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Cell Growth and Development

Interleukin-1 (IL-1) Receptor-Associated Kinase Leads to Activation of TAK1 by Inducing TAB2 Translocation in the IL-1 Signaling Pathway

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Pages 2475-2484 | Received 06 Sep 2000, Accepted 12 Jan 2001, Published online: 27 Mar 2023

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Crossref
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Crossref
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Crossref
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Crossref
W. He & B. N. Cronstein. (2012) Adenosine A1 receptor regulates osteoclast formation by altering TRAF6/TAK1 signaling. Purinergic Signalling 8:2, pages 327-337.
Crossref
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Crossref
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Crossref
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Crossref
E Omori, K Matsumoto & J Ninomiya-Tsuji. (2011) Non-canonical β-catenin degradation mediates reactive oxygen species-induced epidermal cell death. Oncogene 30:30, pages 3336-3344.
Crossref
Yanbao Xiong, Fu Qiu, Wenji Piao, Chang Song, Larry M. Wahl & Andrei E. Medvedev. (2011) Endotoxin Tolerance Impairs IL-1 Receptor-Associated Kinase (IRAK) 4 and TGF-β-activated Kinase 1 Activation, K63-linked Polyubiquitination and Assembly of IRAK1, TNF Receptor-associated Factor 6, and IκB Kinase γ and Increases A20 Expression. Journal of Biological Chemistry 286:10, pages 7905-7916.
Crossref
Hanna M Larner-Svensson, Andrew E Williams, Eleni Tsitsiou, Mark M Perry, Xiaoying Jiang, Kian F Chung & Mark A Lindsay. (2010) Pharmacological studies of the mechanism and function of interleukin-1β-induced miRNA-146a expression in primary human airway smooth muscle. Respiratory Research 11:1.
Crossref
Renato Ostuni, Ivan Zanoni & Francesca Granucci. (2010) Deciphering the complexity of Toll-like receptor signaling. Cellular and Molecular Life Sciences 67:24, pages 4109-4134.
Crossref
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Crossref
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Crossref
Roland Scholz, Corinne L. Sidler, Ramon F. Thali, Nicolas Winssinger, Peter C.F. Cheung & Dietbert Neumann. (2010) Autoactivation of Transforming Growth Factor β-activated Kinase 1 Is a Sequential Bimolecular Process. Journal of Biological Chemistry 285:33, pages 25753-25766.
Crossref
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Crossref
Axel WeberPeter WasiliewMichael Kracht. (2010) Interleukin-1 (IL-1) Pathway. Science Signaling 3:105.
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Hisaaki Shinohara & Tomohiro Kurosaki. (2009) Comprehending the complex connection between PKCβ, TAK1, and IKK in BCR signaling. Immunological Reviews 232:1, pages 300-318.
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Kohsuke YamazakiJin GohdaAtsuhiro KanayamaYusei MiyamotoHiroaki SakuraiMasahiro YamamotoShizuo AkiraHidetoshi HayashiBing SuJun-ichiro Inoue. (2009) Two Mechanistically and Temporally Distinct NF-κB Activation Pathways in IL-1 Signaling. Science Signaling 2:93.
Crossref
Sung Il Kim, Joon Hyeok Kwak, Hee-Jun Na, Jin Kuk Kim, Yan Ding & Mary E. Choi. (2009) Transforming Growth Factor-β (TGF-β1) Activates TAK1 via TAB1-mediated Autophosphorylation, Independent of TGF-β Receptor Kinase Activity in Mesangial Cells. Journal of Biological Chemistry 284:33, pages 22285-22296.
Crossref
Dong Gao, Ruipeng Wang, Bingfeng Li, Yongkang Yang, Zhonghe Zhai & Dan-Ying Chen. (2009) WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-κB activation pathway. Cellular and Molecular Life Sciences 66:15, pages 2573-2584.
Crossref
Joanna Shoenfelt, Robert J Mitkus, Rolf Zeisler, Rabia O Spatz, Jan Powell, Matthew J Fenton, Katherine A Squibb & Andrei E Medvedev. (2009) Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter. Journal of Leukocyte Biology 86:2, pages 303-312.
Crossref
Yasumasa Minoda, Hiroaki Sakurai, Takashi Kobayashi, Akihiko Yoshimura & Giichi Takaesu. (2009) An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1β signaling pathway. Biochemical and Biophysical Research Communications 381:3, pages 412-417.
