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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 18, 2015 - Issue 4
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Original Research Papers

Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial

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Read on this site (18)

Xinyu Nie, Xinru Dong, Yuge Hu, Fangjun Xu, Cong Hu & Chang Shu. (2023) Coenzyme Q10 Stimulate Reproductive Vatality. Drug Design, Development and Therapy 17, pages 2623-2637.
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Zahra Mousavi-Shirazi-Fard, Zohreh Mazloom, Sadegh Izadi & Mohammad Fararouei. (2021) The effects of modified anti-inflammatory diet on fatigue, quality of life, and inflammatory biomarkers in relapsing-remitting multiple sclerosis patients: a randomized clinical trial. International Journal of Neuroscience 131:7, pages 657-665.
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Nadia Turton, Nathan Bowers, Sam Khajeh, Iain P Hargreaves & Robert A Heaton. (2021) Coenzyme Q10 and the exclusive club of diseases that show a limited response to treatment. Expert Opinion on Orphan Drugs 9:5, pages 151-160.
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Mohammad Parohan, Payam Sarraf, Mohammad Hassan Javanbakht, Abbas Rahimi Foroushani, Sakineh Ranji-Burachaloo & Mahmoud Djalali. (2021) The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial. Nutritional Neuroscience 24:4, pages 317-326.
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Shiva Taghizadeh, Azimeh Izadi, Shabnam Shirazi, Marziyeh Parizad & Bahram Pourghassem Gargari. (2021) The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients. Gynecological Endocrinology 37:1, pages 26-30.
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Mohammad Parohan, Payam Sarraf, Mohammad Hassan Javanbakht, Sakineh Ranji-Burachaloo & Mahmoud Djalali. (2020) Effect of coenzyme Q10 supplementation on clinical features of migraine: a systematic review and dose–response meta-analysis of randomized controlled trials. Nutritional Neuroscience 23:11, pages 868-875.
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Áine Maguire, April Hargreaves & Michael Gill. (2020) Coenzyme Q10 and neuropsychiatric and neurological disorders: relevance for schizophrenia. Nutritional Neuroscience 23:10, pages 756-769.
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Pablo Villoslada & Lawrence Steinman. (2020) New targets and therapeutics for neuroprotection, remyelination and repair in multiple sclerosis. Expert Opinion on Investigational Drugs 29:5, pages 443-459.
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Tobore Onojighofia Tobore. (2020) Towards a comprehensive etiopathogenetic and pathophysiological theory of multiple sclerosis. International Journal of Neuroscience 130:3, pages 279-300.
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Nazanin Zahrooni, Seyed Ahmad Hosseini, Ahmad Ahmadzadeh, Kambiz Ahmadi Angali & Mohammad Ali Assarehzadegan. (2019) The Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Growth Factor and Serum Levels of Interleukin 6 and 8 in Women with Breast Cancer: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Therapeutics and Clinical Risk Management 15, pages 1403-1410.
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Monireh Dahri, Ali Tarighat-Esfanjani, Mohammad Asghari-Jafarabadi & Mazyar Hashemilar. (2019) Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers. Nutritional Neuroscience 22:9, pages 607-615.
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Sanaz Nasoohi, Leila Simani, Fariba Khodagholi, Sara Nikseresht, Mehrdad Faizi & Nima Naderi. (2019) Coenzyme Q10 supplementation improves acute outcomes of stroke in rats pretreated with atorvastatin. Nutritional Neuroscience 22:4, pages 264-272.
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Elham Rahmani, Mehri Jamilian, Mansooreh Samimi, Maryam Zarezade Mehrizi, Esmat Aghadavod, Elmira Akbari, Omid Reza Tamtaji & Zatollah Asemi. (2018) The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome. Gynecological Endocrinology 34:3, pages 217-222.
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Justin T. Morrison, Chris T. Longenecker, Alison Mittelsteadt, Ying Jiang, Sara M. Debanne & Grace A. McComsey. (2016) Effect of rosuvastatin on plasma coenzyme Q10 in HIV-infected individuals on antiretroviral therapy. HIV Clinical Trials 17:4, pages 140-146.
