160
Views
34
CrossRef citations to date
0
Altmetric
Key Paper Evaluation

Rho-kinase inhibitors show promise in pulmonary hypertension

NAGAOKA T, FAGAN KA, GEBB SA et al.: Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am. J. Respir. Crit. Care Med. (2005) 171:494-499. FUKUMOTO Y, MATOBA T, ITO A et al.: Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart (2005) 91:391-392.

Pages 1157-1159 | Published online: 22 Aug 2005

Bibliography

  • BADESCH DB, McLAUGHLIN VV, DELCROIX M et al.: Prostanoid therapy for pulmonary arterial hypertension. J. Am. Coll. CardioL (2004) 43(12 Suppl. S):56S–61S.
  • LIU C, CHENG J: Endothelin receptor antagonists for pulmonary arterial hypertension. Cochrane Database Syst. Rev. (2005) 1:CD004434.
  • KANTHAPILLAI P, LASSERSON T, WALTERS E: Sildenatil for pulmonary hypertension. Cochrane Database Syst. Rev. (2004) 4:CD003562.
  • LOWSON SM: Inhaled alternatives to nitric oxide. Crit. Care Med. (2005) 33\(Suppl. 3):5188–5195.
  • SWARD K, MITA M, WILSON DP et aL: The role of RhoA and Rho-associated in vascular smooth muscle contraction. Curr. Hypertens. Rep. (2003) 5:66–72.
  • NAGAOKA T, MORIO Y, CASANOVA N et al.: Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am. J. PhysioL Lung MoL PhysioL (2004) 287:L665–L672.
  • NAGAOKA T, FAGAN KA, GEBB SA et al.: Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am. J. Respir. Crit. Care Med. (2005) 171:494–499.
  • FUKUMOTO Y, MATOBA T, ITO A et al.: Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart (2005) 91:391–392.
  • ABE K, SHIMOKAWA H, K et al.: Long-term treatment with a Rho-kinase inhibitor improved monocrotaline-induced fatal pulmonary hypertension in rats. Circ. Res. (2004) 94:385–393.

Websites

  • http://www.nhlbi.nih.gov/health/dci/ Diseases/pah/pah_all.html Blood, Lung and Heart Institute's pulmonary hypertension index.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.