35
Views
53
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Defects in Translational Regulation Mediated by the α Subunit of Eukaryotic Initiation Factor 2 Inhibit Antiviral Activity and Facilitate the Malignant Transformation of Human Fibroblasts

&
Pages 2025-2040 | Received 19 Aug 2003, Accepted 04 Dec 2003, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Amit Kumar, Anu Rahal, Jagdip Singh Sohal & Vivek Kumar Gupta. (2021) Bacterial stress response: understanding the molecular mechanics to identify possible therapeutic targets. Expert Review of Anti-infective Therapy 19:2, pages 121-127.
Read now
Mafalda Santos, Patricia M. Pereira, A. Sofia Varanda, Joana Carvalho, Mafalda Azevedo, Denisa D. Mateus, Nuno Mendes, Patricia Oliveira, Fábio Trindade, Marta Teixeira Pinto, Renata Bordeira-Carriço, Fátima Carneiro, Rui Vitorino, Carla Oliveira & Manuel A. S. Santos. (2018) Codon misreading tRNAs promote tumor growth in mice. RNA Biology 15:6, pages 773-786.
Read now
Mohamed Rahmani, Eric Maynard Davis, Timothy Ryan Crabtree, Joseph Reza Habibi, Tri K. Nguyen, Paul Dent & Steven Grant. (2007) The Kinase Inhibitor Sorafenib Induces Cell Death through a Process Involving Induction of Endoplasmic Reticulum Stress. Molecular and Cellular Biology 27:15, pages 5499-5513.
Read now

Articles from other publishers (50)

Barkha Ramnani, Shelby Powell, Adarsh G. Shetty, Praveen Manivannan, Brian R. Hibbard, Douglas W. Leaman & Krishnamurthy Malathi. (2023) Viral Hemorrhagic Septicemia Virus Activates Integrated Stress Response Pathway and Induces Stress Granules to Regulate Virus Replication. Viruses 15:2, pages 466.
Crossref
Giou-Teng Yiang, Chia-Chao Wu, Chien-Lin Lu, Wan-Chung Hu, Yi-Ju Tsai, Yiao-Mien Huang, Wen-Lin Su & Kuo-Cheng Lu. (2023) Endoplasmic Reticulum Stress in Elderly Patients with COVID-19: Potential of Melatonin Treatment. Viruses 15:1, pages 156.
Crossref
Bowen Xu, Peng Zhang, Xiaolong Tang, Shiguan Wang, Jing Shen, Yuanwen Zheng, Chao Gao, Ping Mi, Cuijuan Zhang, Hui Qu, Shiyang Li & Detian Yuan. (2022) Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia–Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis. Advanced Science 9:35.
Crossref
Mafalda Santos, Ana Fidalgo, Ana Sofia Varanda, Ana Raquel Soares, Gabriela M. Almeida, Diana Martins, Nuno Mendes, Carla Oliveira & Manuel A. S. Santos. (2022) Upregulation of tRNA-Ser-AGA-2-1 Promotes Malignant Behavior in Normal Bronchial Cells. Frontiers in Molecular Biosciences 9.
Crossref
Masashi Arakawa, Keisuke Tabata, Kotaro Ishida, Makiko Kobayashi, Arisa Arai, Tomohiro Ishikawa, Ryosuke Suzuki, Hiroaki Takeuchi, Lokesh P. Tripathi, Kenji Mizuguchi & Eiji Morita. (2022) Flavivirus recruits the valosin-containing protein–NPL4 complex to induce stress granule disassembly for efficient viral genome replication. Journal of Biological Chemistry 298:3, pages 101597.
Crossref
Karina Galoian, Victoria Dahl, Andres Perez, Carina Denny, Beatrice Becker, Anil Sedani, Alexandra Moran, Daniel Martinez, Aaron Hoyt & Jeffrey Brown. (2022) PRP-1, a toll-like receptor ligand, upregulates the unfolded protein response in human chondrosarcoma cells. Cancer Treatment and Research Communications 33, pages 100644.
Crossref
Xiaobing Tian, Shengliang Zhang, Lanlan Zhou, Attila A. Seyhan, Liz Hernandez Borrero, Yiqun Zhang & Wafik S. El-Deiry. (2021) Targeting the Integrated Stress Response in Cancer Therapy. Frontiers in Pharmacology 12.
Crossref
Ji-Ae Choi & Chang-Hwa Song. (2020) Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases. Frontiers in Immunology 10.
Crossref
Yiming Wang, Song Chen, Zuoqin Yan & Ming Pei. (2019) A prospect of cell immortalization combined with matrix microenvironmental optimization strategy for tissue engineering and regeneration. Cell & Bioscience 9:1.
Crossref
Saima Naz, Srikanth Battu, Rafiq Ahmad Khan, Sumbul Afroz, Jeevan Giddaluru, Sandeep Kumar Vishwakarma, Vishnupriya Satti, Md Aejaz Habeeb, Aleem Ahmed Khan & Nooruddin Khan. (2019) Activation of integrated stress response pathway regulates IL‐1β production through posttranscriptional and translational reprogramming in macrophages. European Journal of Immunology 49:2, pages 277-289.
