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Cell Growth and Development

Cytoplasmic Death Signal Triggered by Src-Mediated Phosphorylation of the Adenovirus E4orf4 Protein

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Pages 41-56 | Received 10 May 2001, Accepted 02 Oct 2001, Published online: 27 Mar 2023

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Kévin Jacquet, Marc-Antoine Rodrigue, Darren E. Richard & Josée N. Lavoie. (2020) The adenoviral protein E4orf4: a probing tool to decipher mechanical stress-induced nuclear envelope remodeling in tumor cells. Cell Cycle 19:22, pages 2963-2981.
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Tamar Kleinberger. (2015) Mechanisms of Cancer Cell Killing by the Adenovirus E4orf4 Protein. Viruses 7:5, pages 2334-2357.
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Shishir Kumar Gupta, Ravi Kumar Gandham, A. P. Sahoo & A. K. Tiwari. (2014) Viral genes as oncolytic agents for cancer therapy. Cellular and Molecular Life Sciences 72:6, pages 1073-1094.
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Roberta Biasiotto & Göran Akusjärvi. (2015) Regulation of Human Adenovirus Alternative RNA Splicing by the Adenoviral L4-33K and L4-22K Proteins. International Journal of Molecular Sciences 16:2, pages 2893-2912.
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Sara Bergström Lind, Konstantin A. Artemenko, Lioudmila Elfineh, Yanhong Zhao, Jonas Bergquist & Ulf Pettersson. (2012) The phosphoproteome of the adenovirus type 2 virion. Virology 433:1, pages 253-261.
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A. Brestovitsky, R. Sharf, K. Mittelman & T. Kleinberger. (2011) The adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes. Nucleic Acids Research 39:15, pages 6414-6427.
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Josée N. Lavoie, Marie-Claude Landry, Robert L. Faure & Claudia Champagne. (2010) Src-family kinase signaling, actin-mediated membrane trafficking and organellar dynamics in the control of cell fate: Lessons to be learned from the adenovirus E4orf4 death factor. Cellular Signalling 22:11, pages 1604-1614.
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Steve Jean, Alexander Mikryukov, Michel G. Tremblay, Joëlle Baril, François Guillou, Sabrina Bellenfant & Tom Moss. (2010) Extended-Synaptotagmin-2 Mediates FGF Receptor Endocytosis and ERK Activation In Vivo. Developmental Cell 19:3, pages 426-439.
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Mathieu H.M. Noteborn. (2009) Proteins selectively killing tumor cells. European Journal of Pharmacology 625:1-3, pages 165-173.
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Yu Zhou, Hong Chen, Xiao-Li Ma, Hai-Jun Xie, Cun-Lin Wang, Sheng-Hua Zhang, Xin Wang & Bing-Ren Huang. (2009) Fusion protein of adenovirus E4orf4 and human epidermal growth factor inhibits tumor cell growth. International Journal of Cancer 125:5, pages 1186-1192.
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Marie-Joëlle Miron, Paola Blanchette, Peter Groitl, Frederic Dallaire, Jose G. Teodoro, Suiyang Li, Thomas Dobner & Philip E. Branton. (2009) Localization and Importance of the Adenovirus E4orf4 Protein during Lytic Infection. Journal of Virology 83:4, pages 1689-1699.
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Nicolas Smadja-Lamére, Marie-Chloé Boulanger, Claudia Champagne, Philip E. Branton & Josée N. Lavoie. (2008) JNK-mediated Phosphorylation of Paxillin in Adhesion Assembly and Tension-induced Cell Death by the Adenovirus Death Factor E4orf4. Journal of Biological Chemistry 283:49, pages 34352-34364.
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Steve Jean & Tom Moss. (2008) A ubiquitin-conjugating enzyme, ube2d3.2, regulates xMLK2 and pronephros formation in Xenopus. Differentiation 76:4, pages 431-441.
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Claude BackendorfAstrid E. VisserA.G. de BoerRhyenne ZimmermanMijke VisserPatrick VoskampYing-Hui ZhangMathieu Noteborn. (2008) Apoptin: Therapeutic Potential of an Early Sensor of Carcinogenic Transformation. Annual Review of Pharmacology and Toxicology 48:1, pages 143-169.
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Amélie RobertNicolas Smadja-LamèreMarie-Claude LandryClaudia ChampagneRyan Petrie, Nathalie Lamarche-Vane, Hiroshi Hosoya & Josée N. Lavoie. (2006) Adenovirus E4orf4 Hijacks Rho GTPase-dependent Actin Dynamics to Kill Cells: A Role for Endosome-associated Actin Assembly. Molecular Biology of the Cell 17:7, pages 3329-3344.
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Dong-Mei Wang, Yu Zhou, Hai-Jun Xie, Xiao-Li Ma, Xin Wang, Hong Chen & Bing-Ren Huang. (2006) Cytotoxicity of a recombinant fusion protein of adenovirus early region 4 open reading frame 4 (E4orf4) and human epidermal growth factor on p53-deficient tumor cells. Anti-Cancer Drugs 17:5, pages 527-537.
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Nicolas Bilodeau, Annie Fiset, Guy G. Poirier, Suzanne Fortier, Marie-Claude Gingras, Josee N. Lavoie & Robert L Faure. (2006) Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-Src. FEBS Journal 273:5, pages 992-1003.
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Tsofnat Maoz, Roni Koren, Inbal Ben-Ari & Tamar Kleinberger. (2005) YND1 Interacts with CDC55 and Is a Novel Mediator of E4orf4-induced Toxicity. Journal of Biological Chemistry 280:50, pages 41270-41277.
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Matthew D Weitzman & David A Ornelles. (2005) Inactivating intracellular antiviral responses during adenovirus infection. Oncogene 24:52, pages 7686-7696.
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Marie-Joëlle Miron, Imed-Eddine Gallouzi, Josée N Lavoie & Philip E Branton. (2004) Nuclear localization of the adenovirus E4orf4 protein is mediated through an arginine-rich motif and correlates with cell death. Oncogene 23:45, pages 7458-7468.
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Claudia Champagne, Marie-Claude Landry, Marie-Claude Gingras & Josée N. Lavoie. (2004) Activation of Adenovirus Type 2 Early Region 4 ORF4 Cytoplasmic Death Function by Direct Binding to Src Kinase Domain. Journal of Biological Chemistry 279:24, pages 25905-25915.
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Chantale I. Morin & Jacques Huot. (2004) Recent Advances in Stress Signaling in Cancer. Cancer Research 64:5, pages 1893-1898.
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T. Kleinberger. 2004. Viruses and Apoptosis. Viruses and Apoptosis 245 267 .
Amélie Robert, Marie-Joëlle Miron, Claudia Champagne, Marie-Claude Gingras, Philip E. Branton & Josée N. Lavoie. (2002) Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein. The Journal of Cell Biology 158:3, pages 519-528.
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