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Expert Opinion on Investigational Drugs Volume 14, 2005 - Issue 6
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Review

Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up?

Jennifer S Isaacs Urologic Oncology Branch, Center for Cancer Research, NCI, National Institutes of Health, Rockville, MD, USA. [email protected]
Pages 569-589 | Published online: 11 Jul 2005

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Hong Pyo Kim, Danielle Morse & Augustine MK Choi. (2006) Heat-shock proteins: new keys to the development of cytoprotective therapies. Expert Opinion on Therapeutic Targets 10:5, pages 759-769.
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Articles from other publishers (21)

Len Neckers & Mehdi Mollapour. 2015. The Molecular Basis of Cancer. The Molecular Basis of Cancer 779 788.e3 .
J. M. Patki & S. S. Pawar. (2013) HSP90: Chaperone-me-not. Pathology & Oncology Research 19:4, pages 631-640.
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Daisuke Miwa, Tomohisa Sakaue, Hirofumi Inoue, Nobuaki Takemori, Maki Kurokawa, Shinji Fukuda, Kazuya Omi, Katsutoshi Goishi & Shigeki Higashiyama. (2013) Protein kinase D2 and heat shock protein 90 beta are required for BCL6-associated zinc finger protein mRNA stabilization induced by vascular endothelial growth factor-A. Angiogenesis 16:3, pages 675-688.
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David G. I. Kingston & David J. Newman. 2012. Natural Products in Chemical Biology. Natural Products in Chemical Biology 325 349 .
Laszlo OtvosJr.Jr.. 2011. Cancer Epigenetics. Cancer Epigenetics 315 335 .
Udhayakumar Gopal, Jessica E. Bohonowych, Carla Lema-Tome, Angen Liu, Elizabeth Garrett-Mayer, Bingcheng Wang & Jennifer S. Isaacs. (2011) A Novel Extracellular Hsp90 Mediated Co-Receptor Function for LRP1 Regulates EphA2 Dependent Glioblastoma Cell Invasion. PLoS ONE 6:3, pages e17649.
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Zhiqiang Qin, Michael DeFee, Jennifer S. Isaacs & Chris Parsons. (2010) Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV. Virology 403:1, pages 92-102.
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J. E. Bohonowych, U. Gopal & J. S. Isaacs. (2010) Hsp90 as a Gatekeeper of Tumor Angiogenesis: Clinical Promise and Potential Pitfalls. Journal of Oncology 2010, pages 1-17.
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Tadhg P. BegleyDavid G. I. Kingston & David J. Newman. 2007. Wiley Encyclopedia of Chemical Biology. Wiley Encyclopedia of Chemical Biology.
Len Neckers. 2008. The Molecular Basis of Cancer. The Molecular Basis of Cancer 701 710 .
Len Neckers & Percy Ivy. 2008. Molecular Targeting in Oncology. Molecular Targeting in Oncology 75 95 .
Len Neckers, Adam Kern & Shinji Tsutsumi. (2007) Hsp90 Inhibitors Disrupt Mitochondrial Homeostasis in Cancer Cells. Chemistry & Biology 14:11, pages 1204-1206.
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Len Neckers. (2007) Heat shock protein 90: The cancer chaperone. Journal of Biosciences 32:3, pages 517-530.
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Wanping Xu & Len Neckers. (2007) Targeting the Molecular Chaperone Heat Shock Protein 90 Provides a Multifaceted Effect on Diverse Cell Signaling Pathways of Cancer Cells. Clinical Cancer Research 13:6, pages 1625-1629.
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Len Neckers. 2007. Heat Shock Proteins in Cancer. Heat Shock Proteins in Cancer 231 252 .
Len Neckers & Percy Ivy. 2007. Cell Stress Proteins. Cell Stress Proteins 341 363 .
Ana I. Robles, Mollie H. Wright, Bheru Gandhi, Steven S. Feis, Christin L. Hanigan, Adrian Wiestner & Lyuba Varticovski. (2006) Schedule-Dependent Synergy between the Heat Shock Protein 90 Inhibitor 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin and Doxorubicin Restores Apoptosis to p53-Mutant Lymphoma Cell Lines. Clinical Cancer Research 12:21, pages 6547-6556.
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Lata T. GooljarsinghChristine FernandesKang YanHong Zhang, Michael Grooms, Kyung Johanson, Robert H. Sinnamon, Robert B. Kirkpatrick, John Kerrigan, Tia Lewis, Marc Arnone, Alastair J. King, Zhihong LaiRobert A. CopelandPeter J. Tummino. (2006) A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues. Proceedings of the National Academy of Sciences 103:20, pages 7625-7630.
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Sharon Sanderson, Melanie Valenti, Sharon Gowan, Lisa Patterson, Zahida Ahmad, Paul Workman & Suzanne A. Eccles. (2006) Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis. Molecular Cancer Therapeutics 5:3, pages 522-532.
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AMERE S. SREEDHAR. (2006) Hyperthermia and Pharmacological Intervention of Heat Shock Proteins in Anticancer Treatments. Thermal Medicine 22:4, pages 211-227.
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Yves L. Janin. (2005) Heat Shock Protein 90 Inhibitors. A Text Book Example of Medicinal Chemistry?. Journal of Medicinal Chemistry 48:24, pages 7503-7512.
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