14002–14007.
   PubMed Web of Science ®Google Scholar
• Ptushkina, M., T. von der Haar, M. M. Karim, J. M. Hughes, and J. E. McCarthy. 1999. Repressor binding to a dorsal regulatory site traps human eIF4E in a high cap-affinity state. EMBO J. 18:4068–4075.
   PubMed Web of Science ®Google Scholar
• Pyronnet, S., H. Imataka, A. C. Gingras, R. Fukunaga, T. Hunter, and N. Sonenberg. 1999. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J. 18:270–279.
   PubMed Web of Science ®Google Scholar
• Rau, M., T. Ohlmann, S. J. Morley, and V. M. Pain. 1996. A reevaluation of the cap-binding protein, eIF4E, as a rate-limiting factor for initiation of translation in reticulocyte lysate. J. Biol. Chem. 271:8983–8990.
   PubMedGoogle Scholar
• Raught, B., and A. C. Gingras. 1999. eIF4E activity is regulated at multiple levels. Int. J. Biochem. Cell Biol. 31:43–57.
   PubMed Web of Science ®Google Scholar
• Raught, B., A. C. Gingras, S. P. Gygi, H. Imataka, S. Morino, A. Gradi, R. Aebersold, and N. Sonenberg. 2000. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J. 19:434–444.
   PubMed Web of Science ®Google Scholar
• Rhoads, R. E.. 1999. Signal transduction pathways that regulate eukaryotic protein synthesis. J. Biol. Chem. 274:30337–30340.
   PubMed Web of Science ®Google Scholar
• Rousseau, D., R. Kaspar, I. Rosenwald, L. Gehrke, and N. Sonenberg. 1996. Translation initiation of omithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc. Natl. Acad. Sci. USA 93:1065–1070.
   PubMed Web of Science ®Google Scholar
• Scheper, G. C., N. A. Morrice, M. Kleijn, and C. G. Proud. 2001. The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. Mol. Cell. Biol. 21:743–754.
   PubMed Web of Science ®Google Scholar
• Slentz-Kesler, K., J. T. Moore, M. Lombard, J. Zhang, R. Hollingsworth, and M. P. Weiner. 2000. Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor β. Genomics 69:63–71.
   PubMed Web of Science ®Google Scholar
• Sonenberg, N., and A.C. Gingras. 1998. The mRNA 5′ cap-binding protein eIF4E and control of cell growth. Curr. Opin. Cell Biol. 10:268–275.
   PubMed Web of Science ®Google Scholar
• Tschopp, C., U. Knauf, M. Brauchle, M. Zurini, P. Ramage, D. Glueck, L. New, J. Han, and H. Gram. 2000. Phosphorylation of eIF4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies. Mol. Cell Biol. Res. Commun. 3:205–211.
   PubMedGoogle Scholar
• Wang, X., A. Flynn, A. J. Waskiewicz, B. L. Webb, R. G. Vries, I. A. Baines, J. A. Cooper, and C. G. Proud. 1998. The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways. J. Biol. Chem. 273:9373–9377.
   PubMed Web of Science ®Google Scholar
• Waskiewicz, A. J., A. Flynn, C. G. Proud, and J. A. Cooper. 1997. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16:1909–1920.
   PubMed Web of Science ®Google Scholar
• Waskiewicz, A. J., J. C. Johnson, B. Penn, M. Mahalingam, S. R. Kimball, and J. A. Cooper. 1999. Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol. Cell. Biol. 19:1871–1880.
   PubMed Web of Science ®Google Scholar
• Whalen, S. G., A. C. Gingras, L. Amankwa, S. Mader, P. E. Branton, R. Aebersold, and N. Sonenberg. 1996. Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins. J. Biol. Chem. 271:11831–11837.
   PubMedGoogle Scholar