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Molecular and Cellular Biology Volume 23, 2003 - Issue 20
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Mammalian Genetic Models with Minimal or Complex Phenotypes

Targeted Disruption of the Gene for the PAK5 Kinase in Mice

Xiaofan LiDepartment of Biological Sciences, Columbia University, New York, New York10027
&
Audrey MindenDepartment of Biological Sciences, Columbia University, New York, New York10027Correspondence[email protected]
Pages 7134-7142 | Received 09 Apr 2003, Accepted 07 Jul 2003, Published online: 27 Mar 2023

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Yi-Yang Wen, Jun-Nian Zheng & Dong-Sheng Pei. (2014) An oncogenic kinase: putting PAK5 forward. Expert Opinion on Therapeutic Targets 18:7, pages 807-815.
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Melody A. Furnari, Michelle L. Jobes, Tanya Nekrasova, Audrey Minden & George C. Wagner. (2014) Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight. Nutritional Neuroscience 17:3, pages 109-115.
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Mollie L. Kelly & Jonathan Chernoff. (2012) Mouse models of PAK function. Cellular Logistics 2:2, pages 84-88.
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Wayne Huang, Zikai Zhou, Suhail Asrar, Mark Henkelman, Wei Xie & Zhengping Jia. (2011) p21-Activated Kinases 1 and 3 Control Brain Size through Coordinating Neuronal Complexity and Synaptic Properties. Molecular and Cellular Biology 31:3, pages 388-403.
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Julia V Kichina, Anna Goc, Belal Al-Husein, Payaningal R Somanath & Eugene S Kandel. (2010) PAK1 as a therapeutic target. Expert Opinion on Therapeutic Targets 14:7, pages 703-725.
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Sophie Cotteret & Jonathan Chernoff. (2006) Nucleocytoplasmic Shuttling of Pak5 Regulates Its Antiapoptotic Properties. Molecular and Cellular Biology 26:8, pages 3215-3230.
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Marta S. Cammarano, Tanya Nekrasova, Beatrice Noel & Audrey Minden. (2005) Pak4 Induces Premature Senescence via a Pathway Requiring p16INK4/p19ARF and Mitogen-Activated Protein Kinase Signaling. Molecular and Cellular Biology 25:21, pages 9532-9542.
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Jian Qu, Xiaofan Li, Bennet G. Novitch, Ye Zheng, Matthew Kohn, Jian-Ming Xie, Spencer Kozinn, Roderick Bronson, Amer A. Beg & Audrey Minden. (2003) PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development. Molecular and Cellular Biology 23:20, pages 7122-7133.
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Articles from other publishers (45)

