Advanced search
Publication Cover
Molecular and Cellular Biology Volume 25, 2005 - Issue 21
Submit an article Journal homepage
31
Views
51
CrossRef citations to date
0
Altmetric
Signal Transduction

Role of the UBL-UBA Protein KPC2 in Degradation of p27 at G1 Phase of the Cell Cycle

Taichi Hara1 Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka812-8582, Japan;2 CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama332-0012, Japan;3 Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo113-8613, Japan
,
Takumi Kamura1 Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka812-8582, Japan;2 CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama332-0012, Japan
,
Shuhei Kotoshiba1 Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka812-8582, Japan;2 CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama332-0012, Japan
,
Hidehisa Takahashi1 Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka812-8582, Japan;2 CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama332-0012, Japan
,
Kenichiro Fujiwara4 Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehiro, Tsurumi, Yokohama, Kanagawa230-0045, Japan
,
Ichiro Onoyama1 Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka812-8582, Japan;2 CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama332-0012, Japan
,
Masahiro Shirakawa4 Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehiro, Tsurumi, Yokohama, Kanagawa230-0045, Japan
,
Noboru Mizushima3 Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo113-8613, Japan
&
Keiichi I. Nakayama1 Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka812-8582, Japan;2 CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama332-0012, JapanCorrespondence[email protected]
 show all
Pages 9292-9303 | Received 07 Apr 2005, Accepted 30 Jul 2005, Published online: 27 Mar 2023

Citations (51)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (7)

Daisuke Kaida, Takayuki Satoh, Ken Ishida, Rei Yoshimoto & Kanae Komori. (2022) A Truncated Form of the p27 Cyclin-Dependent Kinase Inhibitor Translated from Pre-mRNA Causes G2-Phase Arrest. Molecular and Cellular Biology 42:11.
Read now
Wei Jia, Ming-Xiao He, Ian X McLeod, Jian Guo, Dong Ji & You-Wen He. (2015) Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1. Autophagy 11:12, pages 2335-2345.
Read now
Debora Bencivenga, Annunziata Tramontano, Alessia Borgia, Aide Negri, Ilaria Caldarelli, Adriana Oliva, Silverio Perrotta, Fulvio Della Ragione & Adriana Borriello. (2014) p27Kip1 serine 10 phosphorylation determines its metabolism and interaction with cyclin-dependent kinases. Cell Cycle 13:23, pages 3768-3782.
Read now
Amina El Ayadi, Emily S. Stieren, José M. Barral & Darren Boehning. (2013) Ubiquilin-1 and protein quality control in Alzheimer disease. Prion 7:2, pages 164-169.
Read now
Yu Lu, Olasunkanmi A. J. Adegoke, Alain Nepveu, Keiichi I. Nakayama, Nathalie Bedard, Dongmei Cheng, Junmin Peng & Simon S. Wing. (2009) USP19 Deubiquitinating Enzyme Supports Cell Proliferation by Stabilizing KPC1, a Ubiquitin Ligase for p27Kip1. Molecular and Cellular Biology 29:2, pages 547-558.
Read now
Etsuo Susaki, Keiko Nakayama & Keiichi I. Nakayama. (2007) Cyclin D2 Translocates p27 out of the Nucleus and Promotes Its Degradation at the G0-G1 Transition. Molecular and Cellular Biology 27:13, pages 4626-4640.
Read now
Yelena Ivantsiv, Ludmila Kaplun, Regina Tzirkin-Goldin, Nitzan Shabek & Dina Raveh. (2006) Unique Role for the UbL-UbA Protein Ddi1 in Turnover of SCFUfo1 Complexes. Molecular and Cellular Biology 26:5, pages 1579-1588.
Read now

Articles from other publishers (44)

Xiao‐Li Zhang, Xiao‐Qing Gong, Xin‐Jian Su, Hai‐Xia Yu, Si‐Yuan Cheng, Jing‐Wen Huang, Dan‐Yang Li, Zhao‐Long Lei, Ming‐jun Li & Feng‐wang Ma. (2023) The ubiquitin‐binding protein MdRAD23D1 mediates drought response by regulating degradation of the proline‐rich protein MdPRP6 in apple ( Malus domestica ) . Plant Biotechnology Journal 21:8, pages 1560-1576.
