Targeted Disruption of the Gene for the PAK5 Kinase in Mice

REFERENCES

• Abo, A., J. Qu, M. S. Cammarano, C. Dan, A. Fritsch, V. Baud, B. Belisle, and A. Minden. 1998. PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. EMBO J. 17: 6527–6540.
   PubMed Web of Science ®Google Scholar
• Allen, K. M., J. G. Gleeson, S. Bagrodia, M. W. Partington, J. C. MacMillan, R. A. Cerione, J. C. Mulley, and C. A. Walsh. 1998. PAK3 mutation in nonsyndromic X-linked mental retardation. Nat. Genet. 20: 25–30.
   PubMed Web of Science ®Google Scholar
• Bishop, A. L., and A. Hall. 2000. Rho GTPase and their effector proteins. Biochem. J. 348: 241–255.
   PubMed Web of Science ®Google Scholar
• Callow, M. G., F. Clairvoyant, S. Zhu, B. Schryver, D. B. Whyte, J. R. Bischoff, B. Jallal, and T. Smeal. 2002. Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. J. Biol. Chem. 277: 550–558.
   PubMed Web of Science ®Google Scholar
• Dan, C., N. Nath, M. Liberto, and A. Minden. 2002. PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells. Mol. Cell. Biol. 22: 567–577.
   PubMed Web of Science ®Google Scholar
• Dan, I., N. M. Watanabe, and A. Kusumi. 2001. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol. 11: 220–230.
   PubMed Web of Science ®Google Scholar
• Daniels, R. H., and G. M. Bokoch. 1999. p21-activated protein kinase: a crucial component of morphological signaling? Trends Biochem. Sci. 24: 350–355.
   PubMed Web of Science ®Google Scholar
• Fourney, R. M., J. Miyakoshi, R. S. Day III, and M. C. Patterson. 1988. Northern blotting: efficient RNA staining and transfer. Focus 10: 5–7.
   Google Scholar
• Gnesutta, N., J. Qu, and A. G. Minden. 2001. The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. J. Biol. Chem. 276: 14414–14419.
   PubMed Web of Science ®Google Scholar
• Hanks, S. K., A. M. Quinn, and T. Hunter. 1988. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241: 42–52.
   PubMed Web of Science ®Google Scholar
• Harden, N., J. Lee, H. Y. Loh, Y. M. Ong, I. Tan, T. Leung, E. Manser, and L. Lim. 1996. A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures. Mol. Cell. Biol. 16: 1896–1908.
   PubMedGoogle Scholar
• Hing, H., J. Xiao, N. Harden, L. Lim, and S. L. Zipursky. 1999. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell 97: 853–863.
   PubMed Web of Science ®Google Scholar
• Huang, H. P., K. Chu, E. Nemoz-Gaillard, D. Elberg, and M. J. Tsai. 2002. Neogenesis of beta-cells in adult BETA2/NeuroD-deficient mice. Mol. Endocrinol. 16: 541–551.
   PubMedGoogle Scholar
• Jaffer, Z. M., and J. Chernoff. 2002. p21-Activated kinases: three more join the Pak. Int. J. Biochem. Cell Biol. 34: 713–717.
   PubMed Web of Science ®Google Scholar
• Knaus, U. G., and G. M. Bokoch. 1998. The p21Rac/Cdc42-activated kinases (PAKs). Int. J. Biochem. Cell Biol. 30: 857–862.
   PubMed Web of Science ®Google Scholar
• Lee, S. R., S. M. Ramos, A. Ko, D. Masiello, K. D. Swanson, M. L. Lu, and S. P. Balk. 2002. AR and ER interaction with a p21-activated kinase (PAK6). Mol. Endocrinol. 16: 85–99.
   PubMed Web of Science ®Google Scholar
• Luo, L. 2000. Rho GTPases in neuronal morphogenesis. Nat. Rev. Neurosci. 1: 173–180.
   PubMed Web of Science ®Google Scholar
• Manser, E., H. Y. Huang, T. H. Loo, X. Q. Chen, J. M. Dong, T. Leung, and L. Lim. 1997. Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes. Mol. Cell. Biol. 17: 1129–1143.
   PubMed Web of Science ®Google Scholar
• Melzig, J., K. H. Rein, U. Schafer, H. Pfister, H. Jackle, M. Heisenberg, and T. Raabe. 1998. A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in the Drosophila adult central nervous system. Curr. Biol. 8: 1223–1226.
   PubMedGoogle Scholar
• Montagutelli, X. 2000. Effect of the genetic background on the phenotype of mouse mutations. J. Am. Soc. Nephrol. 16(Suppl. 11): S101–S105.
   Google Scholar
• Mueller, B. K. 1999. Growth cone guidance: first steps toward a deeper understanding. Annu. Rev. Neurosci. 22: 351–388.
   PubMed Web of Science ®Google Scholar
• Pandey, A., I. Dan, T. Z. Kristiansen, N. M. Watanabe, J. Voldby, E. Kajikawa, R. Khosravi-Far, B. Blagoev, and M. Mann. 2002. Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain. Oncogene 21: 3939–3948.
   PubMed Web of Science ®Google Scholar
• Qu, J., M. S. Cammarano, Q. Shi, K. C. Ha, P. de Lanerolle, and A. Minden. 2001. Activated PAK4 regulates cell adhesion and anchorage-independent growth. Mol. Cell. Biol. 21: 3523–3533.
   PubMedGoogle Scholar
• Qu, J., X. Li, B. G. Novitch, Y. Zheng, M. Kohn, J.-M. Xie, S. Kozinn, R. Bronson, A. A. Beg, and A. Minden. 2003. PAK4 kinase is essential for embryonic lethality and for proper neuronal development. Mol. Cell. Biol. 23: 7122-7133.
   PubMed Web of Science ®Google Scholar
• Schneeberger, D., and T. Raabe. 2003. Mbt, a Drosophila PAK protein, combines with Cdc42 to regulate photoreceptor cell morphogenesis. Development 130: 427–437.
   PubMedGoogle Scholar
• Sells, M. A., and J. Chernoff. 1997. Emerging from the Pak: the p21-activated protein kinase family. Trends Cell Biol. 7: 162–167.
   PubMed Web of Science ®Google Scholar
• Sells, M. A., U. G. Knaus, S. Bagrodia, D. M. Ambrose, G. M. Bokoch, and J. Chernoff. 1997. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr. Biol. 7: 202–210.
   PubMed Web of Science ®Google Scholar
• Tybulewicz, V. L., C. E. Crawford, P. K. Jackson, R. T. Bronson, and R. C. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65: 1153–1163.
   PubMed Web of Science ®Google Scholar
• Van Aelst, L., and C. D'Souza-Schorey. 1997. Rho GTPases and signaling networks. Genes Dev. 11: 2295–2322.
   PubMed Web of Science ®Google Scholar
• Yang, F., X. Li, M. Sharma, M. Zarnegar, B. Lim, and Z. Sun. 2001. Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J. Biol. Chem. 276: 15345–15353.
   PubMed Web of Science ®Google Scholar