Crossref
Keiko Koga, Giichi Takaesu, Ryoko Yoshida, Mako Nakaya, Takashi Kobayashi, Ichiko Kinjyo & Akihiko Yoshimura. (2009) Cyclic Adenosine Monophosphate Suppresses the Transcription of Proinflammatory Cytokines via the Phosphorylated c-Fos Protein. Immunity 30:3, pages 372-383.
Crossref
Wei Chao. (2009) Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart. American Journal of Physiology-Heart and Circulatory Physiology 296:1, pages H1-H12.
Crossref
Claudia Orelio, Esther Haak, Marian Peeters & Elaine Dzierzak. (2008) Interleukin-1–mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo. Blood 112:13, pages 4895-4904.
Crossref
Maiko Inagaki, Emily Omori, Jae-Young Kim, Yoshihiro Komatsu, Greg Scott, Manas K. Ray, Gen Yamada, Kunihiro Matsumoto, Yuji Mishina & Jun Ninomiya-Tsuji. (2008) TAK1-binding Protein 1, TAB1, Mediates Osmotic Stress-induced TAK1 Activation but Is Dispensable for TAK1-mediated Cytokine Signaling. Journal of Biological Chemistry 283:48, pages 33080-33086.
Crossref
Gang Liu, Young-Jun Park & Edward Abraham. (2008) Interleukin‐1 receptor‐associated kinase (IRAK) ‐1‐ mediated NF‐κ activation requires cytosolic and nuclear activity. The FASEB Journal 22:7, pages 2285-2296.
Crossref
Hirokazu Katsura, Koichi Obata, Kan Miyoshi, Takashi Kondo, Hiroki Yamanaka, Kimiko Kobayashi, Yi Dai, Tetsuo Fukuoka, Masafumi Sakagami & Koichi Noguchi. (2008) Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury. Glia 56:7, pages 723-733.
Crossref
Mark M. Perry, Sterghios A. Moschos, Andrew E. Williams, Neil J. Shepherd, Hanna M. Larner-Svensson & Mark A. Lindsay. (2008) Rapid Changes in MicroRNA-146a Expression Negatively Regulate the IL-1β-Induced Inflammatory Response in Human Lung Alveolar Epithelial Cells. The Journal of Immunology 180:8, pages 5689-5698.
Crossref
Elizabeth Lye, Salim Dhanji, Thomas Calzascia, Alisha R. Elford & Pamela S. Ohashi. (2008) IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses. European Journal of Immunology 38:3, pages 870-876.
Crossref
Sandra Blanco, Marta Sanz-García, Claudio R. Santos & Pedro A. Lazo. (2008) Modulation of Interleukin-1 Transcriptional Response by the Interaction between VRK2 and the JIP1 Scaffold Protein. PLoS ONE 3:2, pages e1660.
Crossref
Andrei E. Medvedev & Stefanie N. Vogel. 2008. Innate Immunity of Plants, Animals, and Humans. Innate Immunity of Plants, Animals, and Humans 135 167 .
Gang Liu, Yuko Tsuruta, Zhiqian Gao, Young-Jun Park & Edward Abraham. (2007) Variant IL-1 Receptor-Associated Kinase-1 Mediates Increased NF-κB Activity. The Journal of Immunology 179:6, pages 4125-4134.
Crossref
Jianhong Yao, Tae Whan Kim, Jinzhong Qin, Zhengfan Jiang, Youcun Qian, Hui Xiao, Yi Lu, Wen Qian, Muhammet Fatih Gulen, Nywana Sizemore, Joseph DiDonato, Shintaro Sato, Shizuo Akira, Bing Su & Xiaoxia Li. (2007) Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFκB Activation Pathways Bifurcate at IL-1 Receptor-associated Kinase Modification. Journal of Biological Chemistry 282:9, pages 6075-6089.
Crossref
Hong Cheng, Terri Addona, Hasmik Keshishian, Erik Dahlstrand, Chafen Lu, Marion Dorsch, Zhi Li, Anlai Wang, Timothy D. Ocain, Ping Li, Thomas F. Parsons, Bruce Jaffee & Yajun Xu. (2007) Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop. Biochemical and Biophysical Research Communications 352:3, pages 609-616.
