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Molecular and Cellular Biology Volume 24, 2004 - Issue 7
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Cell Growth and Development

Cellular Senescence Requires CDK5 Repression of Rac1 Activity

Kamilah AlexanderDepartment of Pathology, Harvard Medical School, Boston, Massachusetts02115
,
Hai-Su YangDepartment of Pathology, Harvard Medical School, Boston, Massachusetts02115
&
Philip W. HindsDepartment of Pathology, Harvard Medical School, Boston, Massachusetts02115Correspondence[email protected]
Pages 2808-2819 | Received 01 Aug 2003, Accepted 22 Dec 2003, Published online: 27 Mar 2023

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Q. Pan, F. Qiao, C. Gao, B. Norman, L. Optican & Peggy S. Zelenka. (2011) Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75). Cellular and Molecular Life Sciences 68:20, pages 3425-3436.
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Morgan Gallazzini, Gary E. Heussler, Margarita Kunin, Yuichiro Izumi, Maurice B. Burg & Joan D. Ferraris. (2011) High NaCl–induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization. Molecular Biology of the Cell 22:5, pages 703-714.
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Sebastian Jessberger, Fred H. Gage, Amelia J. Eisch & Diane C. Lagace. (2009) Making a neuron: Cdk5 in embryonic and adult neurogenesis. Trends in Neurosciences 32:11, pages 575-582.
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M. Cecilia Caino, John Meshki & Marcelo G. Kazanietz. (2009) Hallmarks for senescence in carcinogenesis: novel signaling players. Apoptosis 14:4, pages 392-408.
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Hans O. Kalkman. (2009) Altered growth factor signaling pathways as the basis of aberrant stem cell maturation in schizophrenia. Pharmacology & Therapeutics 121:1, pages 115-122.
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Fatema A. Dhariwala & Medha S. Rajadhyaksha. (2008) An Unusual Member of the Cdk Family: Cdk5. Cellular and Molecular Neurobiology 28:3, pages 351-369.
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Quanwen Li, Stefanie Roshy Mullins, Bonnie F. Sloane & Raymond R. Mattingly. (2008) p21-Activated Kinase 1 Coordinates Aberrant Cell Survival and Pericellular Proteolysis in a Three-Dimensional Culture Model for Premalignant Progression of Human Breast Cancer. Neoplasia 10:4, pages 314-IN1.
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Sharla M. O. Phipps, Joel B. Berletch, Lucy G. Andrews & Trygve O. Tollefsbol. 2007. Biological Aging. Biological Aging 9 19 .
Marcella Debidda, David A. Williams & Yi Zheng. (2006) Rac1 GTPase Regulates Cell Genomic Stability and Senescence. Journal of Biological Chemistry 281:50, pages 38519-38528.
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Jesusa L. Rosales & Ki-Young Lee. (2006) Extraneuronal roles of cyclin-dependent kinase 5. BioEssays 28:10, pages 1023-1034.
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Lisa A. Fortier & Brian J. Miller. (2006) Signaling through the small G-protein Cdc42 is involved in insulin-like growth factor-I resistance in aging articular chondrocytes. Journal of Orthopaedic Research 24:8, pages 1765-1772.
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Hi-Su Yang & Philip W. Hinds. (2006) Phosphorylation of Ezrin by Cyclin-Dependent Kinase 5 Induces the Release of Rho GDP Dissociation Inhibitor to Inhibit Rac1 Activity in Senescent Cells. Cancer Research 66:5, pages 2708-2715.
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Samantha Cicero & Karl Herrup. (2005) Cyclin-Dependent Kinase 5 Is Essential for Neuronal Cell Cycle Arrest and Differentiation. The Journal of Neuroscience 25:42, pages 9658-9668.
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Dolena R. Ledee, Chun Y. Gao, Ranjana Seth, Robert N. Fariss, Brajendra K. Tripathi & Peggy S. Zelenka. (2005) A Specific Interaction between Muskelin and the Cyclin-dependent Kinase 5 Activator p39 Promotes Peripheral Localization of Muskelin. Journal of Biological Chemistry 280:22, pages 21376-21383.
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