Crossref
Shanzhi Huang, Min Cui, Juan Huang, Ziyu Wu, Anchun Cheng, Mingshu Wang, Dekang Zhu, Shun Chen, Mafeng Liu, Xinxin Zhao, Ying Wu, Qiao Yang, Shaqiu Zhang, Xumin Ou, Sai Mao, Qun Gao, Bin Tian, Di Sun, Zhongqiong Yin, Bo Jing & Renyong Jia. (2023) RNF123 Mediates Ubiquitination and Degradation of SOCS1 To Regulate Type I Interferon Production during Duck Tembusu Virus Infection. Journal of Virology 97:4.
Crossref
Yelena Kravtsova-Ivantsiv, Gilad Goldhirsh, Ciprian Tomuleasa, Eli Pikarsky & Aaron Ciechanover. (2023) The NF-ĸB p50 subunit generated by KPC1-mediated ubiquitination and limited proteasomal processing, suppresses tumor growth. Cancer Cell International 23:1.
Crossref
Jean-Philippe Guégan, Justine Pollet, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Marcus E. Peter & Patrick Legembre. (2021) CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism. iScience 24:12, pages 103538.
Crossref
Michelle Y. Fry, Shyam M. Saladi & William M. ClemonsJrJr. (2021) The STI1‐domain is a flexible alpha‐helical fold with a hydrophobic groove. Protein Science 30:4, pages 882-898.
Crossref
Weizhe Li, Jinqing Liang, Patricia Outeda, Stacey Turner, Barbara T. Wakimoto & Terry Watnick. (2020) A genetic screen in Drosophila reveals an unexpected role for the KIP1 ubiquitination-promoting complex in male fertility. PLOS Genetics 16:12, pages e1009217.
Crossref
Noémie Deneyer, Laure Bridoux, Céline Bombled, Tamara Pringels, Isabelle Bergiers, Sébastien Pyr dit Ruys, Didier Vertommen, Jean-Claude Twizere & René Rezsohazy. (2019) HOXA2 activity regulation by cytoplasmic relocation, protein stabilization and post-translational modification. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1862:9, pages 194404.
Crossref
Salinee Jantrapirom, Luca Lo Piccolo & Masamitsu Yamaguchi. (2019) Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration. International Journal of Molecular Sciences 20:8, pages 1893.
Crossref
Zhe Ma, Haodan Zhu, Yiqi Su, Yu Meng, Huixing Lin, Kongwang He & Hongjie Fan. (2018) Screening of Streptococcus Suis serotype 2 resistance genes with GWAS and transcriptomic microarray analysis. BMC Genomics 19:1.
Crossref
Cristina E. Tognon, Bo Rafn, Naniye Malli Cetinbas, Takumi Kamura, Genny Trigo, Barak Rotblat, Fumihiko Okumura, Masaki Matsumoto, Christine Chow, Monika Davare, Michael Pollak, Thibault Mayor & Poul H. Sorensen. (2018) Insulin-like growth factor 1 receptor stabilizes the ETV6–NTRK3 chimeric oncoprotein by blocking its KPC1/Rnf123-mediated proteasomal degradation. Journal of Biological Chemistry 293:32, pages 12502-12515.
Crossref
Samuel Gilberto & Matthias Peter. (2017) Dynamic ubiquitin signaling in cell cycle regulation. Journal of Cell Biology 216:8, pages 2259-2271.
Crossref
Kun Zhuang, Lingxia Zhang, Xin Zhang, Hailing Tang, Jun Zhang, Yuan Yan, Kun Han & Hanqing Guo. (2017) Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901. International Journal of Oncology 50:6, pages 2091-2100.
Crossref
Shuai Wang, Yong‐Kang Yang, Tao Chen, Heng Zhang, Wei‐Wei Yang, Sheng‐Sheng Song, Zhong‐He Zhai & Dan‐Ying Chen. (2016) RNF 123 has an E3 ligase‐independent function in RIG ‐I‐like receptor‐mediated antiviral signaling . EMBO reports 17:8, pages 1155-1168.
Crossref
Laure Bridoux, Isabelle Bergiers, Amandine Draime, Mathias Halbout, Noémie Deneyer, Jean-Claude Twizere & René Rezsohazy. (2015) KPC2 relocalizes HOXA2 to the cytoplasm and decreases its transcriptional activity. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1849:10, pages 1298-1311.
