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Bioscience, Biotechnology, and Biochemistry Volume 75, 2011 - Issue 5
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Original Articles

Suppression by Fucoidan of Liver Fibrogenesis via the TGF-β/Smad Pathway in Protecting against Oxidative Stress

Sang-Won HONGDepartment of Biomedical Sciences and NCEED, School of Medicine, Inha University
,
Kyung Hee JUNGDepartment of Biomedical Sciences and NCEED, School of Medicine, Inha University
,
Hee-Seung LEEDepartment of Biomedical Sciences and NCEED, School of Medicine, Inha University
,
Hong-Mei ZHENGDepartment of Biomedical Sciences and NCEED, School of Medicine, Inha University
,
Myung-Joo CHOIDepartment of Biomedical Sciences and NCEED, School of Medicine, Inha University
,
Chongmu LEEDepartment of Materials Science and Engineering, Inha University
&
Soon-Sun HONGDepartment of Biomedical Sciences and NCEED, School of Medicine, Inha University
 show all
Pages 833-840 | Received 19 Aug 2010, Accepted 17 Feb 2011, Published online: 22 May 2014

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Sara M. Soliman, Shaimaa Mosallam, Mohamed A. Mamdouh, Mohammed Abdalla Hussein & Shady M. Abd El-Halim. (2022) Design and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats. Drug Delivery 29:1, pages 427-439.
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Akika Fukawa, Orie Kobayashi, Makoto Yamaguchi, Masayuki Uchida & Akira Hosono. (2017) Bovine milk-derived α-lactalbumin prevents hepatic fibrosis induced by dimethylnitrosamine via nitric oxide pathway in rats. Bioscience, Biotechnology, and Biochemistry 81:10, pages 1941-1947.
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Jingjing Li, Kan Chen, Sainan Li, Jiao Feng, Tong Liu, Fan Wang, Rong Zhang, Shizan Xu, Yuqing Zhou, Shunfeng Zhou, Yujing Xia, Jie Lu, Yingqun Zhou & Chuanyong Guo. (2016) Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy. Drug Design, Development and Therapy 10, pages 619-630.
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Mika Takai, Yoshiyuki Miyazaki, Hirofumi Tachibana & Koji Yamada. (2014) The enhancing effect of fucoidan derived from Undaria pinnatifida on immunoglobulin production by mouse spleen lymphocytes. Bioscience, Biotechnology, and Biochemistry 78:10, pages 1743-1747.
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Zhen Li, Jun-Feng Zhu & Hao Ouyang. (2023) Progress on traditional Chinese medicine in improving hepatic fibrosis through inhibiting oxidative stress. World Journal of Hepatology 15:10, pages 1091-1108.
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Xiaojuan Zhao, Ting Yang, Jiayan Zhou, Yanli Chen, Qian Shen, Jiankang Zhang & Qianqian Qiu. (2023) Fucoidan alleviates the hepatorenal syndrome through inhibition organic solute transporter α/β to reduce bile acids reabsorption. Current Research in Pharmacology and Drug Discovery 5, pages 100159.
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Sayena Jabbehdari & James T. Handa. (2021) Oxidative stress as a therapeutic target for the prevention and treatment of early age-related macular degeneration. Survey of Ophthalmology 66:3, pages 423-440.
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Şinasi BAYRAM, Onur ERSOY, Ayşegül ÇERKEZKAYABEKİR, Melike SAPMAZ, Turan KARACA & Gülnur KIZILAY ÖZFİDAN. (2020) Fukoidanın Diyabetik Sıçan Testis Dokularındaki PCNA, INSL3, JNK, TGF-β1, IL-1β ve Akt İfadelerine EtkisiEffect of Fucoidan on PCNA, INSL3, JNK, TGF-β1, IL-1β and Akt Expressions in Diabetic Rat Testicular Tissues. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46:3, pages 277-284.
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Jingjing Li, Chuanyong Guo & Jianye Wu. (2020) Fucoidan: Biological Activity in Liver Diseases. The American Journal of Chinese Medicine 48:07, pages 1617-1632.
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Li-Mei Chen, Po-Yen Liu, Yen-An Chen, Hong-Yu Tseng, Pei-Chun Shen, Pai-An Hwang & Hsin-Ling Hsu. (2017) Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression. Scientific Reports 7:1.
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Mahmoud M. Said, Magda K. Ezz & Azza A. Matloub. (2017) Protective effect of sulfated polysaccharide isolated from Ulva fasciata against galactosamine-induced liver injury in rats . Journal of Food Biochemistry 41:4, pages e12383.
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Gehan H. Heeba & Mohamed A. Morsy. (2015) Fucoidan ameliorates steatohepatitis and insulin resistance by suppressing oxidative stress and inflammatory cytokines in experimental non-alcoholic fatty liver disease. Environmental Toxicology and Pharmacology 40:3, pages 907-914.
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Juan Chale-Dzul, Rosa Moo-Puc, Daniel Robledo & Yolanda Freile-Pelegrín. (2014) Hepatoprotective effect of the fucoidan from the brown seaweed Turbinaria tricostata. Journal of Applied Phycology 27:5, pages 2123-2135.
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Yanlu Zan, Yuxia Zhang & Po Tien. (2013) Hepatitis B virus e antigen induces activation of rat hepatic stellate cells. Biochemical and Biophysical Research Communications 435:3, pages 391-396.
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Moon Yong Song, Sae Kwang Ku, Hyun Jee Kim & Jin Soo Han. (2012) Low molecular weight fucoidan ameliorating the chronic cisplatin-induced delayed gastrointestinal motility in rats. Food and Chemical Toxicology 50:12, pages 4468-4478.
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Seema Patel. (2012) Therapeutic importance of sulfated polysaccharides from seaweeds: updating the recent findings. 3 Biotech 2:3, pages 171-185.
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Sang-Won Hong, Hee-Seung Lee, Kyung Hee Jung, Hyunseung Lee & Soon-Sun Hong. (2012) Protective effect of fucoidan against acetaminophen-induced liver injury. Archives of Pharmacal Research 35:6, pages 1099-1105.
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