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Novel therapies for cutaneous T-cell lymphoma: what does the future hold?

, MD PhD, , MD PhD, , MD, , PhD, , MD & , MD PhD

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Rositsa Mihaylova, Aleksandar Shkondrov, Denitsa Aluani, Iliana Ionkova, Virginia Tzankova & Ilina Krasteva. (2021) In vitro antitumour and immunomodulating activity of saponins from Astragalus glycyphyllos . Biotechnology & Biotechnological Equipment 35:1, pages 1948-1955.
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Ieva Saulite, Desislava Ignatova, Yun-Tsan Chang, Christina Fassnacht, Florentia Dimitriou, Eleni Varypataki, Florian Anzengruber, Mirjam Nägeli, Antonio Cozzio, Reinhard Dummer, Julia Scarisbrick, Steve Pascolo, Wolfram Hoetzenecker, Malgorzata Bobrowicz & Emmanuella Guenova. (2020) Blockade of programmed cell death protein 1 (PD-1) in Sézary syndrome reduces Th2 phenotype of non-tumoral T lymphocytes but may enhance tumor proliferation. OncoImmunology 9:1.
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Mauro Alaibac. (2018) Small molecule inhibitors for cutaneous T-cell lymphomas. Expert Opinion on Orphan Drugs 6:5, pages 345-350.
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Mauro Alaibac. (2017) Monoclonal antibodies against cutaneous T-cell lymphomas. Expert Opinion on Biological Therapy 17:12, pages 1503-1510.
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Articles from other publishers (19)

