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Molecular and Cellular Biology Volume 23, 2003 - Issue 19
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Cell Growth and Development

Functional Analysis of the Caenorhabditis elegans UNC-73B PH Domain Demonstrates a Role in Activation of the Rac GTPase In Vitro and Axon Guidance In Vivo

Terrance J. Kubiseski1 Samuel Lunenfeld Research Institute of Mt. Sinai Hospital, Toronto, OntarioM5S 1X5
,
Joe Culotti1 Samuel Lunenfeld Research Institute of Mt. Sinai Hospital, Toronto, OntarioM5S 1X5;2 Department of Molecular and Medical Genetics, University of Toronto, Toronto, OntarioM5S 1A8, Canada
&
Tony Pawson1 Samuel Lunenfeld Research Institute of Mt. Sinai Hospital, Toronto, OntarioM5S 1X5;2 Department of Molecular and Medical Genetics, University of Toronto, Toronto, OntarioM5S 1A8, CanadaCorrespondence[email protected]
Pages 6823-6835 | Received 16 May 2003, Accepted 01 Jul 2003, Published online: 27 Mar 2023

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Elise Walck-Shannon & Jeff Hardin. (2016) Another morphogenetic movement on the map: Charting dorsal intercalation in C. elegans. Worm 5:2.
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Jamie O. Dyer, Rafael S. Demarco & Erik A Lundquist. (2010) Distinct roles of Rac GTPases and the UNC-73/Trio and PIX-1 Rac GTP exchange factors in neuroblast protrusion and migration in C. elegans . Small GTPases 1:1, pages 44-61.
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Josie E. Bircher, Ellen E. Corcoran, TuKiet T. Lam, Michael J. Trnka & Anthony J. Koleske. (2022) Autoinhibition of the GEF activity of cytoskeletal regulatory protein Trio is disrupted in neurodevelopmental disorder-related genetic variants. Journal of Biological Chemistry 298:9, pages 102361.
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Chaogu Zheng, Margarete Diaz-Cuadros & Martin Chalfie. (2016) GEFs and Rac GTPases control directional specificity of neurite extension along the anterior–posterior axis. Proceedings of the National Academy of Sciences 113:25, pages 6973-6978.
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Jaffar M. Bhat, Jie Pan & Harald Hutter. (2015) PLR-1, a putative E3 ubiquitin ligase, controls cell polarity and axonal extensions in C. elegans. Developmental Biology 398:1, pages 44-56.
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Marjorie Côte, Camille Fos, Ann J. Canonigo-Balancio, Klaus Ley, Stéphane Bécart & Amnon Altman. (2015) SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1. Journal of Cell Science.
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Elise Walck-Shannon, David Reiner & Jeff Hardin. (2015) Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegans . Development.
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Srimoyee Ghosh & Paul W. Sternberg. (2014) Spatial and molecular cues for cell outgrowth during C. elegans uterine development. Developmental Biology 396:1, pages 121-135.
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Pooja Jadiya & Aamir Nazir. (2014) A Pre- and Co-Knockdown of RNAseT Enzyme, Eri-1, Enhances the Efficiency of RNAi Induced Gene Silencing in Caenorhabditis elegans. PLoS ONE 9:1, pages e87635.
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Amita Pandey & Girdhar K. PandeyAmita Pandey & Girdhar K. Pandey. 2014. The UNC-53-mediated Interactome. The UNC-53-mediated Interactome 47 71 .
Klaus Scheffzek & Stefan Welti. (2012) Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms. FEBS Letters 586:17, pages 2662-2673.
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Rafael S. Demarco, Eric C. Struckhoff & Erik A. Lundquist. (2012) The Rac GTP Exchange Factor TIAM-1 Acts with CDC-42 and the Guidance Receptor UNC-40/DCC in Neuronal Protrusion and Axon Guidance. PLoS Genetics 8:4, pages e1002665.
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Nancy Marcus-Gueret, Kristopher L Schmidt & Eve G Stringham. (2012) Distinct Cell Guidance Pathways Controlled by the Rac and Rho GEF Domains of UNC-73/TRIO in Caenorhabditis elegans . Genetics 190:1, pages 129-142.
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Shuang Hu, Tony Pawson & Robert M Steven. (2011) UNC-73/Trio RhoGEF-2 Activity Modulates Caenorhabditis elegans Motility Through Changes in Neurotransmitter Signaling Upstream of the GSA-1/Gαs Pathway . Genetics 189:1, pages 137-151.
