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Review

Drug–drug interactions with statins: will pitavastatin overcome the statins’ Achilles’ heel?

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Pages 1551-1562 | Accepted 16 May 2011, Published online: 17 Jun 2011

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Isabella Damiani, Alberto Corsini & Stefano Bellosta. (2020) Potential statin drug interactions in elderly patients: a review. Expert Opinion on Drug Metabolism & Toxicology 16:12, pages 1133-1145.
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Paul Chan, Li Shao, Brian Tomlinson, Yuzhen Zhang & Zhong-Min Liu. (2019) An evaluation of pitavastatin for the treatment of hypercholesterolemia. Expert Opinion on Pharmacotherapy 20:1, pages 103-113.
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Stefano Bellosta & Alberto Corsini. (2018) Statin drug interactions and related adverse reactions: an update. Expert Opinion on Drug Safety 17:1, pages 25-37.
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Miao Hu & Brian Tomlinson. (2014) Evaluation of the pharmacokinetics and drug interactions of the two recently developed statins, rosuvastatin and pitavastatin. Expert Opinion on Drug Metabolism & Toxicology 10:1, pages 51-65.
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Yasushi Kono, Shota Fukuda, Kenei Shimada, Koki Nakanishi, Kenichiro Otsuka, Tomoichiro Kubo, Satoshi Jissho, Haruyuki Taguchi, Junichi Yoshikawa & Minoru Yoshiyama. (2013) Very rapid effect of pitavastatin on microvascular function in comparison to rosuvastatin: reactive hyperemia peripheral arterial tonometric study. Drug Design, Development and Therapy 7, pages 369-374.
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Vivencio Barrios, Carlos Escobar & José L Zamorano. (2013) Searching the place of pitavastatin in the current treatment of patients with dyslipidemia. Expert Review of Cardiovascular Therapy 11:12, pages 1597-1612.
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Shilpa Bhardwaj, Shalini Selvarajah & Eric B Schneider. (2013) Muscular effects of statins in the elderly female: a review. Clinical Interventions in Aging 8, pages 47-59.
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Stefano Bellosta & Alberto Corsini. (2012) Statin drug interactions and related adverse reactions. Expert Opinion on Drug Safety 11:6, pages 933-946.
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Claudio Borghi & Arrigo Fg Cicero. (2012) Which statin is the ideal statin for polymedicated patients?. Clinical Lipidology 7:sup1, pages 11-16.
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Alberico L Catapano. (2012) Pitavastatin: a different pharmacological profile. Clinical Lipidology 7:sup1, pages 3-9.
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Craig Thomas, Henry Ellison & George E. Taffet. (2023) Deprescribing statins, considerations for informed decision making. Journal of the American Geriatrics Society 71:8, pages 2685-2689.
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Joanna Bojarska, Martin Breza, Milan Remko, Paweł Borowiecki, Andrzej Fruziński, Izabela D. Madura, Krzysztof Kaczmarek, Zbigniew Leśnikowski, Agata Kraj, Piotr Zielenkiewicz & Wojciech M. Wolf. (2022) Supramolecular synthon hierarchy in cyclopropyl-containing peptide-derived compounds. CrystEngComm 24:48, pages 8372-8389.
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Marina G. Bubnova. (2022) Optimizing therapy for cardiovascular diseases: proven organ-protective and preventive effects of pitavastatin and lercanidipine: A review. CardioSomatics 13:1, pages 31-42.
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Cesare R Sirtori, Shizuya Yamashita, Maria Francesca Greco, Alberto Corsini, Gerald F Watts & Massimiliano Ruscica. (2019) Recent advances in synthetic pharmacotherapies for dyslipidaemias. European Journal of Preventive Cardiology 27:15, pages 1576-1596.
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Yongin Cho, Hyangkyu Lee, Hyun Ki Park, Eun Yeong Choe, Hye Jin Wang, Ryeong-Hyeon Kim, Youjin Kim & Eun Seok Kang. (2020) Differential Diabetogenic Effect of Pitavastatin and Rosuvastatin, <i>in vitro</i> and <i>in vivo </i>. Journal of Atherosclerosis and Thrombosis 27:5, pages 429-440.
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Han Saem Jeong, Soon Jun Hong, Serhim Son, Hyonggin An, Hyungdon Kook, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu & Do-Sun Lim. (2019) Incidence of new-onset diabetes with 1 mg versus 4 mg pitavastatin in patients at high risk of developing diabetes during a 3-year follow-up. Cardiovascular Diabetology 18:1.
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Julia Bird, Philip Calder & Manfred Eggersdorfer. (2018) The Role of n-3 Long Chain Polyunsaturated Fatty Acids in Cardiovascular Disease Prevention, and Interactions with Statins. Nutrients 10:6, pages 775.
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Leigh Anne Hylton Gravatt, Rachel W. Flurie, Estela Lajthia & Dave L. Dixon. (2017) Clinical Guidance for Managing Statin and Antimicrobial Drug-Drug Interactions. Current Atherosclerosis Reports 19:11.
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Jens Barthelmes & Isabella Sudano. (2017) Medikamentöse Senkung des LDL-Cholesterins. Praxis 106:17, pages 933-940.
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Sheridan M. Hoy. (2017) Pitavastatin: A Review in Hypercholesterolemia. American Journal of Cardiovascular Drugs 17:2, pages 157-168.
