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Molecular and Cellular Biology Volume 26, 2006 - Issue 3
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Article

The Chinese Hamster Dihydrofolate Reductase Replication Origin Decision Point Follows Activation of Transcription and Suppresses Initiation of Replication within Transcription Units

Takayo SasakiDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 East Adams St., Syracuse, New York13210
,
Sunita RamanathanDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 East Adams St., Syracuse, New York13210
,
Yukiko OkunoDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 East Adams St., Syracuse, New York13210
,
Chiharu KumagaiDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 East Adams St., Syracuse, New York13210
,
Seemab S. ShaikhDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 East Adams St., Syracuse, New York13210
&
David M. GilbertDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 East Adams St., Syracuse, New York13210Correspondencegilbertd@upstate
Pages 1051-1062 | Received 07 Sep 2005, Accepted 15 Nov 2005, Published online: 27 Mar 2023

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Read on this site (3)

Alessia Errico & Vincenzo Costanzo. (2012) Mechanisms of replication fork protection: a safeguard for genome stability. Critical Reviews in Biochemistry and Molecular Biology 47:3, pages 222-235.
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Takayo Sasaki, Anatoliy Li, Peter J. Gillespie, J. Julian Blow & David M. Gilbert. (2011) Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity. Nucleus 2:5, pages 455-464.
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Hiroyuki Minami, Junko Takahashi, Asami Suto, Yasushi Saitoh & Ken-ichi Tsutsumi. (2006) Binding of AlF-C, an Orc1-Binding Transcriptional Regulator, Enhances Replicator Activity of the Rat Aldolase B Origin. Molecular and Cellular Biology 26:23, pages 8770-8780.
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Articles from other publishers (34)

