133
Views
464
CrossRef citations to date
0
Altmetric
Cell Growth and Development

The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

, , , , , , , , & show all
Pages 3864-3874 | Received 12 Dec 2001, Accepted 21 Feb 2002, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (23)

Belinda S Hall, Scott J Dos Santos, Louise Tzung-Harn Hsieh, Maria Manifava, Marie-Thérèse Ruf, Gerd Pluschke, Nicholas Ktistakis & Rachel E Simmonds. (2022) Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity. Autophagy 18:4, pages 841-859.
Read now
Fabrizio Barbetti, Novella Rapini, Riccardo Schiaffini, Carla Bizzarri & Stefano Cianfarani. (2022) The application of precision medicine in monogenic diabetes. Expert Review of Endocrinology & Metabolism 17:2, pages 111-129.
Read now
Hsiao-Sang Chu, Cornelia Peterson, Albert Jun & James Foster. (2021) Targeting the integrated stress response in ophthalmology. Current Eye Research 46:8, pages 1075-1088.
Read now
Nicolas C. Nicolaides, Christina Kanaka-Gantenbein, Nektaria Papadopoulou-Marketou, Amalia Sertedaki, George P. Chrousos & Ioannis Papassotiriou. (2020) Emerging technologies in pediatrics: the paradigm of neonatal diabetes mellitus. Critical Reviews in Clinical Laboratory Sciences 57:8, pages 522-531.
Read now
Man Liu & Samuel C Dudley$suffix/text()$suffix/text(). (2018) The role of the unfolded protein response in arrhythmias. Channels 12:1, pages 335-345.
Read now
Jeffrey M. Axten. (2017) Protein kinase R(PKR)–like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015). Expert Opinion on Therapeutic Patents 27:1, pages 37-48.
Read now
Harun-Or Rashid, Raj Kumar Yadav, Hyung-Ryong Kim & Han-Jung Chae. (2015) ER stress: Autophagy induction, inhibition and selection. Autophagy 11:11, pages 1956-1977.
Read now
Jae-Seon So, Sungyun Cho, Sang-Hyun Min, Scot R. Kimball & Ann-Hwee Lee. (2015) IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis. Molecular and Cellular Biology 35:16, pages 2761-2770.
Read now
Yan Gao, Daniel J. Sartori, Changhong Li, Qian-Chun Yu, Jake A. Kushner, M. Celeste Simon & J. Alan Diehl. (2012) PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis. Molecular and Cellular Biology 32:24, pages 5129-5139.
Read now
Stephanie K. Dougan, Chih-Chi Andrew Hu, Marie-Eve Paquet, Matthew B. Greenblatt, Jun Kim, Brendan N. Lilley, Nicki Watson & Hidde L. Ploegh. (2011) Derlin-2-Deficient Mice Reveal an Essential Role for Protein Dislocation in Chondrocytes. Molecular and Cellular Biology 31:6, pages 1145-1159.
Read now
Maria Almira Correia, Peter R. Sinclair & Francesco De Matteis. (2011) Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal. Drug Metabolism Reviews 43:1, pages 1-26.
Read now
Matthew H. Brush & Shirish Shenolikar. (2008) Control of Cellular GADD34 Levels by the 26S Proteasome . Molecular and Cellular Biology 28:23, pages 6989-7000.
Read now
Jaime D. Blais, Christina L. Addison, Robert Edge, Theresa Falls, Huijun Zhao, Kishore Wary, Costas Koumenis, Heather P. Harding, David Ron, Martin Holcik & John C. Bell. (2006) Perk-Dependent Translational Regulation Promotes Tumor Cell Adaptation and Angiogenesis in Response to Hypoxic Stress. Molecular and Cellular Biology 26:24, pages 9517-9532.
Read now
Osamu Hori, Mayuki Miyazaki, Takashi Tamatani, Kentaro Ozawa, Katsura Takano, Masaru Okabe, Masahito Ikawa, Enno Hartmann, Petra Mai, David M. Stern, Yasuko Kitao & Satoshi Ogawa. (2006) Deletion of SERP1/RAMP4, a Component of the Endoplasmic Reticulum (ER) Translocation Sites, Leads to ER Stress. Molecular and Cellular Biology 26:11, pages 4257-4267.
Read now
Julia B. Smirnova, Julian N. Selley, Fatima Sanchez-Cabo, Kathleen Carroll, A. Alan Eddy, John E. G. McCarthy, Simon J. Hubbard, Graham D. Pavitt, Chris M. Grant & Mark P. Ashe. (2005) Global Gene Expression Profiling Reveals Widespread yet Distinctive Translational Responses to Different Eukaryotic Translation Initiation Factor 2B-Targeting Stress Pathways. Molecular and Cellular Biology 25:21, pages 9340-9349.
Read now
Eelco van Anken & Ineke Braakman. (2005) Endoplasmic Reticulum Stress and the Making of a Professional Secretory Cell. Critical Reviews in Biochemistry and Molecular Biology 40:5, pages 269-283.
Read now
Jing Deng, Phoebe D. Lu, Yuhong Zhang, Donalyn Scheuner, Randal J. Kaufman, Nahum Sonenberg, Heather P. Harding & David Ron. (2004) Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2. Molecular and Cellular Biology 24:23, pages 10161-10168.
Read now
Sara B. Cullinan, John D. Gordan, Jianping Jin, J. Wade Harper & J. Alan Diehl. (2004) The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase. Molecular and Cellular Biology 24:19, pages 8477-8486.
Read now
Hao-Yuan Jiang, Sheree A. Wek, Barbara C. McGrath, Dan Lu, Tsonwin Hai, Heather P. Harding, Xiaozhong Wang, David Ron, Douglas R. Cavener & Ronald C. Wek. (2004) Activating Transcription Factor 3 Is Integral to the Eukaryotic Initiation Factor 2 Kinase Stress Response. Molecular and Cellular Biology 24:3, pages 1365-1377.
Read now
Sara B. Cullinan, Donna Zhang, Mark Hannink, Edward Arvisais, Randal J. Kaufman & J. Alan Diehl. (2003) Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival. Molecular and Cellular Biology 23:20, pages 7198-7209.
Read now
Hao-Yuan Jiang, Sheree A. Wek, Barbara C. McGrath, Donalyn Scheuner, Randal J. Kaufman, Douglas R. Cavener & Ronald C. Wek. (2003) Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF-κB in Response to Diverse Cellular Stresses. Molecular and Cellular Biology 23:16, pages 5651-5663.
Read now
Peichuan Zhang, Barbara C. McGrath, Jamie Reinert, DeAnne S. Olsen, Li Lei, Sangeeta Gill, Sheree A. Wek, Krishna M. Vattem, Ronald C. Wek, Scot R. Kimball, Leonard S. Jefferson & Douglas R. Cavener. (2002) The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice. Molecular and Cellular Biology 22:19, pages 6681-6688.
Read now

Articles from other publishers (441)

Takaaki Tamura, Yusuke Yoshioka, Shinichi Sakamoto, Tomohiko Ichikawa & Takahiro Ochiya. (2022) Extracellular vesicles in bone homeostasis: key roles of physiological and pathological conditions. Journal of Bone and Mineral Metabolism 41:3, pages 345-357.
Crossref
Sisi Pu, Yangyang Pan, Qian Zhang, Ting You, Tao Yue, Yuxing Zhang & Meng Wang. (2023) Endoplasmic Reticulum Stress and Mitochondrial Stress in Drug-Induced Liver Injury. Molecules 28:7, pages 3160.
