Advanced search
Publication Cover
Expert Opinion on Therapeutic Targets Volume 13, 2009 - Issue 1
Submit an article Journal homepage
331
Views
36
CrossRef citations to date
0
Altmetric
Review

Targeting bone morphogenetic protein antagonists: in vitro and in vivo evidence of their role in bone metabolism

Evaggelos Tsialogiannis Clinical and Research Fellow Leeds School of Medicine, Academic Orthopaedic Unit, Leeds General Infirmary, Leeds, UK
, MD,
Ioannis Polyzois Clinical and Research Fellow Leeds School of Medicine, Academic Orthopaedic Unit, Leeds General Infirmary, Leeds, UK
, MB ChB MRCS,
Quen Oak Tang Research Fellow Leeds School of Medicine, Academic Orthopaedic Unit, Leeds General Infirmary, Leeds, UK
, BSc(Hons),
George Pavlou Specialist Registrar Orthopaedic and Trauma Leeds School of Medicine, Academic Orthopaedic Unit, Leeds General Infirmary, Leeds, UK
, MBBS MRCS,
Evgenios Tsiridis Consultant Cardiothoracic Anaesthetist Blue Cross Hospital, Cardio-Thoracic Anaesthetic Unit, Thessaloniki, Greece
, MD,
Manolis Heliotis Consultant Maxillofacial Surgeon Northwick Patrick Hospital, Maxillofacial Unit, Regional North West London, Wattford Road, Harrow, London, UK
, MBBS MSc FDS FRCS &
Eleftherios Tsiridis Consultant Orthopaedic and Trauma Surgeon Leeds University, Leeds Teaching Hospitals NHS Trust, School of Medicine, Academic Department of Trauma Orthopaedics Surgery, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK +44 113 3922621; +44 113 3922621; [email protected]
, MD MSc PhD FRCS show all
Pages 123-137 | Published online: 08 Dec 2008

Citations (36)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Zhengqiu Dai & Guoqiang Wei. (2022) Inhibition of miRNA-100 facilitates bone regeneration defects of mesenchymal stem cells in osteoporotic mice through the protein kinase B pathway. Bioengineered 13:1, pages 963-973.
Read now
Ersi Voskaridou, Ioannis Ntanasis-Stathopoulos, Dimitrios Christoulas, Linda Sonnleitner, Athanasios Papaefstathiou, Maria Dimopoulou, Albert Missbichler, Nikolaos Kanellias, Konstantina Repa, Athanasios Papatheodorou, Melpomeni Peppa, Gerhard Hawa & Evangelos Terpos. (2019) Denosumab effects on serum levels of the bone morphogenetic proteins antagonist noggin in patients with transfusion-dependent thalassemia and osteoporosis. Hematology 24:1, pages 318-324.
Read now
Zakareya Gamie, Nectarios Korres, Andreas Leonidou, Andrew C Gray & Eleftherios Tsiridis. (2012) Sclerostin monoclonal antibodies on bone metabolism and fracture healing. Expert Opinion on Investigational Drugs 21:10, pages 1523-1534.
Read now
Gui Tong Tran, Joseph Pagkalos, Evgenios Tsiridis, Amir Ali Narvani, Manolis Heliotis, Athanasios Mantalaris & Eleftherios Tsiridis. (2009) Growth hormone: does it have a therapeutic role in fracture healing?. Expert Opinion on Investigational Drugs 18:7, pages 887-911.
Read now

Articles from other publishers (32)