Crossref
João O. Malva & Liliana Bernardino. 2007. Interaction Between Neurons and Glia in Aging and Disease. Interaction Between Neurons and Glia in Aging and Disease 3 35 .
Taisuke Kajino, Hong Ren, Shun-ichiro Iemura, Tohru Natsume, Bjarki Stefansson, David L. Brautigan, Kunihiro Matsumoto & Jun Ninomiya-Tsuji. (2006) Protein Phosphatase 6 Down-regulates TAK1 Kinase Activation in the IL-1 Signaling Pathway. Journal of Biological Chemistry 281:52, pages 39891-39896.
Crossref
María E. Alvarez, Juan I. Fuxman Bass, Jorge R. Geffner, Paula X. Fernández Calotti, Mónica Costas, Omar A. Coso, Romina Gamberale, Mónica E. Vermeulen, Gabriela Salamone, Diego Martinez, Tamara Tanos & Analía S. Trevani. (2006) Neutrophil Signaling Pathways Activated by Bacterial DNA Stimulation. The Journal of Immunology 177:6, pages 4037-4046.
Crossref
Wei-Chun HuangFu, Emily Omori, Shizuo Akira, Kunihiro Matsumoto & Jun Ninomiya-Tsuji. (2006) Osmotic Stress Activates the TAK1-JNK Pathway While Blocking TAK1-mediated NF-κB Activation. Journal of Biological Chemistry 281:39, pages 28802-28810.
Crossref
Helle FrobøseSif Groth RønnPeter E. HedingHeidi MendozaPhilip CohenThomas Mandrup-Poulsen & Nils Billestrup. (2006) Suppressor of Cytokine Signaling-3 Inhibits Interleukin-1 Signaling by Targeting the TRAF-6/TAK1 Complex. Molecular Endocrinology 20:7, pages 1587-1596.
Crossref
Jinzhong Qin, Jianhong Yao, Grace Cui, Hui Xiao, Tae Whan Kim, Jerzy Fraczek, Paul Wightman, Shintaro Sato, Shizuo Akira, Anne Puel, Jean-Laurent Casanova, Bing Su & Xiaoxia Li. (2006) TLR8-mediated NF-κB and JNK Activation Are TAK1-independent and MEKK3-dependent. Journal of Biological Chemistry 281:30, pages 21013-21021.
Crossref
Zi-Heng Zhuang, Lei Sun, Ling Kong, Jun-Hao Hu, Ming-Can Yu, Peter Reinach, Jing-Wu Zang & Bao-Xue Ge. (2006) Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB. Cellular Signalling 18:7, pages 964-970.
Crossref
Andrei E. MedvedevIan Sabroe, Jeffrey D. Hasday & Stefanie N. Vogel. (2016) Invited review: Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. Journal of Endotoxin Research 12:3, pages 133-150.
Crossref
Kent Z. Q. Wang, Nawarat Wara-Aswapati, Jason A. Boch, Yasuhiro Yoshida, Chang-Deng Hu, Deborah L. Galson & Philip E. Auron. (2006) TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src. Journal of Cell Science 119:8, pages 1579-1591.
Crossref
Jun Ninomiya-Tsuji & Kunihiro Matsumoto. (2006) Tab1. AfCS-Nature Molecule Pages.
Crossref
Noriyuki Uemura, Taisuke Kajino, Hideki Sanjo, Shintaro Sato, Shizuo Akira, Kunihiro Matsumoto & Jun Ninomiya-Tsuji. (2006) TAK1 Is a Component of the Epstein-Barr Virus LMP1 Complex and Is Essential for Activation of JNK but Not of NF-κB. Journal of Biological Chemistry 281:12, pages 7863-7872.
Crossref
Andreas R. Klatt, Gabriele Klinger, Olga Neumüller, Bernd Eidenmüller, Ingrid Wagner, Tatjana Achenbach, Thomas Aigner & Eckart Bartnik. (2006) TAK1 downregulation reduces IL-1β induced expression of MMP13, MMP1 and TNF-alpha. Biomedicine & Pharmacotherapy 60:2, pages 55-61.
Crossref
Jun Ninomiya-Tsuji & Kunihiro Matsumoto. (2006) Tak1. AfCS-Nature Molecule Pages.
