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Diabetes: Original articles

Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: findings from the 52-week CANTATA-M study

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Pages 163-175 | Accepted 20 Sep 2013, Published online: 28 Oct 2013

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Yingnan Zhao, Yanping Li, Qinhui Liu, Qin Tang, Zijing Zhang, Jinhang Zhang, Cuiyuan Huang, Hui Huang, Guorong Zhang, Jian Zhou, Jiamin Yan, Yan Xia, Zhiyong Zhang & Jinhan He. (2021) Canagliflozin Facilitates Reverse Cholesterol Transport Through Activation of AMPK/ABC Transporter Pathway. Drug Design, Development and Therapy 15, pages 2117-2128.
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Haroon Jakher, Tara I Chang, Marilyn Tan & Kenneth W Mahaffey. (2019) Canagliflozin review – safety and efficacy profile in patients with T2DM. Diabetes, Metabolic Syndrome and Obesity 12, pages 209-215.
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Katherine Merton, Michael J. Davies, Ujjwala Vijapurkar, Doreen Inman & Gary Meininger. (2018) Achieving the composite endpoint of HbA1c, body weight, and systolic blood pressure reduction with canagliflozin in patients with type 2 diabetes. Current Medical Research and Opinion 34:2, pages 313-318.
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Konstantinos P. Imprialos, Konstantinos Stavropoulos, Michael Doumas, Asterios Karagiannis & Vasilios G. Athyros. (2017) The effect of SGLT2 inhibitors on cardiovascular events and renal function. Expert Review of Clinical Pharmacology 10:11, pages 1251-1261.
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Nicole M Gerlanc, Jennifer Cai, Joseph Tkacz, Susan C Bolge & Brenna L Brady. (2017) The association of weight loss with patient experience and outcomes in a population of patients with type 2 diabetes mellitus prescribed canagliflozin. Diabetes, Metabolic Syndrome and Obesity 10, pages 89-99.
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Michael J Davies, Katherine W Merton, Ujjwala Vijapurkar, Dainius A Balis & Mehul Desai. (2017) Canagliflozin improves risk factors of metabolic syndrome in patients with type 2 diabetes mellitus and metabolic syndrome. Diabetes, Metabolic Syndrome and Obesity 10, pages 47-55.
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Rong Qiu, Dainius Balis, John Xie, Michael J. Davies, Mehul Desai & Gary Meininger. (2017) Longer-term safety and tolerability of canagliflozin in patients with type 2 diabetes: a pooled analysis. Current Medical Research and Opinion 33:3, pages 553-562.
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Guntram Schernthaner, Fernando J. Lavalle-González, Jaime A. Davidson, Holly Jodon, Ujjwala Vijapurkar, Rong Qiu & William Canovatchel. (2016) Canagliflozin provides greater attainment of both HbA1c and body weight reduction versus sitagliptin in patients with type 2 diabetes. Postgraduate Medicine 128:8, pages 725-730.
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Lawrence Blonde, Kaj Stenlöf, Albert Fung, John Xie, William Canovatchel & Gary Meininger. (2016) Effects of canagliflozin on body weight and body composition in patients with type 2 diabetes over 104 weeks. Postgraduate Medicine 128:4, pages 371-380.
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Vlado Perkovic, Meg Jardine, Ujjwala Vijapurkar & Gary Meininger. (2015) Renal effects of canagliflozin in type 2 diabetes mellitus. Current Medical Research and Opinion 31:12, pages 2219-2231.
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Lawrence Blonde, Vincent Woo, Chantal Mathieu, Jacqueline Yee, Ujjwala Vijapurkar, William Canovatchel & Gary Meininger. (2015) Achievement of treatment goals with canagliflozin in patients with type 2 diabetes mellitus: a pooled analysis of randomized controlled trials. Current Medical Research and Opinion 31:11, pages 1993-2000.
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Michael A Nauck. (2014) Update on developments with SGLT2 inhibitors in the management of type 2 diabetes. Drug Design, Development and Therapy 8, pages 1380-1380.
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Rosemarie Lajara. (2014) The potential role of sodium glucose co-transporter 2 inhibitors in combination therapy for type 2 diabetes mellitus. Expert Opinion on Pharmacotherapy 15:17, pages 2565-2585.
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Jaime A. Davidson & Louis Kuritzky. (2014) Sodium Glucose Co-Transporter 2 Inhibitors and Their Mechanism for Improving Glycemia in Patients with Type 2 Diabetes. Postgraduate Medicine 126:6, pages 33-48.
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Stephen Brunton & Timothy S. Reid. (2014) Canagliflozin, a Sodium Glucose Co-transporter 2 Inhibitor, for the Management of Type 2 Diabetes. Hospital Practice 42:3, pages 96-108.
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Henri Gouraud, Joshua D Wallach, Rémy Boussageon, Joseph S Ross & Florian Naudet. (2022) Vibration of effect in more than 16 000 pooled analyses of individual participant data from 12 randomised controlled trials comparing canagliflozin and placebo for type 2 diabetes mellitus: multiverse analysis. BMJ Medicine 1:1, pages e000154.