Payaningal R. Somanath, Jonathan Chernoff, Brian S. Cummings, Sandip M. Prasad & Harvey D. Homan. (2023) Targeting P21-Activated Kinase-1 for Metastatic Prostate Cancer. Cancers 15:8, pages 2236.
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Yohendran Baskaran, Felicia Pei-Ling Tay, Elsa Yuen Wai Ng, Claire Lee Foon Swa, Sheena Wee, Jayantha Gunaratne & Edward Manser. (2021) Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions. Nature Communications 12:1.
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Hui Liu, Kangdong Liu & Zigang Dong. (2021) The Role of p21-Activated Kinases in Cancer and Beyond: Where Are We Heading?. Frontiers in Cell and Developmental Biology 9.
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Parisa Rabieifar, Ting Zhuang, Tânia D. F. Costa, Miao Zhao & Staffan Strömblad. (2019) Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion. Scientific Reports 9:1.
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Irene Ramos-Alvarez & R. T. Jensen. (2018) P21-activated kinase 4 in pancreatic acinar cells is activated by numerous gastrointestinal hormones/neurotransmitters and growth factors by novel signaling, and its activation stimulates secretory/growth cascades. American Journal of Physiology-Gastrointestinal and Liver Physiology 315:2, pages G302-G317.
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Miao Zhao, Parisa Rabieifar, Tânia D. F. Costa, Ting Zhuang, Audrey Minden, Matthias Löhr, Rainer Heuchel & Staffan Strömblad. (2017) Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development. Scientific Reports 7:1.
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Kiruthikah Thillai, Hoyin Lam, Debashis Sarker & Claire M. Wells. (2016) Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?. Oncotarget 8:8, pages 14173-14191.
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Chao Li, Jian Chen, Yupeng Wang, Guohe Song, Chao Xiao, Dongwang Yan, Lin Zhong, Xing Sun, Xiaoliang Wang, Fudong Yu, Yang Yu, Huamei Tang & Zhihai Peng. (2016) High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma. Oncotarget 7:29, pages 46042-46055.
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Bahareh Tabanifar, Zhuoshen Zhao & Ed Manser. (2016) PAK5 is auto-activated by a central domain that promotes kinase oligomerization. Biochemical Journal 473:12, pages 1777-1789.
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Byung Hak Ha, Elizabeth M. Morse, Benjamin E. Turk & Titus J. Boggon. (2015) Signaling, Regulation, and Specificity of the Type II p21-activated Kinases. Journal of Biological Chemistry 290:21, pages 12975-12983.
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Saima Aslam, M. Shahid Mansuri & Alok Bhattacharya. 2015. Amebiasis. Amebiasis 207 230 .
Kun Han, Yan Zhou, Zhi‐Hua Gan, Wei‐Xiang Qi, Jian‐Jun Zhang, Tao Fen, Wei Meng, Ling Jiang, Zan Shen & Da‐Liu Min. (2014) p21‐activated kinase 7 is an oncogene in human osteosarcoma. Cell Biology International 38:12, pages 1394-1402.
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Laila Elsherif, Mehmet Ozler, Mohamed A. Zayed, Jessica H. Shen, Jonathan Chernoff, James E. Faber & Leslie V. Parise. (2014) Potential Compensation among Group I PAK Members in Hindlimb Ischemia and Wound Healing. PLoS ONE 9:11, pages e112239.
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Zheng-Xiang Han, Xiao-Xia Wang, Shang-Nuan Zhang, Jin-Xia Wu, He-ya Qian, Yi-yang Wen, Hui Tian, Dong-Sheng Pei & Jun-Nian Zheng. (2013) Downregulation of PAK5 inhibits glioma cell migration and invasion potentially through the PAK5-Egr1-MMP2 signaling pathway. Brain Tumor Pathology 31:4, pages 234-241.
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Yu-ting Alex ChiangTianru Jin. (2014) p21-Activated protein kinases and their emerging roles in glucose homeostasis. American Journal of Physiology-Endocrinology and Metabolism 306:7, pages E707-E722.
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Maria Radu, Galina Semenova, Rachelle Kosoff & Jonathan Chernoff. (2013) PAK signalling during the development and progression of cancer. Nature Reviews Cancer 14:1, pages 13-25.
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Helen King, Nicole S. Nicholas & Claire M. Wells. 2014. 347 387 .
Yi-Yang Wen, Xiao-Xia Wang, Dong-Sheng Pei & Jun-Nian Zheng. (2013) p21-Activated kinase 5: A pleiotropic kinase. Bioorganic & Medicinal Chemistry Letters 23:24, pages 6636-6639.
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Xiao-Xia Wang, Qian Cheng, Shang-Nuan Zhang, He-ya Qian, Jin-Xia Wu, Hui Tian, Dong-Sheng Pei & Jun-Nian Zheng. (2013) PAK5-Egr1-MMP2 signaling controls the migration and invasion in breast cancer cell. Tumor Biology 34:5, pages 2721-2729.
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Melody A. Furnari, Michelle L. Jobes, Tanya Nekrasova, Audrey Minden & George C. Wagner. (2013) Functional Deficits in Pak5, Pak6 and Pak5/Pak6 Knockout Mice. PLoS ONE 8:4, pages e61321.
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Hiroshi Maruta. 2013. Paks, Rac/Cdc42 (p21)-activated Kinases. Paks, Rac/Cdc42 (p21)-activated Kinases xi xvii .
