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Carbonic anhydrase inhibition as a cancer therapy: a review of patent literature, 2007 – 2009

, PhD
Pages 795-806 | Published online: 17 May 2010

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Read on this site (10)

Chandra Bhushan Mishra, Raj Kumar Mongre, Amresh Prakash, Raok Jeon, Claudiu T. Supuran & Myeong-Sok Lee. (2021) Anti-breast cancer action of carbonic anhydrase IX inhibitor 4-[4-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-benzylidene-hydrazinocarbonyl]-benzenesulfonamide (BSM-0004): in vitro and in vivo studies. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 954-963.
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Sonia Del Prete, Rosa Merlo, Anna Valenti, Rosanna Mattossovich, Mosè Rossi, Vincenzo Carginale, Claudiu T. Supuran, Giuseppe Perugino & Clemente Capasso. (2019) Thermostability enhancement of the α-carbonic anhydrase from Sulfurihydrogenibium yellowstonense by using the anchoring-and-self-labelling-protein-tag system (ASL). Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 946-954.
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Claudiu T. Supuran & Clemente Capasso. (2018) Biomedical applications of prokaryotic carbonic anhydrases. Expert Opinion on Therapeutic Patents 28:10, pages 745-754.
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Belma Zengin Kurt, Fatih Sönmez, Çiğdem Bilen, Adem Ergun, Nahit Gençer, Oktay Arslan & Mustafa Kucukislamoglu. (2016) Synthesis, antioxidant and carbonic anhydrase I and II inhibitory activities of novel sulphonamide-substituted coumarylthiazole derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 991-998.
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Claudiu T Supuran & Jean-Yves Winum. (2015) Designing carbonic anhydrase inhibitors for the treatment of breast cancer. Expert Opinion on Drug Discovery 10:6, pages 591-597.
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Aamer Saeed, Mariya al-Rashida, Mehwish Hamayoun, Amara Mumtaz & Jamshed Iqbal. (2014) Carbonic anhydrase inhibition by 1-aroyl-3-(4-aminosulfonylphenyl)thioureas. Journal of Enzyme Inhibition and Medicinal Chemistry 29:6, pages 901-905.
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Deborah Sneddon & Sally-Ann Poulsen. (2014) Agents described in the Molecular Imaging and Contrast Agent Database for imaging carbonic anhydrase IX expression. Journal of Enzyme Inhibition and Medicinal Chemistry 29:5, pages 753-763.
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Fatih Sonmez, Cigdem Bilen, Sinem Sumersan, Nahit Gencer, Semra Isik, Oktay Arslan & Mustafa Kucukislamoglu. (2014) In vitro inhibition effect and structure–activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II. Journal of Enzyme Inhibition and Medicinal Chemistry 29:1, pages 118-123.
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Jean-Yves Winum & Clemente Capasso. (2013) Novel antibody to a carbonic anhydrase: patent evaluation of WO2011138279A1. Expert Opinion on Therapeutic Patents 23:6, pages 757-760.
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Articles from other publishers (30)

Benas Balandis, Tomas Šimkūnas, Vaida Paketurytė-Latvė, Vilma Michailovienė, Aurelija Mickevičiūtė, Elena Manakova, Saulius Gražulis, Sergey Belyakov, Visvaldas Kairys, Vytautas Mickevičius, Asta Zubrienė & Daumantas Matulis. (2022) Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases. Pharmaceuticals 15:4, pages 477.
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Claudiu T. Supuran & Clemente Capasso. 2020. Physiological and Biotechnological Aspects of Extremophiles. Physiological and Biotechnological Aspects of Extremophiles 295 306 .
Erik R Swenson. (2019) The many acid–base manifestations and consequences of hypoxia. Current Opinion in Physiology 7, pages 72-81.
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Clemente Capasso & Mihail Barboiu. 2019. Carbonic Anhydrases. Carbonic Anhydrases 495 514 .
