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Cell Growth and Development

The Translocation (6;9), Associated with a Specific Subtype of Acute Myeloid Leukemia, Results in the Fusion of Two Genes, dek and can, and the Expression of a Chimeric, Leukemia-Specific dek-can mRNA

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Pages 1687-1697 | Received 11 Dec 1991, Accepted 24 Jan 1992, Published online: 31 Mar 2023

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Jinglong Zhou, Lihong Zhao, Yajie Wu, Xiaojian Zhang, Sheng Cheng, Feng Wei, Yalin Zhang, Heqin Zhu, Yi Zhou, Zili Feng & Hongjie Feng. (2022) A DEK domain-containing protein GhDEK2D mediated Gossypium hirsutum enhanced resistance to Verticillium dahliae. Plant Signaling & Behavior 17:1.
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Qianqian Yang, Honglan Qian, Zhenlin Jin, Zhijie Yu, Kang Yu, Shenghui Zhang & Songfu Jiang. (2020) SET-CAN fusion gene as poor prognosis predictor in adult T-cell acute lymphoblastic leukemia. Leukemia & Lymphoma 61:1, pages 217-220.
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Felix Lohmann, Mohan Dangeti, Shefali Soni, Xiaoyong Chen, Antanas Planutis, Margaret H. Baron, Kyunghee Choi & James J. Bieker. (2015) The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells. Molecular and Cellular Biology 35:21, pages 3726-3738.
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Jing Chen, Chao Li, Yingchao Zhu, Ling Sun, Hui Sun, Yanfang Liu, Zhenxiang Zhang & Chong Wang. (2015) Integrating GO and KEGG terms to characterize and predict acute myeloid leukemia-related genes. Hematology 20:6, pages 336-342.
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Kee-Beom Kim, Yun-Cheol Chae, Arim Han, Joo-Young Kang, Hyeonsoo Jung, Jin Woo Park, Ja Young Hahm, Seryeon Kim & Sang-Beom Seo. (2014) Negative regulation of peroxiredoxin 6 (Prdx 6) transcription by nuclear oncoprotein DEK during leukemia cell differentiation. Animal Cells and Systems 18:5, pages 318-323.
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Lisa M. Privette Vinnedge, Ferdinand Kappes, Nicolas Nassar & Susanne I. Wells. (2013) Stacking the DEK: From chromatin topology to cancer stem cells. Cell Cycle 12:1, pages 51-66.
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Dong-Mei Wang, Ling Liu, Lei Fan, Zhi-Jian Zou, Li-Na Zhang, Shu Yang, Jian-Yong Li & Wei Xu. (2012) Expression level of DEK in chronic lymphocytic leukemia is regulated by fludarabine and Nutlin-3 depending on p53 status. Cancer Biology & Therapy 13:14, pages 1522-1528.
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F. Kappes, J. Fahrer, M. S. Khodadoust, A. Tabbert, C. Strasser, N. Mor-Vaknin, M. Moreno-Villanueva, A. Bürkle, D. M. Markovitz & E. Ferrando-May. (2008) DEK Is a Poly(ADP-Ribose) Acceptor in Apoptosis and Mediates Resistance to Genotoxic Stress. Molecular and Cellular Biology 28:10, pages 3245-3257.
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Nirit Mor-Vaknin, Antonello Punturieri, Kajal Sitwala, Neil Faulkner, Maureen Legendre, Michael S. Khodadoust, Ferdinand Kappes, Jeffrey H. Ruth, Alisa Koch, David Glass, Lilli Petruzzelli, Barbara S. Adams & David M. Markovitz. (2006) The DEK Nuclear Autoantigen Is a Secreted Chemotactic Factor. Molecular and Cellular Biology 26:24, pages 9484-9496.
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Trisha M. Wise-Draper, Hillary V. Allen, Elizabeth E. Jones, Kristen B. Habash, Hiroshi Matsuo & Susanne I. Wells. (2006) Apoptosis Inhibition by the Human DEK Oncoprotein Involves Interference with p53 Functions. Molecular and Cellular Biology 26:20, pages 7506-7519.
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Saskia Hutten & Ralph H. Kehlenbach. (2006) Nup214 Is Required for CRM1-Dependent Nuclear Protein Export In Vivo. Molecular and Cellular Biology 26:18, pages 6772-6785.
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Chi-Chung Wang, Jeremy JW Chen & Pan-Chyr Yang. (2006) Multifunctional transcription factor YY1: a therapeutic target in human cancer?. Expert Opinion on Therapeutic Targets 10:2, pages 253-266.
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Chonghui Cheng & Phillip A. Sharp. (2006) Regulation of CD44 Alternative Splicing by SRm160 and Its Potential Role in Tumor Cell Invasion. Molecular and Cellular Biology 26:1, pages 362-370.
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Ferdinand Kappes, Catalina Damoc, Rolf Knippers, Michael Przybylski, Lorenzo A. Pinna & Claudia Gruss. (2004) Phosphorylation by Protein Kinase CK2 Changes the DNA Binding Properties of the Human Chromatin Protein DEK. Molecular and Cellular Biology 24:13, pages 6011-6020.
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Ferdinand Kappes, Ingo Scholten, Nicole Richter, Claudia Gruss & Tanja Waldmann. (2004) Functional Domains of the Ubiquitous Chromatin Protein DEK. Molecular and Cellular Biology 24:13, pages 6000-6010.
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Sílvia Casas, Bálint Nagy, Erkki Elonen, Anna Aventín, Marcelo L. Larramendy, Jorge Sierra, Tapani Ruutu & Sakari Knuutila. (2003) Aberrant Expression of HOXA9, DEK, CBL and CSF1R in Acute Myeloid Leukemia. Leukemia & Lymphoma 44:11, pages 1935-1941.
