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Original Articles

Isolation and Identification of the 3-Hydroxy-5-hydroxymethyl-pyridinium Compound as a Novel Advanced Glycation End Product on Glyceraldehyde-related Maillard Reaction

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Pages 930-932 | Received 12 Nov 2002, Accepted 25 Jan 2003, Published online: 22 May 2014

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Shiori Fujimoto, Yoto Murakami, Haruna Miyake, Fumitaka Hayase & Hirohito Watanabe. (2019) Identification of a novel advanced glycation end product derived from lactaldehyde. Bioscience, Biotechnology, and Biochemistry 83:6, pages 1136-1145.
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Yoto Murakami, Takayuki Fujino, Ryotaro Kurachi, Toshiki Hasegawa, Teruyuki Usui, Fumitaka Hayase & Hirohito Watanabe. (2018) Identification of pyridinoline, a collagen crosslink, as a novel intrinsic ligand for the receptor for advanced glycation end-products (RAGE). Bioscience, Biotechnology, and Biochemistry 82:9, pages 1508-1514.
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Takanobu Takata. (2023) Is the Novel Slot Blot a Useful Method for Quantification of Intracellular Advanced Glycation End-Products?. Metabolites 13:4, pages 564.
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Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino & Yoshiki Koriyama. (2022) Effects of Toxic AGEs (TAGE) on Human Health. Cells 11:14, pages 2178.
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Robert Rau & Marcus A. Glomb. (2022) Novel Pyridinium Cross-Link Structures Derived from Glycolaldehyde and Glyoxal. Journal of Agricultural and Food Chemistry 70:14, pages 4434-4444.
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Yoshihiro Kobashigawa, Toshiya Ohara, Kosuke Morita, Yuya Toyota, Teruya Nakamura, Shunsuke Kotani, Takao Arimori, Soichiro Yamauchi, Chenjiang Liu, Masaya Kitazaki, Yukari Wakeyama-Miyazaki, Yoshiaki Suwa, Makiyo Uchida-Kamekura, Natsuki Fukuda, Takashi Sato, Makoto Nakajima, Junichi Takagi, Yuriko Yamagata & Hiroshi Morioka. (2021) Molecular recognition of a single-chain Fv antibody specific for GA-pyridine, an advanced glycation end-product (AGE), elucidated using biophysical techniques and synthetic antigen analogues. The Journal of Biochemistry 170:3, pages 379-387.
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Tomoaki Shigeta, Kazumi Sasamoto & Tetsuro Yamamoto. (2021) Glyceraldehyde-derived advanced glycation end-products having pyrrolopyridinium-based crosslinks. Biochemistry and Biophysics Reports 26, pages 100963.
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Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino, Yoshiki Koriyama, Chigusa Kikuchi, Ayako Furukawa, Kentaro Nagamine, Takamitsu Hori & Tamihide Matsunaga. (2021) Intracellular Toxic AGEs (TAGE) Triggers Numerous Types of Cell Damage. Biomolecules 11:3, pages 387.
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Masayoshi Takeuchi. (2020) Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyle. Diabetology & Metabolic Syndrome 12:1.
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Haruka Morimoto, Lihao Gu, Haifeng Zeng & Kazuhisa Maeda. (2017) Amino Carbonylation of Epidermal Basement Membrane Inhibits Epidermal Cell Function and Is Suppressed by Methylparaben. Cosmetics 4:4, pages 38.
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Takanori Matsui, Eriko Oda, Yuichiro Higashimoto & Sho-ichi Yamagishi. (2015) Glyceraldehyde-derived pyridinium (GLAP) evokes oxidative stress and inflammatory and thrombogenic reactions in endothelial cells via the interaction with RAGE. Cardiovascular Diabetology 14:1.
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Masayoshi Takeuchi, Mina Iwaki, Jun-ichi Takino, Hikari Shirai, Mihoko Kawakami, Richard Bucala & Sho-ichi Yamagishi. (2010) Immunological detection of fructose-derived advanced glycation end-products. Laboratory Investigation 90:7, pages 1117-1127.
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Teruyuki Usui, Hirohito Watanabe & Fumitaka Hayase. 2009. Endogenous Toxins. Endogenous Toxins 213 225 .
Ludmil T. Benov. 2009. Endogenous Toxins. Endogenous Toxins 151 171 .
Shigeyuki Matsumoto, Takuya Yoshida, Hiroko Murata, Shusaku Harada, Naoko Fujita, Shota Nakamura, Yasuhiko Yamamoto, Takuo Watanabe, Hideto Yonekura, Hiroshi Yamamoto, Tadayasu Ohkubo & Yuji Kobayashi. (2008) Solution Structure of the Variable-Type Domain of the Receptor for Advanced Glycation End Products: New Insight into AGE−RAGE Interaction , . Biochemistry 47:47, pages 12299-12311.
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Fumitaka Hayase, Teruyuki Usui, Yoriyuki Ono, Yoshinobu Shirahashi, Tomomi Machida, Takashi Ito, Nozomu Nishitani, Kazuhito Shimohira & Hirohito Watanabe. (2008) Formation Mechanisms of Melanoidins and Fluorescent Pyridinium Compounds as Advanced Glycation End Products . Annals of the New York Academy of Sciences 1126:1, pages 53-58.
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Chuyen Van Nguyen. (2006) Toxicity of the AGEs generated from the Maillard reaction: On the relationship of food‐AGEs and biological‐AGEs. Molecular Nutrition & Food Research 50:12, pages 1140-1149.
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Takashi Sato, Noriko Shimogaito, Xuegang Wu, Seiji Kikuchi, Sho-ichi Yamagishi & Masayoshi Takeuchi. (2016) Toxic Advanced Glycation End Products (TAGE) Theory in Alzheimer’s Disease. American Journal of Alzheimer's Disease & Other Dementiasr 21:3, pages 197-208.
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T USUI, K SHIMOHIRA, H WATANABE & F HAYASE. (2006) Isolation and Identification of Glyceraldehyde‐Derived Advanced Glycation End Products. Annals of the New York Academy of Sciences 1043:1, pages 899-899.
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FUMITAKA HAYASE, TERUYUKI USUI, KAZUYUKI NISHIYAMA, SHIGEYUKI SASAKI, YOSHINOBU SHIRAHASHI, NAOYUKI TSUCHIYA, NAOKO NUMATA & HIROHITO WATANABE. (2006) Chemistry and Biological Effects of Melanoidins and Glyceraldehyde‐Derived Pyridinium as Advanced Glycation End Products. Annals of the New York Academy of Sciences 1043:1, pages 104-110.
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Ognyan K. Argirov, Bin Lin & Beryl J. Ortwerth. (2004) 2-Ammonio-6-(3-oxidopyridinium-1-yl)hexanoate (OP-lysine) Is a Newly Identified Advanced Glycation End Product in Cataractous and Aged Human Lenses. Journal of Biological Chemistry 279:8, pages 6487-6495.
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Teruyuki Usui, Kazuhito Shimohira, Hirohito Watanabe & Fumitaka Hayase. (2004) Detection and determination of glyceraldehyde-derived advanced glycation end product. BioFactors 21:1-4, pages 391-394.
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