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Cell Growth and Development

BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets

Timothy K. MacLachlan1 Laboratory of Molecular Oncology and Cell Cycle Regulation;2 Howard Hughes Medical Institute
,
Rishu Takimoto1 Laboratory of Molecular Oncology and Cell Cycle Regulation;2 Howard Hughes Medical Institute
&
Wafik S. El-Deiry1 Laboratory of Molecular Oncology and Cell Cycle Regulation;2 Howard Hughes Medical Institute;3 Genetics;4 Pharmacology;5 Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104;6 Departments of MedicineCorrespondence[email protected]
Pages 4280-4292 | Received 05 Sep 2001, Accepted 08 Mar 2002, Published online: 27 Mar 2023

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Talayeh S. Ghezelayagh, Kathryn P. Pennington, Barbara M. Norquist, Nithisha Khasnavis, Marc R. Radke, Mark R. Kilgore, Rochelle L. Garcia, Ming Lee, Ronit Katz, Kimberly K. Leslie, Rosa Ana Risques & Elizabeth M. Swisher. (2021) Characterizing TP53 mutations in ovarian carcinomas with and without concurrent BRCA1 or BRCA2 mutations. Gynecologic Oncology 160:3, pages 786-792.
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Yu-Chu Wang, Jau-Ling Huang, Ka-Wo Lee, Hsing-Han Lu, Yuan-Jen Lin, Long-Fong Chen, Chung-Sheng Wang, Yun-Chiao Cheng, Zih-Ting Zeng, Pei-Yi Chu & Chang-Shen Lin. (2020) Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53’s DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption. Cancers 12:8, pages 2053.
Crossref
Guangan He, Xiaolei Xie & Zahid H. Siddik. (2020) Protein expression profiling identifies differential modulation of homologous recombination by platinum-based antitumor agents. Cancer Chemotherapy and Pharmacology 85:6, pages 1129-1140.
Crossref
Xuedan Sun, Rick Francis Thorne, Xu Dong Zhang, Miao He, Jinming Li, Shanshan Feng, Xiaoying Liu & Mian Wu. (2020) Lnc RNA GUARDIN suppresses cellular senescence through a LRP 130‐ PGC 1α‐ FOXO 4‐p21‐dependent signaling axis . EMBO reports 21:4.
Crossref
Martina Rama & Benjamin Bonavida. 2020. Prognostic and Therapeutic Applications of RKIP in Cancer. Prognostic and Therapeutic Applications of RKIP in Cancer 175 209 .
Jianbin Guo, Ying Zhang, Haili Qian, Fei Ma, Xiujuan Cui & Hua Duan. (2019) The clinical characteristics and prognosis of endometrial carcinomas that occur after breast cancer: does hormone receptor status of breast cancer matter?. Archives of Gynecology and Obstetrics 300:5, pages 1399-1404.
Crossref
Xiaowen Zhang & Rong Li. (2018) BRCA1-Dependent Transcriptional Regulation: Implication in Tissue-Specific Tumor Suppression. Cancers 10:12, pages 513.
Crossref
Sumegha Mitra. 2018. Ovarian Cancer - From Pathogenesis to Treatment. Ovarian Cancer - From Pathogenesis to Treatment.
Sheng-Yong Yang, Yi Li, Guo-Shun An, Ju-Hua Ni, Hong-Ti Jia & Shu-Yan Li. (2018) DNA Damage-Response Pathway Heterogeneity of Human Lung Cancer A549 and H1299 Cells Determines Sensitivity to 8-Chloro-Adenosine. International Journal of Molecular Sciences 19:6, pages 1587.
Crossref
Babita Sharma, Raman Preet Kaur, Sonali Raut & Anjana Munshi. (2018) BRCA1 mutation spectrum, functions, and therapeutic strategies: The story so far. Current Problems in Cancer 42:2, pages 189-207.