Crossref
Yun Cheng, Zikang Niu, Yafei Cai & Wei Zhang. (2023) Emerging role of UFMylation in secretory cells involved in the endocrine system by maintaining ER proteostasis. Frontiers in Endocrinology 13.
Crossref
Harper S. Kim & Andrew M. Pickering. (2023) Protein translation paradox: Implications in translational regulation of aging. Frontiers in Cell and Developmental Biology 11.
Crossref
Hong Wa Yung, Xiaohui Zhao, Luke Glover, Charlotte Burrin, Poh-Choo Pang, Carolyn J.P. Jones, Carolyn Gill, Kate Duhig, Matts Olovsson, Lucy C. Chappell, Stuart M. Haslam, Anne Dell, Graham J. Burton & D. Stephen Charnock-Jones. (2023) Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism. iScience 26:1, pages 105911.
Crossref
Shuntaro Morikawa & Fumihiko Urano. (2022) The Role of ER Stress in Diabetes: Exploring Pathological Mechanisms Using Wolfram Syndrome. International Journal of Molecular Sciences 24:1, pages 230.
Crossref
M. S. Kukharsky, M. W. Everett, O. A. Lytkina, M. A. Raspopova, E. A. Kovrazhkina, R. K. Ovchinnikov, A. I. Antohin & A. A. Moskovtsev. (2022) Protein Homeostasis Dysregulation in Pathogenesis of Neurodegenerative Diseases. Molecular Biology 56:6, pages 967-978.
Crossref
Lydia F. Daniels Gatward, Yujin Kim, Aerin Loe, Yiyang Liu, Line Kristensen & Aileen J. F. King. (2022) Beta cell endoplasmic reticulum stress drives diabetes in the KINGS mouse without causing mass beta cell loss . Diabetic Medicine 39:12.
Crossref
Tamás Gáll, Péter Nagy, Dorottya Garai, László Potor, György Jázon Balla, György Balla & József Balla. (2022) Overview on hydrogen sulfide-mediated suppression of vascular calcification and hemoglobin/heme-mediated vascular damage in atherosclerosis. Redox Biology 57, pages 102504.
Crossref
Michael E. Stokes, Matthew D. Surman, Veronica Calvo, David Surguladze, An-Hu Li, Jennifer Gasparek, Matthew Betzenhauser, Guangyu Zhu, Hongwen Du, Alan C. Rigby & Mark J. Mulvihill. (2022) Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors. Pharmaceutics 14:10, pages 2233.
Crossref
Hani J. Shayya, Jerome K. Kahiapo, Rachel Duffié, Katherine S. Lehmann, Lisa Bashkirova, Kevin Monahan, Ryan P. Dalton, Joanna Gao, Song Jiao, Ira Schieren, Leonardo Belluscio & Stavros Lomvardas. (2022) ER stress transforms random olfactory receptor choice into axon targeting precision. Cell 185:21, pages 3896-3912.e22.
Crossref
Sauyeun Shin, Jacobo Solorzano, Mehdi Liauzun, Stéphane Pyronnet, Corinne Bousquet & Yvan Martineau. (2022) Translational alterations in pancreatic cancer: a central role for the integrated stress response. NAR Cancer 4:4.
Crossref
Mingkwan Greenwood, Benjamin T. Gillard, Rizwan Farrukh, Alex Paterson, Ferdinand Althammer, Valery Grinevich, David Murphy & Michael P. Greenwood. (2022) Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells. Molecular Metabolism 63, pages 101542.
Crossref
Kanika Jain, Tarun TyagiJing DuXiaoyue HuKanchi PatellKathleen A. Martin & John Hwa. (2022) Unfolded Protein Response Differentially Modulates the Platelet Phenotype. Circulation Research 131:4, pages 290-307.
Crossref
Melanie Kny & Jens Fielitz. (2022) Hidden Agenda - The Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response in Inflammation-Induced Muscle Wasting. Frontiers in Immunology 13.
Crossref
Dan Zhang, Yutong Liu, Yezhang Zhu, Qian Zhang, Hongxing Guan, Shengduo Liu, Shasha Chen, Chen Mei, Chen Chen, Zhiyong Liao, Ying Xi, Songying Ouyang, Xin-Hua Feng, Tingbo Liang, Li Shen & Pinglong Xu. (2022) A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis. Nature Cell Biology 24:5, pages 766-782.
Crossref
Alyssa M. English, Katelyn M. Green & Stephanie L. Moon. (2021) A (dis)integrated stress response: Genetic diseases of eIF2α regulators . WIREs RNA 13:3.
Crossref
Nerea Corbacho-Alonso, Tamara Sastre-Oliva, Cecilia Corros, Teresa Tejerina, Jorge Solis, Luis F. López-Almodovar, Luis R. Padial, Laura Mourino-Alvarez & Maria G. Barderas. (2022) Prioritization of Candidate Biomarkers for Degenerative Aortic Stenosis through a Systems Biology-Based In-Silico Approach. Journal of Personalized Medicine 12:4, pages 642.
Crossref
Hongjie Wang, Srikanth Karnati & Thati Madhusudhan. (2022) Regulation of the Homeostatic Unfolded Protein Response in Diabetic Nephropathy. Pharmaceuticals 15:4, pages 401.
Crossref
Stefan J. Marciniak, Joseph E. Chambers & David Ron. (2021) Pharmacological targeting of endoplasmic reticulum stress in disease. Nature Reviews Drug Discovery 21:2, pages 115-140.
Crossref
Hui Li, Wen Wen & Jia Luo. (2022) Targeting Endoplasmic Reticulum Stress as an Effective Treatment for Alcoholic Pancreatitis. Biomedicines 10:1, pages 108.
Crossref
Medha Mittal, Shankar Dhungel, Harini Bandarpalli & Anuradha Rai. (2022) Wolcott rallison syndrome: Beyond neonatal diabetes. Indian Pediatrics Case Reports 2:4, pages 212.
Crossref
M. Teresa Borrello, Mickenzie B. Martin & Christopher L. Pin. (2022) The unfolded protein response: An emerging therapeutic target for pancreatitis and pancreatic ductal adenocarcinoma. Pancreatology 22:1, pages 148-159.
Crossref
Mengxiong Wang, Mary E. Law & Brian K. Law. 2022. Mechanisms of Cell Death and Opportunities for Therapeutic Development. Mechanisms of Cell Death and Opportunities for Therapeutic Development 119 174 .
Agnieszka Krzyzosiak, Aleksandra P. Pitera & Anne Bertolotti. 2022. The Integrated Stress Response. The Integrated Stress Response 3 18 .
Hongxing Xu, Xinhai Ye, Yajun Yang, Yi Yang, Yu H Sun, Yang Mei, Shijiao Xiong, Kang He, Le Xu, Qi Fang, Fei Li, Gongyin Ye & Zhongxian Lu. (2021) Comparative Genomics Sheds Light on the Convergent Evolution of Miniaturized Wasps. Molecular Biology and Evolution 38:12, pages 5539-5554.
Crossref
Tao Zhu, Xin Qi, Yu Chen, Liang Wang, Xueze Lv, Weifang Yang, Jianwei Zhang, Kaiyang Li, Zhonghua Ning, Zhihua Jiang & Lujiang Qu. (2021) Positive selection of skeleton-related genes during duck domestication revealed by whole genome sequencing. BMC Ecology and Evolution 21:1.