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H. Sims, K. H. Smith, P. Bramlage & J. Minguet. (2018) Sotagliflozin: a dual sodium‐glucose co‐transporter‐1 and ‐2 inhibitor for the management of Type 1 and Type 2 diabetes mellitus. Diabetic Medicine 35:8, pages 1037-1048.
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Crossref
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Crossref
Emma D. Deeks & André J. Scheen. (2017) Canagliflozin: A Review in Type 2 Diabetes. Drugs 77:14, pages 1577-1592.
Crossref
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Crossref
Niki Katsiki, Nikolaos Tentolouris & Dimitri P. Mikhailidis. (2017) Dyslipidaemia in type 2 diabetes mellitus. Current Opinion in Cardiology 32:4, pages 422-429.
Crossref
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Crossref
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Crossref
Jennifer L. Sherr, Eda Cengiz, Michelle A. Van Name, Stuart A. Weinzimer & William V. Tamborlane. 2017. Textbook of Diabetes. Textbook of Diabetes 985 999 .
Rhona Johnston, Olalekan Uthman, Ewen Cummins, Christine Clar, Pamela Royle, Jill Colquitt, Bee Kang Tan, Andrew Clegg, Saran Shantikumar, Rachel Court, J Paul O’Hare, David McGrane, Tim Holt & Norman Waugh. (2017) Canagliflozin, dapagliflozin and empagliflozin monotherapy for treating type 2 diabetes: systematic review and economic evaluation. Health Technology Assessment 21:2, pages 1-218.
Crossref
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Crossref
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Crossref
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Crossref
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H. Drexel & C. H. Säly. (2016) Kardiovaskuläre Effekte von SGLT-2-HemmernCardiovascular effects of SGLT2 inhibitors. Der Diabetologe 12:3, pages 195-200.
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Hui WangXiufei LiuMin LongYi HuangLinlin ZhangRui ZhangYi ZhengXiaoyu LiaoYuren WangQian LiaoWenjie LiZili TangQiang TongXiaocui WangFang FangMontserrat Rojo de la VegaQin OuyangDonna D. ZhangShicang YuHongting Zheng. (2016) NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis. Science Translational Medicine 8:334.
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L.A. Leiter, T. Forst, D. Polidori, D.A. Balis, J. Xie & S. Sha. (2016) Effect of canagliflozin on liver function tests in patients with type 2 diabetes. Diabetes & Metabolism 42:1, pages 25-32.
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Crossref
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Crossref
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Crossref
Konstantinos P. Imprialos, Pantelis A. Sarafidis & Asterios I. Karagiannis. (2015) Sodium–glucose cotransporter-2 inhibitors and blood pressure decrease. Journal of Hypertension 33:11, pages 2185-2197.
Crossref
S. Ikeda, Y. Takano, O. Cynshi, R. Tanaka, A. D. Christ, V. Boerlin, U. Beyer, A. Beck, C. Ciorciaro, M. Meyer & T. Kadowaki. (2015) A novel and selective sodium-glucose cotransporter-2 inhibitor, tofogliflozin, improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus. Diabetes, Obesity and Metabolism 17:10, pages 984-993.
Crossref
Yehuda Handelsman. (2015) Potential Place of SGLT2 Inhibitors in Treatment Paradigms for type 2 Diabetes Mellitus. Endocrine Practice 21:9, pages 1054-1065.
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N. B. Amin, X. Wang, J. R. Mitchell, D. S. Lee, G. Nucci & J. M. Rusnak. (2015) Blood pressure-lowering effect of the sodium glucose co-transporter-2 inhibitor ertugliflozin, assessed via ambulatory blood pressure monitoring in patients with type 2 diabetes and hypertension. Diabetes, Obesity and Metabolism 17:8, pages 805-808.
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M. D. Sharma. (2015) Potential for combination of dipeptidyl peptidase‐4 inhibitors and sodium‐glucose co‐transporter‐2 inhibitors for the treatment of type 2 diabetes. Diabetes, Obesity and Metabolism 17:7, pages 616-621.
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Gary Meininger, William Canovatchel, David Polidori & Norm Rosenthal. (2015) Canagliflozin for the treatment of adults with Type 2 diabetes. Diabetes Management 5:3, pages 183-201.
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John P.H. Wilding, Lawrence Blonde, Lawrence A. Leiter, Sonia Cerdas, Cindy Tong, Jacqueline Yee & Gary Meininger. (2015) Efficacy and safety of canagliflozin by baseline HbA1c and known duration of type 2 diabetes mellitus. Journal of Diabetes and its Complications 29:3, pages 438-444.