Crossref
Xi Zhang, Simone Hofmann, Nadia Harbeck, Udo Jeschke & Sophie Sixou. (2017) Impact of Etoposide on BRCA1 Expression in Various Breast Cancer Cell Lines. Drugs in R&D 17:4, pages 569-583.
Crossref
Jung-Lye Kim, Geun-Hyoung Ha, Loredana Campo, Mitchell F. Denning, Tarun B. Patel, Clodia Osipo, Shiaw-Yih Lin & Eun-Kyoung Breuer. (2015) The role of Rak in the regulation of stability and function of BRCA1. Oncotarget 8:49, pages 86799-86815.
Crossref
Huda H. Al-Khalaf, Shreeram C. Nallar, Dhananjaya V. Kalvakolanu & Abdelilah Aboussekhra. (2017) p16 INK4A enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction . Molecular Carcinogenesis 56:7, pages 1687-1702.
Crossref
Rikke D. Rasmussen, Madhavsai K. Gajjar, Lucie Tuckova, Kamilla E. Jensen, Apolinar Maya-Mendoza, Camilla B. Holst, Kjeld Møllgaard, Jane S. Rasmussen, Jannick Brennum, Jiri BartekJrJr, Martin Syrucek, Eva Sedlakova, Klaus K. Andersen, Marie H. Frederiksen, Jiri Bartek & Petra Hamerlik. (2016) BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity. Nature Communications 7:1.
Crossref
Samra Khalid, Rumeza Hanif, Samar H.K. Tareen, Amnah Siddiqa, Zurah Bibi & Jamil Ahmad. (2016) Formal modeling and analysis of ER- α associated Biological Regulatory Network in breast cancer . PeerJ 4, pages e2542.
Crossref
A Desantis, T Bruno, V Catena, F De Nicola, F Goeman, S Iezzi, C Sorino, M P Gentileschi, S Germoni, V Monteleone, M Pellegrino, M Kann, P D De Meo, M Pallocca, K Höpker, F Moretti, E Mattei, H C Reinhardt, A Floridi, C Passananti, T Benzing, G Blandino & M Fanciulli. (2015) Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53. Cell Death & Disease 6:5, pages e1764-e1764.
Crossref
Wenwen Zhang, Jiayan Luo, Fengxia Chen, Fang Yang, Wei Song, Aiyu Zhu & Xiaoxiang Guan. (2015) BRCA1 regulates PIG3-mediated apoptosis in a p53-dependent manner. Oncotarget 6:10, pages 7608-7618.
Crossref
Kienan I. Savage & D. Paul Harkin. (2015) BRCA1, a ‘complex’ protein involved in the maintenance of genomic stability. The FEBS Journal 282:4, pages 630-646.
Crossref
Satoru Hayano, Yoshihiro Komatsu, Haichun Pan & Yuji Mishina. (2015) Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis. Development.
Crossref
Honglei Zhou & Isidore Rigoutsos. (2014) The emerging roles of GPRC5A in diseases. Oncoscience 1:12, pages 765-776.
Crossref
Galina Selivanova. (2014) Wild type p53 reactivation: From lab bench to clinic. FEBS Letters 588:16, pages 2628-2638.
Crossref
Yong Yi, Hyo Kang & Insoo Bae. (2014) BRCA1 and Oxidative Stress. Cancers 6:2, pages 771-795.
Crossref
Hua Wang & Guang Peng. (2013) Mathematical Model of Dynamic Protein Interactions Regulating p53 Protein Stability for Tumor Suppression. Computational and Mathematical Methods in Medicine 2013, pages 1-6.
Crossref
Min Jeong Jeon, Wonseok Yang, Hye-Sook Seo, Emily Shizen Wang & Incheol Shin. (2012) Down-regulation of estrogen receptor α (ERα) transcriptional activity by p27 is mediated by inhibition of ERα nuclear localization and modulation of the ERα transcriptional complex. Cellular Signalling 24:12, pages 2249-2258.