Crossref
Xuan Li & Wei Yang. (2021) An update on the unfolded protein response in brain ischemia: Experimental evidence and therapeutic opportunities. Neurochemistry International 151, pages 105218.
Crossref
Yasmeena Jan, Muneeb Malik, Vasudha Sharma, Mifftha Yaseen, Jinku Bora & Afrozul Haq. (2021) Utilization of whey for formulation of whey jamun juice ice pops with antidiabetic potential. Food Frontiers 2:4, pages 486-493.
Crossref
Michael A Kalwat, Donalyn Scheuner, Karina Rodrigues-dos-Santos, Decio L Eizirik & Melanie H Cobb. (2021) The Pancreatic ß-cell Response to Secretory Demands and Adaption to Stress. Endocrinology 162:11.
Crossref
Francesco Longo, Maria Mancini, Pierre L. Ibraheem, Sameer Aryal, Caterina Mesini, Jyoti C. Patel, Elena Penhos, Nazia Rahman, Maggie Mamcarz, Emanuela Santini, Margaret E. Rice & Eric Klann. (2021) Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function. Molecular Psychiatry 26:11, pages 6427-6450.
Crossref
Jingjie Hu, Rebecca A. Bourne, Barbara C. McGrath, Alice Lin, Zifei Pei & Douglas R. Cavener. (2021) Co-opting regulation bypass repair as a gene-correction strategy for monogenic diseases. Molecular Therapy 29:11, pages 3274-3292.
Crossref
Danni Jin, Sheree A. Wek, Nathan T. Kudlapur, William A. Cantara, Marina Bakhtina, Ronald C. Wek & Karin Musier-Forsyth. (2021) Disease-associated mutations in a bifunctional aminoacyl-tRNA synthetase gene elicit the integrated stress response. Journal of Biological Chemistry 297:4, pages 101203.
Crossref
Zhenyan He, Linh Lieu, Yanbin Dong, Sadia Afrin, Dominic Chau, Anita Kabahizi, Briana Wallace, Jianhong Cao, Eun-Sang Hwang, Ting Yao, Yiru Huang, Jennifer Okolo, Bo Cheng, Yong Gao, Ling Hu & Kevin W. Williams. (2021) PERK in POMC neurons connects celastrol with metabolism. JCI Insight 6:18.
Crossref
Man Liu, Hong Liu, Preethy Parthiban, Gyeoung-Jin Kang, Guangbin Shi, Feng Feng, Anyu Zhou, Lianzhi Gu, Courtney Karnopp, Elena G. Tolkacheva & Samuel C. DudleyJr.Jr.. (2021) Inhibition of the unfolded protein response reduces arrhythmia risk after myocardial infarction. Journal of Clinical Investigation 131:18.
Crossref
Maxime J. Derisbourg, Matías D. Hartman & Martin S. Denzel. (2021) Modulating the integrated stress response to slow aging and ameliorate age-related pathology. Nature Aging 1:9, pages 760-768.
Crossref
Nadejda Capatina, Myriam Hemberger, Graham J. Burton, Erica D. Watson & Hong Wa Yung. (2021) Excessive endoplasmic reticulum stress drives aberrant mouse trophoblast differentiation and placental development leading to pregnancy loss. The Journal of Physiology 599:17, pages 4153-4181.
Crossref
Daniela Ricci, Tali Gidalevitz & Yair Argon. (2021) The special unfolded protein response in plasma cells. Immunological Reviews 303:1, pages 35-51.
Crossref
Zichao Xiang, Qionghui Wu, Yu Wang, Peng Wang, Yingyou He & Jihua Li. (2021) eIF2α–ATF4 Pathway Activated by a Change in the Calcium Environment Participates in BCP-Mediated Bone Regeneration. ACS Biomaterials Science & Engineering 7:7, pages 3256-3268.
Crossref
Eelco van Anken, Anush Bakunts, Chih-Chi Andrew Hu, Sophie Janssens & Roberto Sitia. (2021) Molecular Evaluation of Endoplasmic Reticulum Homeostasis Meets Humoral Immunity. Trends in Cell Biology 31:7, pages 529-541.
Crossref
Yingying Shi, Yichao Lu & Jian You. (2021) Unfolded protein response in the activation-induced biological processes of CD8+ T cells. Pharmacological Research 169, pages 105654.
Crossref
Yuntian Shen, Ran Li, Shu Yu, Qiang Zhao, Zhuoran Wang, Huaxin Sheng & Wei Yang. (2021) Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice. Journal of the American Heart Association 10:12.
Crossref
Ye-Ya Tan, Yin Zhang, Bin Li, Yang-Wen Ou, Shu-Juan Xie, Pei-Pei Chen, Shi-Qiang Mei, Qiao-Juan Huang, Ling-Ling Zheng & Liang-Hu Qu. (2021) PERK Signaling Controls Myoblast Differentiation by Regulating MicroRNA Networks. Frontiers in Cell and Developmental Biology 9.
Crossref
Mabruka Alfaidi, Matthew L. Scott & Anthony Wayne Orr. (2021) Sinner or Saint?: Nck Adaptor Proteins in Vascular Biology. Frontiers in Cell and Developmental Biology 9.
Crossref
Mariapaola Sidoli, Chelsey B. Reed, Cristina Scapin, Pablo Paez, Douglas R. Cavener, Randal J. Kaufman, Maurizio D'Antonio, M. Laura Feltri & Lawrence Wrabetz. (2021) Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B Demyelinating Neuropathy. The Journal of Neuroscience 41:20, pages 4536-4548.
Crossref
Sentiljana Gumeni, Chiara Vantaggiato, Monica Montopoli & Genny Orso. (2021) Hereditary Spastic Paraplegia and Future Therapeutic Directions: Beneficial Effects of Small Compounds Acting on Cellular Stress. Frontiers in Neuroscience 15.
Crossref
Fei Xue, Jianwen Lu, Samuel C. Buchl, Liankang Sun, Vijay H. Shah, Harmeet Malhi & Jessica L. Maiers. (2021) Coordinated signaling of activating transcription factor 6α and inositol-requiring enzyme 1α regulates hepatic stellate cell-mediated fibrogenesis in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology 320:5, pages G864-G879.
Crossref
Fatima M. Al‐Fadhli, Manal Afqi, Mona Hamza Sairafi, Makki Almuntashri, Essa Alharby, Ghadeer Alharbi, Firoz Abdud Samad, Jamil Amjad Hashmi, Dimah Zaytuni, Ahmed A. Bahashwan, Jin Huk Choi, Roy W. A. Peake, Bruce Beutler & Naif A. M. Almontashiri. (2021) Biallelic loss of function variant in the unfolded protein response gene PDIA6 is associated with asphyxiating thoracic dystrophy and neonatal‐onset diabetes . Clinical Genetics 99:5, pages 694-703.
Crossref
Imke L. Lemmer, Nienke Willemsen, Nazia Hilal & Alexander Bartelt. (2021) A guide to understanding endoplasmic reticulum stress in metabolic disorders. Molecular Metabolism 47, pages 101169.
Crossref
Haoyi Chen. (2021) Review on the Endoplasmic Reticulum Stress and Related Diseases. Review on the Endoplasmic Reticulum Stress and Related Diseases.
