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Research Article

Rifaximin, a non-absorbable rifamycin, for the treatment of hepatic encephalopathy. A double-blind, randomised trial

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Pages 593-601 | Accepted 21 May 1997, Published online: 12 Aug 2008

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Nina Kimer, Aleksander Krag & Lise L Gluud. (2014) Safety, efficacy, and patient acceptability of rifaximin for hepatic encephalopathy. Patient Preference and Adherence 8, pages 331-338.
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Maddalena Diana Iadevaia, Anna Del Prete, Claudia Cesaro, Laura Gaeta, Claudio Zulli & Carmelina Loguercio. (2011) Rifaximin in the treatment of hepatic encephalopathy. Hepatic Medicine: Evidence and Research 3, pages 109-117.
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Kevin Mullen & Ravi Prakash. (2010) Rifaximin for the treatment of hepatic encephalopathy. Expert Review of Gastroenterology & Hepatology 4:6, pages 665-677.
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Jessica Cottreau, Shannon F Baker, Herbert L DuPont & Kevin W Garey. (2010) Rifaximin: a nonsystemic rifamycin antibiotic for gastrointestinal infections. Expert Review of Anti-infective Therapy 8:7, pages 747-760.
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Laura Gerard, Kevin W Garey & Herbert L DuPont. (2005) Rifaximin: a nonabsorbable rifamycin antibiotic for use in nonsystemic gastrointestinal infections. Expert Review of Anti-infective Therapy 3:2, pages 201-211.
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Paulina Vidal-Cevallos, Norberto C. Chávez-Tapia & Misael Uribe. (2022) Current approaches to hepatic encephalopathy. Annals of Hepatology 27:6, pages 100757.
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Chathur Acharya & Jasmohan S. Bajaj. 2017. Schiff's Diseases of the Liver. Schiff's Diseases of the Liver 387 410 .
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J. S. Bajaj. (2016) Review article: potential mechanisms of action of rifaximin in the management of hepatic encephalopathy and other complications of cirrhosis. Alimentary Pharmacology & Therapeutics 43, pages 11-26.
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Juan Cordoba. (2014) Hepatic Encephalopathy: From the Pathogenesis to the New Treatments. ISRN Hepatology 2014, pages 1-16.
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Barjesh Chander Sharma, Praveen Sharma, Manish Kumar Lunia, Siddharth Srivastava, Rohit Goyal & S K Sarin. (2013) A Randomized, Double-Blind, Controlled Trial Comparing Rifaximin Plus Lactulose With Lactulose Alone in Treatment of Overt Hepatic Encephalopathy. American Journal of Gastroenterology 108:9, pages 1458-1463.
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Lewis W. Teperman. (2013) Impact of Pretransplant Hepatic Encephalopathy on Liver Posttransplantation Outcomes. International Journal of Hepatology 2013, pages 1-9.
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Guy W. Neff, Michael Jones, Taylor Broda, Mark Jonas, Ravinuthala Ravi, David Novick, Tiffany E. Kaiser & Nyingi Kemmer. (2012) Durability of Rifaximin Response in Hepatic Encephalopathy. Journal of Clinical Gastroenterology 46:2, pages 168-171.
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Seong Choon ChoeDong Ho Lee. (2012) Use of Oral Antibiotics in Elderly Gastrointestinal Patients. Journal of the Korean Geriatrics Society 16:3, pages 108.
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&NA;. (2011) Non-absorbable disaccharides and antibacterials are the treatment of choice for hepatic encephalopathy. Drugs & Therapy Perspectives 27:6, pages 17-21.
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Paula V. Phongsamran, Jiwon W. Kim, Jennifer Cupo Abbott & Angela Rosenblatt. (2010) Pharmacotherapy for Hepatic Encephalopathy. Drugs 70:9, pages 1131-1148.
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Thomas D Schiano. (2010) Treatment Options for Hepatic Encephalopathy. Pharmacotherapy 30:5, part 2, pages 16S-21S.
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E. HUANG, E. ESRAILIAN & B. M. R. SPIEGEL. (2007) The cost-effectiveness and budget impact of competing therapies in hepatic encephalopathy - a decision analysis. Alimentary Pharmacology & Therapeutics 26:8, pages 1147-1161.
Crossref
N. M. BASS. (2007) Review article: the current pharmacological therapies for hepatic encephalopathy. Alimentary Pharmacology & Therapeutics 25, pages 23-31.
