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Focusing on new monoamine oxidase inhibitors

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Pages 909-939 | Published online: 16 Jun 2010

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Paolo Guglielmi, Simone Carradori, Ilaria D’Agostino, Cristina Campestre & Jacobus P. Petzer. (2022) An updated patent review on monoamine oxidase (MAO) inhibitors. Expert Opinion on Therapeutic Patents 32:8, pages 849-883.
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Fisayo A. Olotu, Monu Joy, Mohamed A. Abdelgawad, Siju E. Narayanan, Mahmoud E. Soliman & Bijo Mathew. (2021) Revealing the role of fluorine pharmacophore in chalcone scaffold for shifting the MAO-B selectivity: investigation of a detailed molecular dynamics and quantum chemical study. Journal of Biomolecular Structure and Dynamics 39:16, pages 6126-6139.
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Oludotun A. Phillips, Mira A. Bosso & Charles I. Ezeamuzie. (2020) Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1471-1482.
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Ahreum Hong, Le Cam Tu, Inho Yang, Kyung-Min Lim & Sang-Jip Nam. (2020) Marine natural products with monoamine oxidase (MAO) inhibitory activity. Pharmaceutical Biology 58:1, pages 716-720.
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Paolo Guglielmi, Simone Carradori, Alessandra Ammazzalorso & Daniela Secci. (2019) Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement?. Expert Opinion on Drug Discovery 14:10, pages 995-1035.
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Paolo Guglielmi, Daniela Secci, Anél Petzer, Donatella Bagetta, Paola Chimenti, Giulia Rotondi, Claudio Ferrante, Lucia Recinella, Sheila Leone, Stefano Alcaro, Gokhan Zengin, Jacobus P. Petzer, Francesco Ortuso & Simone Carradori. (2019) Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1511-1525.
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Daniela Secci, Simone Carradori, Anél Petzer, Paolo Guglielmi, Melissa D’Ascenzio, Paola Chimenti, Donatella Bagetta, Stefano Alcaro, Gokhan Zengin, Jacobus P. Petzer & Francesco Ortuso. (2019) 4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 597-612.
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Simone Carradori, Daniela Secci & Jacques P. Petzer. (2018) MAO inhibitors and their wider applications: a patent review. Expert Opinion on Therapeutic Patents 28:3, pages 211-226.
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Melissa D’Ascenzio, Paola Chimenti, Maria Concetta Gidaro, Celeste De Monte, Daniela De Vita, Arianna Granese, Luigi Scipione, Roberto Di Santo, Giosuè Costa, Stefano Alcaro, Matilde Yáñez & Simone Carradori. (2015) (Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 908-919.
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Simone Carradori & Jacobus P Petzer. (2015) Novel monoamine oxidase inhibitors: a patent review (2012 – 2014). Expert Opinion on Therapeutic Patents 25:1, pages 91-110.
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Simone Carradori, Daniela Secci, Adriana Bolasco, Paola Chimenti & Melissa D'Ascenzio. (2012) Patent-related survey on new monoamine oxidase inhibitors and their therapeutic potential. Expert Opinion on Therapeutic Patents 22:7, pages 759-801.
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Egon Heuson, Morten Storgaard, Tri H. V. Huynh, Franck Charmantray, Thierry Gefflaut & Lennart Bunch. (2014) Profiling substrate specificity of two series of phenethylamine analogs at monoamine oxidase A and B. Org. Biomol. Chem. 12:43, pages 8689-8695.
Crossref
Emanuela Bonaiuto, Andrea Milelli, Giorgio Cozza, Vincenzo Tumiatti, Chiara Marchetti, Enzo Agostinelli, Carmela Fimognari, Patrizia Hrelia, Anna Minarini & Maria Luisa Di Paolo. (2013) Novel polyamine analogues: From substrates towards potential inhibitors of monoamine oxidases. European Journal of Medicinal Chemistry 70, pages 88-101.
Crossref
F Sánchez-Jiménez, M V Ruiz-Pérez, J L Urdiales & M A Medina. (2013) Pharmacological potential of biogenic amine-polyamine interactions beyond neurotransmission. British Journal of Pharmacology 170:1, pages 4-16.
Crossref
Rossella Fioravanti, Nicoletta Desideri, Mariangela Biava, Luca Proietti Monaco, Laura Grammatica & Matilde Y??ez. (2013) Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles. Bioorganic & Medicinal Chemistry Letters 23:18, pages 5128-5130.
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Ross J. BaldessariniRoss J. Baldessarini. 2013. Chemotherapy in Psychiatry. Chemotherapy in Psychiatry 155 250 .
Simone Carradori, Melissa D'Ascenzio, Celeste De Monte, Daniela Secci & Matilde Yáñez. (2013) Synthesis and Selective Human Monoamine Oxidase B Inhibition of Heterocyclic Hybrids Based on Hydrazine and Thiazole Scaffolds. Archiv der Pharmazie 346:1, pages 17-22.
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Dalip Sethi, Chang-Po Chen, Rui-Yan Jing, Mathew L. Thakur & Eric Wickstrom. (2012) Fluorescent Peptide–PNA Chimeras for Imaging Monoamine Oxidase A mRNA in Neuronal Cells. Bioconjugate Chemistry 23:2, pages 158-163.
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Wisut Wichitnithad, James P. O’Callaghan, Diane B. Miller, Brian C. Train & Patrick S. Callery. (2011) Time-dependent slowly-reversible inhibition of monoamine oxidase A by N-substituted 1,2,3,6-tetrahydropyridines. Bioorganic & Medicinal Chemistry 19:24, pages 7482-7492.
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Daniela Secci, Simone Carradori, Adriana Bolasco, Paola Chimenti, Matilde Yáñez, Francesco Ortuso & Stefano Alcaro. (2011) Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives. European Journal of Medicinal Chemistry 46:10, pages 4846-4852.
Crossref
Werner J. Geldenhuys, Kristin S. Ko, Hilary Stinnett, Cornelis J. Van der Schyf & Mi Hee Lim. (2011) Identification of multifunctional small molecule-based reversible monoamine oxidase inhibitors. MedChemComm 2:11, pages 1099.
Crossref
Grayson Richards, Juerg Messer, Henry J. Waldvogel, Hannah M. Gibbons, Mike Dragunow, Richard L.M. Faull & Josep Saura. (2011) Up-regulation of the isoenzymes MAO-A and MAO-B in the human basal ganglia and pons in Huntington's disease revealed by quantitative enzyme radioautography. Brain Research 1370, pages 204-214.
Crossref
Andrew D. Krystal. (2010) Antidepressant and Antipsychotic Drugs. Sleep Medicine Clinics 5:4, pages 571-589.
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