Zhen Han, Xiwei Wu, Hanjun Qin, Yate-Ching Yuan, Jasmine Zain, D. Lynne Smith, Oleg E. Akilov, Steven T. Rosen, Mingye Feng & Christiane Querfeld. (2023) Blockade of the Immune Checkpoint CD47 by TTI-621 Potentiates the Response to Anti−PD-L1 in Cutaneous T-Cell Lymphoma. Journal of Investigative Dermatology 143:8, pages 1569-1578.e5.
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E. Guenova, P. L. Ortiz‐Romero, B. Poligone & C. Querfeld. (2023) Mechanism of action of chlormethine gel in mycosis fungoides. Journal of the European Academy of Dermatology and Venereology.
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Gabriela Blanchard, Francoise Solly, Valentin Basset, Lionel Fontao, Maël Blanchard & Emmanuella Guenova. (2023) Vorinostat for treatment‐refractory bullous pemphigoid. Journal of the European Academy of Dermatology and Venereology.
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G. Blanchard & E. Guenova. (2022) Mogamulizumab-associated rash (MAR) mars its efficacy in the treatment of cutaneous lymphoma. British Journal of Dermatology 186:1, pages 15-16.
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Malgorzata Bobrowicz, Aleksander Slusarczyk, Joanna Domagala, Michal Dwojak, Desislava Ignatova, Yun‑Tsan Chang, Christoph Iselin, Nina Miazek‑Zapala, Katsiaryna Marhelava, Emmanuella Guenova & Magdalena Winiarska. (2020) Selective inhibition of HDAC6 sensitizes cutaneous T‑cell lymphoma to PI3K inhibitors. Oncology Letters 20:1, pages 533-540.
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Malgorzata Bobrowicz, Christina Fassnacht, Desislava Ignatova, Yun-Tsan Chang, Florentia Dimitriou & Emmanuella Guenova. (2020) Pathogenesis and Therapy of Primary Cutaneous T-Cell Lymphoma: Collegium Internationale Allergologicum (CIA) Update 2020. International Archives of Allergy and Immunology 181:10, pages 733-745.
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Malgorzata Bobrowicz, Radoslaw Zagozdzon, Joanna Domagala, Roberta Vasconcelos-Berg, Emmanuella Guenova & Magdalena Winiarska. (2019) Monoclonal Antibodies in Dermatooncology—State of the Art and Future Perspectives. Cancers 11:10, pages 1420.
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Lilach Moyal, Neta Goldfeiz, Batia Gorovitz, Ada Rephaeli, Efrat Tal, Nataly Tarasenko, Abraham Nudelman, Yael Ziv & Emmilia Hodak. (2017) AN-7, a butyric acid prodrug, sensitizes cutaneous T-cell lymphoma cell lines to doxorubicin via inhibition of DNA double strand breaks repair. Investigational New Drugs 36:1, pages 1-9.
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L. Moyal, S. Yehezkel, B. Gorovitz, A. Keren, A. Gilhar, I. Lubin, S. Sherman & E. Hodak. (2017) Oncogenic role of microRNA‐155 in mycosis fungoides: an in vitro and xenograft mouse model study . British Journal of Dermatology 177:3, pages 791-800.
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Hiroaki Kamijo, Makoto Sugaya, Naomi Takahashi, Tomonori Oka, Tomomitsu Miyagaki, Yoshihide Asano & Shinichi Sato. (2017) BET bromodomain inhibitor JQ1 decreases CD30 and CCR4 expression and proliferation of cutaneous T-cell lymphoma cell lines. Archives of Dermatological Research 309:6, pages 491-497.
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Sima Rozati, Phil F. Cheng, Daniel S. Widmer, Kazuyasu Fujii, Mitchell P. Levesque & Reinhard Dummer. (2016) Romidepsin and Azacitidine Synergize in their Epigenetic Modulatory Effects to Induce Apoptosis in CTCL. Clinical Cancer Research 22:8, pages 2020-2031.
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Pier Luigi Zinzani, Vijayveer Bonthapally, Dirk Huebner, Richard Lutes, Andy Chi & Stefano Pileri. (2016) Panoptic clinical review of the current and future treatment of relapsed/refractory T-cell lymphomas: Cutaneous T-cell lymphomas. Critical Reviews in Oncology/Hematology 99, pages 228-240.
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Pier Luigi Zinzani, Vijayveer Bonthapally, Dirk Huebner, Richard Lutes, Andy Chi & Stefano Pileri. (2016) Panoptic clinical review of the current and future treatment of relapsed/refractory T-cell lymphomas: Peripheral T-cell lymphomas. Critical Reviews in Oncology/Hematology 99, pages 214-227.
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Lilach Moyal, Nataly Feldbaum, Neta Goldfeiz, Ada Rephaeli, Abraham Nudelman, Michal Weitman, Nataly Tarasenko, Batia Gorovitz, Leah Maron, Shiran Yehezkel, Iris Amitay-Laish, Ido Lubin & Emmilia Hodak. (2016) The Therapeutic Potential of AN-7, a Novel Histone Deacetylase Inhibitor, for Treatment of Mycosis Fungoides/Sezary Syndrome Alone or with Doxorubicin. PLOS ONE 11:1, pages e0146115.
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Ieva Saulite, Wolfram Hoetzenecker, Stephan Weidinger, Antonio Cozzio, Emmanuella Guenova & Ulrike Wehkamp. (2016) Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets. BioMed Research International 2016, pages 1-15.
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Catherine G. Chung & Brian Poligone. (2015) Cutaneous T cell Lymphoma: an Update on Pathogenesis and Systemic Therapy. Current Hematologic Malignancy Reports 10:4, pages 468-476.
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S Esmailzadeh, Y Huang, M-W Su, Y Zhou & X Jiang. (2015) BIN1 tumor suppressor regulates Fas/Fas ligand–mediated apoptosis through c-FLIP in cutaneous T-cell lymphoma. Leukemia 29:6, pages 1402-1413.
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R. Dummer, M. Duvic, J. Scarisbrick, E.A. Olsen, S. Rozati, N. Eggmann, S.M. Goldinger, K. Hutchinson, L. Geskin, T.M. Illidge, E. Giuliano, J. Elder & Y.H. Kim. (2014) Final results of a multicenter phase II study of the purine nucleoside phosphorylase (PNP) inhibitor forodesine in patients with advanced cutaneous t-cell lymphomas (CTCL) (Mycosis fungoides and Sézary syndrome). Annals of Oncology 25:9, pages 1807-1812.
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Rudolf Stadler. (2014) Kutane T-Zell-Lymphome: Immer noch eine therapeutische Herausforderung. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 12:8, pages 647-648.
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