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Drug Evaluation

Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson’s disease

Pages 729-738 | Published online: 11 Jul 2005

Keep up to date with the latest research on this topic with citation updates for this article.

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Thomas Müller. (2023) The role of istradefylline in the Parkinson’s disease armamentarium. Expert Opinion on Pharmacotherapy 24:7, pages 863-871.
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Nabil Al-Zaqri, T. Pooventhiran, Ali Alsalme, D. Jagadeeswara Rao, Siriki Srinivasa Rao, A. Sankar & Renjith Thomas. (2022) First-Principle Studies of Istradefylline with Emphasis on the Stability, Reactivity, Interactions and Wavefunction-Dependent Properties. Polycyclic Aromatic Compounds 42:6, pages 3238-3252.
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Peter Jenner, Akihisa Mori, Stephen D. Aradi & Robert A. Hauser. (2021) Istradefylline – a first generation adenosine A2A antagonist for the treatment of Parkinson’s disease. Expert Review of Neurotherapeutics 21:3, pages 317-333.
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Margherita Torti, Laura Vacca & Fabrizio Stocchi. (2018) Istradefylline for the treatment of Parkinson’s disease: is it a promising strategy?. Expert Opinion on Pharmacotherapy 19:16, pages 1821-1828.
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Ruxandra Julia Vorovenci & Angelo Antonini. (2015) The efficacy of oral adenosine A2A antagonist istradefylline for the treatment of moderate to severe Parkinson’s disease. Expert Review of Neurotherapeutics 15:12, pages 1383-1390.
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Chuan Zhu, Guowei Wang, Jinqing Li, Li Chen, Chaoli Wang, Yajie Wang, Ping Lin & Hong Ran. (2014) Adenosine A2A receptor antagonist istradefylline 20 versus 40 mg/day as augmentation for Parkinson’s disease: a meta-analysis. Neurological Research 36:11, pages 1028-1034.
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Murty Deverakonda, Raghu Prasad Mailavaram, Pran Kishore Deb, Narsaiah Banda & Girija Sastry Vedula. (2012) Rapid and Efficient, Microwave-Assisted, Base-Catalyzed Synthesis of Some Novel 2,7-Disubstituted Pyrrolopyrimidinones. Synthetic Communications 42:21, pages 3103-3111.
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Annalisa Pinna. (2009) Novel investigational adenosine A2A receptor antagonists for Parkinson's disease. Expert Opinion on Investigational Drugs 18:11, pages 1619-1631.
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Roberto Scatena, Giuseppe E Martorana, Patrizia Bottoni, Giorgia Botta, Paola Pastore & Bruno Giardina. (2007) An update on pharmacological approaches to neurodegenerative diseases. Expert Opinion on Investigational Drugs 16:1, pages 59-72.
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Aloke K Dutta PhD & Weidong Le MD, PhD. (2006) Existing dopaminergic therapies for Parkinson’s disease. Expert Opinion on Therapeutic Patents 16:12, pages 1613-1625.
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Thomas Müller & Hermann Russ. (2006) Levodopa, motor fluctuations and dyskinesia in Parkinson’s disease. Expert Opinion on Pharmacotherapy 7:13, pages 1715-1730.
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