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Molecular and Cellular Biology Volume 23, 2003 - Issue 20
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Cell Growth and Development

Degradation of Transcription Repressor ZBRK1 through the Ubiquitin-Proteasome Pathway Relieves Repression of Gadd45a upon DNA Damage

Jeanho YunDepartment of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas78245
&
Wen-Hwa LeeDepartment of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas78245Correspondence[email protected]
Pages 7305-7314 | Received 19 Mar 2003, Accepted 16 Jul 2003, Published online: 27 Mar 2023

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Francesca R Santoni de Sio. (2014) Kruppel-associated box (KRAB) proteins in the adaptive immune system. Nucleus 5:2, pages 138-148.
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Jun Wu, Alibiati Eni, Eliar Roussuri & Binlin Ma. (2021) Correlation between ZBRK1/ZNF350 gene polymorphism and breast cancer. BMC Medical Genomics 14:1.
Crossref
Danna Yeerken, Ruoxi Hong, Yan Wang, Ying Gong, Rui Liu, Di Yang, Jinting Li, Jiawen Fan, Jie Chen, Weimin Zhang & Qimin Zhan. (2020) PFKP is transcriptionally repressed by BRCA1/ZBRK1 and predicts prognosis in breast cancer. PLOS ONE 15:5, pages e0233750.
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Katelyn B. Cassidy, Scott Bang, Manabu Kurokawa & Scott A. Gerber. (2019) Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1. The FEBS Journal 287:10, pages 1985-1999.
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Ruoxi Hong, Weimin Zhang, Xi Xia, Kai Zhang, Yan Wang, Mengjiao Wu, Jiawen Fan, Jinting Li, Wen Xia, Fei Xu, Jie Chen, Shusen Wang & Qimin Zhan. (2019) Preventing BRCA 1/ ZBRK 1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation . Molecular Oncology 13:4, pages 959-977.
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Guo-Qian He, Wen-Ming Xu, Hui-Juan Liao, Chuan Jiang, Chang-Qing Li & Wei Zhang. (2019) Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion. Neural Regeneration Research 14:11, pages 1977.
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Nasha ZhangYouhua LuXijun LiuDianke YuZheng LvMing Yang. (2018) Functional Evaluation of ZNF350 Missense Genetic Variants Associated with Breast Cancer Susceptibility . DNA and Cell Biology 37:6, pages 543-550.
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Jin Gu Cho, Seho Park, Chae Hyun Lim, Hong Sook Kim, Seung Yong Song, Tae-Young Roh, Jong-Hyuk Sung, Wonhee Suh, Seok-Jin Ham, Key-Hwan Lim & Sang Gyu Park. (2016) ZNF224, Krüppel like zinc finger protein, induces cell growth and apoptosis-resistance by down-regulation of p21 and p53 via miR-663a. Oncotarget 7:21, pages 31177-31190.
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Gernot Wolf, David Greenberg & Todd S. Macfarlan. (2015) Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family. Mobile DNA 6:1.
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Guo-qian He, Wen-ming Xu, Jin-fang Li, Shuai-shuai Li, Bin Liu, Xiao-dan Tan & Chang-qing Li. (2015) Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells. Molecular Brain 8:1.
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Key-Hwan Lim & Sang Gyu Park. (2016) Transcriptional regulation of KRAB-ZFPs in cancer. Molecular & Cellular Toxicology 11:4, pages 389-394.
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Sofia Khan, Rainer Fagerholm, Sajjad Rafiq, William Tapper, Kristiina Aittomäki, Jianjun Liu, Carl Blomqvist, Diana Eccles & Heli Nevanlinna. (2015) Polymorphism at 19q13.41 Predicts Breast Cancer Survival Specifically after Endocrine Therapy. Clinical Cancer Research 21:18, pages 4086-4096.
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Ke Chen, Gan Yu, Kiranmai Gumireddy, Anping Li, Weimin Yao, Lu Gao, Shuliang Chen, Jun Hao, Ji Wang, Qihong Huang, Hua Xu & Zhangqun Ye. (2015) ZBRK1, a novel tumor suppressor, activates VHL gene transcription through formation of a complex with VHL and p300 in renal cancer. Oncotarget 6:9, pages 6959-6976.