Crossref
Andrei E. Medvedev, Douglas B. Kuhns, John I. Gallin & Stefanie N. Vogel. 2005. Toll-like Receptors in Inflammation. Toll-like Receptors in Inflammation 173 192 .
Vikki M. Abrahams & Gil Mor. 2006. Immunology of Pregnancy. Immunology of Pregnancy 15 25 .
Zhi-Wei Li & Michael Karin. 2006. NF-κB/Rel Transcription Factor Family. NF-κB/Rel Transcription Factor Family 12 25 .
Marzenna Blonska, Prashant B. Shambharkar, Masayuki Kobayashi, Dongyu Zhang, Hiroaki Sakurai, Bing Su & Xin Lin. (2005) TAK1 Is Recruited to the Tumor Necrosis Factor-α (TNF-α) Receptor 1 Complex in a Receptor-interacting Protein (RIP)-dependent Manner and Cooperates with MEKK3 Leading to NF-κB Activation. Journal of Biological Chemistry 280:52, pages 43056-43063.
Crossref
Jae-Hyuck Shim, Changchun Xiao, Amber E. Paschal, Shannon T. Bailey, Ping Rao, Matthew S. Hayden, Ki-Young Lee, Crystal Bussey, Michael Steckel, Nobuyuki Tanaka, Gen Yamada, Shizuo Akira, Kunihiro Matsumoto & Sankar Ghosh. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes & Development 19:22, pages 2668-2681.
Crossref
V.M. Abrahams & G. Mor. (2005) Toll-like Receptors and their Role in the Trophoblast. Placenta 26:7, pages 540-547.
Crossref
Axel Thiefes, Sabine Wolter, J. Frederic Mushinski, Elke Hoffmann, Oliver Dittrich-Breiholz, Nadine Graue, Anneke Dörrie, Heike Schneider, Dagmar Wirth, Bruno Luckow, Klaus Resch & Michael Kracht. (2005) Simultaneous Blockade of NFκB, JNK, and p38 MAPK by a Kinase-inactive Mutant of the Protein Kinase TAK1 Sensitizes Cells to Apoptosis and Affects a Distinct Spectrum of Tumor Necrosis Target Genes. Journal of Biological Chemistry 280:30, pages 27728-27741.
Crossref
Andrei E. Medvedev, Karen Thomas, Agnes Awomoyi, Douglas B. Kuhns, John I. Gallin, Xiaoxia Li & Stefanie N. Vogel. (2005) Cutting Edge: Expression of IL-1 Receptor-Associated Kinase-4 (IRAK-4) Proteins with Mutations Identified in a Patient with Recurrent Bacterial Infections Alters Normal IRAK-4 Interaction with Components of the IL-1 Receptor Complex. The Journal of Immunology 174:11, pages 6587-6591.
Crossref
Jeong-a Kim, Deborah C. Yeh, Marel Ver, Yunhua Li, Andrea Carranza, Thomas P. Conrads, Timothy D. Veenstra, Maureen A. Harrington & Michael J. Quon. (2005) Phosphorylation of Ser24 in the Pleckstrin Homology Domain of Insulin Receptor Substrate-1 by Mouse Pelle-like Kinase/Interleukin-1 Receptor-associated Kinase. Journal of Biological Chemistry 280:24, pages 23173-23183.
Crossref
Satoshi Kishida, Hideki Sanjo, Shizuo Akira, Kunihiro Matsumoto & Jun Ninomiya-Tsuji. (2005) TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway. Genes to Cells 10:5, pages 447-454.
Crossref
Xiaoxia Li. 2005. Nutrients and Cell Signaling. Nutrients and Cell Signaling.
Pattama Singhirunnusorn, Shunsuke Suzuki, Noritaka Kawasaki, Ikuo Saiki & Hiroaki Sakurai. (2005) Critical Roles of Threonine 187 Phosphorylation in Cellular Stress-induced Rapid and Transient Activation of Transforming Growth Factor-β-activated Kinase 1 (TAK1) in a Signaling Complex Containing TAK1-binding Protein TAB1 and TAB2. Journal of Biological Chemistry 280:8, pages 7359-7368.
Crossref
Mark S. Nanes & Roberto Pacifici. 2005. Bone Resorption. Bone Resorption 67 90 .
