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Novel thyrotropin-releasing hormone analogs: a patent review

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Pages 1673-1691 | Published online: 22 Oct 2011

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Kaoru Kobayashi, Yoshikazu Abe, Hiroshi Harada, Emiko Oota, Takuro Endo & Hiroo Takeda. (2019) Non-clinical pharmacokinetic profiles of rovatirelin, an orally available thyrotropin-releasing hormone analogue. Xenobiotica 49:1, pages 106-119.
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Elena Alvarez-Salas, Cinthia García-Luna & Patricia de Gortari. (2023) New Efforts to Demonstrate the Successful Use of TRH as a Therapeutic Agent. International Journal of Molecular Sciences 24:13, pages 11047.
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Radka Trubacova, Zdenka Drastichova & Jiri Novotny. (2022) Biochemical and physiological insights into TRH receptor-mediated signaling. Frontiers in Cell and Developmental Biology 10.
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Marijke H. Algera, Joseph F. Cotten, Monique van Velzen, Marieke Niesters, Martijn Boon, Daniel S. Shoham, Kaye E. Dandrea, Rutger van der Schrier & Albert Dahan. (2022) Respiratory effects of thyrotropin-releasing hormone and its analogue taltirelin on opioid-induced respiratory depression. British Journal of Anaesthesia 129:1, pages e4-e6.
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V. P. Martinovich & K. U. Baradzina. (2022) Peptide Hormones in Medicine: A 100-Year History. Russian Journal of Bioorganic Chemistry 48:2, pages 221-232.
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Fan Yang, Huanhuan Zhang, Xianyu Meng, Yingge Li, Yingxin Zhou, Shenglong Ling, Demeng Sun, Pei Lv, Lei Liu, Pan Shi & Changlin Tian. (2022) Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue. Cell Research 32:9, pages 858-861.
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Katalin Prokai-Tatrai, Vien Nguyen & Laszlo Prokai. (2021) [β-Glu2]TRH Is a Functional Antagonist of Thyrotropin-Releasing Hormone (TRH) in the Rodent Brain. International Journal of Molecular Sciences 22:12, pages 6230.
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Wen-Ying Liu, Hattie Liu, Jasmin Aggarwal, Zhi-Li Huang & Richard L Horner. (2020) Differential activating effects of thyrotropin-releasing hormone and its analog taltirelin on motor output to the tongue musculature in vivo. Sleep 43:9.
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Tomoyuki Ijiro, Atsushi Yaguchi, Ayaka Yokoyama, Yoshikazu Abe & Sumiyoshi Kiguchi. (2020) Ameliorating effect of rovatirelin on the ataxia in rolling mouse Nagoya. European Journal of Pharmacology 882, pages 173271.
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Jean-Louis Charli, Adair Rodríguez-Rodríguez, Karina Hernández-Ortega, Antonieta Cote-Vélez, Rosa María Uribe, Lorraine Jaimes-Hoy & Patricia Joseph-Bravo. (2020) The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target?. Frontiers in Pharmacology 11.
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Katalin Prokai-Tatrai, Daniel L. De La Cruz, Vien Nguyen, Benjamin P. Ross, Istvan Toth & Laszlo Prokai. (2019) Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach. Pharmaceutics 11:7, pages 349.
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Eleonore Fröhlich & Richard Wahl. (2019) The forgotten effects of thyrotropin-releasing hormone: Metabolic functions and medical applications. Frontiers in Neuroendocrinology 52, pages 29-43.
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Michael Wilkinson & S. Ali Imran. 2018. Clinical Neuroendocrinology. Clinical Neuroendocrinology 97 117 .
Cong Zheng, Guiqin Chen, Yang Tan, Weiqi Zeng, Qiwei Peng, Ji Wang, Chi Cheng, Xiaoman Yang, Shuke Nie, Yan Xu, Zhentao Zhang, Stella M. Papa, Keqiang Ye & Xuebing Cao. (2018) TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone. Frontiers in Cellular Neuroscience 12.
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Fabrice Duval. (2018) Thyroid Hormone Treatment of Mood Disorders. Current Treatment Options in Psychiatry 5:4, pages 363-376.
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Cong Zheng, Guiqin Chen, Yang Tan, Weiqi Zeng, Qiwei Peng, Ji Wang, Chi Cheng, Xiaoman Yang, Shuke Nie, Yan Xu, Zhentao Zhang, Stella M. Papa, Keqiang Ye & Xuebing Cao. (2018) TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect. Frontiers in Cellular Neuroscience 12.
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Naotake Kobayashi, Norihito Sato, Yuko Fujimura, Tsuyoshi Kihara, Katsuji Sugita, Kouji Takahashi, Katsumi Koike, Tamio Sugawara, Yukio Tada, Hiroshi Nakai & Takayoshi Yoshikawa. (2018) Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1-{ N -[(4 S ,5 S )-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)- l -alanyl}-(2 R )-2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate) . ACS Omega 3:10, pages 13647-13666.
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James D. Boghosian, Anita Luethy & Joseph F. Cotten. (2018) Intravenous and Intratracheal Thyrotropin Releasing Hormone and Its Analog Taltirelin Reverse Opioid-Induced Respiratory Depression in Isoflurane Anesthetized Rats. Journal of Pharmacology and Experimental Therapeutics 366:1, pages 105-112.
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Hadi Zarif, Agnès Petit-Paitel, Catherine Heurteaux, Joëlle Chabry & Alice Guyon. (2016) TRH modulates glutamatergic synaptic inputs on CA1 neurons of the mouse hippocampus in a biphasic manner. Neuropharmacology 110, pages 69-81.
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Chhuttan L. Meena, Avinash Thakur, Prajwal P. Nandekar, Shyam S. Sharma, Abhay T. Sangamwar & Rahul Jain. (2016) Synthesis and biology of ring-modified l-Histidine containing thyrotropin-releasing hormone (TRH) analogues. European Journal of Medicinal Chemistry 111, pages 72-83.
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Malcolm J. Low. 2016. Williams Textbook of Endocrinology. Williams Textbook of Endocrinology 109 175 .
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Ralf Paus, Ewan A. Langan, Silvia Vidali, Yuval Ramot & Bogi Andersen. (2014) Neuroendocrinology of the hair follicle: principles and clinical perspectives. Trends in Molecular Medicine 20:10, pages 559-570.
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Yuval Ramot & Ralf Paus. (2014) Harnessing neuroendocrine controls of keratin expression: A new therapeutic strategy for skin diseases?. BioEssays 36:7, pages 672-686.
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Katalin Prokai-Tatrai, Vien Nguyen, Szabolcs Szarka, Krisztina Konya & Laszlo Prokai. (2013) Design and Exploratory Neuropharmacological Evaluation of Novel Thyrotropin-Releasing Hormone Analogs and Their Brain-Targeting Bioprecursor Prodrugs. Pharmaceutics 5:4, pages 318-328.
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Nanthakumar Thirunarayanan, Eshel A Nir, Bruce M Raaka & Marvin C Gershengorn. (2012) Thyrotropin-Releasing Hormone Receptor Type 1 (TRH-R1), not TRH-R2, Primarily Mediates Taltirelin Actions in the CNS of Mice. Neuropsychopharmacology 38:6, pages 950-956.
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