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Expert Opinion on Biological Therapy Volume 8, 2008 - Issue 5
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Antibody–cytokine fusion proteins: applications in cancer therapy

Elizabeth Ortiz-Sánchez Postdoctoral Fellow University of California, Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, Los Angeles, CA 90095, USA
, PhD,
Gustavo Helguera Assistant Researcher University of California, Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, Los Angeles, CA 90095, USA
, PhD,
Tracy R Daniels Postdoctoral Fellow University of California, Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, Los Angeles, CA 90095, USA
, PhD &
Manuel L Penichet Assistant Professor UCLA, Division of Surgical Oncology, Department of Surgery, 10833 Le Conte Avenue, CHS 54-140, Box 951782, Los Angeles, CA 90095-1782, USA +1 310 825 1304; +1 310 825 7575; [email protected]; Assistant Professor University of California, Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, Los Angeles, CA 90095, USA; Assistant Professor University of California, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA
, MD PhD
Pages 609-632 | Published online: 13 Apr 2008

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Christian Klein, Inja Waldhauer, Valeria G. Nicolini, Anne Freimoser-Grundschober, Tapan Nayak, Danielle J. Vugts, Claire Dunn, Marije Bolijn, Jörg Benz, Martine Stihle, Sabine Lang, Michaele Roemmele, Thomas Hofer, Erwin van Puijenbroek, David Wittig, Samuel Moser, Oliver Ast, Peter Brünker, Ingo H. Gorr, Sebastian Neumann, Maria Cristina de Vera Mudry, Heather Hinton, Flavio Crameri, Jose Saro, Stefan Evers, Christian Gerdes, Marina Bacac, Guus van Dongen, Ekkehard Moessner & Pablo Umaña. (2017) Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines. OncoImmunology 6:3.
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Roland Kontermann. (2012) Dual targeting strategies with bispecific antibodies. mAbs 4:2, pages 182-197.
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Chien-Hsing Chang, Pankaj Gupta & David M Goldenberg. (2009) Advances and challenges in developing cytokine fusion proteins as improved therapeutics. Expert Opinion on Drug Discovery 4:2, pages 181-194.
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Articles from other publishers (33)