Hiroko Tsutsui, Tomohiro Yoshimoto, Nobuki Hayashi, Hitoshi Mizutani & Kenji Nakanishi. (2004) Induction of allergic inflammation by interleukin-18 in experimental animal models. Immunological Reviews 202:1, pages 115-138.
Crossref
Eric Y. Denkers, Barbara A. Butcher, Laura Del Rio & Leesun Kim. (2004) Manipulation of mitogen-activated protein kinase/nuclear factor-kappaB-signaling cascades during intracellular Toxoplasma gondii infection. Immunological Reviews 201:1, pages 191-205.
Crossref
Youcun Qian, Jinzhong Qin, Grace Cui, Mayumi Naramura, E.Charles Snow, Carl F. Ware, Robert L. Fairchild, Sidne A. Omori, Robert C. Rickert, Martin Scott, Brian L. Kotzin & Xiaoxia Li. (2004) Act1, a Negative Regulator in CD40- and BAFF-Mediated B Cell Survival. Immunity 21:4, pages 575-587.
Crossref
Matthew S. Hayden & Sankar Ghosh. (2004) Signaling to NF-κB. Genes & Development 18:18, pages 2195-2224.
Crossref
Elizabeth Lye, Christine Mirtsos, Nobutaka Suzuki, Shinobu Suzuki & Wen-Chen Yeh. (2004) The Role of Interleukin 1 Receptor-associated Kinase-4 (IRAK-4) Kinase Activity in IRAK-4-mediated Signaling. Journal of Biological Chemistry 279:39, pages 40653-40658.
Crossref
Shyamasree Datta, Michael Novotny, Xiaoxia Li, Julie Tebo & Thomas A. Hamilton. (2004) Toll IL-1 Receptors Differ in Their Ability to Promote the Stabilization of Adenosine and Uridine-Rich Elements Containing mRNA. The Journal of Immunology 173:4, pages 2755-2761.
Crossref
Shoko Akiyama, Takayuki Yonezawa, Tada-aki Kudo, Ming Guang Li, Hong Wang, Michihiko Ito, Katsuji Yoshioka, Jun Ninomiya-Tsuji, Kunihiro Matsumoto, Ryunosuke Kanamaru, Shinri Tamura & Takayasu Kobayashi. (2004) Activation Mechanism of c-Jun Amino-terminal Kinase in the Course of Neural Differentiation of P19 Embryonic Carcinoma Cells. Journal of Biological Chemistry 279:35, pages 36616-36620.
Crossref
Dehuang Guo, Manyu Li, Yan Zhang, Ping Yang, Sarah Eckenrode, Diane Hopkins, Weipeng Zheng, Sharad Purohit, Robert H Podolsky, Andrew Muir, Jinzhao Wang, Zheng Dong, Todd Brusko, Mark Atkinson, Paolo Pozzilli, Adina Zeidler, Leslie J Raffel, Chaim O Jacob, Yongsoo Park, Manuel Serrano-Rios, Maria T Martinez Larrad, Zixin Zhang, Henri-Jean Garchon, Jean-Francois Bach, Jerome I Rotter, Jin-Xiong She & Cong-Yi Wang. (2004) A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes. Nature Genetics 36:8, pages 837-841.
Crossref
Sang Hoon Rhee, Andrew C. Keates, Mary P. Moyer & Charalabos Pothoulakis. (2004) MEK Is a Key Modulator for TLR5-induced Interleukin-8 and MIP3α Gene Expression in Non-transformed Human Colonic Epithelial Cells. Journal of Biological Chemistry 279:24, pages 25179-25188.
Crossref
Chuan-Min Chen, Yusong Gong, Min Zhang & Jian-Jun Chen. (2004) Reciprocal Cross-talk between Nod2 and TAK1 Signaling Pathways. Journal of Biological Chemistry 279:24, pages 25876-25882.
Crossref
Derek S. Wheeler, John D. Catravas, Kelli Odoms, Alvin Denenberg, Vivek Malhotra & Hector R. Wong. (2004) Epigallocatechin-3-gallate, a Green Tea–Derived Polyphenol, Inhibits IL-1β-Dependent Proinflammatory Signal Transduction in Cultured Respiratory Epithelial Cells. The Journal of Nutrition 134:5, pages 1039-1044.