Crossref
Athanassios Kotsinas, Vimla Aggarwal, E-Jean Tan, Brynn Levy & Vassilis G. Gorgoulis. (2012) PIG3: A novel link between oxidative stress and DNA damage response in cancer. Cancer Letters 327:1-2, pages 97-102.
Crossref
Yingjuan Qian, Yong-Sam Jung & Xinbin Chen. (2012) Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. Proceedings of the National Academy of Sciences 109:28, pages 11300-11305.
Crossref
Miljana Tanic, Magdalena Zajac, Gonzalo Gómez-López, Javier Benítez & Beatriz Martínez-Delgado. (2011) Integration of BRCA1-mediated miRNA and mRNA profiles reveals microRNA regulation of TRAF2 and NFκB pathway. Breast Cancer Research and Treatment 134:1, pages 41-51.
Crossref
Ammar Abou-Kandil, Rachel Chamias, Mahmoud Huleihel, W. T. Godbey & Mordechai Aboud. (2012) Differential Role of PKC-Induced c-Jun in HTLV-1 LTR Activation by 12-O-Tetradecanoylphorbol-13-acetate in Different Human T-cell Lines. PLoS ONE 7:1, pages e29934.
Crossref
Nadia Rucci, Luca Ventura & Anna Teti. 2012. Biotargets of Cancer in Current Clinical Practice. Biotargets of Cancer in Current Clinical Practice 195 219 .
YanLing Wang, Bing Wang, Hong Zhang, Ning Li, Kaoru Tanaka, Xin Zhou, RuPing Chen & Xin Zhang. (2011) BRCA1 involved in regulation of Bcl-2 expression and apoptosis susceptibility to ionizing radiation. Science China Physics, Mechanics and Astronomy 54:5, pages 916-922.
Crossref
Young-Ho Lee, Mark T. Bedford & Michael R. Stallcup. (2011) Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Genes & Development 25:2, pages 176-188.
Crossref
Weijun Liu, Wenjun Zong, George Wu, Takeo Fujita, Wenqi Li, Judy Wu & Yong Wan. (2010) Turnover of BRCA1 Involves in Radiation-Induced Apoptosis. PLoS ONE 5:12, pages e14484.
Crossref
Anja Taubert, Klaus Wimmers, Siriluck Ponsuksili, Cristina Arce Jimenez, Horst Zahner & Carlos Hermosilla. (2010) Microarray-based transcriptional profiling of Eimeria bovis -infected bovine endothelial host cells . Veterinary Research 41:5, pages 70.
Crossref
Melissa Price & Alvaro N.A. Monteiro. (2010) Fine tuning chemotherapy to match BRCA1 status. Biochemical Pharmacology 80:5, pages 647-653.
Crossref
Ning Li, Hong Zhang, YanLing Wang & JiFang Hao. (2010) BRCA1 and its phosphorylation involved in caffeine-inhibitable event upstream of G2 checkpoint. Science China Physics, Mechanics and Astronomy 53:7, pages 1281-1285.
Crossref
Janet C. Koon & Terrance J. Kubiseski. (2010) Developmental Arrest of Caenorhabditis elegans BRAP-2 Mutant Exposed to Oxidative Stress Is Dependent on BRC-1. Journal of Biological Chemistry 285:18, pages 13437-13443.
Crossref
Galina Selivanova. (2010) Therapeutic targeting of p53 by small molecules. Seminars in Cancer Biology 20:1, pages 46-56.
Crossref
Adriana De Siervi, Paola De Luca, Jung S. Byun, Li Jun Di, Temesgen Fufa, Cynthia M. Haggerty, Elba Vazquez, Cristian Moiola, Dan L. Longo & Kevin Gardner. (2010) Transcriptional Autoregulation by BRCA1. Cancer Research 70:2, pages 532-542.