Crossref
Huy-Dung Hoang, Tyson E. Graber & Tommy Alain. (2018) Battling for Ribosomes: Translational Control at the Forefront of the Antiviral Response. Journal of Molecular Biology 430:14, pages 1965-1992.
Crossref
Andrew M. Bogorad, Kai Ying Lin & Assen Marintchev. (2017) Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation. Nucleic Acids Research 45:20, pages 11962-11979.
Crossref
Muhammad Umar Ali, Muhammad Saif Ur Rahman, Zhenyu Jia & Cao Jiang. (2017) Eukaryotic translation initiation factors and cancer. Tumor Biology 39:6, pages 101042831770980.
Crossref
Holland M. Hendrick, Brenda H. Welter, Matthew A. Hapstack, Steven E. Sykes, William J. Sullivan & Lesly A. Temesvari. (2016) Phosphorylation of Eukaryotic Initiation Factor-2α during Stress and Encystation in Entamoeba Species. PLOS Pathogens 12:12, pages e1006085.
Crossref
Jennifer Chu, Marie Cargnello, Ivan Topisirovic & Jerry Pelletier. (2016) Translation Initiation Factors: Reprogramming Protein Synthesis in Cancer. Trends in Cell Biology 26:12, pages 918-933.
Crossref
Karolina Pakos‐Zebrucka, Izabela Koryga, Katarzyna Mnich, Mila Ljujic, Afshin Samali & Adrienne M Gorman. (2016) The integrated stress response. EMBO reports 17:10, pages 1374-1395.
Crossref
Melanie Keil, Jana K. Sonner, Tobias V. Lanz, Iris Oezen, Theresa Bunse, Stefan Bittner, Hannah V. Meyer, Sven G. Meuth, Wolfgang Wick & Michael Platten. (2016) General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation. Journal of Neuroimmunology 297, pages 117-126.
Crossref
Noemie Legrand, Pascale Jaquier-Gubler & Joseph Curran. (2015) The impact of the phosphomimetic eIF2αS/D on global translation, reinitiation and the integrated stress response is attenuated in N2a cells. Nucleic Acids Research 43:17, pages 8392-8404.
Crossref
Nancy L. Maas & J. Alan Diehl. (2015) Molecular Pathways: The PERKs and Pitfalls of Targeting the Unfolded Protein Response in Cancer. Clinical Cancer Research 21:4, pages 675-679.
Crossref
Michael J. Clemens, Androulla Elia & Simon J. Morley. 2015. Systems Biology of Cancer. Systems Biology of Cancer 70 92 .
. 2015. Systems Biology of Cancer. Systems Biology of Cancer 35 92 .
Bertal H. Aktas & Ting Chen. 2014. Translation and Its Regulation in Cancer Biology and Medicine. Translation and Its Regulation in Cancer Biology and Medicine 195 221 .
Neysan Donnelly, Adrienne M. Gorman, Sanjeev Gupta & Afshin Samali. (2013) The eIF2α kinases: their structures and functions. Cellular and Molecular Life Sciences 70:19, pages 3493-3511.
Crossref
Tom Verfaillie, Abhishek D. Garg & Patrizia Agostinis. (2013) Targeting ER stress induced apoptosis and inflammation in cancer. Cancer Letters 332:2, pages 249-264.
Crossref
B Luo & A S Lee. (2012) The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene 32:7, pages 805-818.
Crossref
Qing-you Zheng, Ping-ping Li, Feng-suo Jin, Chen Yao, Guo-hui Zhang, Tong Zang & Xing Ai. (2013) Ursolic acid induces ER stress response to activate ASK1–JNK signaling and induce apoptosis in human bladder cancer T24 cells. Cellular Signalling 25:1, pages 206-213.
Crossref
Olga Lihoradova, Birte Kalveram, Sabarish V. Indran, Nandadeva Lokugamage, Terry L. Juelich, Terence E. Hill, Chien-Te K. Tseng, Bin Gong, Shuetsu Fukushi, Shigeru Morikawa, Alexander N. Freiberg & Tetsuro Ikegami. (2012) The Dominant-Negative Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR Increases the Efficacy of Rift Valley Fever Virus MP-12 Vaccine. Journal of Virology 86:14, pages 7650-7661.
Crossref
C.J. Rodriguez-Hernandez, J.J. Guinovart & J.R. Murguia. (2012) Anti-diabetic and anti-obesity agent sodium tungstate enhances GCN pathway activation through Glc7p inhibition. FEBS Letters 586:3, pages 270-276.
Crossref
Rachel Elsby, Joshua F. Heiber, Peter Reid, Scot R. Kimball, Graham D. Pavitt & Glen N. Barber. (2011) The Alpha Subunit of Eukaryotic Initiation Factor 2B (eIF2B) Is Required for eIF2-Mediated Translational Suppression of Vesicular Stomatitis Virus. Journal of Virology 85:19, pages 9716-9725.
Crossref
Agnieszka PindelAnthony Sadler. (2011) The Role of Protein Kinase R in the Interferon Response. Journal of Interferon & Cytokine Research 31:1, pages 59-70.