Crossref
Ke-Jun Han, Xiaoqin Su, Liang-Guo Xu, Liang-Hua Bin, Jun Zhang & Hong-Bing Shu. (2004) Mechanisms of the TRIF-induced Interferon-stimulated Response Element and NF-κB Activation and Apoptosis Pathways. Journal of Biological Chemistry 279:15, pages 15652-15661.
Crossref
Kelli Odoms, Thomas P. Shanley & Hector R. Wong. (2004) Short-term modulation of interleukin-1β signaling by hyperoxia: uncoupling of IκB kinase activation and NF-κB-dependent gene expression. American Journal of Physiology-Lung Cellular and Molecular Physiology 286:3, pages L554-L562.
Crossref
Hao Wu & Joseph R. Arron. (2003) TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. BioEssays 25:11, pages 1096-1105.
Crossref
Hiroaki Sakurai, Shunsuke Suzuki, Noritaka Kawasaki, Hiroyasu Nakano, Tatsuma Okazaki, Atsushi Chino, Takahiro Doi & Ikuo Saiki. (2003) Tumor Necrosis Factor-α-induced IKK Phosphorylation of NF-κB p65 on Serine 536 Is Mediated through the TRAF2, TRAF5, and TAK1 Signaling Pathway. Journal of Biological Chemistry 278:38, pages 36916-36923.
Crossref
David Wald, Jinzhong Qin, Zhendong Zhao, Youcun Qian, Mayumi Naramura, Liping Tian, Jennifer Towne, John E Sims, George R Stark & Xiaoxia Li. (2003) SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling. Nature Immunology 4:9, pages 920-927.
Crossref
Weiling Xu, Suzy A. A. Comhair, Shuo Zheng, Shan C. Chu, Joanna Marks-Konczalik, Joel Moss, S. Jaharul Haque & Serpil C. Erzurum. (2003) STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation . American Journal of Physiology-Lung Cellular and Molecular Physiology 285:1, pages L137-L148.
Crossref
Liang-Hua Bin, Liang-Guo Xu & Hong-Bing Shu. (2003) TIRP, a Novel Toll/Interleukin-1 receptor (TIR) Domain-containing Adapter Protein Involved in TIR Signaling. Journal of Biological Chemistry 278:27, pages 24526-24532.
Crossref
Seon-Ju Yeo, Demetrius Gravis, Jae-Geun Yoon & Ae-Kyung Yi. (2003) Myeloid Differentiation Factor 88-dependent Transcriptional Regulation of Cyclooxygenase-2 Expression by CpG DNA. Journal of Biological Chemistry 278:25, pages 22563-22573.
Crossref
Zhengfan Jiang, Maryam Zamanian-Daryoush, Huiqing Nie, Aristobolo M. Silva, Bryan R.G. Williams & Xiaoxia Li. (2003) Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR. Journal of Biological Chemistry 278:19, pages 16713-16719.
Crossref
Jun Ninomiya-Tsuji, Taisuke Kajino, Koichiro Ono, Toshihiko Ohtomo, Masahiko Matsumoto, Masashi Shiina, Masahiko Mihara, Masayuki Tsuchiya & Kunihiro Matsumoto. (2003) A Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase Kinase. Journal of Biological Chemistry 278:20, pages 18485-18490.
Crossref
Hiroshi Takatsuna, Hiroki Kato, Jin Gohda, Taishin Akiyama, Ayaka Moriya, Yoshinari Okamoto, Yuriko Yamagata, Masami Otsuka, Kazuo Umezawa, Kentaro Semba & Jun-ichiro Inoue. (2003) Identification of TIFA as an Adapter Protein That Links Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) to Interleukin-1 (IL-1) Receptor-associated Kinase-1 (IRAK-1) in IL-1 Receptor Signaling. Journal of Biological Chemistry 278:14, pages 12144-12150.
Crossref
Megumi Funakoshi-Tago, Kenji Tago, Yoshiko Sonoda, Shin-ichi Tominaga & Tadashi Kasahara. (2003) TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway. European Journal of Biochemistry 270:6, pages 1257-1268.
Crossref
Sophie Janssens & Rudi Beyaert. (2003) Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members. Molecular Cell 11:2, pages 293-302.
Crossref
Giichi Takaesu, Rama M. Surabhi, Kyu-Jin Park, Jun Ninomiya-Tsuji, Kunihiro Matsumoto & Richard B. Gaynor. (2003) TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway. Journal of Molecular Biology 326:1, pages 105-115.