Crossref
Ekram M. Saleh, Raafat A. El-Awady, Mervat A. Abdel Alim & Abdel Hady A. Abdel Wahab. (2009) Altered Expression of Proliferation-Inducing and Proliferation-Inhibiting Genes Might Contribute to Acquired Doxorubicin Resistance in Breast Cancer Cells. Cell Biochemistry and Biophysics 55:2, pages 95-105.
Crossref
Panagiotis J. Vlachostergios, Anna Patrikidou, Danai D. Daliani & Christos N. Papandreou. (2009) The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 2: transcriptional regulation. Journal of Cellular and Molecular Medicine 13:9b, pages 3019-3031.
Crossref
Ayala Hubert, Bela Mali, Tamar Hamburger, Yakir Rottenberg, Beatrice Uziely, Tamar Peretz & Luna Kadouri. (2008) Response to neo-adjuvant chemotherapy in BRCA1 and BRCA2 related stage III breast cancer. Familial Cancer 8:3, pages 173-177.
Crossref
Marek Rusin, Artur Zajkowicz & Dorota Butkiewicz. (2009) Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. Mechanisms of Ageing and Development 130:8, pages 528-537.
Crossref
Xin Wang, Anna Zhenchuk, Klas G. Wiman & Freidoun Albertioni. (2009) Regulation of p53R2 and its role as potential target for cancer therapy. Cancer Letters 276:1, pages 1-7.
Crossref
Yan-ling Wang, Hong Zhang, Ning Li, Xiao-hu Wang, Ji-fang Hao & Wei-ping Zhao. (2009) Potential mechanisms involved in resistant phenotype of MCF-7 breast carcinoma cells to ionizing radiation induced apoptosis. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 267:6, pages 1001-1006.
Crossref
Kienan Savage & D. Paul Harkin. 2009. The DNA Damage Response: Implications on Cancer Formation and Treatment. The DNA Damage Response: Implications on Cancer Formation and Treatment 415 443 .
Noemí Reguart, Andrés Felipe Cardona, Esther Carrasco, Patricia Gomez, Miquel Taron & Rafael Rosell. (2008) BRCA1: A New Genomic Marker for Non–Small-Cell Lung Cancer. Clinical Lung Cancer 9:6, pages 331-339.
Crossref
Hung-Yun Lin, MingZeng Sun, Heng-Yuan Tang, Tessa M. Simone, Yun-Hsuan Wu, Jennifer R. Grandis, H. James Cao, Paul J. Davis & Faith B. Davis. (2008) Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells. Journal of Cellular Biochemistry 104:6, pages 2131-2142.
Crossref
G. P. Huang, Z. J. Pan, J. P. Huang, J. F. Yang, C. J. Guo, Y. G. Wang, Q. Zheng, R. Chen, Y. L. Xu, G. Z. Wang, Y. M. Xi, D. Shen, J. Jin & J. F. Wang. (2008) Proteomic analysis of human bone marrow mesenchymal stem cells transduced with human telomerase reverse transcriptase gene during proliferation. Cell Proliferation 41:4, pages 625-644.
Crossref
Ying Yan, Claudine P. Black, Phu T. Cao, Jamie L. Haferbier, Ryan H. Kolb, Rebecca S. Spieker, Alexandra M. Ristow & Kenneth H. Cowan. (2008) γ-Irradiation–Induced DNA Damage Checkpoint Activation Involves Feedback Regulation between Extracellular Signal-Regulated Kinase 1/2 and BRCA1. Cancer Research 68:13, pages 5113-5121.
Crossref
Abde M. Abukhdeir & Ben Ho Park. (2008) p21 and p27: roles in carcinogenesis and drug resistance. Expert Reviews in Molecular Medicine 10.
Crossref
Kirsimari Aaltonen, Carl Blomqvist, Rose-Marie Amini, Hannaleena Eerola, Kristiina Aittomäki, Päivi Heikkilä & Heli Nevanlinna. (2008) Familial Breast Cancers without Mutations in BRCA1 or BRCA2 Have Low Cyclin E and High Cyclin D1 in Contrast to Cancers in BRCA Mutation Carriers. Clinical Cancer Research 14:7, pages 1976-1983.