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Lumbini R. Yadav, Mahamaya N. Biswal, Vikrant, M.V. Hosur & Ashok K. Varma. (2014) Tetrameric ZBRK1 DNA binding domain has affinity towards cognate DNA in absence of zinc ions. Biochemical and Biophysical Research Communications 450:1, pages 283-288.
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Jiajia Chen, Daqing Zhang, Wenyu Zhang, Yifei Tang, Wenying Yan, Lingchuan Guo & Bairong Shen. (2013) Clear cell renal cell carcinoma associated microRNA expression signatures identified by an integrated bioinformatics analysis. Journal of Translational Medicine 11:1.
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Li-Fang Lin, Chien-Feng Li, Wei-Jan Wang, Wen-Ming Yang, Dennis Ding-Hwa Wang, Wen-Chang Chang, Wen-Hwa Lee & Ju-Ming Wang. (2013) Loss of ZBRK1 Contributes to the Increase of KAP1 and Promotes KAP1-Mediated Metastasis and Invasion in Cervical Cancer. PLoS ONE 8:8, pages e73033.
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Jae Duk Choi, Mi Ae Park & Jong-Soo Lee. (2012) Suppression and recovery of BRCA1-mediated transcription by HP1γ via modulation of promoter occupancy. Nucleic Acids Research 40:22, pages 11321-11338.
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Ae Jeong Kim, Hyun-Ju Kim, Hye Jin Jee, Naree Song, Minjee Kim, Yoe-Sik Bae, Jay H. Chung & Jeanho Yun. (2011) Glucose deprivation is associated with Chk1 degradation through the ubiquitin–proteasome pathway and effective checkpoint response to replication blocks. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:6, pages 1230-1238.
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L. Hallen, H. Klein, C. Stoschek, S. Wehrmeyer, U. Nonhoff, M. Ralser, J. Wilde, C. Rohr, M. R. Schweiger, K. Zatloukal, M. Vingron, H. Lehrach, Z. Konthur & S. Krobitsch. (2010) The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2 gene transcription through direct interaction with its gene product, ataxin-2. Human Molecular Genetics 20:1, pages 104-114.
Crossref
Ching-Chun Liao, Connie Y. Tsai, Wen-Chang Chang, Wen-Hwa Lee & Ju-Ming Wang. (2010) RB·E2F1 Complex Mediates DNA Damage Responses through Transcriptional Regulation of ZBRK1*. Journal of Biological Chemistry 285:43, pages 33134-33143.
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Ronit I. Yarden, Eitan Friedman, Sally Metsuyanim, Tzvia Olender, Edna Ben-Asher & Moshe Z. Papa. (2010) Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent. Molecular Carcinogenesis 49:6, pages 545-555.
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Li-Fang Lin, Chih-Hung Chuang, Chien-Feng Li, Ching-Chun Liao, Chun-Pei Cheng, Tian-Lu Cheng, Meng-Ru Shen, Joseph T. Tseng, Wen-Chang Chang, Wen-Hwa Lee & Ju-Ming Wang. (2010) ZBRK1 Acts as a Metastatic Suppressor by Directly Regulating MMP9 in Cervical Cancer . Cancer Research 70:1, pages 192-201.
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Sebastiano Battaglia, Orla Maguire & Moray J. Campbell. (2010) Transcription factor co-repressors in cancer biology: roles and targeting. International Journal of Cancer, pages NA-NA.
Crossref
Xiang Huo, Cheng Lu, Xinen Huang, Zhibin Hu, Guangfu Jin, Hongxia Ma, Xuechen Wang, Jianwei Qin, Xinru Wang, Hongbing Shen & Jinhai Tang. (2009) Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women. Journal of Cancer Research and Clinical Oncology 135:11, pages 1569-1575.
Crossref
Yasuhide Itokawa, Toshihide Yanagawa, Hisashi Yamakawa, Naoko Watanabe, Hisashi Koga & Takahiro Nagase. (2009) KAP1-independent transcriptional repression of SCAN-KRAB-containing zinc finger proteins. Biochemical and Biophysical Research Communications 388:4, pages 689-694.
