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Original Research

Acceptability of switching adalimumab from a prefilled syringe to an autoinjection pen

, PharmD PhD, , MD, , PharmD PhD, , PharmD & , PharmD PhD
Pages 301-307 | Published online: 08 Jan 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (14)

James Hawthorne, Dimos Katsaros, Amy Rinaldi, Katherine Brigham, Matthew D’Auria, Erika Bajars, Chris Franzese & Marty Coyne. (2022) The current paradigm for biologic initiation: a confirmatory quantitative analysis of self-injection training practices. Expert Opinion on Drug Delivery 19:6, pages 733-742.
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Donghoon Shin, Younsoo Kim, Ahra Go & Maria Velinova. (2020) Comparison of the Pharmacokinetics, Safety, and Tolerability of the Autoinjector (AI) and Pre-Filled Syringe (PFS) of SB4 in Healthy Subjects. Drug Design, Development and Therapy 14, pages 43-50.
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Naceur Rekaya, Alexandra Pickersgill & Louisa Harvey. (2019) Addition Of A Sleeve To The Etanercept Autoinjector (Enbrel® MyClic®) Improves Ease Of Use In Patients With Rheumatoid Arthritis. Medical Devices: Evidence and Research 12, pages 443-450.
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Jeehoon Ghil, Agnieszka Zielińska & Younju Lee. (2019) Usability and safety of SB5 (an adalimumab biosimilar) prefilled syringe and autoinjector in patients with rheumatoid arthritis. Current Medical Research and Opinion 35:3, pages 497-502.
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Bernd Tischer & Andrea Mehl. (2018) Patients’ and nurses’ preferences for autoinjectors for rheumatoid arthritis: results of a European survey. Patient Preference and Adherence 12, pages 1413-1424.
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Donghoon Shin, Younju Lee, Deokyoon Jeong & Rod Ellis-Pegler. (2018) Comparative pharmacokinetics of an adalimumab biosimilar SB5 administered via autoinjector or prefilled syringe in healthy subjects. Drug Design, Development and Therapy 12, pages 3799-3805.
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Barbara Domańska, Brenda VanLunen, Luke Peterson, Irina Mountian & Michael Schiff. (2017) Comparative usability study for a certolizumab pegol autoinjection device in patients with rheumatoid arthritis. Expert Opinion on Drug Delivery 14:1, pages 15-22.
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David H. Collier, Bojena Bitman, Andrew Coles, Lyrica Liu, Sandeep Kumar & Clinton Judd. (2017) A novel electromechanical autoinjector, AutoTouch™, for self-injection of etanercept: real-world use and benefits. Postgraduate Medicine 129:1, pages 118-125.
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André Frenzel, Thomas Schirrmann & Michael Hust. (2016) Phage display-derived human antibodies in clinical development and therapy. mAbs 8:7, pages 1177-1194.
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Chika Ohata, Takako Shintani, Masataka Arakawa, Kazuhiro Yoshimura, Bungo Ohyama, Norito Ishii, Fumitake Ono, Takahiro Hamada, Tadashi Karashima & Minao Furumura. (2015) Frequent office visits for injections may reduce adalimumab survival rate in patients with psoriasis. Journal of Dermatological Treatment 26:4, pages 312-313.
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Joaquín Borrás-Blasco, Antonio Gracia-Pérez, M Dolores-Elvira Casterá, J Dolores Rosique-Robles & Javier Abad. (2013) Educational session as a tool to increase patient satisfaction of switching etanercept from the prefilled syringe to the autoinjection pen. Expert Opinion on Biological Therapy 13:8, pages 1103-1108.
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Hèctor Corominas, Silvia Garcia-Diaz, Lucinda Sanchez-Eslava & Ramon Fíguls. (2012) “Switching adalimumab from syringe to pen. Expected outcomes”. Expert Opinion on Biological Therapy 12:6, pages 805-806.
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Peter Varunok, Eric Lawitz, Kimberly L Beavers, Gary Matusow, Ruby Leong, Nathalie Lambert, Coen Bernaards, Jonathan Solsky, Barbara J Brennan, Cynthia Wat & Anne Bertasso. (2011) Evaluation of pharmacokinetics, user handling, and tolerability of peginterferon alfa-2a (40 kDa) delivered via a disposable autoinjector device. Patient Preference and Adherence 5, pages 587-599.
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Articles from other publishers (27)

Rieke Alten, Simon Moss, Stefanie Hahne, Angela T. Muriset, David Gruben & Mark Latymer. (2023) High Usability and Applicability Ratings for the New SmartClic®/ClicWise® Injection Device: Evidence from a Health Care Professional Opinion Study. Rheumatology and Therapy 10:2, pages 477-487.
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Amy Perrin Ross, Christian Besser, Shubhanvita Naval, Dee Stoneman, Harriet Gaunt & Noreen Barker. (2023) Patient and nurse preference for Sensoready autoinjector pen versus other autoinjectors in multiple sclerosis: results from a pilot multicenter survey. BMC Neurology 23:1.
