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Molecular and Cellular Biology Volume 25, 2005 - Issue 6
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Gene Expression

p21WAF1/CIP1 Selectively Controls the Transcriptional Activity of Estrogen Receptor α

Asmaà FritahInstitut National de la Santé et de la Recherche Médicale U482, Hôpital Saint-Antoine, Paris, France
,
Cécile SaucierInstitut National de la Santé et de la Recherche Médicale U482, Hôpital Saint-Antoine, Paris, France
,
Jan MesterInstitut National de la Santé et de la Recherche Médicale U482, Hôpital Saint-Antoine, Paris, France
,
Gérard RedeuilhInstitut National de la Santé et de la Recherche Médicale U482, Hôpital Saint-Antoine, Paris, France
&
Michèle SabbahInstitut National de la Santé et de la Recherche Médicale U482, Hôpital Saint-Antoine, Paris, FranceCorrespondence[email protected]
Pages 2419-2430 | Received 13 May 2004, Accepted 21 Dec 2004, Published online: 27 Mar 2023

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Crossref
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Crossref
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