Juncheng Wei & Deyu Fang. (2021) Endoplasmic Reticulum Stress Signaling and the Pathogenesis of Hepatocarcinoma. International Journal of Molecular Sciences 22:4, pages 1799.
Crossref
Malgorzata Furmanik, Rick van GorpMeredith Whitehead, Sadia AhmadJayanta Bordoloi, Alexander Kapustin, Leon J. Schurgers & Catherine M. Shanahan. (2021) Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78 (Glucose-Regulated Protein, 78 kDa)-Loaded Extracellular Vesicles. Arteriosclerosis, Thrombosis, and Vascular Biology 41:2, pages 898-914.
Crossref
Shuangchan Wu, Sarrabeth Stone, Yuan Yue & Wensheng Lin. (2020) Endoplasmic reticulum associated degradation is required for maintaining endoplasmic reticulum homeostasis and viability of mature Schwann cells in adults . Glia 69:2, pages 489-506.
Crossref
Laura Sanchez Caballero, Vyron Gorgogietas, Maria Nicol Arroyo & Mariana Igoillo-Esteve. 2021. Pancreatic ß-Cell Biology in Health and Disease. Pancreatic ß-Cell Biology in Health and Disease 139 256 .
Kun Li, Lei Chen, Zhangying Lin, Junwei Zhu, Yang Fang, Juan Du, Bing Shen, Kaile Wu & Yehai Liu. (2020) Role of the AMPK/ACC Signaling Pathway in TRPP2-Mediated Head and Neck Cancer Cell Proliferation. BioMed Research International 2020, pages 1-9.
Crossref
Marina S. Gorbatyuk, Christopher R. Starr & Oleg S. Gorbatyuk. (2020) Endoplasmic reticulum stress: New insights into the pathogenesis and treatment of retinal degenerative diseases. Progress in Retinal and Eye Research 79, pages 100860.
Crossref
Shuangchan Wu, Sarrabeth Stone, Klaus-Armin Nave & Wensheng Lin. (2020) The Integrated UPR and ERAD in Oligodendrocytes Maintain Myelin Thickness in Adults by Regulating Myelin Protein Translation. The Journal of Neuroscience 40:43, pages 8214-8232.
Crossref
Deepika Vasudevan, Sarah D. Neuman, Amy Yang, Lea Lough, Brian Brown, Arash Bashirullah, Timothy Cardozo & Hyung Don Ryoo. (2020) Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR. Nature Communications 11:1.
Crossref
Takaaki Tamura, Yusuke Yoshioka, Shinichi Sakamoto, Tomohiko Ichikawa & Takahiro Ochiya. (2020) Extracellular Vesicles in Bone Metastasis: Key Players in the Tumor Microenvironment and Promising Therapeutic Targets. International Journal of Molecular Sciences 21:18, pages 6680.
Crossref
Kristopher Burkewitz, Gaomin Feng, Sneha Dutta, Charlotte A. Kelley, Michael Steinbaugh, Erin J. Cram & William B. Mair. (2020) Atf-6 Regulates Lifespan through ER-Mitochondrial Calcium Homeostasis. Cell Reports 32:10, pages 108125.
Crossref
Neha Shrestha, Rachel B. Reinert & Ling Qi. (2020) Endoplasmic Reticulum Protein Quality Control in β Cells. Seminars in Cell & Developmental Biology 103, pages 59-67.
Crossref
Ya-chao WangXuan LiYuntian ShenJingjun LyuHuaxin ShengWulf PaschenWei Yang. (2020) PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis. Stroke 51:5, pages 1570-1577.
Crossref
Mauro Costa-Mattioli & Peter Walter. (2020) The integrated stress response: From mechanism to disease. Science 368:6489.
Crossref
Giusy Di Conza & Ping-Chih Ho. (2020) ER Stress Responses: An Emerging Modulator for Innate Immunity. Cells 9:3, pages 695.
Crossref
Sarrabeth Stone, Shuangchan Wu, Klaus-Armin Nave & Wensheng Lin. (2020) The UPR preserves mature oligodendrocyte viability and function in adults by regulating autophagy of PLP. JCI Insight 5:5.
Crossref
Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, Takashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki & Hideki Nishitoh. (2020) ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue. Life Science Alliance 3:3, pages e201900576.
Crossref
Elisa De Franco, Richard CaswellMatthew B. JohnsonMatthew N. WakelingAmnon Zung, Vũ Chí Dũng, Cấn Thị Bích Ngọc, Rajiv GoonetillekeMaritza Vivanco Jury, Mohammed El-Khateeb, Sian EllardSarah E. FlanaganDavid RonAndrew T. Hattersley. (2020) De Novo Mutations in EIF2B1 Affecting eIF2 Signaling Cause Neonatal/Early-Onset Diabetes and Transient Hepatic Dysfunction . Diabetes 69:3, pages 477-483.
Crossref
Sonam Chawla, Babita Rahar, Rajkumar Tulswani & Shweta Saxena. (2020) Preventive preclinical efficacy of intravenously administered sphingosine-1-phosphate (S1P) in strengthening hypoxia adaptive responses to acute and sub-chronic hypobaric hypoxia. European Journal of Pharmacology 870, pages 172877.
Crossref
Alisson C. Cardoso, Nicholas T. Lam, Jainy J. Savla, Yuji Nakada, Ana Helena M. Pereira, Abdallah Elnwasany, Ivan Menendez-Montes, Emily L. Ensley, Ursa Bezan Petric, Gaurav Sharma, A. Dean Sherry, Craig R. Malloy, Chalermchai Khemtong, Michael T. Kinter, Wilson Lek Wen Tan, Chukwuemeka G. Anene-Nzelu, Roger Sik-Yin Foo, Ngoc Uyen Nhi Nguyen, Shujuan Li, Mahmoud Salama Ahmed, Waleed M. Elhelaly, Salim Abdisalaam, Aroumougame Asaithamby, Chao Xing, Mohammed Kanchwala, Gonçalo Vale, Kaitlyn M. Eckert, Matthew A. Mitsche, Jeffrey G. McDonald, Joseph A. Hill, Linzhang Huang, Philip W. Shaul, Luke I. Szweda & Hesham A. Sadek. (2020) Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression. Nature Metabolism 2:2, pages 167-178.
Crossref
Irina X Zhang, Malini Raghavan & Leslie S Satin. (2020) The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells. Endocrinology 161:2.
Crossref
Federica Zatterale, Michele Longo, Jamal Naderi, Gregory Alexander Raciti, Antonella Desiderio, Claudia Miele & Francesco Beguinot. (2020) Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes. Frontiers in Physiology 10.
Crossref
Yoshiaki Morishita & Peter Arvan. (2020) Lessons from animal models of endocrine disorders caused by defects of protein folding in the secretory pathway. Molecular and Cellular Endocrinology 499, pages 110613.
Crossref
Anirban Roy & Ashok Kumar. (2019) ER Stress and Unfolded Protein Response in Cancer Cachexia. Cancers 11:12, pages 1929.
Crossref
Asmita Bhattacharya & Ling Qi. (2019) ER-associated degradation in health and disease – from substrate to organism. Journal of Cell Science 132:23.
Crossref
Tarah H. Fatani. (2019) EIF2AK3 novel mutation in a child with early-onset diabetes mellitus, a case report. BMC Pediatrics 19:1.
Crossref
Yingying Sun, Yanzhi Liu, Xiaohui Sun, Yurui Lin, Daiqing Yin, Shixia Xu & Guang Yang. (2019) Insights into body size variation in cetaceans from the evolution of body-size-related genes. BMC Evolutionary Biology 19:1.