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Joaquin Borrás‐Blasco, Esther Vicente‐Escrig, Francisco José Rodríguez‐Lucena, Ana García‐Monsalve, Elena Arroyo‐Domingo, Raul Ferrando‐Piqueres, Elvira Casterá & Andrés Navarro‐Ruiz. (2022) Six months multicentre pilot open label single‐arm study to evaluate patient experience, acceptability and satisfaction of switching certolizumab pegol from a prefilled syringe or autoinjection pen to an AVA ® e‐Device in rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis patients . Journal of Clinical Pharmacy and Therapeutics 47:12, pages 2345-2349.
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Yifei Liu, Joakim Söderberg & Jingdong Chao. (2022) Adherence to and Persistence with Adalimumab Therapy among Swedish Patients with Crohn’s Disease. Pharmacy 10:4, pages 87.
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Roy M. Fleischmann, Amy E. Bock, Wuyan Zhang, Charles M. Godfrey, Ivana Vranic, Carol Cronenberger & Eva Dokoupilová. (2022) Usability Study of PF-06410293, an Adalimumab Biosimilar, by Prefilled Pen: Open-Label, Single-Arm, Sub-Study of a Phase 3 Trial in Patients with Rheumatoid Arthritis. Rheumatology and Therapy 9:3, pages 839-850.
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Sang‐Hoon Lee, Yong‐Gil Kim, Seung‐Geun Lee, Soo Hyun Lee, Young‐Joo Kim, Ja‐Young Jeon, Joo‐Young Jo, Hyun‐Jeong Yoo, Juneyoung Lee & Tae‐Hwan Kim. (2022) Treatment pattern, satisfaction, and productivity loss of patients with ankylosing spondylitis treated with tumor necrosis factor inhibitors in Korea: A multicenter cross‐sectional observational study. International Journal of Rheumatic Diseases 25:5, pages 523-531.
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Ahad Sabet, Daniel S. Dickerson, Eugenia E. Kunina, Anna Lucia Buccarello & Joëlle Monnet. (2022) A Randomised Controlled Trial Comparing the Pharmacokinetics and Tolerability of the Proposed Adalimumab Biosimilar MSB11022 Delivered via Autoinjector and Pre-filled Syringe in Healthy Subjects. Rheumatology and Therapy 9:2, pages 693-704.
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Antonia Davidson, Darin Brimhall, Jonathan Kay, Edward Keystone, Sang Joon Lee, Sung Hyun Kim, Yun Ju Bae, Eun Jin Choi & Daniel E. Furst. (2021) Randomised, phase I pharmacokinetic study of adalimumab biosimilar CT‐P17 (40 mg/0.4 mL) by autoinjector and prefilled syringe in healthy subjects. British Journal of Clinical Pharmacology 87:11, pages 4323-4333.
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Wenhui Zhang, Helen Tyrrell, Han Ting Ding, Jennifer Pulley, Audrey Boruvka, Rich Erickson, Mariam Abouhossein, Renato Ravanello & Meina Tao Tang. (2021) Comparable Pharmacokinetics, Safety, and Tolerability of Etrolizumab Administered by Prefilled Syringe or Autoinjector in a Randomized Trial in Healthy Volunteers. Advances in Therapy 38:5, pages 2418-2434.
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Helen Tyrrell, Renato Ravanello, Jennifer Pulley, Meina Tao Tang, Wenhui Zhang, Mariam Abouhossein & Swati Tole. (2021) An Open-Label Tolerability and Actual-Use Human Factors Study of Etrolizumab Autoinjector in Healthy Volunteers. Advances in Therapy 38:5, pages 2406-2417.
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Justyna Roszkiewicz, Zbigniew Swacha & Elżbieta Smolewska. (2020) Prefilled pen versus prefilled syringe: a pilot study evaluating two different methods of methotrexate subcutaneous injection in patients with JIA. Pediatric Rheumatology 18:1.
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Naceur Rekaya, Steven M. Vicik, Bors T. Hulesch & Laura L. McDonald. (2020) Enhancement of an Auto-Injector Device for Self-Administration of Etanercept in Patients With Rheumatoid Arthritis Confers Emotional and Functional Benefits. Rheumatology and Therapy 7:3, pages 537-552.
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Christof Maucksch, Peer M. Aries, Silke Zinke & Ulf Müller-Ladner. (2020) Patient Satisfaction with the Etanercept Biosimilar SB4 Device, Among Rheumatoid Arthritis and Spondyloarthropathy Patients - A German Observational Study. The Open Rheumatology Journal 14:1, pages 7-14.