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Farnaz Farsi, Majid Mohammadshahi, Pezhman Alavinejad, Afshin Rezazadeh, Mehdi Zarei & Kambiz Ahmadi Engali. (2016) Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Journal of the American College of Nutrition 35:4, pages 346-353.
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Meisam Sanoobar, Parvin Dehghan, Mohammad Khalili, Amirreza Azimi & Fatemeh Seifar. (2016) Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial. Nutritional Neuroscience 19:3, pages 138-143.
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Jacobo Cambil-Martín, Noelia Galiano-Castillo, Elena Muñoz-Hellín, Lourdes Díaz-Rodríguez, Sofía Laguarta-Val, César Fernández-de-las-Peñas & Manuel Arroyo-Morales. (2016) Influence of body mass index on psychological and functional outcomes in patients with multiple sclerosis: a cross-sectional study. Nutritional Neuroscience 19:2, pages 79-85.
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Hamid Zahednasab, Seyed Alireza Mesbah-Namin & Mohammad Balood. (2015) Coenzyme Q10 supplementation and multiple sclerosis. Nutritional Neuroscience 18:4, pages 192-192.
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Articles from other publishers (73)

Alireza Ebrahimi, Amirhossein Kamyab, Sahar Hosseini, Sedigheh Ebrahimi & Soheil Ashkani-Esfahani. (2023) Involvement of Coenzyme Q10 in Various Neurodegenerative and Psychiatric Diseases. Biochemistry Research International 2023, pages 1-11.
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Dániel Pukoli & László Vécsei. (2023) Smouldering Lesion in MS: Microglia, Lymphocytes and Pathobiochemical Mechanisms. International Journal of Molecular Sciences 24:16, pages 12631.
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Shanshan Hou, Zezhong Tian, Dan Zhao, Ying Liang, Suming Dai, Qiuhua Ji, Zhiying Fan, Zhihao Liu, Meitong Liu & Yan Yang. (2023) Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation‐Related Biomarkers: A GRADE‐Assessed Systematic Review and Updated Meta‐Analysis of Randomized Controlled Trials. Molecular Nutrition & Food Research 67:13.
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Hormoz Ayromlou, Samaneh Hosseini, Mohammad Khalili, Samin Ayromlou, Shagayeg Khamudchiyan, Fereshteh Farajdokht, Sina Hassannezhad & Shirin Amiri Moghadam. (2023) Insulin resistance is associated with cognitive dysfunction in multiple sclerosis patients: A cross‐sectional study. Journal of Neuroendocrinology 35:6.
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Marc P. McRae. (2023) Coenzyme Q10 Supplementation in Reducing Inflammation: An Umbrella Review. Journal of Chiropractic Medicine 22:2, pages 131-137.
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David Mantle. (2023) Multiple sclerosis: is there a role for coenzyme Q10?. British Journal of Neuroscience Nursing 19:Sup3, pages S21-S25.
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Torsak Tippairote, Geir Bjørklund, Amin Gasmi, Yuliya Semenova, Massimiliano Peana, Salvatore Chirumbolo & Tony Hangan. (2022) Combined Supplementation of Coenzyme Q10 and Other Nutrients in Specific Medical Conditions. Nutrients 14:20, pages 4383.
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Nicolas Collongues, Guillaume Becker, Valérie Jolivel, Estelle Ayme-Dietrich, Jérôme de Seze, Fabien Binamé, Christine Patte-Mensah, Laurent Monassier & Ayikoé Guy Mensah-Nyagan. (2022) A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis. Neurology and Therapy 11:3, pages 981-1042.
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Priyanka Joshi, Akansha Bisht, Sushil Joshi, Deepak Semwal, Neelesh Kumar Nema, Jaya Dwivedi & Swapnil Sharma. (2022) Ameliorating potential of curcumin and its analogue in central nervous system disorders and related conditions: A review of molecular pathways. Phytotherapy Research 36:8, pages 3143-3180.