Crossref
Tatiana Danilova, Emilia Galli, Emmi Pakarinen, Erik Palm, Päivi Lindholm, Mart Saarma & Maria Lindahl. (2019) Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function. Frontiers in Endocrinology 10.
Crossref
Shiqun Liu, Xin Li, Jing Yang, Ruimin Zhu, Zhenqian Fan, Xiaoxi Xu, Wenli Feng, Jingqiu Cui, Jinhong Sun & Ming Liu. (2019) Misfolded proinsulin impairs processing of precursor of insulin receptor and insulin signaling in β cells. The FASEB Journal 33:10, pages 11338-11348.
Crossref
Natalia Siwecka, Wioletta Rozpędek, Dariusz Pytel, Adam Wawrzynkiewicz, Adam Dziki, Łukasz Dziki, J. Alan Diehl & Ireneusz Majsterek. (2019) Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis. International Journal of Molecular Sciences 20:18, pages 4354.
Crossref
G. Elif Karagöz, Diego Acosta-Alvear & Peter Walter. (2019) The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum. Cold Spring Harbor Perspectives in Biology 11:9, pages a033886.
Crossref
Yoshika Janapala, Thomas Preiss & Nikolay E. Shirokikh. (2019) Control of Translation at the Initiation Phase During Glucose Starvation in Yeast. International Journal of Molecular Sciences 20:16, pages 4043.
Crossref
Ruimin Zhu, Xin Li, Jialu Xu, Cesar Barrabi, Dilini Kekulandara, James Woods, Xuequn Chen & Ming Liu. (2019) Defective endoplasmic reticulum export causes proinsulin misfolding in pancreatic β cells. Molecular and Cellular Endocrinology 493, pages 110470.
Crossref
Katarzyna A. Piróg, Ella P. Dennis, Claire L. Hartley, Robert M. Jackson, Jamie Soul, Jean-Marc Schwartz, John F. Bateman, Raymond P. Boot-Handford & Michael D. Briggs. (2019) XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease. PLOS Genetics 15:7, pages e1008215.
Crossref
Sarah R. Chadwick & Patrick Lajoie. (2019) Endoplasmic Reticulum Stress Coping Mechanisms and Lifespan Regulation in Health and Diseases. Frontiers in Cell and Developmental Biology 7.
Crossref
Yan Bao, Ying Ao, Bo Yi & Jo Batubayier. (2019) High levels of glucose induce epithelial-mesenchymal transition in renal proximal tubular cells through PERK-eIF2α pathway. Chinese Medical Journal 132:7, pages 868-872.
Crossref
Kefan Zhang, Miaomiao Wang, Yingjiang Li, Chunping Li, Shaidi Tang, Xiuxia Qu, Ninghan Feng & Yu Wu. (2019) The PERK-EIF2α-ATF4 signaling branch regulates osteoblast differentiation and proliferation by PTH. American Journal of Physiology-Endocrinology and Metabolism 316:4, pages E590-E604.
Crossref
Steffen Preissler & David Ron. (2019) Early Events in the Endoplasmic Reticulum Unfolded Protein Response. Cold Spring Harbor Perspectives in Biology 11:4, pages a033894.
Crossref
Cheng‐Tien Wu, Ya‐Wen Chen, Yen‐Hao Su, Chen‐Yuan Chiu, Siao‐Syun Guan, Rong‐Seg Yang & Shing‐Hwa Liu. (2019) Gender difference of CCAAT/enhancer binding protein homologous protein deficiency in susceptibility to osteopenia. Journal of Orthopaedic Research 37:4, pages 942-947.
Crossref
Milena Vitale, Anush Bakunts, Andrea Orsi, Federica Lari, Laura Tadè, Alberto Danieli, Claudia Rato, Caterina Valetti, Roberto Sitia, Andrea Raimondi, John C Christianson & Eelco van Anken. (2019) Inadequate BiP availability defines endoplasmic reticulum stress. eLife 8.
Crossref
Huabin Zhu, Brinda Bhatt, Sathish Sivaprakasam, Yafei Cai, Siyang Liu, Sai Karthik Kodeboyina, Nikhil Patel, Natasha M. Savage, Ashok Sharma, Randal J. Kaufman, Honglin Li & Nagendra Singh. (2019) Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR. Nature Communications 10:1.
Crossref
Sahana Mitra & Hyung Don Ryoo. (2019) The unfolded protein response in metazoan development. Journal of Cell Science 132:5.
Crossref
Yann S. Gallot, Kyle R. Bohnert, Alex R. Straughn, Guangyan Xiong, Sajedah M. Hindi & Ashok Kumar. (2018) PERK regulates skeletal muscle mass and contractile function in adult mice. The FASEB Journal 33:2, pages 1946-1962.
Crossref
Sarrabeth Stone, Yuan Yue, Milos Stanojlovic, Shuangchan Wu, Gerard Karsenty & Wensheng Lin. (2019) Neuron-specific PERK inactivation exacerbates neurodegeneration during experimental autoimmune encephalomyelitis. JCI Insight 4:2.
Crossref
Dil Afroze & Ashok Kumar. (2019) ER stress in skeletal muscle remodeling and myopathies. The FEBS Journal 286:2, pages 379-398.
Crossref
P. A. Bell, E. P. Dennis, C. L. Hartley, R. M. Jackson, A. Porter, R. P. Boot-Handford, K. A. Pirog & M. D. Briggs. (2018) Mesencephalic astrocyte-derived neurotropic factor is an important factor in chondrocyte ER homeostasis. Cell Stress and Chaperones 24:1, pages 159-173.
Crossref
Caia S. Dominicus, Vruti Patel, Joseph E. Chambers, Elke Malzer & Stefan J. Marciniak. 2019. The Unfolded Protein Response in Cancer. The Unfolded Protein Response in Cancer 17 47 .
Malgorzata Furmanik & Catherine M. Shanahan. (2018) ER stress regulates alkaline phosphatase gene expression in vascular smooth muscle cells via an ATF4-dependent mechanism. BMC Research Notes 11:1.
Crossref
Tamás Dolinay, Chanat Aonbangkhen, William Zacharias, Edward Cantu, Jennifer Pogoriler, Alec Stablow, Gladys G. Lawrence, Yoshikazu Suzuki, David M. Chenoweth, Edward Morrisey, Jason D. Christie, Michael F. Beers & Susan S. Margulies. (2018) Protein kinase R-like endoplasmic reticulum kinase is a mediator of stretch in ventilator-induced lung injury. Respiratory Research 19:1.
Crossref
Soroush Tahmasebi, Arkady Khoutorsky, Michael B. Mathews & Nahum Sonenberg. (2018) Translation deregulation in human disease. Nature Reviews Molecular Cell Biology 19:12, pages 791-807.
Crossref
Troy L. Merry & Maxim S. Petrov. (2018) The rise of genetically engineered mouse models of pancreatitis: A review of literature. Biomolecular Concepts 9:1, pages 103-114.
Crossref
Tatiana Danilova & Maria Lindahl. (2018) Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes. Frontiers in Physiology 9.
Crossref
Kalaivanan Kalpana, Emayavaramban Priyadarshini, S. Sreeja, Kalivarathan Jagan & Carani Venkatraman Anuradha. (2018) Scopoletin intervention in pancreatic endoplasmic reticulum stress induced by lipotoxicity. Cell Stress and Chaperones 23:5, pages 857-869.