Wen-Jiao Wu, Chang-Liang Xia, Shuan-Ji Ou, Yang Yang, Yun-Fei Ma, Yi-Long Hou, Qing-Po Yang, Jun Zhang, Jian-Wei Li, Yong Qi & Chang-Peng Xu. (2021) Novel Elongator Protein 2 Inhibitors Mitigating Tumor Necrosis Factor-α Induced Osteogenic Differentiation Inhibition. BioMed Research International 2021, pages 1-11.
Crossref
Jamie Mollentze, Chrisna Durandt & Michael S. Pepper. (2021) An In Vitro and In Vivo Comparison of Osteogenic Differentiation of Human Mesenchymal Stromal/Stem Cells. Stem Cells International 2021, pages 1-23.
Crossref
Mohamed Al-Shabrawey, Khaled Hussein, Fang Wang, Ming Wan, Khaled Elmasry, Nehal Elsherbiny, Heba Saleh, Paul B. Yu, Amany Tawfik & Ahmed S. Ibrahim. (2021) Bone Morphogenetic Protein-2 Induces Non-Canonical Inflammatory and Oxidative Pathways in Human Retinal Endothelial Cells. Frontiers in Immunology 11.
Crossref
Gengyang Shen, Hui Ren, Qi Shang, Wenhua Zhao, Zhida Zhang, Xiang Yu, Kai Tang, Jingjing Tang, Zhidong Yang, De Liang & Xiaobing Jiang. (2020) Foxf1 knockdown promotes BMSC osteogenesis in part by activating the Wnt/β-catenin signalling pathway and prevents ovariectomy-induced bone loss. EBioMedicine 52, pages 102626.
Crossref
Adil AkkouchSteven EliasonMason E. SweatMiguel Romero-BustillosMin ZhuFang QianBrad A. AmendtLiu Hong. (2019) Enhancement of MicroRNA-200c on Osteogenic Differentiation and Bone Regeneration by Targeting Sox2-Mediated Wnt Signaling and Klf4. Human Gene Therapy 30:11, pages 1405-1418.
Crossref
Chang‐Peng Xu, Hong‐Tao Sun, Ya‐Jun Yang, Zhuang Cui, Jian Wang, Bin Yu, Fa‐Zheng Wang, Qing‐Po Yang & Yong Qi. (2019) ELP2 negatively regulates osteoblastic differentiation impaired by tumor necrosis factor α in MC3T3–E1 cells through STAT3 activation. Journal of Cellular Physiology 234:10, pages 18075-18085.
Crossref
Hany Mohamed Khattab, Satoshi Kubota, Masaharu Takigawa, Takuo Kuboki & Walter Sebald. (2018) The BMP-2 mutant L51P: a BMP receptor IA binding-deficient inhibitor of noggin. Journal of Bone and Mineral Metabolism 37:2, pages 199-205.
Crossref
Chang-Peng Xu, Yong Qi, Zhuang Cui, Ya-Jun Yang, Jian Wang, Yan-Jun Hu, Bin Yu, Fa-Zheng Wang, Qing-Po Yang & Hong-Tao Sun. (2019) Discovery of novel elongator protein 2 inhibitors by compound library screening using surface plasmon resonance. RSC Advances 9:3, pages 1696-1704.
Crossref
Mohamed I. Elashry, Nadine Baulig, Manuela Heimann, Caroline Bernhardt, Sabine Wenisch & Stefan Arnhold. (2018) Osteogenic differentiation of equine adipose tissue derived mesenchymal stem cells using CaCl 2. Research in Veterinary Science 117, pages 45-53.
Crossref
F.M. Klenke & K.A. Siebenrock. 2016. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Patricio C. Smith, Constanza Martínez, Mónica Cáceres & Jorge Martínez. (2015) Research on growth factors in periodontology. Periodontology 2000 67:1, pages 234-250.
Crossref
Chang-Peng Xu, Xue Li, Yan-Jun Hu, Zhuang Cui, Lei Wang, Liang Liang, Yi-Lin Zhou, Ya-Jun Yang & Bin Yu. (2015) Quantitative proteomics reveals ELP2 as a regulator to the inhibitory effect of TNF-α on osteoblast differentiation. Journal of Proteomics 114, pages 234-246.
Crossref
Hany Mohamed Khattab, Mitsuaki Ono, Wataru Sonoyama, Yasutaka Oida, Shigehiko Shinkawa, Yuya Yoshioka, Kenji Maekawa, Yasuhiko Tabata, Kazushige Sugama, Walter Sebald & Takuo Kuboki. (2014) The BMP2 antagonist inhibitor L51P enhances the osteogenic potential of BMP2 by simultaneous and delayed synergism. Bone 69, pages 165-173.
Crossref
Hellen SchneiderBita SedaghatiAndreas NaumannMichael C. HackerMichaela Schulz-Siegmund. (2014) Gene Silencing of Chordin Improves BMP-2 Effects on Osteogenic Differentiation of Human Adipose Tissue-Derived Stromal Cells. Tissue Engineering Part A 20:1-2, pages 335-345.
