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Review

Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders

Pages 417-426 | Published online: 23 Feb 2005

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Y. Levkovitz, J.E. Alpert, C.E. Brintz, D. Mischoulon & G.I. Papakostas. (2020) Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder. European Psychiatry 27:7, pages 518-521.
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Yechiel Levkovitz, Jonathan E. Alpert, Carrie E. Brintz, David Mischoulon & George I. Papakostas. (2012) Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder. Journal of Affective Disorders 136:3, pages 1174-1178.
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Michael Serra, Amy Chan, Maya Dubey, Vladimir Gilman & Thomas B Shea. (2008) Folate and S -adenosylmethionine modulate synaptic activity in cultured cortical neurons: acute differential impact on normal and apolipoprotein-deficient mice . Physical Biology 5:4, pages 044002.
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Aron M. Troen, Wei-Hsun Chao, Natalia A. Crivello, Kristen E. D’Anci, Barbara Shukitt-Hale, Don E. Smith, Jacob Selhub & Irwin H. Rosenberg. (2008) Cognitive Impairment in Folate-Deficient Rats Corresponds to Depleted Brain Phosphatidylcholine and Is Prevented by Dietary Methionine without Lowering Plasma Homocysteine. The Journal of Nutrition 138:12, pages 2502-2509.
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Kati Erdmann, Belinda W.Y. Cheung, Stephan Immenschuh & Henning Schröder. (2008) Heme oxygenase-1 is a novel target and antioxidant mediator of S-adenosylmethionine. Biochemical and Biophysical Research Communications 368:4, pages 937-941.
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M. Chishty, A. Reichel, N.J. Abbott & D.J. Begley. (2002) S-adenosylmethionine is substrate for carrier mediated transport at the blood–brain barrier in vitro. Brain Research 942:1-2, pages 46-50.
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Richard P Brown, Patricia Gerbarg & Teodoro Bottiglieri. (2002) S-Adenosylmethionine (SAMe) for Depression. Psychiatric Annals 32:1, pages 29-44.
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Paolo Pancheri. (2002) Effects of a Low Dose of Oral Ademetionine (SAMe) on Behaviour and Quality of Life in Elderly Patients with Mild Mood Disorders. Clinical Drug Investigation 22:5, pages 321-327.
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Janet E. Settle. 2002. Handbook of Complementary and Alternative Therapies in Mental Health. Handbook of Complementary and Alternative Therapies in Mental Health 115 131 .
Elena Consogno, Ettore Tiraboschi, Emilio Iuliano, Massimo Gennarelli, Giorgio Racagni & Maurizio Popoli. (2001) Long-term treatment with s-adenosylmethionine induces changes in presynaptic cam kinase II and synapsin I. Biological Psychiatry 50:5, pages 337-344.
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RICHARD P. BROWN & PATRICIA L. GERBARG. (2001) Herbs and Nutrients in the Treatment of Depression, Anxiety, Insomnia, Migraine, and Obesity. Journal of Psychiatric Practice 7:2, pages 75-91.
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S Zanotti, S Mori, R Radaelli, J Perez, G Racagni & M Popoli. (1998) Modifications in brain cAMP- and calcium/calmodulin-dependent protein kinases induced by treatment with S-adenosylmethionine. Neuropharmacology 37:8, pages 1081-1089.
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