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Cristina Gely, Laura Marín, Jordi Gordillo, Míriam Mañosa, Federico Bertoletti, Fiorella Cañete, Carlos González-Muñoza, Margalida Calafat, Eugeni Domènech & Esther Garcia-Planella. (2020) Impact of pain associated with the subcutaneous administration of adalimumab. Gastroenterología y Hepatología 43:1, pages 9-13.
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Cristina Gely, Laura Marín, Jordi Gordillo, Míriam Mañosa, Federico Bertoletti, Fiorella Cañete, Carlos González-Muñoza, Margalida Calafat, Eugeni Domènech & Esther Garcia-Planella. (2020) Impact of pain associated with the subcutaneous administration of adalimumab. Gastroenterología y Hepatología (English Edition) 43:1, pages 9-13.
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Agnès Portron, Paul Jordan, Kristy Draper, Christopher Muenzer, Daniel Dickerson, Thijs van Iersel & Carsten Hofmann. (2020) A Phase I Study to Assess the Effect of Speed of Injection on Pain, Tolerability, and Pharmacokinetics After High-volume Subcutaneous Administration of Gantenerumab in Healthy Volunteers. Clinical Therapeutics 42:1, pages 108-120.e1.
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Steve Fenwick, Kunal Thakur & Duncan Munro. (2019) Nurse and Patient Perceptions and Preferences for Subcutaneous Autoinjectors for Inflammatory Joint or Bowel Disease: Findings from a European Survey. Rheumatology and Therapy 6:2, pages 195-206.
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Steven Ramael, Benjamin Van Hoorick, Renger Tiessen, Thijs van Iersel, Viktoria Moschetti, Benjamin Lang, Ivo Sonderegger, Sabrina Wiebe, Bernd Liedert & Girish Jayadeva. (2018) Similar Pharmacokinetics of the Adalimumab (Humira®) Biosimilar BI 695501 Whether Administered via Subcutaneous Autoinjector or Prefilled Syringe (VOLTAIRE®-AI and VOLTAIRE®-TAI): Phase 1, Randomized, Open-Label, Parallel-Group Trials. Rheumatology and Therapy 5:2, pages 403-421.
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Nikos Maniadakis, Emese Toth, Michael Schiff, Xuan Wang, Maria Nassim, Boglarka Szegvari, Irina Mountian & Jeffrey R. Curtis. (2018) A Targeted Literature Review Examining Biologic Therapy Compliance and Persistence in Chronic Inflammatory Diseases to Identify the Associated Unmet Needs, Driving Factors, and Consequences. Advances in Therapy 35:9, pages 1333-1355.
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Raphael J. Dehoratius, Lawrence H. Brent, Jeffrey R. Curtis, Lorie A Ellis & Kezhen L. Tang. (2018) Satisfaction with Subcutaneous Golimumab and its Auto-Injector among Rheumatoid Arthritis Patients with Inadequate Response to Adalimumab or Etanercept. The Patient - Patient-Centered Outcomes Research 11:3, pages 361-369.
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Kunal Thakur, Anna Biberger, Alexandra Handrich & Mourad Farouk Rezk. (2016) Patient Perceptions and Preferences of Two Etanercept Autoinjectors for Rheumatoid Arthritis: Findings from a Patient Survey in Europe. Rheumatology and Therapy 3:2, pages 245-256.
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G. Candelas, V. Villaverde, S. García, M. Guerra, M. J. León & J. D. Cañete. (2016) Benefit of health education by a training nurse in patients with axial and/or peripheral psoriatic arthritis: A systematic literature review. Rheumatology International 36:11, pages 1493-1506.
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Colin H. Ridyard, Dalia M. M. Dawoud, Lorna V. Tuersley & Dyfrig A. Hughes. (2016) A Systematic Review of Patients’ Perspectives on the Subcutaneous Route of Medication Administration. The Patient - Patient-Centered Outcomes Research 9:4, pages 281-292.
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Diane V. Doughty, Corbin Z. Clawson, William Lambert & J. Anand Subramony. (2016) Understanding Subcutaneous Tissue Pressure for Engineering Injection Devices for Large-Volume Protein Delivery. Journal of Pharmaceutical Sciences 105:7, pages 2105-2113.
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Kunal Thakur, Anna Biberger, Alexandra Handrich & Mourad Farouk Rezk. (2016) Perceptions and Preferences of Two Etanercept Autoinjectors for Rheumatoid Arthritis: A New European Union-Approved Etanercept Biosimilar (Benepali®) Versus Etanercept (Enbrel®) - Findings from a Nurse Survey in Europe. Rheumatology and Therapy 3:1, pages 77-89.
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Nozomi Ami & Hideki Satou. (2015) The use of rat spinal reflexes to quantify injection pain. European Journal of Pharmaceutical Sciences 74, pages 36-39.
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Maria López, Laura Moreno, Angelina Dosal, Marta Maria Pujol, Mercedes Vergara & Montserrat Gil. (2011) Interferon and the Fear of Needles. Gastroenterology Nursing 34:5, pages 384-388.
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