Crossref
Ozlem Keskin, Attila Gursoy, Buyong Ma & Ruth Nussinov. (2008) Principles of Protein−Protein Interactions: What are the Preferred Ways For Proteins To Interact?. Chemical Reviews 108:4, pages 1225-1244.
Crossref
M.M. MurrayP.B. MullanD.P. Harkin. (2007) Role played by BRCA1 in transcriptional regulation in response to therapy. Biochemical Society Transactions 35:5, pages 1342-1346.
Crossref
Shulin Wang & Wafik S. El-Deiry. 2007. 25 Years of p53 Research. 25 Years of p53 Research 141 163 .
Kimberly A. Scata & Wafik S. El-Deiry. 2007. Breast Cancer Chemosensitivity. Breast Cancer Chemosensitivity 70 86 .
Jin Liu, Yongping Pan, Buyong Ma & Ruth Nussinov. (2006) “Similarity Trap” in Protein-Protein Interactions Could Be Carcinogenic: Simulations of p53 Core Domain Complexed with 53BP1 and BRCA1 BRCT Domains. Structure 14:12, pages 1811-1821.
Crossref
Paul B. Mullan, Julia J. Gorski & D. Paul Harkin. (2006) BRCA1—A good predictive marker of drug sensitivity in breast cancer treatment?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1766:2, pages 205-216.
Crossref
Jurgen M. J. Piek, Josephine C. Dorsman, Leon F. Massuger, Anca C. Ansink, Jitske Weegenaar, Avi Shvarts, Peter Kenemans & René H. M. Verheijen. (2006) BRCA1 and p53 protein expression in cultured ovarian surface epithelial cells derived from women with and without a BRCA1 germline mutation. Archives of Gynecology and Obstetrics 274:6, pages 327-331.
Crossref
P B Mullan, J E Quinn & D P Harkin. (2006) The role of BRCA1 in transcriptional regulation and cell cycle control. Oncogene 25:43, pages 5854-5863.
Crossref
Vladimir V Ternovoi, David T Curiel, Bruce F Smith & Gene P Siegal. (2006) Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma. Laboratory Investigation 86:8, pages 748-766.
Crossref
S A Gatz & L Wiesmüller. (2006) p53 in recombination and repair. Cell Death & Differentiation 13:6, pages 1003-1016.
Crossref
Yoshiaki Tabuchi, Ichiro Takasaki, Takeshi Doi, Yoshiyuki Ishii, Hideki Sakai & Takashi Kondo. (2006) Genetic networks responsive to sodium butyrate in colonic epithelial cells. FEBS Letters 580:13, pages 3035-3041.
Crossref
Eliot M. Rosen, Saijun Fan & Yongxian Ma. (2006) BRCA1 regulation of transcription. Cancer Letters 236:2, pages 175-185.
Crossref
M Peng, R Litman, Z Jin, G Fong & S B Cantor. (2006) BACH1 is a DNA repair protein supporting BRCA1 damage response. Oncogene 25:15, pages 2245-2253.
Crossref
Kyle Rosenke, Melanie A. Samuel, Eric T. McDowell, Melissa A. Toerne & Elizabeth A. Fortunato. (2006) An intact sequence-specific DNA-binding domain is required for human cytomegalovirus-mediated sequestration of p53 and may promote in vivo binding to the viral genome during infection. Virology 348:1, pages 19-34.
Crossref
Mei Kuen Tang, Chun Mei Wang, Sze Wan Shan, Yiu Loon Chui, Arthur Kar Keung Ching, Pak Ham Chow, Lars Grotewold, John Yeuk Hon Chan & Kenneth Ka Ho Lee. (2006) Comparative proteomic analysis reveals a function of the novel death receptor-associated protein BRE in the regulation of prohibitin and p53 expression and proliferation. PROTEOMICS 6:8, pages 2376-2385.