Crossref
George Kefalas, Nathalie Jouvet, Cindy Baldwin, Jennifer L. Estall & Louise Larose. (2018) Peptide-based sequestration of the adaptor protein Nck1 in pancreatic β cells enhances insulin biogenesis and protects against diabetogenic stresses. Journal of Biological Chemistry 293:32, pages 12516-12524.
Crossref
Tsun-Kai Chang, David A. Lawrence, Min Lu, Jenille Tan, Jonathan M. Harnoss, Scot A. Marsters, Peter Liu, Wendy Sandoval, Scott E. Martin & Avi Ashkenazi. (2018) Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate. Molecular Cell 71:4, pages 629-636.e5.
Crossref
Mengxiong Wang, Mary E. Law, Ronald K. Castellano & Brian K. Law. (2018) The unfolded protein response as a target for anticancer therapeutics. Critical Reviews in Oncology/Hematology 127, pages 66-79.
Crossref
Yasmeen M. Taalab, Nour Ibrahim, Ahmed Maher, Mubashir Hassan, Wael Mohamed, Ahmed A. Moustafa, Mohamed Salama, Dina Johar & Larry Bernstein. (2018) Mechanisms of disordered neurodegenerative function: concepts and facts about the different roles of the protein kinase RNA-like endoplasmic reticulum kinase (PERK). Reviews in the Neurosciences 29:4, pages 387-415.
Crossref
Rose Ghemrawi, Shyue-Fang Battaglia-Hsu & Carole Arnold. (2018) Endoplasmic Reticulum Stress in Metabolic Disorders. Cells 7:6, pages 63.
Crossref
Chinar Berry, Megha Lal & B. K. Binukumar. (2018) Crosstalk Between the Unfolded Protein Response, MicroRNAs, and Insulin Signaling Pathways: In Search of Biomarkers for the Diagnosis and Treatment of Type 2 Diabetes. Frontiers in Endocrinology 9.
Crossref
Hao G. NguyenCrystal S. Conn, Yae Kye, Lingru Xue, Craig M. Forester, Janet E. Cowan, Andrew C. Hsieh, John T. Cunningham, Charles Truillet, Feven Tameire, Michael J. Evans, Christopher P. Evans, Joy C. YangByron Hann, Constantinos Koumenis, Peter Walter, Peter R. CarrollDavide Ruggero. (2018) Development of a stress response therapy targeting aggressive prostate cancer. Science Translational Medicine 10:439.
Crossref
Michela Rossi, Giulia Battafarano, Matteo D’Agostini & Andrea Del Fattore. (2018) The Role of Extracellular Vesicles in Bone Metastasis. International Journal of Molecular Sciences 19:4, pages 1136.
Crossref
Anoop Arunagiri, Leena Haataja, Corey N. Cunningham, Neha Shrestha, Billy Tsai, Ling Qi, Ming Liu & Peter Arvan. (2018) Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes. Annals of the New York Academy of Sciences 1418:1, pages 5-19.
Crossref
Carrie R. Sowers, Rong Wang, Rebecca A. Bourne, Barbara C. McGrath, Jingjie Hu, Sarah C. Bevilacqua, James C. Paton, Adrienne W. Paton, Sophie Collardeau-Frachon, Marc Nicolino & Douglas R. Cavener. (2018) The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones. Journal of Biological Chemistry 293:14, pages 5134-5149.
Crossref
Man Liu, Guangbin Shi, Anyu Zhou, Cassady E. Rupert, Kareen L.K. Coulombe & Samuel C. DudleyJrJr. (2018) Activation of the unfolded protein response downregulates cardiac ion channels in human induced pluripotent stem cell-derived cardiomyocytes. Journal of Molecular and Cellular Cardiology 117, pages 62-71.
Crossref
Joy Ogbechi, Belinda S. Hall, Thomas Sbarrato, Jack Taunton, Anne E. Willis, Ronald C. Wek & Rachel E. Simmonds. (2018) Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4. Cell Death & Disease 9:3.
Crossref
Min Joo Kim, Se Hee Min, Seon Young Shin, Mi Na Kim, Hakmo Lee, Jin Young Jang, Sun-Whe Kim, Kyong Soo Park & Hye Seung Jung. (2018) Attenuation of PERK enhances glucose-stimulated insulin secretion in islets. Journal of Endocrinology 236:3, pages 125-136.
Crossref
Mohammed Bensellam, Jean-Christophe Jonas & D Ross Laybutt. (2018) Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions. Journal of Endocrinology 236:2, pages R109-R143.
Crossref
George Kefalas & Louise Larose. (2018) PERK leads a hub dictating pancreatic β cell homoeostasis. Biology of the Cell 110:2, pages 27-32.
Crossref
Weijing Cai, Lilibeth A. Salvador-Reyes, Wei Zhang, Qi-Yin Chen, Susan Matthew, Ranjala Ratnayake, Soo Jung Seo, Simon Dolles, Daniel J. Gibson, Valerie J. Paul & Hendrik Luesch. (2017) Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing. ACS Chemical Biology 13:1, pages 91-99.
Crossref
Satoshi Hisanaga, Masato Miyake, Shusuke Taniuchi, Miho Oyadomari, Masatoshi Morimoto, Ryosuke Sato, Jun Hirose, Hiroshi Mizuta & Seiichi Oyadomari. (2018) PERK-mediated translational control is required for collagen secretion in chondrocytes. Scientific Reports 8:1.
Crossref
Jumana Yousuf Al-Aama, Hams Saeed Al-Zahrani, Musharraf Jelani, Hesham Salih Sabir, Saad Abdullah Al-Saeedi & Saleem Ahmed. (2018) Novel splice site mutation in EIF2AK3 gene causes Wolcott-Rallison syndrome in a consanguineous family from Saudi Arabia . Congenital Anomalies 58:1, pages 39-40.
Crossref
Yiwen Bu, Akihiro Yoshida, Nilesh Chitnis, Brian J. Altman, Feven Tameire, Amanda Oran, Victoria Gennaro, Kent E. Armeson, Steven B. McMahon, Gerald B. Wertheim, Chi V. Dang, Davide Ruggero, Constantinos Koumenis, Serge Y. Fuchs & J. Alan Diehl. (2017) A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nature Cell Biology 20:1, pages 104-115.
Crossref
Yanfei Wang, Xiangguo Liu & Zhigang Xu. (2017) Endoplasmic Reticulum Stress in Hearing Loss. Journal of Otorhinolaryngology, Hearing and Balance Medicine 1:1, pages 3.
Crossref
Andrey V. Cybulsky. (2017) Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases. Nature Reviews Nephrology 13:11, pages 681-696.
Crossref
Cynthia A. Martin-Jiménez, Ángela García-Vega, Ricardo Cabezas, Gjumrakch Aliev, Valentina Echeverria, Janneth González & George E. Barreto. (2017) Astrocytes and endoplasmic reticulum stress: A bridge between obesity and neurodegenerative diseases. Progress in Neurobiology 158, pages 45-68.
Crossref
Yu-Xiong Feng, Dexter X. Jin, Ethan S. Sokol, Ferenc Reinhardt, Daniel H. Miller & Piyush B. Gupta. (2017) Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1. Nature Communications 8:1.
Crossref
Asma Deeb, Faisal Al-Zidgali & Bibian N Ofoegbu. (2017) Multicystic dysplastic kidney: a new association of Wolcott–Rallison syndrome. Endocrinology, Diabetes & Metabolism Case Reports 2017.