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Shraman Kumar Bohra, Raghu Ram Achar, Saravana Babu Chidambaram, Christophe Pellegrino, Jerome Laurin, Mojgan Masoodi & Asha Srinivasan. (2022) Current perspectives on mitochondrial dysfunction in migraine. European Journal of Neuroscience 56:1, pages 3738-3754.
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Kait F. Al, Laura J Craven, Shaeley Gibbons, Seema Nair Parvathy, Ana Christina Wing, Chantelle Graf, Kate A Parham, Steven M Kerfoot, Hannah Wilcox, Jeremy P Burton, Marcelo Kremenchutzky, Sarah A Morrow, Courtney Casserly, Jon Meddings, Manas Sharma & Michael S. Silverman. (2022) Fecal microbiota transplantation is safe and tolerable in patients with multiple sclerosis: A pilot randomized controlled trial. Multiple Sclerosis Journal - Experimental, Translational and Clinical 8:2, pages 205521732210866.
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P. B. Vani P. B. Vani & V. Chitra V. Chitra. (2022) The Role of the Proinflammatory and Anti-inflammatory Cytokines in Multiple Sclerosis. Biomedical and Pharmacology Journal 15:1, pages 137-146.
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Ahmed O. Babalghith. (2022) Coenzyme Q10 regulates Gene expression of Myocardial Infarction in Isoproterenol Model. Archives Of Pharmacy Practice 13:2, pages 1-6.
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Jinan Xu, Xingjiang Jin, Zuting Ye, Dandan Wang, Hang Zhao & Zhiqian Tong. (2022) Opposite Roles of Co-enzyme Q10 and Formaldehyde in Neurodegenerative Diseases. American Journal of Alzheimer's Disease & Other Dementias® 37, pages 153331752211432.
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H Rauchová. (2021) Coenzyme Q10 effects in neurological diseases. Physiological Research:S4, pages S683-S714.
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Dariush Haghmorad, Esmaeil Yazdanpanah, Bizhan Sadighimoghaddam, Bahman Yousefi, Pegah Sahafi, Narges Ghorbani, Ali Rashidy-Pour & Parviz Kokhaei. (2020) Kombucha ameliorates experimental autoimmune encephalomyelitis through activation of Treg and Th2 cells. Acta Neurologica Belgica 121:6, pages 1685-1692.
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Ferdinando Franzoni, Giorgia Scarfò, Sara Guidotti, Jonathan Fusi, Muzaffar Asomov & Carlo Pruneti. (2021) Oxidative Stress and Cognitive Decline: The Neuroprotective Role of Natural Antioxidants. Frontiers in Neuroscience 15.
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Afshin Derakhshani, Hossein Safarpour, Mahdi Abdoli Shadbad, Nima Hemmat, Patrizia Leone, Zahra Asadzadeh, Mehrdad Pashazadeh, Behzad Baradaran & Vito Racanelli. (2021) The Role of Hemoglobin Subunit Delta in the Immunopathy of Multiple Sclerosis: Mitochondria Matters. Frontiers in Immunology 12.
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Jesús Castro-Marrero, Maria Jose Segundo, Marcos Lacasa, Alba Martinez-Martinez, Ramon Sanmartin Sentañes & Jose Alegre-Martin. (2021) Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 13:8, pages 2658.
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Behnaz Abiri & Mohammadreza Vafa. (2021) Impact of coenzyme Q10 on inflammatory biomarkers and its role in future therapeutic strategies. Clinical Nutrition ESPEN 43, pages 25-30.
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David Mantle, Robert A. Heaton & Iain P. Hargreaves. (2021) Coenzyme Q10 and Immune Function: An Overview. Antioxidants 10:5, pages 759.
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Chary López-Pedrera, José Manuel Villalba, Alejandra Mª Patiño-Trives, Maria Luque-Tévar, Nuria Barbarroja, Mª Ángeles Aguirre, Alejandro Escudero-Contreras & Carlos Pérez-Sánchez. (2021) Therapeutic Potential and Immunomodulatory Role of Coenzyme Q10 and Its Analogues in Systemic Autoimmune Diseases. Antioxidants 10:4, pages 600.
