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RITA - a small-molecule anticancer drug that targets p53

ISSAEVA N, BOZKO P, ENGE M et al.: Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumours. Nat. Med. (2004) 12:1321-1328.

Pages 739-742 | Published online: 11 Jul 2005

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Taylor P Berke, Simon H Slight & Salman M Hyder. (2022) Role of Reactivating Mutant p53 Protein in Suppressing Growth and Metastasis of Triple-Negative Breast Cancer. OncoTargets and Therapy 15, pages 23-30.
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Ahmad Kazemi, Majid Safa & Atefeh Shahbazi. (2011) RITA enhances chemosensivity of pre-B ALL cells to doxorubicin by inducing p53-dependent apoptosis. Hematology 16:4, pages 225-231.
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Qing Ye, Rebecca A. Raese, Dajie Luo, Juan Feng, Wenjun Xin, Chunlin Dong, Yong Qian & Nancy Lan Guo. (2023) MicroRNA-Based Discovery of Biomarkers, Therapeutic Targets, and Repositioning Drugs for Breast Cancer. Cells 12:14, pages 1917.
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Avinash Kumar, Ekta Rathi, Raghu Chandrashekar Hariharapura & Suvarna G. Kini. (2020) Is viral E6 oncoprotein a viable target? A critical analysis in the context of cervical cancer. Medicinal Research Reviews 40:5, pages 2019-2048.
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Brian D. Peyser, Ann Hermone, Joseph M. Salamoun, James C. Burnett, Melinda G. Hollingshead, Connor F. McGrath, Rick Gussio & Peter Wipf. (2019) Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy . Molecular Cancer Therapeutics 18:10, pages 1765-1774.
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Leonid V. Romashov & Valentine P. Ananikov. (2017) Alkynylation of Bio-Based 5-Hydroxymethylfurfural to Connect Biomass Processing with Conjugated Polymers and Furanic Pharmaceuticals. Chemistry - An Asian Journal 12:20, pages 2652-2655.
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S. Emami. (2011) Interplay between p53-family, their regulators, and PARPs in DNA repair. Clinics and Research in Hepatology and Gastroenterology 35:2, pages 98-104.
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Manujendra N. Saha, Hua Jiang, Asuka Mukai & Hong Chang. (2010) RITA Inhibits Multiple Myeloma Cell Growth through Induction of p53-Mediated Caspase-Dependent Apoptosis and Synergistically Enhances Nutlin-Induced Cytotoxic Responses. Molecular Cancer Therapeutics 9:11, pages 3041-3051.
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Aldo AndreaniSilvia BurnelliMassimiliano GranaiolaAlberto LeoniAlessandra LocatelliRita MorigiMirella RambaldiLucilla VaroliLaura LandiCecilia PrataMichael V. BerridgeCarole GrassoHeinz-Herbert FiebigGerhard KelterAngelika M. BurgerMark W. Kunkel. (2008) Antitumor Activity of Bis-indole Derivatives. Journal of Medicinal Chemistry 51:15, pages 4563-4570.
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Gretchen A. LaRusch, Mark W. Jackson, James D. Dunbar, Robert S. Warren, David B. Donner & Lindsey D. Mayo. (2007) Nutlin3 Blocks Vascular Endothelial Growth Factor Induction by Preventing the Interaction between Hypoxia Inducible Factor 1α and Hdm2. Cancer Research 67:2, pages 450-454.
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