Crossref
Mari McMahon, Afshin Samali & Eric Chevet. (2017) Regulation of the unfolded protein response by noncoding RNA. American Journal of Physiology-Cell Physiology 313:3, pages C243-C254.
Crossref
Elena N. Fazio, Claire C. Young, Jelena Toma, Michael Levy, Kurt R. Berger, Charis L. Johnson, Rashid Mehmood, Patrick Swan, Alphonse Chu, Sean P. Cregan, F. Jeffrey Dilworth, Christopher J. Howlett & Christopher L. Pin. (2017) Activating transcription factor 3 promotes loss of the acinar cell phenotype in response to cerulein-induced pancreatitis in mice. Molecular Biology of the Cell 28:18, pages 2347-2359.
Crossref
Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve & Paraskevi Salpea. (2017) Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells. Molecular Metabolism 6:9, pages 1024-1039.
Crossref
Rizaldy C. Zapata, Arashdeep Singh, Adel Pezeshki, Traj Nibber & Prasanth K. Chelikani. (2017) Whey Protein Components - Lactalbumin and Lactoferrin - Improve Energy Balance and Metabolism. Scientific Reports 7:1.
Crossref
Tamas Dolinay, Blanca E. Himes, Maya Shumyatcher, Gladys Gray Lawrence & Susan S. Margulies. (2017) Integrated Stress Response Mediates Epithelial Injury in Mechanical Ventilation. American Journal of Respiratory Cell and Molecular Biology 57:2, pages 193-203.
Crossref
Courtney M. Karner & Fanxin Long. (2016) Wnt signaling and cellular metabolism in osteoblasts. Cellular and Molecular Life Sciences 74:9, pages 1649-1657.
Crossref
Martin Larhammar, Sarah Huntwork-Rodriguez, Zhiyu Jiang, Hilda Solanoy, Arundhati Sengupta Ghosh, Bei Wang, Joshua S Kaminker, Kevin Huang, Jeffrey Eastham-Anderson, Michael Siu, Zora Modrusan, Madeline M Farley, Marc Tessier-Lavigne, Joseph W Lewcock & Trent A Watkins. (2017) Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult. eLife 6.
Crossref
Guangyan Xiong, Sajedah M Hindi, Aman K Mann, Yann S Gallot, Kyle R Bohnert, Douglas R Cavener, Scott R Whittemore & Ashok Kumar. (2017) The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration. eLife 6.
Crossref
Julia Schumacher, Hans Zischler & Holger Herlyn. (2017) Effects of different kinds of essentiality on sequence evolution of human testis proteins. Scientific Reports 7:1.
Crossref
Jeyapriya R. Sundaram, Irene C.J. Lee & Shirish Shenolikar. (2017) Translating protein phosphatase research into treatments for neurodegenerative diseases. Biochemical Society Transactions 45:1, pages 101-112.
Crossref
Fatemeh Navid & Robert A. Colbert. (2016) Causes and consequences of endoplasmic reticulum stress in rheumatic disease. Nature Reviews Rheumatology 13:1, pages 25-40.
Crossref
Mauro Costa-Mattioli & Eric Klann. 2017. Learning and Memory: A Comprehensive Reference. Learning and Memory: A Comprehensive Reference 311 328 .
Erkan Yilmaz. 2017. Obesity and Lipotoxicity. Obesity and Lipotoxicity 261 276 .
Dariusz Pytel, Yan Gao, Katarzyna Mackiewicz, Yuliya V. Katlinskaya, Kirk A. Staschke, Maria C. G. Paredes, Akihiro Yoshida, Shuo Qie, Gao Zhang, Olga S. Chajewski, Lawrence Wu, Ireneusz Majsterek, Meenhard Herlyn, Serge Y. Fuchs & J. Alan Diehl. (2016) PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. PLOS Genetics 12:12, pages e1006518.
Crossref
Siying Zhu, Barbara C. McGrath, Yuting Bai, Xin Tang & Douglas R. Cavener. (2016) PERK regulates Gq protein-coupled intracellular Ca2+ dynamics in primary cortical neurons. Molecular Brain 9:1.
Crossref
R. P. Dias, C. R. Buchanan, N. Thomas, S. Lim, G. Solanki, SEJ Connor, T. G. Barrett & R. R. Kapoor. (2016) Os odontoideum in wolcott-rallison syndrome: a case series of 4 patients. Orphanet Journal of Rare Diseases 11:1.
Crossref
Mariapaola Sidoli, Nicolò Musner, Nicholas Silvestri, Daniela Ungaro, Maurizio D'Antonio, Douglas R. Cavener, M. Laura Feltri & Lawrence Wrabetz. (2016) Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse . The Journal of Neuroscience 36:44, pages 11350-11361.
Crossref
Xiaoquan Xiong, Qing Li, Wei Cui, Zu-Hua Gao & Jun-Li Liu. (2016) Deteriorated high-fat diet-induced diabetes caused by pancreatic β-cell-specific overexpression of Reg3β gene in mice. Endocrine 54:2, pages 360-370.
Crossref
Stéphanie Moortgat, Julie Désir, Valérie Benoit, Sébastien Boulanger, Hélène Pendeville, Marie-Cécile Nassogne, Damien Lederer & Isabelle Maystadt. (2016) Two novel EIF2S3 mutations associated with syndromic intellectual disability with severe microcephaly, growth retardation, and epilepsy . American Journal of Medical Genetics Part A 170:11, pages 2927-2933.
Crossref
Arkady KhoutorskyRobert E. SorgeMasha Prager-KhoutorskySophie Anne PawlowskiGeraldine LongoSeyed Mehdi JafarnejadSoroush TahmasebiLoren J. MartinMark H. PitcherChristos G. GkogkasReza Sharif-Naeini, Alfredo Ribeiro-da-SilvaCharles W. BourqueFernando CerveroJeffrey S. MogilNahum Sonenberg. (2016) eIF2α phosphorylation controls thermal nociception. Proceedings of the National Academy of Sciences 113:42, pages 11949-11954.
Crossref
Gökhan S. Hotamisligil & Roger J. Davis. (2016) Cell Signaling and Stress Responses. Cold Spring Harbor Perspectives in Biology 8:10, pages a006072.
Crossref
Allison Kupsco & Daniel Schlenk. (2016) Molecular mechanisms of selenium-Induced spinal deformities in fish. Aquatic Toxicology 179, pages 143-150.
Crossref
Siying Zhu, Keely Henninger, Barbara C. McGrath & Douglas R. Cavener. (2016) PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility. PLOS ONE 11:9, pages e0162766.
Crossref
Kyle R. Bohnert, Yann S. Gallot, Shuichi Sato, Guangyan Xiong, Sajedah M. Hindi & Ashok Kumar. (2016) Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia. The FASEB Journal 30:9, pages 3053-3068.
Crossref
Keisuke Horiuchi, Takahide Tohmonda & Hideo Morioka. (2016) The unfolded protein response in skeletal development and homeostasis. Cellular and Molecular Life Sciences 73:15, pages 2851-2869.
Crossref
Lauren N. Guthrie, Kavitha Abiraman, Emily S. Plyler, Neil T. Sprenkle, Sara A. Gibson, Braden C. McFarland, Rajani Rajbhandari, Amber L. Rowse, Etty N. Benveniste & Gordon P. Meares. (2016) Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses. Journal of Biological Chemistry 291:30, pages 15830-15840.
