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Drug Evaluations

MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy

, , & , PhD
Pages 1563-1573 | Published online: 16 Jul 2012

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Jian-Ang Li, Yefei Rong, Weilin Mao, Lei Zhang, Tiantao Kuang & Wenhui Lou. (2022) Gene expression profiling reveals the genomic changes caused by MLN4924 and the sensitizing effects of NAPEPLD knockdown in pancreatic cancer. Cell Cycle 21:2, pages 152-171.
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Xin Li, Ekinci Elmira, Sagar Rohondia, Jicang Wang, Jinbao Liu & Q. Ping Dou. (2018) A patent review of the ubiquitin ligase system: 2015–2018. Expert Opinion on Therapeutic Patents 28:12, pages 919-937.
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Annabelle Suisse, Miklós Békés, Tony T. Huang & Jessica E. Treisman. (2018) The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity. Fly 12:2, pages 118-126.
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Maryam Oladghaffari, Jalil Pirayesh Islamian, Behzad Baradaran & Ali Shabestani Monfared. (2016) MLN4924 therapy as a novel approach in cancer treatment modalities. Journal of Chemotherapy 28:2, pages 74-82.
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Román González-Prieto, Sabine AG Cuijpers, Ramesh Kumar, Ivo A Hendriks & Alfred CO Vertegaal. (2015) c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4. Cell Cycle 14:12, pages 1859-1872.
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Yanchun Wang, Zhongguang Luo, Yongfu Pan, Weige Wang, Xiaoyan Zhou, Lak Shin Jeong, Yiwei Chu, Jie Liu & Lijun Jia. (2015) Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells. Cancer Biology & Therapy 16:3, pages 420-429.
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