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Nicola Ferrara, Graziamaria Corbi, Klara Komici & Giuseppe Rengo. 2017. Cardiac Management in the Frail Elderly Patient and the Oldest Old. Cardiac Management in the Frail Elderly Patient and the Oldest Old 63 70 .
Vivencio Barrios & Carlos Escobar. (2016) Clinical benefits of pitavastatin: focus on patients with diabetes or at risk of developing diabetes. Future Cardiology 12:4, pages 449-466.
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Michele Thai, Emily Reeve, Sarah N Hilmer, Katie Qi, Sallie-Anne Pearson & Danijela Gnjidic. (2016) Prevalence of statin-drug interactions in older people: a systematic review. European Journal of Clinical Pharmacology 72:5, pages 513-521.
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Annett Kunze, Birk Poller, Jörg Huwyler & Gian Camenisch. (2015) Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins. Drug Metabolism and Personalized Therapy 30:3, pages 175-188.
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Weiqi Chen, Fangjun Xiong, Qian Liu, Lingjun Xu, Yan Wu & Fener Chen. (2015) Substrate stereocontrol in bromine-induced intermolecular cyclization: asymmetric synthesis of pitavastatin calcium. Tetrahedron 71:29, pages 4730-4737.
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Natalia Mora Cuadrado. (2015) Pitavastatin: Other statin to be used and monitored. Revista Española de Enfermedades Digestivas.
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Lorenzo Arnaboldi & Alberto Corsini. (2015) Could changes in adiponectin drive the effect of statins on the risk of new-onset diabetes? The case of pitavastatin. Atherosclerosis Supplements 16, pages 1-27.
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Yufan Wu, Boleslaw Lach, John P. Provias, Mark A. Tarnopolsky & Steven K. Baker. (2014) Statin-associated Autoimmune Myopathies: A Pathophysiologic Spectrum. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 41:5, pages 638-647.
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Craig A. Sponseller, Roger E. Morgan, Vladimir A. Kryzhanovski, Stuart E. Campbell & Michael H. Davidson. (2014) Comparison of the Lipid-Lowering Effects of Pitavastatin 4 mg Versus Pravastatin 40 mg in Adults With Primary Hyperlipidemia or Mixed (Combined) Dyslipidemia: A Phase IV, Prospective, US, Multicenter, Randomized, Double-blind, Superiority Trial. Clinical Therapeutics 36:8, pages 1211-1222.
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Montserrat Cofan Pujol. (2014) Mecanismos básicos. Absorción y excreción de colesterol y otros esteroles. Clínica e Investigación en Arteriosclerosis 26:1, pages 41-47.
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Hirokazu Kakuda, Junji Kobayashi, Mio Nakato & Noboru Takekoshi. (2013) Short-Term Effect of Pitavastatin Treatment on Glucose and Lipid Metabolism and Oxidative Stress in Fasting and Postprandial State Using a Test Meal in Japanese Men. Cholesterol 2013, pages 1-7.
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A. S. Trenin. (2013) Microbial metabolites inhibiting sterol biosynthesis: Their chemical diversity and characteristics of the mechanism of action. Russian Journal of Bioorganic Chemistry 39:6, pages 565-587.
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Venkata M. Alla, Vrinda Agrawal, Andrew DeNazareth, Syed Mohiuddin, Sudha Ravilla & Marc Rendell. (2013) A Reappraisal of the Risks and Benefits of Treating to Target with Cholesterol Lowering Drugs. Drugs 73:10, pages 1025-1054.
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Matthias Hoch, Petra Hoever, Rudolf Theodor & Jasper Dingemanse. (2013) Almorexant effects on CYP3A4 activity studied by its simultaneous and time-separated administration with simvastatin and atorvastatin. European Journal of Clinical Pharmacology 69:6, pages 1235-1245.
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Jonas G. Barlind, Linda K. Buckett, Sharon G. Crosby, Öjvind Davidsson, Hans Emtenäs, Anne Ertan, Ulrik Jurva, Malin Lemurell, Pablo Morentin Gutierrez, Karolina Nilsson, Gavin O’Mahony, Annika U. Petersson, Alma Redzic, Fredrik Wågberg & Zhong-Qing Yuan. (2013) Identification and design of a novel series of MGAT2 inhibitors. Bioorganic & Medicinal Chemistry Letters 23:9, pages 2721-2726.
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Alberto Corsini & Michele Bortolini. (2013) Drug‐Induced Liver Injury: The Role of Drug Metabolism and Transport. The Journal of Clinical Pharmacology 53:5, pages 463-474.
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최선, 이수경, 나현오, 박은하, 한옥연 & 황유경. (2013) Drug Use Evaluation of Statins Focused on Drug-Drug Interactions. Journal of Korean Society of Health-System Pharmacists 30:2, pages 95-107.
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Mariëtte Y.M. van der Wulp, Henkjan J. Verkade & Albert K. Groen. (2013) Regulation of cholesterol homeostasis. Molecular and Cellular Endocrinology 368:1-2, pages 1-16.
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Sivakumar Sathasivam. (2012) Statin induced myotoxicity. European Journal of Internal Medicine 23:4, pages 317-324.
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Jean Davignon. (2012) Pleiotropic effects of pitavastatin. British Journal of Clinical Pharmacology 73:4, pages 518-535.
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