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Catarina Mörck, Vivekanand Vivekanand, Gholamali Jafari & Marc Pilon. (2010) C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective mutants. BMC Developmental Biology 10:1.
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JoAnne E. Waters, Megan V. Astle, Lisa M. Ooms, Demis Balamatsias, Rajendra Gurung & Christina A. Mitchell. (2008) P-Rex1 – a multidomain protein that regulates neurite differentiation. Journal of Cell Science 121:17, pages 2892-2903.
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Juan Daniel Díaz-Valencia, Ma de Jesús Almaraz-Barrera, David Jay, Nora Adriana Hernández-Cuevas, Elizabeth García, Claudia H González-De la Rosa, Luis Enrique Arias-Romero, Rosaura Hernandez-Rivas, Arturo Rojo-Domínguez, Nancy Guillén & Miguel Vargas. (2007) Novel structural and functional findings of the ehFLN protein fromEntamoeba histolytica. Cell Motility and the Cytoskeleton 64:11, pages 880-896.
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Mariya K. Chhatriwala, Laurie Betts, David K. Worthylake & John Sondek. (2007) The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation. Journal of Molecular Biology 368:5, pages 1307-1320.
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Naomi Levy-Strumpf & Joseph G Culotti. (2007) VAB-8, UNC-73 and MIG-2 regulate axon polarity and cell migration functions of UNC-40 in C. elegans. Nature Neuroscience 10:2, pages 161-168.
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Mark A. BaumeisterKent L. RossmanJohn SondekMark A. Lemmon. (2006) The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity. Biochemical Journal 400:3, pages 563-572.
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Martin R. Schiller, Kausik Chakrabarti, Glenn F. King, Noraisha I. Schiller, Betty A. Eipper & Mark W. Maciejewski. (2006) Regulation of RhoGEF Activity by Intramolecular and Intermolecular SH3 Domain Interactions. Journal of Biological Chemistry 281:27, pages 18774-18786.
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Hui Feng, Min Ren & Charles S. Rubin. (2006) Conserved Domains Subserve Novel Mechanisms and Functions in DKF-1, a Caenorhabditis elegans Protein Kinase D. Journal of Biological Chemistry 281:26, pages 17815-17826.
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Juan Daniel Díaz-Valencia, Ma. de Jesús Almaraz-Barrera, Luis Enrique Arias-Romero, Rosaura Hernandez-Rivas, Arturo Rojo-Domínguez, Nancy Guillén & Miguel Vargas. (2005) The ABP-120 C-end region from Entamoeba histolytica interacts with sulfatide, a new lipid target. Biochemical and Biophysical Research Communications 338:3, pages 1527-1536.
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Robert Steven, Lijia Zhang, Joseph Culotti & Tony Pawson. (2005) The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans . Genes & Development 19:17, pages 2016-2029.
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Myeongwoo Lee, Bing Shen, Jean E. Schwarzbauer, Jeong Ahn & John Kwon. (2005) Connections between integrins and Rac GTPase pathways control gonad formation and function in C. elegans. Biochimica et Biophysica Acta (BBA) - General Subjects 1723:1-3, pages 248-255.
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Kent L. Rossman & John Sondek. (2005) Larger than Dbl: new structural insights into RhoA activation. Trends in Biochemical Sciences 30:4, pages 163-165.
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Kent L. Rossman, Channing J. Der & John Sondek. (2005) GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nature Reviews Molecular Cell Biology 6:2, pages 167-180.
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Eve-Ellen Govek, Sarah E. Newey & Linda Van Aelst. (2005) The role of the Rho GTPases in neuronal development. Genes & Development 19:1, pages 1-49.
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David K Worthylake, Kent L Rossman & John Sondek. (2004) Crystal Structure of the DH/PH Fragment of Dbs without Bound GTPase. Structure 12:6, pages 1079-1086.
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Christine Vogel, Sarah A. Teichmann & Cyrus Chothia. (2004) Looking at the bigger picture. Development 131:10, pages 2238-2240.
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Oliver Hobert, Harald Hutter & Richard O. Hynes. (2004) The immunoglobulin superfamily in Caenorhabditis elegans and Drosophila melanogaster . Development 131:10, pages 2237-2238.
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