Crossref
Jennifer K. Hockings, Patricia A. Thorne, Michael Q. Kemp, Sherif S. Morgan, Ornella Selmin & Donato F. Romagnolo. (2006) The Ligand Status of the Aromatic Hydrocarbon Receptor Modulates Transcriptional Activation of BRCA-1 Promoter by Estrogen. Cancer Research 66:4, pages 2224-2232.
Crossref
Christopher L. Brooks & Wei Gu. 2006. Gene Expression and Regulation. Gene Expression and Regulation 257 272 .
Kenji Fukasawa. (2005) Centrosome amplification, chromosome instability and cancer development. Cancer Letters 230:1, pages 6-19.
Crossref
Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood, Roger A. Schultz & Tom Ellenberger. 2005. DNA Repair and Mutagenesis. DNA Repair and Mutagenesis 779 815 .
Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood, Roger A. Schultz & Tom Ellenberger. 2005. DNA Repair and Mutagenesis. DNA Repair and Mutagenesis 663 710 .
Brandon D. Jeffy, Jennifer K. Hockings, Michael Q. Kemp, Sherif S. Morgan, Jill A. Hager, Jason Beliakoff, Luke J. Whitesell, G. Timothy Bowden & Donato F. Romagnolo. (2005) An Estrogen Receptor-α/p300 Complex Activates the BRCA-1 Promoter at an AP-1 Site That Binds Jun/Fos Transcription Factors: Repressive Effects of p53 on BRCA-1 Transcription. Neoplasia 7:9, pages 873-882.
Crossref
Paul B Mullan, Alison M Hosey, Niamh E Buckley, Jennifer E Quinn, Richard D Kennedy, Patrick G Johnston & D Paul Harkin. (2005) The 2,5 oligoadenylate synthetase/RNaseL pathway is a novel effector of BRCA1- and interferon-γ-mediated apoptosis. Oncogene 24:35, pages 5492-5501.
Crossref
Lea M. Starita, Andrew A. Horwitz, Michael-Christopher Keogh, Chikashi Ishioka, Jeffrey D. Parvin & Natsuko Chiba. (2005) BRCA1/BARD1 Ubiquitinate Phosphorylated RNA Polymerase II. Journal of Biological Chemistry 280:26, pages 24498-24505.
Crossref
Ying Yan, Rebecca S Spieker, Min Kim, Scott M Stoeger & Kenneth H Cowan. (2005) BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation. Oncogene 24:20, pages 3285-3296.
Crossref
Nerea Martínez, Margarita Sánchez-Beato, Amancio Carnero, Victoria Moneo, Juan C. Tercero, Isabel Fernández, Mercedes Navarrete, José Jimeno & Miguel A. Piris. (2005) Transcriptional signature of Ecteinascidin 743 (Yondelis, Trabectedin) in human sarcoma cells explanted from chemo-naïve patients. Molecular Cancer Therapeutics 4:5, pages 814-823.
Crossref
Sarah Aiyar, Jian-long Sun & Rong Li. (2005) BRCA1: A locus-specific ?liaison? in gene expression and genetic integrity. Journal of Cellular Biochemistry 94:6, pages 1103-1111.
Crossref
J L Andersen, E S Zimmerman, J L DeHart, S Murala, O Ardon, J Blackett, J Chen & V Planelles. (2005) ATR and GADD45α mediate HIV-1 Vpr-induced apoptosis. Cell Death & Differentiation 12:4, pages 326-334.
Crossref
Xiaolong Wei, Hai Xu & Donald Kufe. (2005) Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell 7:2, pages 167-178.
Crossref
Timothy MacLachlan & Wafik El-Deiry. 2005. The p53 Tumor Suppressor Pathway and Cancer. The p53 Tumor Suppressor Pathway and Cancer 53 80 .