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Judith Boer, Jacqueline Bonten-Surtel & Gerard Grosveld. (1998) Overexpression of the Nucleoporin CAN/NUP214 Induces Growth Arrest, Nucleocytoplasmic Transport Defects, and Apoptosis. Molecular and Cellular Biology 18:3, pages 1236-1247.
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Nelly Panté & Ueli Aebi. (1996) Molecular Dissection of the Nuclear Pore Complex. Critical Reviews in Biochemistry and Molecular Biology 31:2, pages 153-199.
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Hans G. Drexler, Arndt Borkhardt & Johannes W. G. Janssen. (1995) Detection of Chromosomal Translocations :in Leukemia-Lymphoma Cells by Polymerase Chain Reaction. Leukemia & Lymphoma 19:5-6, pages 359-380.
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Peter E. Hollings, Jill Cochrane, Jacqueline A. Bowen, Ingrid Rosman & Peter H. Fitzgerald. (1995) Growth Characteristics in vitro of Myeloid Leukaemic Cells with t(6;9). Leukemia & Lymphoma 17:3-4, pages 281-288.
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Marieke Von Lindern, Sjozèf Van Baal, Joop Wiegant, Anton Raap, Anne Hagemeijer & Gerard Grosveld. (1992) can, a Putative Oncogene Associated with Myeloid Leukemogenesis, May Be Activated by Fusion of Its 3‣ Half to Different Genes: Characterization of the set Gene. Molecular and Cellular Biology 12:8, pages 3346-3355.
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Muhammad Habiburrahman, Muhammad Wardoyo, Stefanus Sutopo & Nur Rahadiani. (2022) Potential of DEK proto‑oncogene as a prognostic biomarker for colorectal cancer: An evidence‑based review . Molecular and Clinical Oncology 17:1.
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Anjan K. SahaFerdinand KappesAmruta MundadeAnja DeutzmannDavid M. RosmarinMaureen LegendreNicolas ChatainZeina Al-ObaidiBarbara S. Adams, Hidde L. PloeghElisa Ferrando-MayNirit Mor-VakninDavid M. Markovitz. (2013) Intercellular trafficking of the nuclear oncoprotein DEK. Proceedings of the National Academy of Sciences 110:17, pages 6847-6852.
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Courtney A. LovejoyXin XuCarol E. BansbachGloria G. GlickRunxiang ZhaoFei Ye, Bianca M. SirbuLaura C. TitusYu Shyr & David Cortez. (2009) Functional genomic screens identify CINP as a genome maintenance protein. Proceedings of the National Academy of Sciences 106:46, pages 19304-19309.
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Johanna Napetschnig, Susanne A. Kassube, Erik W. Debler, Richard W. Wong, Günter Blobel & André Hoelz. (2009) Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19. Proceedings of the National Academy of Sciences 106:9, pages 3089-3094.
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Trisha M. Wise-Draper, Rachael A. Mintz-Cole, Teresa A. Morris, David S. Simpson, Kathryn A. Wikenheiser-Brokamp, Mark A. Currier, Timothy P. Cripe, Gerard C. Grosveld & Susanne I. Wells. (2009) Overexpression of the Cellular DEK Protein Promotes Epithelial Transformation In vitro and In vivo . Cancer Research 69:5, pages 1792-1799.
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Akihiro Urasaki, Kazuhide Asakawa & Koichi Kawakami. (2008) Efficient transposition of the Tol2 transposable element from a single-copy donor in zebrafish . Proceedings of the National Academy of Sciences 105:50, pages 19827-19832.
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Johanna Napetschnig, Günter Blobel & André Hoelz. (2007) Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN. Proceedings of the National Academy of Sciences 104:6, pages 1783-1788.
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Xue-Tao Bai, Bai-Wei Gu, Tong Yin, Chao Niu, Xiao-Dong Xi, Ji Zhang, Zhu Chen & Sai-Juan Chen. (2006) Trans-Repressive Effect of NUP98-PMX1 on PMX1-Regulated c- FOS Gene through Recruitment of Histone Deacetylase 1 by FG Repeats . Cancer Research 66:9, pages 4584-4590.
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Corinna Grasemann, Sandrine Gratias, Harald Stephan, Andreas Schüler, Alexander Schramm, Ludger Klein-Hitpass, Harald Rieder, Stephanie Schneider, Ferdinand Kappes, Angelika Eggert & Dietmar R Lohmann. (2005) Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma. Oncogene 24:42, pages 6441-6449.
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Kajal V Sitwala, Kristine Adams & David M Markovitz. (2002) YY1 and NF-Y binding sites regulate the transcriptional activity of the dek and dek-can promoter. Oncogene 21:57, pages 8862-8870.
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Anita Krithivas, Masahiro Fujimuro, Magdalena Weidner, David B. Young & S. Diane Hayward. (2002) Protein Interactions Targeting the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus to Cell Chromosomes. Journal of Virology 76:22, pages 11596-11604.
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Michael E. Hurwitz, Caterina Strambio-de-Castillia & Günter Blobel. (1998) Two yeast nuclear pore complex proteins involved in mRNA export form a cytoplasmically oriented subcomplex. Proceedings of the National Academy of Sciences 95:19, pages 11241-11245.
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Glenn K. Fu, Gerard Grosveld & David M. Markovitz. (1997) DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer. Proceedings of the National Academy of Sciences 94:5, pages 1811-1815.
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