David M. Gilbert. (2023) Replication licensing during S phase: breaking the law to prevent breaking DNA. Nature Structural & Molecular Biology 30:4, pages 406-408.
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Yixin Hu & Bruce Stillman. (2023) Origins of DNA replication in eukaryotes. Molecular Cell 83:3, pages 352-372.
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Daniel J. Emerson, Peiyao A. Zhao, Ashley L. Cook, R. Jordan Barnett, Kyle N. Klein, Dalila Saulebekova, Chunmin Ge, Linda Zhou, Zoltan Simandi, Miriam K. Minsk, Katelyn R. Titus, Weitao Wang, Wanfeng Gong, Di Zhang, Liyan Yang, Sergey V. Venev, Johan H. Gibcus, Hongbo Yang, Takayo Sasaki, Masato T. Kanemaki, Feng Yue, Job Dekker, Chun-Long Chen, David M. Gilbert & Jennifer E. Phillips-Cremins. (2022) Cohesin-mediated loop anchors confine the locations of human replication origins. Nature 606:7915, pages 812-819.
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Athanasios E. Vouzas & David M. Gilbert. (2021) Mammalian DNA Replication Timing. Cold Spring Harbor Perspectives in Biology 13:7, pages a040162.
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Maxime Lalonde, Manuel Trauner, Marcel Werner & Stephan Hamperl. (2021) Consequences and Resolution of Transcription–Replication Conflicts. Life 11:7, pages 637.
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Nina Kirstein, Alexander Buschle, Xia Wu, Stefan Krebs, Helmut Blum, Elisabeth Kremmer, Ina M Vorberg, Wolfgang Hammerschmidt, Laurent Lacroix, Olivier Hyrien, Benjamin Audit & Aloys Schepers. (2021) Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones. eLife 10.
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Claire Marchal, Jiao Sima & David M. Gilbert. (2019) Control of DNA replication timing in the 3D genome. Nature Reviews Molecular Cell Biology 20:12, pages 721-737.
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Orla Coleman, Srinivas Suda, Justine Meiller, Michael Henry, Markus Riedl, Niall Barron, Martin Clynes & Paula Meleady. (2019) Increased growth rate and productivity following stable depletion of miR-7 in a mAb producing CHO cell line causes an increase in proteins associated with the Akt pathway and ribosome biogenesis. Journal of Proteomics 195, pages 23-32.
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Morgane Macheret & Thanos D. Halazonetis. (2018) Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress. Nature 555:7694, pages 112-116.
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Juan Carlos Rivera-Mulia & David M. Gilbert. (2016) Replicating Large Genomes: Divide and Conquer. Molecular Cell 62:5, pages 756-765.
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Nataliya Petryk, Malik Kahli, Yves d'Aubenton-Carafa, Yan Jaszczyszyn, Yimin Shen, Maud Silvain, Claude Thermes, Chun-Long Chen & Olivier Hyrien. (2016) Replication landscape of the human genome. Nature Communications 7:1.
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Morgane MacheretThanos D. Halazonetis. (2015) DNA Replication Stress as a Hallmark of Cancer. Annual Review of Pathology: Mechanisms of Disease 10:1, pages 425-448.
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Olivier Hyrien. (2015) Peaks cloaked in the mist: The landscape of mammalian replication origins. Journal of Cell Biology 208:2, pages 147-160.
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Rituparna Mukhopadhyay, Julien Lajugie, Nicolas Fourel, Ari Selzer, Michael Schizas, Boris Bartholdy, Jessica Mar, Chii Mei Lin, Melvenia M. Martin, Michael Ryan, Mirit I. Aladjem & Eric E. Bouhassira. (2014) Allele-Specific Genome-wide Profiling in Human Primary Erythroblasts Reveal Replication Program Organization. PLoS Genetics 10:5, pages e1004319.
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Ioanna-Eleni Symeonidou, Stavros Taraviras & Zoi Lygerou. (2012) Control over DNA replication in time and space. FEBS Letters 586:18, pages 2803-2812.
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Yihua Cao, Shuichi Kimura, Takayuki Itoi, Kohsuke Honda, Hisao Ohtake & Takeshi Omasa. (2012) Construction of BAC-based physical map and analysis of chromosome rearrangement in chinese hamster ovary cell lines. Biotechnology and Bioengineering 109:6, pages 1357-1367.
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Tyrone Ryba, Dana Battaglia, Benjamin D Pope, Ichiro Hiratani & David M Gilbert. (2011) Genome-scale analysis of replication timing: from bench to bioinformatics. Nature Protocols 6:6, pages 870-895.
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Yoav Lubelsky, Takayo Sasaki, Marjorie A. Kuipers, Isabelle Lucas, Michelle M. Le Beau, Sandra Carignon, Michelle Debatisse, Joseph A. Prinz, Jonathan H. Dennis & David M. Gilbert. (2011) Pre-replication complex proteins assemble at regions of low nucleosome occupancy within the Chinese hamster dihydrofolate reductase initiation zone. Nucleic Acids Research 39:8, pages 3141-3155.
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Marjorie A. Kuipers, Timothy J. Stasevich, Takayo Sasaki, Korey A. Wilson, Kristin L. Hazelwood, James G. McNally, Michael W. Davidson & David M. Gilbert. (2011) Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload. Journal of Cell Biology 192:1, pages 29-41.
Crossref
Phyllis S Frisa & James W Jacobberger. (2010) Cytometry of chromatin bound Mcm6 and PCNA identifies two states in G1 that are separated functionally by the G1 restriction point1. BMC Cell Biology 11:1.
Crossref
Marcel Méchali. (2010) Eukaryotic DNA replication origins: many choices for appropriate answers. Nature Reviews Molecular Cell Biology 11:10, pages 728-738.
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David M. Gilbert. (2010) Evaluating genome-scale approaches to eukaryotic DNA replication. Nature Reviews Genetics 11:10, pages 673-684.
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Michaela Schwaiger, Hubertus Kohler, Edward J. Oakeley, Michael B. Stadler & Dirk Schübeler. (2010) Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome . Genome Research 20:6, pages 771-780.
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Joon Young Park, Yasuhiro Takagi, Miyuki Yamatani, Kohsuke Honda, Shuichi Asakawa, Nobuyoshi Shimizu, Takeshi Omasa & Hisao Ohtake. (2010) Identification and analysis of specific chromosomal region adjacent to exogenous Dhfr-amplified region in Chinese hamster ovary cell genome. Journal of Bioscience and Bioengineering 109:5, pages 504-511.
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Christelle Cayrou, Philippe Coulombe & Marcel Méchali. (2010) Programming DNA replication origins and chromosome organization. Chromosome Research 18:1, pages 137-145.
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Joyce L. Hamlin, Larry D. Mesner & Pieter A. Dijkwel. (2009) A winding road to origin discovery. Chromosome Research 18:1, pages 45-61.
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Takeshi Omasa, Yihua Cao, Joon Young Park, Yasuhiro Takagi, Shuichi Kimura, Hidenori Yano, Kohsuke Honda, Shuichi Asakawa, Nobuyoshi Shimizu & Hisao Ohtake. (2009) Bacterial artificial chromosome library for genome-wide analysis of Chinese hamster ovary cells. Biotechnology and Bioengineering 104:5, pages 986-994.
Crossref
R. A. SclafaniT. M. Holzen. (2007) Cell Cycle Regulation of DNA Replication. Annual Review of Genetics 41:1, pages 237-280.
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Junjie Lu & David M. Gilbert. (2007) Proliferation-dependent and cell cycle–regulated transcription of mouse pericentric heterochromatin. Journal of Cell Biology 179:3, pages 411-421.
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Mirit I. Aladjem. (2007) Replication in context: dynamic regulation of DNA replication patterns in metazoans. Nature Reviews Genetics 8:8, pages 588-600.
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David M. Gilbert. (2007) Replication origin plasticity, Taylor-made: inhibition vs recruitment of origins under conditions of replication stress. Chromosoma 116:4, pages 341-347.
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Steven J. Gray, Guoqi Liu, Amy L. Altman, Lawrence E. Small & Ellen Fanning. (2007) Discrete functional elements required for initiation activity of the Chinese hamster dihydrofolate reductase origin beta at ectopic chromosomal sites. Experimental Cell Research 313:1, pages 109-120.
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Weihong Xu, Jennifer G Aparicio, Oscar M Aparicio & Simon Tavaré. (2006) Genome-wide mapping of ORC and Mcm2p binding sites on tiling arrays and identification of essential ARS consensus sequences in S. cerevisiae. BMC Genomics 7:1.
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Paolo Norio. (2006) DNA replication: the unbearable lightness of origins. EMBO reports 7:8, pages 779-781.
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