Crossref
Ai-Li Cao, Li Wang, Xia Chen, Yun-Man Wang, Heng-Jiang Guo, Shuang Chu, Cheng Liu, Xue-Mei Zhang & Wen Peng. (2016) Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy. Laboratory Investigation 96:6, pages 610-622.
Crossref
Rupak Chakraborty, Ji Hyeong Baek, Eun Young Bae, Woe-Yeon Kim, Sang Yeol Lee & Min Gab Kim. (2016) Comparison and contrast of plant, yeast, and mammalian ER stress and UPR. Applied Biological Chemistry 59:3, pages 337-347.
Crossref
Nicolò Musner, Mariapaola Sidoli, Desireè Zambroni, Ubaldo Del Carro, Daniela Ungaro, Maurizio D’Antonio, Maria L. Feltri & Lawrence Wrabetz. (2016) Perk Ablation Ameliorates Myelination in S63del-Charcot–Marie–Tooth 1B Neuropathy . ASN Neuro 8:2, pages 175909141664235.
Crossref
Abbas Ali Mahdi, Syed Husain Mustafa Rizvi & Arshiya Parveen. (2015) Role of Endoplasmic Reticulum Stress and Unfolded Protein Responses in Health and Diseases. Indian Journal of Clinical Biochemistry 31:2, pages 127-137.
Crossref
Rajesh Ravindran, Jens Loebbermann, Helder I. Nakaya, Nooruddin Khan, Hualing Ma, Leonardo Gama, Deepa K. Machiah, Benton Lawson, Paul Hakimpour, Yi-chong Wang, Shuzhao Li, Prachi Sharma, Randal J. Kaufman, Jennifer Martinez & Bali Pulendran. (2016) The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature 531:7595, pages 523-527.
Crossref
D Pytel, I Majsterek & J A Diehl. (2015) Tumor progression and the different faces of the PERK kinase. Oncogene 35:10, pages 1207-1215.
Crossref
Daisuke Kamimura, Yasunobu Arima, Mineko Tsuruoka, Jing-jing Jiang, Hidenori Bando, Jie Meng, Lavannya Sabharwal, Andrea Stofkova, Naoki Nishikawa, Kotaro Higuchi, Hideki Ogura, Toru Atsumi & Masaaki Murakami. (2016) Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells. International Immunology 28:3, pages 117-126.
Crossref
Kateřina Kratochvílová, Lukáš Moráň, Stanislava Paďourová, Stanislav Stejskal, Lenka Tesařová, Pavel Šimara, Aleš Hampl, Irena Koutná & Petr Vaňhara. (2016) The role of the endoplasmic reticulum stress in stemness, pluripotency and development. European Journal of Cell Biology 95:3-5, pages 115-123.
Crossref
Sumaira Z Hasnain, Johannes B Prins & Michael A McGuckin. (2016) Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes. Journal of Molecular Endocrinology 56:2, pages R33-R54.
Crossref
Daniela Eletto, Davide Eletto, Sarah Boyle & Yair Argon. (2015) PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1. The FASEB Journal 30:2, pages 653-665.
Crossref
Feyza Engin. (2016) ER stress and development of type 1 diabetes. Journal of Investigative Medicine 64:1, pages 2-6.
Crossref
Man Liu & Samuel DudleyJr.Jr.. (2015) Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias. International Journal of Molecular Sciences 17:1, pages 52.
Crossref
Qiujing YuBin ZhaoJun GuiKanstantsin V. KatlinskiAngela BriceYan GaoChangHong LiJake A. KushnerConstantinos Koumenis, J. Alan DiehlSerge Y. Fuchs. (2015) Type I interferons mediate pancreatic toxicities of PERK inhibition. Proceedings of the National Academy of Sciences 112:50, pages 15420-15425.
Crossref
Bairong Xia, Shanshan Yang, Tianbo Liu & Ge Lou. (2015) miR-211 suppresses epithelial ovarian cancer proliferation and cell-cycle progression by targeting Cyclin D1 and CDK6. Molecular Cancer 14:1.
Crossref
Lama Yamani, Bing Li & Louise Larose. (2015) Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling. Cellular Signalling 27:12, pages 2555-2567.
Crossref
Kristin D. Kernohan, Martine Tétreault, Urszula Liwak-Muir, Michael T. Geraghty, Wen Qin, Sunita Venkateswaran, Jorge Davila, Martin Holcik, Jacek Majewski, Julie Richer & Kym M. Boycott. (2015) Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B , is associated with severe microcephaly, short stature and intellectual disability . Human Molecular Genetics 24:22, pages 6293-6300.
Crossref
Sophie Collardeau-Frachon, Alexandre Vasiljevic, Anne Jouvet, Raymonde Bouvier, Valérie Senée & Marc Nicolino. (2015) Microscopic and ultrastructural features in Wolcott-Rallison syndrome, a permanent neonatal diabetes mellitus: about two autopsy cases. Pediatric Diabetes 16:7, pages 510-520.
Crossref
Min Ge, Ronghu Ke, Tianyi Cai, Junyi Yang & Xiongzheng Mu. (2015) Identification and proteomic analysis of osteoblast-derived exosomes. Biochemical and Biophysical Research Communications 467:1, pages 27-32.
Crossref
François Binet & Przemyslaw Sapieha. (2015) ER Stress and Angiogenesis. Cell Metabolism 22:4, pages 560-575.
Crossref
Mauricio Torres, José Manuel Matamala, Claudia Duran-Aniotz, Victor Hugo Cornejo, Andrew Foley & Claudio Hetz. (2015) ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders. Virus Research 207, pages 69-75.
Crossref
Wiep Scheper & Jeroen J. M. Hoozemans. (2015) The unfolded protein response in neurodegenerative diseases: a neuropathological perspective. Acta Neuropathologica 130:3, pages 315-331.
Crossref
Nicolas Dejeans, Kim Barroso, Martin E. Fernandez-Zapico, Afshin Samali & Eric Chevet. (2015) Novel roles of the unfolded protein response in the control of tumor development and aggressiveness. Seminars in Cancer Biology 33, pages 67-73.
Crossref
Kensuke Shima, Matthias Klinger, Stefan Schütze, Inga Kaufhold, Werner Solbach, Norbert Reiling & Jan Rupp. (2015) The role of endoplasmic reticulum-related BiP/GRP78 in interferon gamma-induced persistent C hlamydia pneumoniae infection . Cellular Microbiology 17:7, pages 923-934.
Crossref
Daisuke Kamimura, Kokichi Katsunuma, Yasunobu Arima, Toru Atsumi, Jing-jing Jiang, Hidenori Bando, Jie Meng, Lavannya Sabharwal, Andrea Stofkova, Naoki Nishikawa, Hironao Suzuki, Hideki Ogura, Naoko Ueda, Mineko Tsuruoka, Masaya Harada, Junya Kobayashi, Takanori Hasegawa, Hisahiro Yoshida, Haruhiko Koseki, Ikuo Miura, Shigeharu Wakana, Keigo Nishida, Hidemitsu Kitamura, Toshiyuki Fukada, Toshio Hirano & Masaaki Murakami. (2015) KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR. Nature Communications 6:1.
Crossref
Robyn Cunard. (2015) Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly. Journal of Clinical Medicine 4:4, pages 715-740.
Crossref

Displaying 200 of 464 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.