Panagiotis K. Chrysanthopoulos, Prashant Mujumdar, Lucy A. Woods, Olan Dolezal, Bin Ren, Thomas S. Peat & Sally-Ann Poulsen. (2017) Identification of a New Zinc Binding Chemotype by Fragment Screening. Journal of Medicinal Chemistry 60:17, pages 7333-7349.
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Gillian M. Fisher, Silvia Bua, Sonia Del Prete, Megan S.J. Arnold, Clemente Capasso, Claudiu T. Supuran, Katherine T. Andrews & Sally-Ann Poulsen. (2017) Investigating the antiplasmodial activity of primary sulfonamide compounds identified in open source malaria data. International Journal for Parasitology: Drugs and Drug Resistance 7:1, pages 61-70.
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Mehlika Dilek Altıntop, Belgin Sever, Gülşen Akalın Çiftçi, Kaan Kucukoglu, Ahmet Özdemir, Seyedeh Sara Soleimani, Hayrunnisa Nadaroglu & Zafer Asım Kaplancıklı. (2017) Synthesis and evaluation of new benzodioxole-based dithiocarbamate derivatives as potential anticancer agents and hCA-I and hCA-II inhibitors. European Journal of Medicinal Chemistry 125, pages 190-196.
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Belma Z. Kurt, Fatih Sonmez, Basak Gokce, Adem Ergun, Nahit Gencer, Taki Demir, Oktay Arslan & Mustafa Kucukislamoglu. (2016) In vitro inhibition effects on erythrocyte carbonic anhydrase I and II and structure-activity relationships of cumarylthiazole derivatives. Russian Journal of Bioorganic Chemistry 42:5, pages 506-511.
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Deborah Sneddon, Raymon Niemans, Matthias Bauwens, Ala Yaromina, Simon J. A. van Kuijk, Natasja G. Lieuwes, Rianne Biemans, Ivo Pooters, Paul A. Pellegrini, Nigel A. Lengkeek, Ivan Greguric, Kathryn F. Tonissen, Claudiu T. Supuran, Philippe Lambin, Ludwig Dubois & Sally-Ann Poulsen. (2016) Synthesis and in Vivo Biological Evaluation of 68 Ga-Labeled Carbonic Anhydrase IX Targeting Small Molecules for Positron Emission Tomography . Journal of Medicinal Chemistry 59:13, pages 6431-6443.
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Lucy A. Woods, Olan Dolezal, Bin Ren, John H. Ryan, Thomas S. Peat & Sally-Ann Poulsen. (2016) Native State Mass Spectrometry, Surface Plasmon Resonance, and X-ray Crystallography Correlate Strongly as a Fragment Screening Combination. Journal of Medicinal Chemistry 59:5, pages 2192-2204.
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Kanae Teruya, Kathryn F. Tonissen & Sally-Ann Poulsen. (2016) Recent developments of small molecule chemical probes for fluorescence-based detection of human carbonic anhydrase II and IX. MedChemComm 7:11, pages 2045-2062.
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Erik R. Swenson. 2016. Hypoxia. Hypoxia 301 323 .
Gregory M. Rankin, Daniela Vullo, Claudiu T. Supuran & Sally-Ann Poulsen. (2015) Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases. Journal of Medicinal Chemistry 58:18, pages 7580-7590.
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Claudiu T Supuran & Jean-Yves Winum. (2015) Carbonic anhydrase IX inhibitors in cancer therapy: an update. Future Medicinal Chemistry 7:11, pages 1407-1414.
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Prashant Mujumdar & Sally-Ann Poulsen. (2015) Natural Product Primary Sulfonamides and Primary Sulfamates. Journal of Natural Products 78:6, pages 1470-1477.
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Yuanxiang Zhou, Reza Bayat Mokhtari, Jie Pan, Ernest Cutz & Herman Yeger. (2015) Carbonic Anhydrase II Mediates Malignant Behavior of Pulmonary Neuroendocrine Tumors. American Journal of Respiratory Cell and Molecular Biology 52:2, pages 183-192.