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G.W. Neff, N. Kemmer, V.C. Zacharias, T. Kaiser, C. Duncan, R. McHenry, M. Jonas, D. Novick, C. Williamson, K. Hess, M. Thomas & J. Buell. (2006) Analysis of Hospitalizations Comparing Rifaximin Versus Lactulose in the Management of Hepatic Encephalopathy. Transplantation Proceedings 38:10, pages 3552-3555.
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J. A. Adachi & H. L. DuPont. (2006) Rifaximin: A Novel Nonabsorbed Rifamycin for Gastrointestinal Disorders. Clinical Infectious Diseases 42:4, pages 541-547.
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Davide Festi, Amanda Vestito, Giuseppe Mazzella, Enrico Roda & Antonio Colecchia. (2006) Management of Hepatic Encephalopathy: Focus on Antibiotic Therapy. Digestion 73:1, pages 94-101.
Crossref
Kevin D. Mullen. 2006. Zakim and Boyer's Hepatology. Zakim and Boyer's Hepatology 311 331 .
David B. Huang & Herbert L. DuPont. (2005) Rifaximin—a novel antimicrobial for enteric infections. Journal of Infection 50:2, pages 97-106.
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Yong-Han PaikKwan Sik LeeKwang-Hyub HanKun Hoon SongMyoung Hwan KimByung Soo MoonSang Hoon AhnSe Joon LeeHyo Jin ParkDong Ki LeeChae Yoon ChonSang In LeeYoung Myoung Moon. (2005) Comparison of Rifaximin and Lactulose for the Treatment of Hepatic Encephalopathy: A Prospective Randomized Study. Yonsei Medical Journal 46:3, pages 399.
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Maria Luisa Zeneroli, Rossella Avallone, Lorenzo Corsi, Ivo Venturini, Claudia Baraldi & Mario Baraldi. (2005) Management of Hepatic Encephalopathy: Role of Rifaximin. Chemotherapy 51:1, pages 90-95.
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Peter Ferenci & Christian Müller. 2004. Evidence‐based Gastroenterology and Hepatology. Evidence‐based Gastroenterology and Hepatology 505 515 .
H.L. DuPont & Z.-D. Jiang. (2004) Influence of rifaximin treatment on the susceptibility of intestinal Gram-negative flora and enterococci. Clinical Microbiology and Infection 10:11, pages 1009-1011.
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Claudia Sama, Antonio Maria Morselli-Labate, Paolo Pianta, Laura Lambertini, Sonia Berardi & Gabriella Martini. (2004) Clinical effects of rifaximin in patientswith hepatic encephalopathy intolerant or nonresponsive to previous lactulose treatment: An open-label, pilot study. Current Therapeutic Research 65:5, pages 413-422.
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Rosa M Infante, Charles D Ericsson, Zhi-Dong Jiang, Shi Ke, Robert Steffen, Lise Riopel, David A Sack & Herbert L Du>Pont. (2004) Enteroaggregative Escherichia coli diarrhea in travelers: response to rifaximin therapy. Clinical Gastroenterology and Hepatology 2:2, pages 135-138.
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Guy de Bruyn & Edward A Graviss. (2001) A systematic review of the diagnostic accuracy of physical examination for the detection of cirrhosis. BMC Medical Informatics and Decision Making 1:1.
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Robert Steffen. (2001) Rifaximin: A Nonabsorbed Antimicrobial as a New Tool for Treatment of Travelers'Diarrhea. Journal of Travel Medicine 8:s2, pages s34-s39.
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Herbert L. DuPont, Zhi‐Dong Jiang, Charles D. Ericsson, Javier A. Adachi, John J. Mathewson, Margaret W. DuPont, Ernesto Palazzini, Lise M. Riopel, David Ashley & Francisco Martinez‐Sandoval. (2001) Rifaximin versus Ciprofloxacin for the Treatment of Traveler's Diarrhea: A Randomized, Double‐Blind Clinical Trial. Clinical Infectious Diseases 33:11, pages 1807-1815.
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Janus P. Ong & Kevin D. Mullen. (2001) Hepatic encephalopathy. European Journal of Gastroenterology & Hepatology 13:4, pages 325-334.
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Zhi-Dong Jiang, Shi Ke, Ernesto Palazzini, Lise Riopel & Herbert Dupont. (2000) In Vitro Activity and Fecal Concentration of Rifaximin after Oral Administration. Antimicrobial Agents and Chemotherapy 44:8, pages 2205-2206.
Crossref
J. Fernández & A. Mas. (2000) Tratamiento de la encefalopatía hepática. Fármacos y mecanismos de acción. Medicine - Programa de Formación Médica Continuada Acreditado 8:10, pages 516-521.
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