Crossref
Marcello Arsura, Ganesh R Panta, Jennifer D Bilyeu, Lakita G Cavin, Mika A Sovak, Aundrea A Oliver, Valentina Factor, Rainer Heuchel, Frank Mercurio, Snorri S Thorgeirsson & Gail E Sonenshein. (2003) Transient activation of NF-κB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation. Oncogene 22:3, pages 412-425.
Crossref
Kimberly Burns, Sophie Janssens, Brian Brissoni, Natalia Olivos, Rudi Beyaert & Jürg Tschopp. (2003) Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4. Journal of Experimental Medicine 197:2, pages 263-268.
Crossref
N. Suzuki, M. Bonnard, S. Suzuki & W.-C Yeh. 2003. Nuclear Factor кB. Nuclear Factor кB 265 294 .
H. Wajant & P. Scheurich. 2004. Invertebrate Cytokines and the Phylogeny of Immunity. Invertebrate Cytokines and the Phylogeny of Immunity 47 72 .
Detlef Neumann, Stefan Lienenklaus, Olaf Rosati & Michael?U. Martin. (2002) IL-1?-induced phosphorylation of PKB/Akt depends on the presence of IRAK-1. European Journal of Immunology 32:12, pages 3689-3698.
Crossref
Michael U Martin & Holger Wesche. (2002) Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1592:3, pages 265-280.
Crossref
Nobutaka Suzuki, Shinobu Suzuki & Wen-Chen Yeh. (2002) IRAK-4 as the central TIR signaling mediator in innate immunity. Trends in Immunology 23:10, pages 503-506.
Crossref
Hiroaki Sakurai, Akito Nishi, Naoya Sato, Junko Mizukami, Hidetaka Miyoshi & Takahisa Sugita. (2002) TAK1–TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-κB signaling pathways. Biochemical and Biophysical Research Communications 297:5, pages 1277-1281.
Crossref
Youcun Qian, Zhendong Zhao, Zhengfan Jiang & Xiaoxia Li. (2002) Role of NFκB activator Act1 in CD40-mediated signaling in epithelial cells. Proceedings of the National Academy of Sciences 99:14, pages 9386-9391.
Crossref
Vidya Mamidipudi & Marie W. Wooten. (2002) Dual role for p75NTR signaling in survival and cell death: Can intracellular mediators provide an explanation?. Journal of Neuroscience Research 68:4, pages 373-384.
Crossref
Jürgen Radons, Stefan Gabler, Holger Wesche, Christian Korherr, Robert Hofmeister & Werner Falk. (2002) Identification of Essential Regions in the Cytoplasmic Tail of Interleukin-1 Receptor Accessory Protein Critical for Interleukin-1 Signaling. Journal of Biological Chemistry 277:19, pages 16456-16463.
Crossref
Xiaoxia Li & George R Stark. (2002) NFκB-dependent signaling pathways. Experimental Hematology 30:4, pages 285-296.
Crossref
Eva Pålsson McDermott & Luke A.J. O'Neill. (2002) Ras Participates in the Activation of p38 MAPK by Interleukin-1 by Associating with IRAK, IRAK2, TRAF6, and TAK-1. Journal of Biological Chemistry 277:10, pages 7808-7815.
Crossref
Jee Y. Chung, Young Chul Park, Hong Ye & Hao Wu. (2002) All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. Journal of Cell Science 115:4, pages 679-688.
Crossref
L. A. J. O’Neill. 2002. Toll-Like Receptor Family Members and Their Ligands. Toll-Like Receptor Family Members and Their Ligands 47 61 .
David Wald, Mairead Commane, George R. Stark & Xiaoxia Li. (2001) IRAK and TAK1 are required for IL-18-mediated signaling. European Journal of Immunology 31:12, pages 3747-3754.
Crossref
Youcun Qian, Mairead Commane, Jun Ninomiya-Tsuji, Kunihiro Matsumoto & Xiaoxia Li. (2001) IRAK-mediated Translocation of TRAF6 and TAB2 in the Interleukin-1-induced Activation of NFκB. Journal of Biological Chemistry 276:45, pages 41661-41667.
Crossref
Neal Silverman & Tom Maniatis. (2001) NF-κB signaling pathways in mammalian and insect innate immunity. Genes & Development 15:18, pages 2321-2342.
Crossref

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