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Janina Moeker, Thomas S. Peat, Laurent F. Bornaghi, Daniela Vullo, Claudiu T. Supuran & Sally-Ann Poulsen. (2014) Cyclic Secondary Sulfonamides: Unusually Good Inhibitors of Cancer-Related Carbonic Anhydrase Enzymes. Journal of Medicinal Chemistry 57:8, pages 3522-3531.
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Hilal Kuday, Fatih Sonmez, Cigdem Bilen, Emre Yavuz, Nahit Gençer & Mustafa Kucukislamoglu. (2014) Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II. BioMed Research International 2014, pages 1-8.
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Marius Ilie, Véronique Hofman, Joséphine Zangari, Johanna Chiche, Jérôme Mouroux, Nathalie M. Mazure, Jacques Pouysségur, Patrick Brest & Paul Hofman. (2013) Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients. Lung Cancer 82:1, pages 16-23.
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Guillaume Bernadat, Claudiu T. Supuran & Bogdan I. Iorga. (2013) Carbonic anhydrase binding site parameterization in OPLS-AA force field. Bioorganic & Medicinal Chemistry 21:6, pages 1427-1430.
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Miroslava Čuperlović-Culf. 2013. NMR Metabolomics in Cancer Research. NMR Metabolomics in Cancer Research 15 138 .
Lucia M. A. Crane, Rick G. Pleijhuis, Marleen van Oosten & Gooitzen M. van Dam. 2013. Ovarian Neoplasm Imaging. Ovarian Neoplasm Imaging 479 496 .
M Cuperlovic-CulfAS Culf, M Touaibia & N Lefort. (2012) Targeting the latest hallmark of cancer: another attempt at ‘magic bullet’ drugs targeting cancers’ metabolic phenotype. Future Oncology 8:10, pages 1315-1330.
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Josiah V. Dungwa, Linda P. Hunt & Pramila Ramani. (2012) Carbonic anhydrase IX up-regulation is associated with adverse clinicopathologic and biologic factors in neuroblastomas. Human Pathology 43:10, pages 1651-1660.
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Fabrizio Carta, Alfonso Maresca, Andrea Scozzafava & Claudiu T. Supuran. (2012) Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII. Bioorganic & Medicinal Chemistry 20:7, pages 2266-2273.
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Janina Moeker, Kanae Teruya, Sabine Rossit, Brendan L. Wilkinson, Marie Lopez, Laurent F. Bornaghi, Alessio Innocenti, Claudiu T. Supuran & Sally-Ann Poulsen. (2012) Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases. Bioorganic & Medicinal Chemistry 20:7, pages 2392-2404.
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Paul C. McDonald, Jean-Yves Winum, Claudiu T. Supuran & Shoukat Dedhar. (2012) Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics. Oncotarget 3:1, pages 84-97.
Crossref
Shyamasri Biswas, Mayank Aggarwal, Özlen Güzel, Andrea Scozzafava, Robert McKenna & Claudiu T. Supuran. (2011) Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms. Bioorganic & Medicinal Chemistry 19:12, pages 3732-3738.
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Yuanmei Lou, Paul C. McDonald, Arusha Oloumi, Stephen Chia, Christina Ostlund, Ardalan Ahmadi, Alastair Kyle, Ulrich auf dem Keller, Samuel Leung, David Huntsman, Blaise Clarke, Brent W. Sutherland, Dawn Waterhouse, Marcel Bally, Calvin Roskelley, Christopher M. Overall, Andrew Minchinton, Fabio Pacchiano, Fabrizio Carta, Andrea Scozzafava, Nadia Touisni, Jean-Yves Winum, Claudiu T. Supuran & Shoukat Dedhar. (2011) Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors. Cancer Research 71:9, pages 3364-3376.
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Marco Radi, Elena Dreassi, Chiara Brullo, Emmanuele Crespan, Cristina Tintori, Vincenzo Bernardo, Massimo Valoti, Claudio Zamperini, Henry Daigl, Francesca Musumeci, Fabio Carraro, Antonella Naldini, Irene Filippi, Giovanni Maga, Silvia Schenone & Maurizio Botta. (2011) Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4- d ]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study . Journal of Medicinal Chemistry 54:8, pages 2610-2626.
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