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Cell Growth and Development

TRAM2 Protein Interacts with Endoplasmic Reticulum Ca2+ Pump Serca2b and Is Necessary for Collagen Type I Synthesis

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Pages 1758-1768 | Received 30 Apr 2003, Accepted 03 Nov 2003, Published online: 27 Mar 2023

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Boris Hinz. (2013) Matrix mechanics and regulation of the fibroblast phenotype. Periodontology 2000 63:1, pages 14-28.
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Le Cai, Dillon Fritz, Lela Stefanovic & Branko Stefanovic. (2010) Nonmuscle Myosin-Dependent Synthesis of Type I Collagen. Journal of Molecular Biology 401:4, pages 564-578.
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Jussi T. Tuusa, Tarja T. Leskelä & Ulla E. Petäjä-Repo. (2010) Human δ opioid receptor biogenesis is regulated via interactions with SERCA2b and calnexin. FEBS Journal 277:13, pages 2815-2829.
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Lauren Van Duyn Graham, Mariya T. Sweetwyne, Manuel A. Pallero & Joanne E. Murphy-Ullrich. (2010) Intracellular Calreticulin Regulates Multiple Steps in Fibrillar Collagen Expression, Trafficking, and Processing into the Extracellular Matrix. Journal of Biological Chemistry 285:10, pages 7067-7078.
Crossref
Le Cai, Dillon Fritz, Lela Stefanovic & Branko Stefanovic. (2010) Binding of LARP6 to the Conserved 5′ Stem–Loop Regulates Translation of mRNAs Encoding Type I Collagen. Journal of Molecular Biology 395:2, pages 309-326.
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Liliana Fernandez, Douglas A. Marchuk, Jennifer L. Moran, David R. Beier & Howard A. Rockman. (2009) An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15. Mammalian Genome 20:5, pages 296-304.
Crossref
Scott L. Friedman. (2008) Hepatic fibrosis—Overview. Toxicology 254:3, pages 120-129.
Crossref
Scott L. Friedman. (2008) Mechanisms of Hepatic Fibrogenesis. Gastroenterology 134:6, pages 1655-1669.
Crossref
Scott L. Friedman. (2008) Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver. Physiological Reviews 88:1, pages 125-172.
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Steven Pregizer, Artem Barski, Charles A. Gersbach, Andrés J. García & Baruch Frenkel. (2007) Identification of novel Runx2 targets in osteoblasts: Cell type-specific BMP-dependent regulation of Tram2. Journal of Cellular Biochemistry 102:6, pages 1458-1471.
Crossref
Jussi T. Tuusa, Piia M.H. Markkanen, Pirjo M. Apaja, Anna E. Hakalahti & Ulla E. Petäjä-Repo. (2007) The Endoplasmic Reticulum Ca2+-pump SERCA2b Interacts with G Protein-coupled Receptors and Enhances their Expression at the Cell Surface. Journal of Molecular Biology 371:3, pages 622-638.
Crossref
S??ren V. Siegmund & David A. Brenner. (2005) Molecular Pathogenesis of Alcohol-Induced Hepatic Fibrosis. Alcoholism: Clinical & Experimental Research 29:Supplement, pages 102S-109S.
Crossref
Bernd Schnabl, Kanghong Hu, Marcus Mühlbauer, Claus Hellerbrand, Branko Stefanovic, David A. Brenner & Jürgen Schölmerich. (2005) Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Biochemical and Biophysical Research Communications 335:1, pages 87-96.
Crossref
Kanghong Hu, Marina Fink, Matthias Froh, Erwin Gäbele, Claus Hellerbrand, Marcus Mühlbauer, Reiner Wiest, Jürgen Schölmerich & Bernd Schnabl. (2005) Characterization of the human zinc finger protein 267 promoter: Essential role of nuclear factor Y. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1729:1, pages 14-23.
Crossref
Lela Stefanovic, Chad E. Stephens, David Boykin & Branko Stefanovic. (2005) Inhibitory effect of dicationic diphenylfurans on production of type I collagen by human fibroblasts and activated hepatic stellate cells. Life Sciences 76:17, pages 2011-2026.
Crossref
Alain Hovnanian. (2004) Darier’s disease: from dyskeratosis to endoplasmic reticulum calcium ATPase deficiency. Biochemical and Biophysical Research Communications 322:4, pages 1237-1244.
Crossref
Fabio Zanini, Xibing Che, Carsten Knutsen, Min Liu, Nina E. Suresh, Racquel Domingo-Gonzalez, Steve H. Dou, Gloria S. Pryhuber, Robert C. Jones, Stephen R. Quake, David N. Cornfield & Cristina M. Alvira. (2022) Developmental Diversity and Unique Sensitivity to Injury of Lung Endothelial Subtypes During a Period of Rapid Postnatal Growth. SSRN Electronic Journal.
Crossref

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