Crossref
Yelena Kravtsova-Ivantsiv, Inna Shomer, Victoria Cohen-Kaplan, Berend Snijder, Giulio Superti-Furga, Hedva Gonen, Thomas Sommer, Tamar Ziv, Arie Admon, Inna Naroditsky, Muhammad Jbara, Ashraf Brik, Eli Pikarsky, Yong Tae Kwon, Ilana Doweck & Aaron Ciechanover. (2015) KPC1-Mediated Ubiquitination and Proteasomal Processing of NF-κB1 p105 to p50 Restricts Tumor Growth. Cell 161:2, pages 333-347.
Crossref
Magdalena Bodnar, Łukasz Szylberg, Wojciech Kaźmierczak & Andrzej Marszałek. (2014) Immunohistochemical expression of p27kip1 in metastatic laryngeal squamous cell carcinoma. Advances in Medical Sciences 59:2, pages 206-212.
Crossref
NEVYANA R. HRISTOVA, KATRIN E. TAGSCHERER, ANNE FASSL, JUERGEN KOPITZ & WILFRIED ROTH. (2013) Notch1-dependent regulation of p27 determines cell fate in colorectal cancer. International Journal of Oncology 43:6, pages 1967-1975.
Crossref
C M Das, P Taylor, M Gireud, A Singh, D Lee, G Fuller, L Ji, J Fangusaro, V Rajaram, S Goldman, C Eberhart & V Gopalakrishnan. (2012) The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation. Oncogene 32:13, pages 1691-1701.
Crossref
Sang Won Byun, Young Jun Chang, In Sik Chung, Steven F. Moss & Sung Soo Kim. (2012) Helicobacter pylori decreases p27 expression through the delta opioid receptor-mediated inhibition of histone acetylation within the p27 promoter. Cancer Letters 326:1, pages 96-104.
Crossref
Olga Voloshin, Anya Bakhrat, Sharon Herrmann & Dina Raveh. (2012) Transfer of Ho Endonuclease and Ufo1 to the Proteasome by the UbL-UbA Shuttle Protein, Ddi1, Analysed by Complex Formation In Vitro. PLoS ONE 7:7, pages e39210.
Crossref
Honghui Li, Huiguang Yang, Yonghua Liu, Weipeng Huan, Shuangwei Zhang, Gang Wu, Qiuhui Lu, Qiuhong Wang & Youhua Wang. (2011) The Cyclin-Dependent Kinase Inhibitor p27Kip1 is a Positive Regulator of Schwann Cell Differentiation In Vitro. Journal of Molecular Neuroscience 45:2, pages 277-283.
Crossref
Hiroko Nagao, Kosei Ijiri, Masataka Hirotsu, Yasuhiro Ishidou, Takuya Yamamoto, Satoshi Nagano, Takumi Takizawa, Kinichi Nakashima, Setsuro Komiya & Takao Setoguchi. (2011) Role of GLI2 in the growth of human osteosarcoma. The Journal of Pathology 224:2, pages 169-179.
Crossref
Yu Lu, Nathalie Bedard, Simone Chevalier & Simon S. Wing. (2011) Identification of Distinctive Patterns of USP19-Mediated Growth Regulation in Normal and Malignant Cells. PLoS ONE 6:1, pages e15936.
Crossref
Elizabeth Rico-Bautista, Chih-Cheng Yang, Lifang Lu, Gregory P Roth & Dieter A Wolf. (2010) Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells. BMC Biology 8:1.
Crossref
Masataka Hirotsu, Takao Setoguchi, Hiromi Sasaki, Yukihiro Matsunoshita, Hui Gao, Hiroko Nagao, Osamu Kunigou & Setsuro Komiya. (2010) Smoothened as a new therapeutic target for human osteosarcoma. Molecular Cancer 9:1.
Crossref
Petra Hänzelmann, Julian Stingele, Kay Hofmann, Hermann Schindelin & Shahri Raasi. (2010) The Yeast E4 Ubiquitin Ligase Ufd2 Interacts with the Ubiquitin-like Domains of Rad23 and Dsk2 via a Novel and Distinct Ubiquitin-like Binding Domain. Journal of Biological Chemistry 285:26, pages 20390-20398.
Crossref
Lisa M. Farmer, Adam J. Book, Kwang-Hee Lee, Ya-Ling Lin, Hongyong Fu & Richard D. Vierstra. (2010) The RAD23 Family Provides an Essential Connection between the 26S Proteasome and Ubiquitylated Proteins in Arabidopsis   . The Plant Cell 22:1, pages 124-142.
Crossref
Zakir Ullah, Chrissie Y Lee & Melvin L DePamphilis. (2009) Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy. Cell Division 4:1.