Crossref
Bruce Neal, Vlado Perkovic, Dick de Zeeuw, Kenneth W. Mahaffey, Greg Fulcher, Kirk Ways, Mehul Desai, Wayne Shaw, George Capuano, Maria Alba, Joel Jiang, Frank Vercruysse, Gary Meininger & David Matthews. (2015) Efficacy and Safety of Canagliflozin, an Inhibitor of Sodium–Glucose Cotransporter 2, When Used in Conjunction With Insulin Therapy in Patients With Type 2 Diabetes. Diabetes Care 38:3, pages 403-411.
Crossref
S. Sha, D. Polidori, K. Farrell, A. Ghosh, J. Natarajan, N. Vaccaro, J. Pinheiro, P. Rothenberg & L. Plum‐Mörschel. (2015) Pharmacodynamic differences between canagliflozin and dapagliflozin: results of a randomized, double‐blind, crossover study. Diabetes, Obesity and Metabolism 17:2, pages 188-197.
Crossref
Curtis TriplittSusan Cornell. (2015) Canagliflozin Treatment in Patients with Type 2 Diabetes Mellitus. Clinical Medicine Insights: Endocrinology and Diabetes 8, pages CMED.S31526.
Crossref
Virginia Valentine & Deborah Hinnen. (2015) Clinical Implications of Canagliflozin Treatment in Patients With Type 2 Diabetes. Clinical Diabetes 33:1, pages 5-13.
Crossref
L. Ji, P. Han, Y. Liu, G. Yang, N. K. Dieu Van, U. Vijapurkar, R. Qiu & G. Meininger. (2015) Canagliflozin in Asian patients with type 2 diabetes on metformin alone or metformin in combination with sulphonylurea. Diabetes, Obesity and Metabolism 17:1, pages 23-31.
Crossref
Alan Sinclair, Bruce Bode, Stewart Harris, Ujjwala Vijapurkar, Cristiana Mayer, Albert Fung, Wayne Shaw, Keith Usiskin, Mehul Desai & Gary Meininger. (2014) Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: a pooled analysis of clinical studies. BMC Endocrine Disorders 14:1.
Crossref
Sanjay Kalra. (2014) Sodium Glucose Co-Transporter-2 (SGLT2) Inhibitors: A Review of Their Basic and Clinical Pharmacology. Diabetes Therapy 5:2, pages 355-366.
Crossref
B Haas, N Eckstein, V Pfeifer, P Mayer & M D S Hass. (2014) Efficacy, safety and regulatory status of SGLT2 inhibitors: focus on canagliflozin. Nutrition & Diabetes 4:11, pages e143-e143.
Crossref
S. Sha, D. Polidori, T. Heise, J. Natarajan, K. Farrell, S.-S. Wang, D. Sica, P. Rothenberg & L. Plum-Mörschel. (2014) Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus. Diabetes, Obesity and Metabolism 16:11, pages 1087-1095.
Crossref
M. A. Abdul-Ghani & R. A. DeFronzo. (2014) Lowering plasma glucose concentration by inhibiting renal sodium-glucose cotransport. Journal of Internal Medicine 276:4, pages 352-363.
Crossref
J.-F. Yale, G. Bakris, B. Cariou, J. Nieto, E. David-Neto, D. Yue, E. Wajs, K. Figueroa, J. Jiang, G. Law, K. Usiskin & G. Meininger. (2014) Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes mellitus and chronic kidney disease. Diabetes, Obesity and Metabolism 16:10, pages 1016-1027.
Crossref
Rong Qiu, George Capuano & Gary Meininger. (2014) Efficacy and safety of twice-daily treatment with canagliflozin, a sodium glucose co-transporter 2 inhibitor, added on to metformin monotherapy in patients with type 2 diabetes mellitus. Journal of Clinical & Translational Endocrinology 1:2, pages 54-60.
Crossref
Theodoros P. Angelopoulos & John Doupis. (2014) Sodium-Glucose Linked Transporter 2 (SGLT2) Inhibitors—Fighting Diabetes from a New Perspective. Advances in Therapy 31:6, pages 579-591.
Crossref
Damayanthi Devineni, Nicole Vaccaro, David Polidori, Sarah Rusch & Ewa Wajs. (2014) Effects of Hydrochlorothiazide on the Pharmacokinetics, Pharmacodynamics, and Tolerability of Canagliflozin, a Sodium Glucose Co-transporter 2 Inhibitor, in Healthy Participants. Clinical Therapeutics 36:5, pages 698-710.
Crossref
Greg L. Plosker. (2014) Canagliflozin: A Review of Its Use in Patients with Type 2 Diabetes Mellitus. Drugs 74:7, pages 807-824.
Crossref
Hala Yamout, Vlado Perkovic, Melanie Davies, Vincent Woo, Dick de Zeeuw, Cristiana Mayer, Ujjwala Vijapurkar, Irina Kline, Keith Usiskin, Gary Meininger & George Bakris. (2014) Efficacy and Safety of Canagliflozin in Patients with Type 2 Diabetes and Stage 3 Nephropathy. American Journal of Nephrology 40:1, pages 64-74.
Crossref

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