Crossref
Xiao-Ling Li, Heather J. Ezelle, Teresa Y. Hsi & Bret A. Hassel. (2011) A central role for RNA in the induction and biological activities of type 1 interferons. Wiley Interdisciplinary Reviews: RNA 2:1, pages 58-78.
Crossref
Lixia Chen, Guoqing Tian, Changxia Shao, Everardo Cobos & Weimin Gao. (2009) Curcumin modulates eukaryotic initiation factors in human lung adenocarcinoma epithelial cells. Molecular Biology Reports 37:7, pages 3105-3110.
Crossref
Chenyang Zhao, Shyamasree Datta, Palash Mandal, Shuqing Xu & Thomas Hamilton. (2010) Stress-sensitive Regulation of IFRD1 mRNA Decay Is Mediated by an Upstream Open Reading Frame. Journal of Biological Chemistry 285:12, pages 8552-8562.
Crossref
Sandra J.M. Healy, Adrienne M. Gorman, Parisa Mousavi-Shafaei, Sanjeev Gupta & Afshin Samali. (2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy. European Journal of Pharmacology 625:1-3, pages 234-246.
Crossref
Aparna C. Ranganathan, Shishir Ojha, Antonis Kourtidis, Douglas S. Conklin & Julio A. Aguirre-Ghiso. (2008) Dual Function of Pancreatic Endoplasmic Reticulum Kinase in Tumor Cell Growth Arrest and Survival. Cancer Research 68:9, pages 3260-3268.
Crossref
Jonathan H. LinPeter WalterT.S. Benedict Yen. (2008) Endoplasmic Reticulum Stress in Disease Pathogenesis. Annual Review of Pathology: Mechanisms of Disease 3:1, pages 399-425.
Crossref
Michael J. Clemens. 2005. The Cancer Handbook. The Cancer Handbook.
Ralph M. Fritsch, Guönter Schneider, Dieter Saur, Melanie Scheibel & Roland M. Schmid. (2007) Translational Repression of MCL-1 Couples Stress-induced eIF2α Phosphorylation to Mitochondrial Apoptosis Initiation. Journal of Biological Chemistry 282:31, pages 22551-22562.
Crossref
Helen L. Eley & Michael J. Tisdale. (2007) Skeletal Muscle Atrophy, a Link between Depression of Protein Synthesis and Increase in Degradation. Journal of Biological Chemistry 282:10, pages 7087-7097.
Crossref
Siddharth Balachandran & Glen N. Barber. 2007. Cancer Genomics and Proteomics. Cancer Genomics and Proteomics 277 301 .
Glen N. Barber. 2007. Gene Therapy for Cancer. Gene Therapy for Cancer 121 140 .
Richard L. BennettWilliam L. BlalockDean M. AbtahiYu PanSue A. MoyerW. Stratford May. (2006) RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection. Blood 108:3, pages 821-829.
Crossref
Donalyn Scheuner, Rupali Patel, Feng Wang, Kuei Lee, Kotlo Kumar, Jun Wu, Anders Nilsson, Michael Karin & Randal J. Kaufman. (2006) Double-stranded RNA-dependent Protein Kinase Phosphorylation of the α-Subunit of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis. Journal of Biological Chemistry 281:30, pages 21458-21468.
Crossref
Massimo Squatrito, Monica Mancino, Leonardo Sala & Giulio F. Draetta. (2006) Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2α phosphorylation. Biochemical and Biophysical Research Communications 344:3, pages 859-868.
Crossref
Kerrington D. Smith, James J. Mezhir, Kai Bickenbach, Jula Veerapong, Jean Charron, Mitchell C. Posner, Bernard Roizman & Ralph R. Weichselbaum. (2006) Activated MEK Suppresses Activation of PKR and Enables Efficient Replication and In Vivo Oncolysis by Δγ 1 34.5 Mutants of Herpes Simplex Virus 1 . Journal of Virology 80:3, pages 1110-1120.
Crossref
Kelley A. Parato, Donna Senger, Peter A. J. Forsyth & John C. Bell. (2005) Recent progress in the battle between oncolytic viruses and tumours. Nature Reviews Cancer 5:12, pages 965-976.
Crossref
John H. Connor & Douglas S. Lyles. (2005) Inhibition of Host and Viral Translation during Vesicular Stomatitis Virus Infection. Journal of Biological Chemistry 280:14, pages 13512-13519.
Crossref
J. Wang, Carol Laschinger, Xiao Han Zhao, Baldwin Mak, A. Seth & C.A. McCulloch. (2005) Mechanical force activates eIF-2α phospho-kinases in fibroblast. Biochemical and Biophysical Research Communications 330:1, pages 123-130.
Crossref
Christopher G. Proud. (2005) eIF2 and the control of cell physiology. Seminars in Cell & Developmental Biology 16:1, pages 3-12.
Crossref
John H. Connor, Christine Naczki, Costas Koumenis & Douglas S. Lyles. (2004) Replication and Cytopathic Effect of Oncolytic Vesicular Stomatitis Virus in Hypoxic Tumor Cells In Vitro and In Vivo. Journal of Virology 78:17, pages 8960-8970.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.