Sol Ferrero, Matías Gatto & Gustavo Helguera. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 28 .
Kirstin A. Zettlitz, Felix B. Salazar, Reiko E. Yamada, K. Ryan Trinh, Alex Vasuthasawat, John M. Timmerman, Sherie L. Morrison & Anna M. Wu. (2022) 89Zr-ImmunoPET Shows Therapeutic Efficacy of Anti-CD20-IFNα Fusion Protein in a Murine B-cell Lymphoma Model. Molecular Cancer Therapeutics 21:4, pages 607-615.
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Pedro Cecílio, James Oristian, Claudio Meneses, Tiago D. Serafim, Jesus G. Valenzuela, Anabela Cordeiro da Silva & Fabiano Oliveira. (2020) Engineering a vector-based pan-Leishmania vaccine for humans: proof of principle. Scientific Reports 10:1.
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Oluwaseyi T. Shofolawe-Bakare, Larry D. Stokes, Mehjabeen Hossain, Adam E. Smith & Thomas A. Werfel. (2020) Immunostimulatory biomaterials to boost tumor immunogenicity. Biomaterials Science 8:20, pages 5516-5537.
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Alina Schneider, Ingo H. Gorr, Vincent Larraillet, Timo Frensing & Oliver Popp. (2019) Reduction of IL‐2 fragmentation during manufacturing of a novel immunocytokine by DoE process optimization. Biotechnology and Bioengineering 116:10, pages 2503-2513.
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Rosendo Luria-Pérez, Pierre V. Candelaria, Tracy R. Daniels-Wells, José A. Rodríguez, Gustavo Helguera & Manuel L. Penichet. (2019) Amino acid residues involved in the heparin-binding activity of murine IL-12 in the context of an antibody-cytokine fusion protein. Cytokine 120, pages 220-226.
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Jesse D. Plotkin, Michael G. Elias, Mohammad Fereydouni, Tracy R. Daniels-Wells, Anthony L. Dellinger, Manuel L. Penichet & Christopher L. Kepley. (2019) Human Mast Cells From Adipose Tissue Target and Induce Apoptosis of Breast Cancer Cells. Frontiers in Immunology 10.
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E. Jensen-Jarolim, H. J. Bax, R. Bianchini, S. Crescioli, T. R. Daniels-Wells, D. Dombrowicz, E. Fiebiger, H. J. Gould, S. Irshad, J. Janda, D. H. Josephs, F. Levi-Schaffer, L. O′Mahony, G. Pellizzari, M. L. Penichet, F. Redegeld, F. Roth-Walter, J. Singer, E. Untersmayr, L. Vangelista & S. N. Karagiannis. (2018) AllergoOncology: Opposite outcomes of immune tolerance in allergy and cancer. Allergy 73:2, pages 328-340.
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Juan C. Almagro, Tracy R. Daniels-Wells, Sonia Mayra Perez-Tapia & Manuel L. Penichet. (2018) Progress and Challenges in the Design and Clinical Development of Antibodies for Cancer Therapy. Frontiers in Immunology 8.
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Zahra Valedkarimi, Hadi Nasiri, Leili Aghebati-Maleki & Jafar Majidi. (2017) Antibody-cytokine fusion proteins for improving efficacy and safety of cancer therapy. Biomedicine & Pharmacotherapy 95, pages 731-742.
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Kuldeep Dhama, Mani Saminathan, Siju Susan Jacob, Mithilesh Singh, K. Karthik, Amarpal .Ruchi Tiwari, Lakshmi Tulasi Sunkara, Yashpal Singh Malik & Raj Kumar Singh. (2015) Effect of Immunomodulation and Immunomodulatory Agents on Health with some Bioactive Principles, Modes of Action and Potent Biomedical Applications. International Journal of Pharmacology 11:4, pages 253-290.
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Barbara Geering & Martin Fussenegger. (2015) Synthetic immunology: modulating the human immune system. Trends in Biotechnology 33:2, pages 65-79.
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Gözde Isik, Thijs van Montfort, Nancy P. Y. Chung, John P. Moore & Rogier W. Sanders. (2014) Autoantibodies Induced by Chimeric Cytokine-HIV Envelope Glycoprotein Immunogens. The Journal of Immunology 192:10, pages 4628-4635.
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Florian Lienert, Jason J. Lohmueller, Abhishek Garg & Pamela A. Silver. (2014) Synthetic biology in mammalian cells: next generation research tools and therapeutics. Nature Reviews Molecular Cell Biology 15:2, pages 95-107.
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Martin Siegemund, Fabian Richter, Oliver Seifert, Felix Unverdorben & Roland E. Kontermann. 2014. Monoclonal Antibodies. Monoclonal Antibodies 273 295 .
Kewal K. JainKewal K. Jain. 2014. Applications of Biotechnology in Oncology. Applications of Biotechnology in Oncology 371 391 .
Hui Ding, Gustavo Helguera, José A. Rodríguez, Janet Markman, Rosendo Luria-Pérez, Pallavi Gangalum, Jose Portilla-Arias, Satoshi Inoue, Tracy R. Daniels-Wells, Keith Black, Eggehard Holler, Manuel L. Penichet & Julia Y. Ljubimova. (2013) Polymalic acid nanobioconjugate for simultaneous immunostimulation and inhibition of tumor growth in HER2/neu-positive breast cancer. Journal of Controlled Release 171:3, pages 322-329.
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Leslie A. Khawli, Peisheng Hu & Alan L. Epstein. 2013. Fusion Protein Technologies for Biopharmaceuticals. Fusion Protein Technologies for Biopharmaceuticals 295 314 .
Stefan R. Schmidt. 2013. Fusion Protein Technologies for Biopharmaceuticals. Fusion Protein Technologies for Biopharmaceuticals 253 269 .
Stefan R. Schmidt. 2013. Fusion Protein Technologies for Biopharmaceuticals. Fusion Protein Technologies for Biopharmaceuticals 1 24 .
Rangaiah Shashidharamurthy, Erica N. Bozeman, Jaina Patel, Ramneet Kaur, Jeyandra Meganathan & Periasamy Selvaraj. (2011) Immunotherapeutic strategies for cancer treatment: A novel protein transfer approach for cancer vaccine development. Medicinal Research Reviews 32:6, pages 1197-1219.
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Roland E. Kontermann. (2012) Antibody–cytokine fusion proteins. Archives of Biochemistry and Biophysics 526:2, pages 194-205.
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Slava Stamova, Stefanie Koristka, Juliane Keil, Claudia Arndt, Anja Feldmann, Irene Michalk, Holger Bartsch, Claudia C. Bippes, Marc Schmitz, Marc Cartellieri & Michael Bachmann. (2012) Cancer Immunotherapy by Retargeting of Immune Effector Cells via Recombinant Bispecific Antibody Constructs. Antibodies 1:2, pages 172-198.
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Andreas A. Hombach & Hinrich Abken. 2012. Antibody Engineering. Antibody Engineering 611 626 .
Jaheli Fuenmayor & Ramon F. Montaño. (2011) Novel Antibody-Based Proteins for Cancer Immunotherapy. Cancers 3:3, pages 3370-3393.
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Masaaki Tamura, Deryl Troyer, Dharmendra Maurya, Atsushi Kawabata & Raja Rachakatla. 2011. Cytokines. Cytokines 173 187 .
Patrick Williams & Jacques Galipeau. (2011) GM-CSF–Based Fusion Cytokines as Ligands for Immune Modulation. The Journal of Immunology 186:10, pages 5527-5532.
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Jonas Winter, Karin Barbin, Camilla Bacci & Thomas Bunte. (2011) A new bioassay for the immunocytokine L19-IL2 for simultaneous analysis of both functional moieties. Journal of Pharmaceutical and Biomedical Analysis 54:1, pages 81-86.
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Jaheli Fuenmayor, Karin Perez-Vazquez, Daniel Perez-Witzke, Manuel L. Penichet & Ramon F. Montano. (2010) Decreased Survival of Human Breast Cancer Cells Expressing HER2/ neu on In vitro Incubation with an Anti-HER2/ neu Antibody Fused to C5a or C5adesArg . Molecular Cancer Therapeutics 9:8, pages 2175-2185.
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Dafne Müller & Jeannette Gerspach. 2010. Antibody Engineering. Antibody Engineering 113 126 .
Michael C. FlickingerGustavo Helguera, Tracy R. Daniels, José A. Rodríguez & Manuel L. Penichet. 2009. Encyclopedia of Industrial Biotechnology. Encyclopedia of Industrial Biotechnology.
Roberto Ronca, Silvano Sozzani, Marco Presta & Patrizia Alessi. (2009) Delivering cytokines at tumor site: The immunocytokine-conjugated anti-EDB-fibronectin antibody case. Immunobiology 214:9-10, pages 800-810.
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Daila S. Gridley, James M. Slater, Xian Luo-Owen, Asma Rizvi, Stephen K. Chapes, Louis S. Stodieck, Virginia L. Ferguson & Michael J. Pecaut. (2009) Spaceflight effects on T lymphocyte distribution, function and gene expression. Journal of Applied Physiology 106:1, pages 194-202.
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