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Kemal Ayengin, Hamit Hakan Alp, Zübeyir Huyut, Serkan Yıldırım, Fikret Altındag & Veli Avci. (2020) The effects of CoQ10 supplement on matrix metalloproteinases, oxidative DNA damage and pro‐inflammatory cytokines in testicular ischaemia/reperfusion injury in rats. Andrologia 53:2.
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Carmen Mannucci, Marco Casciaro, Emanuela Elisa Sorbara, Fabrizio Calapai, Eleonora Di Salvo, Giovanni Pioggia, Michele Navarra, Gioacchino Calapai & Sebastiano Gangemi. (2021) Nutraceuticals against Oxidative Stress in Autoimmune Disorders. Antioxidants 10:2, pages 261.
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Behnam Khalilian, Soheila Madadi, Nima Fattahi & Beheshteh Abouhamzeh. (2020) Coenzyme Q10 enhances remyelination and regulate inflammation effects of cuprizone in corpus callosum of chronic model of multiple sclerosis. Journal of Molecular Histology 52:1, pages 125-134.
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Suhairul Sazali, Salziyan Badrin, Mohd Noor Norhayati & Nur Suhaila Idris. (2021) Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine—a meta-analysis. BMJ Open 11:1, pages e039358.
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Qian-wei Li, Qin Yang, Hong-Yang Liu, Yu-ling Wu, Yu-Hua Hao & Xiao-Qing Zhang. (2020) Protective Role of Coenzyme Q10 in Acute Sepsis-Induced Liver Injury in BALB/c Mice. BioMed Research International 2020, pages 1-9.
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Urban Alehagen, Jan Aaseth, Jan Alexander, Kerstin Brismar & Anders Larsson. (2020) Selenium and Coenzyme Q10 Supplementation Improves Renal Function in Elderly Deficient in Selenium: Observational Results and Results from a Subgroup Analysis of a Prospective Randomised Double-Blind Placebo-Controlled Trial. Nutrients 12:12, pages 3780.
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Gerwyn Morris, Basant K. Puri, Lisa Olive, Andre Carvalho, Michael Berk, Ken Walder, Lise Tuset Gustad & Michael Maes. (2020) Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments. BMC Medicine 18:1.
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Giovanni Pagano, Federico V. Pallardó, Alex Lyakhovich, Luca Tiano, Maria Rosa Fittipaldi, Maria Toscanesi & Marco Trifuoggi. (2020) Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures. International Journal of Molecular Sciences 21:19, pages 7060.
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Kathleen F Holton & Anna E Kirkland. (2019) Moving past antioxidant supplementation for the dietary treatment of multiple sclerosis. Multiple Sclerosis Journal 26:9, pages 1012-1023.
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G. Morris, K. R. Walder, M. Berk, W. Marx, A. J. Walker, M. Maes & B. K. Puri. (2020) The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it?. Molecular Biology Reports 47:7, pages 5587-5620.
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Natalie E Parks, Caitlin S Jackson-Tarlton, Laura Vacchi, Roah Merdad & Bradley C Johnston. (2020) Dietary interventions for multiple sclerosis-related outcomes. Cochrane Database of Systematic Reviews 2020:5.
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Lea Pogačnik, Ajda Ota & Nataša Poklar Ulrih. (2020) An Overview of Crucial Dietary Substances and Their Modes of Action for Prevention of Neurodegenerative Diseases. Cells 9:3, pages 576.
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Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Berk, Ken Walder, Chiara C. Bortolasci, Wolfgang Marx, Andre F. Carvalho & Michael Maes. (2019) The compensatory antioxidant response system with a focus on neuroprogressive disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry 95, pages 109708.