Guillermina Lozano & Gerard P Zambetti. (2005) What have animal models taught us about the p53 pathway?. The Journal of Pathology 205:2, pages 206-220.
Crossref
R. D. Kennedy, J. E. Quinn, P. B. Mullan, P. G. Johnston & D. P. Harkin. (2004) The Role of BRCA1 in the Cellular Response to Chemotherapy. JNCI Journal of the National Cancer Institute 96:22, pages 1659-1668.
Crossref
Kiyotsugu Yoshida & Yoshio Miki. (2004) Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage. Cancer Science 95:11, pages 866-871.
Crossref
Zhihui Feng, Lisa Kachnic, Junran Zhang, Simon N. Powell & Fen Xia. (2004) DNA Damage Induces p53-dependent BRCA1 Nuclear Export. Journal of Biological Chemistry 279:27, pages 28574-28584.
Crossref
Tohru Yamada, Yoshinori Hiraoka, Masateru Ikehata, Kazuhide Kimbara, Benjamin S. Avner, Tapas K. Das Gupta & Ananda M. Chakrabarty. (2004) Apoptosis or growth arrest: Modulation of tumor suppressor p53's specificity by bacterial redox protein azurin. Proceedings of the National Academy of Sciences 101:14, pages 4770-4775.
Crossref
C. Asker, V. J. N. Bykov, C. Mendez-Vidal, G. Selivanova, M. T. Wilhelm & K. G. Wiman. 2004. Transcription Factors. Transcription Factors 209 258 .
Vasu Punj, Tapas K Das Gupta & Ananda M Chakrabarty. (2003) Bacterial cupredoxin azurin and its interactions with the tumor suppressor protein p53. Biochemical and Biophysical Research Communications 312:1, pages 109-114.
Crossref
Yuanshu Dong, Mohamed-Ali Hakimi, Xiaowei Chen, Easwari Kumaraswamy, Neil S Cooch, Andrew K Godwin & Ramin Shiekhattar. (2003) Regulation of BRCC, a Holoenzyme Complex Containing BRCA1 and BRCA2, by a Signalosome-like Subunit and Its Role in DNA Repair. Molecular Cell 12:5, pages 1087-1099.
Crossref
Wafik S El-Deiry. (2003) The role of p53 in chemosensitivity and radiosensitivity. Oncogene 22:47, pages 7486-7495.
Crossref
Eliot M Rosen, Saijun Fan, Richard G Pestell & Itzhak D Goldberg. (2003) BRCA1 in hormone-responsive cancers. Trends in Endocrinology & Metabolism 14:8, pages 378-385.
Crossref
Peiwen Fei & Wafik S El-Deiry. (2003) P53 and radiation responses. Oncogene 22:37, pages 5774-5783.
Crossref
Eliot M. Rosen, Saijun Fan, Richard G. Pestell & Itzhak D. Goldberg. (2003) BRCA1 gene in breast cancer. Journal of Cellular Physiology 196:1, pages 19-41.
Crossref
Pat P Ongusaha, Toru Ouchi, Kyung-tae Kim, Emily Nytko, Jennifer C Kwak, Rosemary B Duda, Chu-Xia Deng & Sam W Lee. (2003) BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest. Oncogene 22:24, pages 3749-3758.
Crossref
Xiaoling Xu, Olga Aprelikova, Peter Moens, Chu-Xia Deng & Priscilla A. Furth. (2003) Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice. Development 130:9, pages 2001-2012.
Crossref
M Oren. (2003) Decision making by p53: life, death and cancer. Cell Death & Differentiation 10:4, pages 431-442.
Crossref
Milena Gasco & Tim Crook. (2003) The p53 network in head and neck cancer. Oral Oncology 39:3, pages 222-231.
Crossref
Mary Ellen Moynahan. (2002) The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans. Oncogene 21:58, pages 8994-9007.
Crossref
Larry H Thompson & David Schild. (2002) Recombinational DNA repair and human disease. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 509:1-2, pages 49-78.
Crossref

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