Crossref
Frank M. Klenke & Klaus A. Siebenrock. 2014. Encyclopedia of Bone Biology. Encyclopedia of Bone Biology 778 792 .
Wilhelm Hofstetter & Raine Egli. 2014. Encyclopedia of Bone Biology. Encyclopedia of Bone Biology 793 800 .
W. Hofstetter & R. Egli. 2014. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Guillaume Grenier, Élisabeth Leblanc, Nathalie Faucheux, Dominique Lauzier, Peter Kloen & Reggie C Hamdy. (2013) BMP-9 expression in human traumatic heterotopic ossification: a case report. Skeletal Muscle 3:1.
Crossref
Asim M. MakhdomReggie C. Hamdy. (2013) The Role of Growth Factors on Acceleration of Bone Regeneration During Distraction Osteogenesis. Tissue Engineering Part B: Reviews 19:5, pages 442-453.
Crossref
Emmanuel Biver, Pierre Hardouin & Joseph Caverzasio. (2013) The “bone morphogenic proteins” pathways in bone and joint diseases: Translational perspectives from physiopathology to therapeutic targets. Cytokine & Growth Factor Reviews 24:1, pages 69-81.
Crossref
Hans-Jörg Sebald, Frank M. Klenke, Mark Siegrist, Christoph E. Albers, Walter Sebald & Wilhelm Hofstetter. (2012) Inhibition of endogenous antagonists with an engineered BMP-2 variant increases BMP-2 efficacy in rat femoral defect healing. Acta Biomaterialia 8:10, pages 3816-3820.
Crossref
Christoph E. Albers, Wilhelm Hofstetter, Hans-Jörg Sebald, Walter Sebald, Klaus A. Siebenrock & Frank M. Klenke. (2012) L51P — A BMP2 variant with osteoinductive activity via inhibition of Noggin. Bone 51:3, pages 401-406.
Crossref
Peter Kloen, Dominique Lauzier & Reggie C. Hamdy. (2012) Co-expression of BMPs and BMP-inhibitors in human fractures and non-unions. Bone 51:1, pages 59-68.
Crossref
Suzanne N. Lissenberg-Thunnissen, David J. J. de Gorter, Cornelis F. M. Sier & Inger B. Schipper. (2011) Use and efficacy of bone morphogenetic proteins in fracture healing. International Orthopaedics 35:9, pages 1271-1280.
Crossref
Evan Argintar, Scott Edwards & John Delahay. (2011) Bone morphogenetic proteins in orthopaedic trauma surgery. Injury 42:8, pages 730-734.
Crossref
F. Forriol. (2010) Proteínas morfogénicas óseas y su aplicación clínica. Revista Española de Cirugía Ortopédica y Traumatología 54, pages 2-10.
Crossref
Ziyad S. Haidar, Reggie C. Hamdy & Maryam Tabrizian. (2010) Biocompatibility and safety of a hybrid core–shell nanoparticulate OP-1 delivery system intramuscularly administered in rats. Biomaterials 31:10, pages 2746-2754.
Crossref
Longmei ZhaoShu JiangBasil M. Hantash. (2010) Transforming Growth Factor β1 Induces Osteogenic Differentiation of Murine Bone Marrow Stromal Cells. Tissue Engineering Part A 16:2, pages 725-733.
Crossref
Jacob Bickels, Talia Weinstein, Dror Robinson & Zvi Nevo. (2010) Common Skeletal Growth Retardation Disorders Resulting from Abnormalities within the Mesenchymal Stem Cells Reservoirs in the Epiphyseal Organs Pertaining to the Long Bones. Journal of Pediatric Endocrinology and Metabolism 23:11.
Crossref
Wenfeng Li, Bin Yu, Mengmeng Li, Daming Sun, Yanjun Hu, Ming Zhao, Cai-Bin Cui & Shuxun Hou. (2010) NEMO-binding domain peptide promotes osteoblast differentiation impaired by tumor necrosis factor alpha. Biochemical and Biophysical Research Communications 391:2, pages 1228-1233.
Crossref
Marc Fajardo, Chuan-Ju Liu & Kenneth Egol. (2009) Levels of Expression for BMP-7 and Several BMP Antagonists May Play an Integral Role in a Fracture Nonunion: A Pilot Study. Clinical Orthopaedics and Related Research® 467:12, pages 3071-3078.
Crossref
Moulay Hicham Alaoui-Ismaili & Dean Falb. (2009) Design of second generation therapeutic recombinant bone morphogenetic proteins. Cytokine & Growth Factor Reviews 20:5-6, pages 501-507.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.