Ovidiu Coste, Christine V. Möser, Marco Sisignano, Katharina L. Kynast, Audrey Minden, Gerd Geisslinger & Ellen Niederberger. (2012) The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors. Behavioural Brain Research 234:1, pages 121-128.
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Tanya Nekrasova & Audrey Minden. (2011) Role for p21-activated kinase PAK4 in development of the mammalian heart. Transgenic Research 21:4, pages 797-811.
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Todd I. StrochlicSusanna ConcilioJulien ViaudRyan A. EberwineLisa Epstein WongAudrey MindenBenjamin E. Turk, Markus Plomann & Jeffrey R. Peterson. (2012) Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking. Proceedings of the National Academy of Sciences 109:11, pages 4116-4121.
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Jerry W. Marlin, Yu-Wen E. Chang, Margaret Ober, Amy Handy, Wenhao Xu & Rolf Jakobi. (2011) Functional PAK-2 knockout and replacement with a caspase cleavage-deficient mutant in mice reveals differential requirements of full-length PAK-2 and caspase-activated PAK-2p34. Mammalian Genome 22:5-6, pages 306-317.
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Yanmei Tian, Liang Lei & Audrey Minden. (2011) A key role for Pak4 in proliferation and differentiation of neural progenitor cells. Developmental Biology 353:2, pages 206-216.
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Lisa Epstein Wong, Albert B. Reynolds, Nadishani T. Dissanayaka & Audrey Minden. (2010) p120-catenin is a binding partner and substrate for Group B Pak kinases. Journal of Cellular Biochemistry 110:5, pages 1244-1254.
Crossref
Claire M. Wells & Gareth E. Jones. (2010) The emerging importance of group II PAKs. Biochemical Journal 425:3, pages 465-473.
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Eric Delpire. (2009) The mammalian family of sterile 20p-like protein kinases. Pflügers Archiv - European Journal of Physiology 458:5, pages 953-967.
Crossref
Yanmei Tian, Liang Lei, Marta Cammarano, Tanya Nekrasova & Audrey Minden. (2009) Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation. Mechanisms of Development 126:8-9, pages 710-720.
Crossref
Wei Gong, Zhengwen An, Yunling Wang, Xinyan Pan, Weigang Fang, Bo Jiang & Hongquan Zhang. (2009) P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration. International Journal of Cancer 125:3, pages 548-555.
Crossref
P R Molli, D Q Li, B W Murray, S K Rayala & R Kumar. (2009) PAK signaling in oncogenesis. Oncogene 28:28, pages 2545-2555.
Crossref
Bettina Dummler, Kazufumi Ohshiro, Rakesh Kumar & Jeffrey Field. (2009) Pak protein kinases and their role in cancer. Cancer and Metastasis Reviews 28:1-2, pages 51-63.
Crossref
Ying Feng, Matthew T. Valley, Josef Lazar, Allison L. Yang, Roderick T. Bronson, Stuart Firestein, William A. Coetzee & James L. Manley. (2009) SRp38 Regulates Alternative Splicing and Is Required for Ca2+ Handling in the Embryonic Heart. Developmental Cell 16:4, pages 528-538.
Crossref
Tanya Nekrasova, Michelle L. Jobes, Jenhao H. Ting, George C. Wagner & Audrey Minden. (2008) Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Developmental Biology 322:1, pages 95-108.
Crossref
Ramneet Kaur, Xin Yuan, Michael L. Lu & Steven P. Balk. (2008) Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. The Prostate 68:14, pages 1510-1516.
Crossref
Jeyanthy Eswaran, Meera Soundararajan, Rakesh Kumar & Stefan Knapp. (2008) UnPAKing the class differences among p21-activated kinases. Trends in Biochemical Sciences 33:8, pages 394-403.
Crossref
Margareta Nikolić. (2008) The Pak1 Kinase: An Important Regulator of Neuronal Morphology and Function in the Developing Forebrain. Molecular Neurobiology 37:2-3, pages 187-202.
Crossref
Luis E. Arias-Romero & Jonathan Chernoff. (2008) A tale of two Paks. Biology of the Cell 100:2, pages 97-108.
Crossref
Nancy Gerits, Sergiy Kostenko & Ugo Moens. (2007) In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice. Transgenic Research 16:3, pages 281-314.
Crossref
Xosé R. Bustelo, Vincent Sauzeau & Inmaculada M. Berenjeno. (2007) GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. BioEssays 29:4, pages 356-370.
Crossref
Xiaofan Li & Audrey Minden. (2005) PAK4 Functions in Tumor Necrosis Factor (TNF) α-induced Survival Pathways by Facilitating TRADD Binding to the TNF Receptor. Journal of Biological Chemistry 280:50, pages 41192-41200.
Crossref
Dorthe Matenia, Bettina Griesshaber, Xiao-yu Li, Anja Thiessen, Cindy Johne, Jian Jiao, Eckhard Mandelkow & Eva-Maria Mandelkow. (2005) PAK5 Kinase Is an Inhibitor of MARK/Par-1, Which Leads to Stable Microtubules and Dynamic Actin. Molecular Biology of the Cell 16:9, pages 4410-4422.
Crossref
Tetyana Shandala, Stephen L. Gregory, Hazel E. Dalton, Masha Smallhorn & Robert Saint. (2004) Citron Kinase is an essential effector of the Pbl-activated Rho signalling pathway in Drosophila melanogaster . Development 131:20, pages 5053-5063.
Crossref
Clemens Hofmann, Mikhail Shepelev & Jonathan Chernoff. (2004) The genetics of Pak. Journal of Cell Science 117:19, pages 4343-4354.
Crossref

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