Crossref
Emmanuelle Pion, Vikram Narayan, Mirjam Eckert & Kathryn L. Ball. (2009) Role of the IRF-1 enhancer domain in signalling polyubiquitination and degradation. Cellular Signalling 21:10, pages 1479-1487.
Crossref
Vivian Su & Alan F. Lau. (2009) Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation. Cellular and Molecular Life Sciences 66:17, pages 2819-2833.
Crossref
Daniel Finley. (2009) Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome. Annual Review of Biochemistry 78:1, pages 477-513.
Crossref
Caroline Grabbe & Ivan Dikic. (2009) Functional Roles of Ubiquitin-Like Domain (ULD) and Ubiquitin-Binding Domain (UBD) Containing Proteins. Chemical Reviews 109:4, pages 1481-1494.
Crossref
Nao HosokawaTaichi HaraTakeshi KaizukaChieko KishiAkito TakamuraYutaka MiuraShun-ichiro IemuraTohru NatsumeKenji Takehana, Naoyuki YamadaJun-Lin Guan, Noriko Oshiro & Noboru Mizushima. (2009) Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy. Molecular Biology of the Cell 20:7, pages 1981-1991.
Crossref
Jian-gang Yang, Nai-xue Sun, Li-jun Cui, Xiao-hua Wang & Zhao-hui Feng. (2009) Adenovirus-mediated delivery of p27KIP1 to prevent wound healing after experimental glaucoma filtration surgery. Acta Pharmacologica Sinica 30:4, pages 413-423.
Crossref
Hyunjeong Yang, Hiroshi Takagi, Yoshiyuki Konishi, Hiroshi Ageta, Koji Ikegami, Ikuko Yao, Showbu Sato, Ken Hatanaka, Kaoru Inokuchi, Dae-Hyun Seog & Mitsutoshi Setou. (2008) Transmembrane and Ubiquitin-Like Domain-Containing Protein 1 (Tmub1/HOPS) Facilitates Surface Expression of GluR2-Containing AMPA Receptors. PLoS ONE 3:7, pages e2809.
Crossref
Joyce Slingerland. 2008. Hormonal Control of Cell Cycle. Hormonal Control of Cell Cycle 89 97 .
Sonia B. JakowlewLeslie I. Gold & Jon Lecanda. 2008. Transforming Growth Factor-β in Cancer Therapy, Volume I. Transforming Growth Factor-β in Cancer Therapy, Volume I 213 242 .
Shahri Raasi & Dieter H. Wolf. (2007) Ubiquitin receptors and ERAD: A network of pathways to the proteasome. Seminars in Cell & Developmental Biology 18:6, pages 780-791.
Crossref
Ortal Bar-On, Ma'anit Shapira & Dan D. Hershko. (2007) Differential effects of doxorubicin treatment on cell cycle arrest and Skp2 expression in breast cancer cells. Anti-Cancer Drugs 18:10, pages 1113-1121.
Crossref
Ryosuke Minami, Masumi Shimada, Hideyoshi Yokosawa & Hiroyuki Kawahara. (2007) Scythe regulates apoptosis through modulating ubiquitin-mediated proteolysis of the Xenopus elongation factor XEF1AO . Biochemical Journal 405:3, pages 495-501.
Crossref
Corinth A. Auld, Karishma M. Fernandes & Ron F. Morrison. (2007) Skp2-mediated p27(Kip1) degradation during S/G2 phase progression of adipocyte hyperplasia. Journal of Cellular Physiology 211:1, pages 101-111.
Crossref
Isabel Chu, Jun Sun, Angel Arnaout, Harriette Kahn, Wedad Hanna, Steven Narod, Ping Sun, Cheng-Keat Tan, Ludger Hengst & Joyce Slingerland. (2007) p27 Phosphorylation by Src Regulates Inhibition of Cyclin E-Cdk2. Cell 128:2, pages 281-294.
Crossref
Hartmut Halfter, Matthias Friedrich, Ansgar Resch, Michael Kullmann, Florian Stögbauer, E. Bernd Ringelstein & Ludger Hengst. (2006) Oncostatin M Induces Growth Arrest by Inhibition of Skp2, Cks1, and Cyclin A Expression and Induced p21 Expression. Cancer Research 66:13, pages 6530-6539.
Crossref
Keiichi I. Nakayama & Keiko Nakayama. (2006) Ubiquitin ligases: cell-cycle control and cancer. Nature Reviews Cancer 6:5, pages 369-381.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.