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Seyed Mostafa Nachvak, Beitollah Alipour, Aida Malek Mahdavi, Mir Amir Aghdashi, Hadi Abdollahzad, Yahya Pasdar, Mehnoosh Samadi & Roghayeh Mostafai. (2019) Effects of coenzyme Q10 supplementation on matrix metalloproteinases and DAS-28 in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. Clinical Rheumatology 38:12, pages 3367-3374.
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Tobore Onojighofia Tobore. (2019) On elucidation of the role of mitochondria dysfunction and oxidative stress in multiple sclerosis. Neurology and Clinical Neuroscience 7:6, pages 305-317.
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Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Maes, Andre F. Carvalho, Ken Walder, Catherine Mazza & Michael Berk. (2019) Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities. Pharmacological Research 148, pages 104450.
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Marcello Moccia, Antonio Capacchione, Roberta Lanzillo, Fortunata Carbone, Teresa Micillo, Giuseppe Matarese, Raffaele Palladino & Vincenzo Brescia Morra. (2019) Sample Size for Oxidative Stress and Inflammation When Treating Multiple Sclerosis with Interferon-β1a and Coenzyme Q10. Brain Sciences 9:10, pages 259.
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Christina Tryfonos, Maria Mantzorou, Dimitris Fotiou, Michael Vrizas, Konstantinos Vadikolias, Eleni Pavlidou & Constantinos Giaginis. (2019) Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives. Medicines 6:3, pages 95.
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James N. Nyariki, Lucy A. Ochola, Ngalla E. Jillani, Nemwel O. Nyamweya, Peris E. Amwayi, Dorcas S. Yole, Laurent Azonvide & Alfred Orina Isaac. (2019) Oral administration of Coenzyme Q10 protects mice against oxidative stress and neuro-inflammation during experimental cerebral malaria. Parasitology International 71, pages 106-120.
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Carin Waslo, Dennis Bourdette, Nora Gray, Kirsten Wright & Rebecca Spain. (2019) Lipoic Acid and Other Antioxidants as Therapies for Multiple Sclerosis. Current Treatment Options in Neurology 21:6.
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Sina Andalib, Mobin Mashhadi-Mousapour, Soroush Bijani & Mir-Jamal Hosseini. (2019) Coenzyme Q10 Alleviated Behavioral Dysfunction and Bioenergetic Function in an Animal Model of Depression. Neurochemical Research 44:5, pages 1182-1191.
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Marcello Moccia, Antonio Capacchione, Roberta Lanzillo, Fortunata Carbone, Teresa Micillo, Francesco Perna, Anna De Rosa, Antonio Carotenuto, Roberto Albero, Giuseppe Matarese, Raffaele Palladino & Vincenzo Brescia Morra. (2019) Coenzyme Q10 supplementation reduces peripheral oxidative stress and inflammation in interferon-β1a-treated multiple sclerosis. Therapeutic Advances in Neurological Disorders 12, pages 175628641881907.
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Maureen Chase, Michael N. Cocchi, Xiaowen Liu, Lars W. Andersen, Mathias J. Holmberg & Michael W. Donnino. (2018) Coenzyme Q10 in acute influenza. Influenza and Other Respiratory Viruses 13:1, pages 64-70.
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Maryam Mehrpooya, Fatemeh Yasrebifar, Mohammad Haghighi, Younes Mohammadi & Leila Jahangard. (2018) Evaluating the Effect of Coenzyme Q10 Augmentation on Treatment of Bipolar Depression. Journal of Clinical Psychopharmacology 38:5, pages 460-466.
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Elyas Nattagh-Eshtivani, Monireh Dahri, Mazyar Hashemilar & Ali Tarighat-Esfanjani. (2018) The effect of Coenzyme Q10 supplementation on serum levels of lactate, pyruvate, matrix metalloproteinase 9 and nitric oxide in women with migraine. A double blind, placebo, controlled randomized clinical trial. European Journal of Integrative Medicine 21, pages 70-76.
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Hadi Abdollahzad, Mir Amir Aghdashi, Mohammad Asghari Jafarabadi & Beitollah Alipour. (2015) Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial. Archives of Medical Research 46:7, pages 527-533.
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