Crossref
Sylvie Desjardins, Pascal Belleau, Yvan Labrie, Geneviève Ouellette, Paul Bessette, Jocelyne Chiquette, Rachel Laframboise, Jean Lépine, Bernard Lespérance, Roxane Pichette, Marie Plante & Francine Durocher. (2008) Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families . International Journal of Cancer 122:1, pages 108-116.
Crossref
Xu Li, Yung-Kang Lee, Jen-Chong Jeng, Yun Yen, David C. Schultz, Hsiu-Ming Shih & David K. Ann. (2007) Role for KAP1 Serine 824 Phosphorylation and Sumoylation/Desumoylation Switch in Regulating KAP1-mediated Transcriptional Repression. Journal of Biological Chemistry 282:50, pages 36177-36189.
Crossref
Jonine D. Figueroa, Núria Malats, Nathaniel Rothman, Francisco X. Real, Debra Silverman, Manolis Kogevinas, Stephen Chanock, Meredith Yeager, Robert Welch, Mustafa Dosemeci, Adonina Tardón, Consol Serra, Alfredo Carrato, Reina García-Closas, Gemma Castaño-Vinyals & Montserrat García-Closas. (2007) Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk. Carcinogenesis 28:8, pages 1788-1793.
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Yung-Kang Lee, Stefani N. Thomas, Austin J. Yang & David K. Ann. (2007) Doxorubicin Down-regulates Krüppel-associated Box Domain-associated Protein 1 Sumoylation That Relieves Its Transcription Repression on p21WAF1/CIP1 in Breast Cancer MCF-7 Cells. Journal of Biological Chemistry 282:3, pages 1595-1606.
Crossref
Ceshi Chen, Arun K. Seth & Andrew E. Aplin. (2006) Genetic and Expression Aberrations of E3 Ubiquitin Ligases in Human Breast Cancer. Molecular Cancer Research 4:10, pages 695-707.
Crossref
P B Mullan, J E Quinn & D P Harkin. (2006) The role of BRCA1 in transcriptional regulation and cell cycle control. Oncogene 25:43, pages 5854-5863.
Crossref
Eliot M. Rosen, Saijun Fan & Yongxian Ma. (2006) BRCA1 regulation of transcription. Cancer Letters 236:2, pages 175-185.
Crossref
François Brégégère, Yoram Milner & Bertrand Friguet. (2006) The ubiquitin–proteasome system at the crossroads of stress-response and ageing pathways: A handle for skin care?. Ageing Research Reviews 5:1, pages 60-90.
Crossref
Peter Azmi & Arun Seth. (2005) RNF11 is a multifunctional modulator of growth factor receptor signalling and transcriptional regulation. European Journal of Cancer 41:16, pages 2549-2560.
Crossref
Vanesa Garcia, José M García, Cristina Peña, Javier Silva, Gemma Domínguez, Rufo Rodríguez, Constanza Maximiano, Ruth Espinosa, Pilar España & Félix Bonilla. (2005) TheGADD45, ZBRK1 andBRCA1 pathway: quantitative analysis of mRNA expression in colon carcinomas. The Journal of Pathology 206:1, pages 92-99.
Crossref
Young S. Kim & J.A. Milner. (2005) Targets for indole-3-carbinol in cancer prevention. The Journal of Nutritional Biochemistry 16:2, pages 65-73.
Crossref
Wei Tan, Seokjoong Kim & Thomas G. Boyer. (2004) Tetrameric Oligomerization Mediates Transcriptional Repression by the BRCA1-dependent Kruppel-associated Box-Zinc Finger Protein ZBRK1. Journal of Biological Chemistry 279:53, pages 55153-55160.
Crossref
Tomohiko Ohta & Mamoru Fukuda. (2004) Ubiquitin and breast cancer. Oncogene 23:11, pages 2079-2088.
Crossref
Wei-Guo Zhang. (2004) Inhibitory effect of ubiquitin-proteasome pathway on proliferation of esophageal carcinoma cells. World Journal of Gastroenterology 10:19, pages 2779.
Crossref

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