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Current Opinion on Therapeutic Patents Volume 3, 1993 - Issue 8
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Research Article

Patent Update: Inhibitors of the Phospholipases A2

Stephen Connolly Department of Medicinal Chemistry, Fisons plc, Pharmaceutical Division, Bakewell Road, Loughborough, Leicestershire, LE11 ORH, UK
&
David H Robinson
Pages 1141-1155 | Published online: 03 Mar 2008

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Afshin Ghasemi, Alwine Schulze Elfringhoff & Matthias Lehr. (2005) Structure–activity relationship studies of 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A2α-mediated arachidonic acid release in intact platelets: variation of the keto moiety. Journal of Enzyme Inhibition and Medicinal Chemistry 20:5, pages 429-437.
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Matthias Lehr. (2001) Phospholipase A2 inhibitors in inflammation. Expert Opinion on Therapeutic Patents 11:7, pages 1123-1136.
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Ulrich Tibes. (1997) Phospholipase A2 inhibitors in development. Expert Opinion on Investigational Drugs 6:3, pages 279-298.
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Stephen Connolly & David H Robinson. (1995) Patent Update: Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: The search for inhibitors of the phospholipases A2. Expert Opinion on Therapeutic Patents 5:7, pages 673-683.
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Articles from other publishers (12)

MATTHIAS LEHR. 2012. Anti-Inflammatory Drug Discovery. Anti-Inflammatory Drug Discovery 35 57 .
Hitoshi NakayamaYuka Morita, Hirohiko KimuraKeiichi Ishihara, Satoshi Akiba & Jun'ichi Uenishi. (2011) Synthesis of N-(Trifluoromethyl-2-pyridinyl)arenesulfonamides as an Inhibitor of Secretory Phospholipase A2. Chemical and Pharmaceutical Bulletin 59:6, pages 783-786.
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Cherukupally Praveen, Javvaji Rama Rao, Padi Pratap Reddy, Kaga Mukkanti & Gade Srinivas Reddy. (2009) Facile synthesis of 6‐aryl‐5 H ‐8‐oxa‐4 b , 7‐diaza‐benzo[ a ]azulen‐9‐one derivatives, new tricyclic heterocycles . Journal of Heterocyclic Chemistry 45:4, pages 1083-1087.
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Melanie Schmitt & Matthias Lehr. (2004) HPLC assay with UV spectrometric detection for the evaluation of inhibitors of cytosolic phospholipase A2. Journal of Pharmaceutical and Biomedical Analysis 35:1, pages 135-142.
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Melanie Schmitt & Matthias Lehr. (2003) High-performance liquid chromatographic assay with ultraviolet spectrometric detection for the evaluation of inhibitors of secretory phospholipase A2. Journal of Chromatography B 783:2, pages 327-333.
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Klaus Griessbach, Monika Klimt, Alwine Schulze Elfringhoff & Matthias Lehr. (2003) Structure‐Activity Relationship Studies of 1‐Substituted 3‐Dodecanoylindole‐2‐carboxylic Acids as Inhibitors of Cytosolic Phospholipase A 2 ‐Mediated Arachidonic Acid Release in Intact Platelets . Archiv der Pharmazie 335:11-12, pages 547-555.
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Matthias Lehr, Monika Klimt & Alwine Schulze Elfringhoff. (2001) Novel 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A2. Bioorganic & Medicinal Chemistry Letters 11:19, pages 2569-2572.
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James L. Kerwin, Joanna K. MacKichan, Melinda J. Semon, Alison M. Wiens, Carolyn C. DeRose & Jessica J. Torvik. (1996) Sterol and steryl ester regulation of phospholipase A2 from the mosquito parasiteLagenidium giganteum. Lipids 31:11, pages 1179-1188.
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GEORGE KOKOTOS, VIOLETTA CONSTANTINOU‐KOKOTOU, CATERINA NOULA, ANNA NICOLAOU & WILLIAM A. GIBBONS. (2009) Synthesis of lipidic amino acid and dipeptide inhibitors of human platelet phospholipase A 2 . International Journal of Peptide and Protein Research 48:2, pages 160-166.
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Rajeewa D. Abeysinghe, Pamela J. Roberts, Chris E. Cooper, Kirsteen H. MacLean, Robert C. Hider & John B. Porter. (1996) The Environment of the Lipoxygenase Iron Binding Site Explored with Novel Hydroxypyridinone Iron Chelators. Journal of Biological Chemistry 271:14, pages 7965-7972.
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Christophe L.M.J. Verlinde & Bauke W. Dijkstra. (1995) Drug or tool, design or serendipity?. Nature Structural & Molecular Biology 2:6, pages 429-432.
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Keith B. Glaser. 1995. 31 66 .

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