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Rho-kinase inhibitors show promise in pulmonary hypertension

NAGAOKA T, FAGAN KA, GEBB SA et al.: Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am. J. Respir. Crit. Care Med. (2005) 171:494-499. FUKUMOTO Y, MATOBA T, ITO A et al.: Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart (2005) 91:391-392.

Pages 1157-1159 | Published online: 22 Aug 2005

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Xiaowen Zhang & Nan Wu. (2018) Fasudil inhibits proliferation and migration of Hep-2 laryngeal carcinoma cells. Drug Design, Development and Therapy 12, pages 373-381.
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Robert Naeije & Sandrine Huez. (2007) Expert opinion on available options treating pulmonary arterial hypertension. Expert Opinion on Pharmacotherapy 8:14, pages 2247-2265.
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