Advanced search
Publication Cover
Expert Opinion on Therapeutic Targets Volume 16, 2012 - Issue 10
Submit an article Journal homepage
717
Views
33
CrossRef citations to date
0
Altmetric
Reviews

Targeting CSCs within the tumor microenvironment for cancer therapy: a potential role of mesenchymal stem cells

Bin BaoWayne State University, Karmanos Cancer Institute, Department of Pathology, Detroit, MI, USA
,
Aamir AhmadWayne State University, Karmanos Cancer Institute, Department of Pathology, Detroit, MI, USA
,
Yiwei LiWayne State University, Karmanos Cancer Institute, Department of Pathology, Detroit, MI, USA
,
Asfar S AzmiWayne State University, Karmanos Cancer Institute, Department of Pathology, Detroit, MI, USA
,
Shadan AliWayne State University, Karmanos Cancer Institute, Department of Oncology, 740 HWCRC, 4100 John R Street, Detroit, MI 48201, USA+1 313 576 8327; +1 313 576 8389; [email protected]
,
Sanjeev BanerjeeWayne State University, Karmanos Cancer Institute, Department of Pathology, Detroit, MI, USA
,
Dejuan KongWayne State University, Karmanos Cancer Institute, Department of Pathology, Detroit, MI, USA
&
Fazlul H SarkarWayne State University, Karmanos Cancer Institute, Department of Pathology, Detroit, MI, USA;Wayne State University, Karmanos Cancer Institute, Department of Oncology, 740 HWCRC, 4100 John R Street, Detroit, MI 48201, USA+1 313 576 8327; +1 313 576 8389; [email protected]
 show all
Pages 1041-1054 | Published online: 09 Aug 2012

Citations (33)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Fei-Ting Hsu, Zung-Hang Wei, Yogi Chang-Yo Hsuan, Willie Lin, Yu-Chin Su, Chia-Hui Liao & Chia-Ling Hsieh. (2018) MRI tracking of polyethylene glycol-coated superparamagnetic iron oxide-labelled placenta-derived mesenchymal stem cells toward glioblastoma stem-like cells in a mouse model. Artificial Cells, Nanomedicine, and Biotechnology 46:sup3, pages 448-459.
Read now
Yiqun Shao, Wenjing Zhu, Jun Da, Mingxi Xu, Yiwei Wang, Juan Zhou & Zhong Wang. (2017) Bisdemethoxycurcumin in combination with α-PD-L1 antibody boosts immune response against bladder cancer. OncoTargets and Therapy 10, pages 2675-2683.
Read now
Yin Zhu, Ming Cheng, Zhen Yang, Chun-Yan Zeng, Jiang Chen, Yong Xie, Shi-Wen Luo, Kun-He Zhang, Shu-Feng Zhou & Nong-Hua Lu. (2014) Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts. Drug Design, Development and Therapy 8, pages 2449-2462.
Read now

Articles from other publishers (30)

Yue Cheng, Shijie Li, Yongying Hou, Weijun Wan, Ke Wang, Shihui Fu, Ye Yuan, Kaidi Yang & Xiufeng Ye. (2023) Glioma-derived small extracellular vesicles induce pericyte-phenotype transition of glioma stem cells under hypoxic conditions. Cellular Signalling 109, pages 110754.
Crossref
Daniel L. Pouliquen, Alice Boissard, Cécile Henry, Olivier Coqueret & Catherine Guette. (2022) Curcuminoids as Modulators of EMT in Invasive Cancers: A Review of Molecular Targets With the Contribution of Malignant Mesothelioma Studies. Frontiers in Pharmacology 13.
Crossref
Neetu Rambharack & Ying Guo. (2021) Proposed Models of Functional Heterogeneity in Cancer and the Effects of Microenvironmental Factors on Cancer Stem Cells: A Literature Review. Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal 5:6, pages 1-7.
Crossref
Aysegül Aksan, Karima Farrag, Sami Aksan, Oliver Schroeder & Jürgen Stein. (2021) Flipside of the Coin: Iron Deficiency and Colorectal Cancer. Frontiers in Immunology 12.
Crossref
Baotao Lv, Fuzhou Li, Xiaoli Liu & Liqiang Lin. (2020) The tumor-suppressive role of microRNA-873 in nasopharyngeal carcinoma correlates with downregulation of ZIC2 and inhibition of AKT signaling pathway. Cancer Gene Therapy.
Crossref
Rowa Y. Alhabbab. (2020) Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells. Frontiers in Genetics 11.
Crossref
Garima Singh, Sarthak Mishra & Harish Chander. (2019) KIBRA Team Up with Partners to Promote Breast Cancer Metastasis. Pathology & Oncology Research 26:2, pages 627-634.
Crossref
Zahra Jabbarpour, Jafar Kiani, Somayeh Keshtkar, Massoud Saidijam, Mohammad H. Ghahremani & Naser Ahmadbeigi. (2019) Effects of human placenta‐derived mesenchymal stem cells with NK4 gene expression on glioblastoma multiforme cell lines. Journal of Cellular Biochemistry 121:2, pages 1362-1373.
Crossref
Elena Butturini, Alessandra Carcereri de Prati, Diana Boriero & Sofia Mariotto. (2019) Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment. International Journal of Molecular Sciences 20:17, pages 4305.
Crossref
Elham Zendehdel, Elham Abdollahi, Amir Abbas Momtazi‐Borojeni, Mitra Korani, Seyedeh Hoda Alavizadeh & Amirhossein Sahebkar. (2018) The molecular mechanisms of curcumin’s inhibitory effects on cancer stem cells. Journal of Cellular Biochemistry 120:4, pages 4739-4747.
Crossref
Ahmed M. Shabana & Marc A. Ilies. 2019. Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity. Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity 223 252 .
Bin Bao & Ananda S. Prasad. 2019. Breast Cancer Metastasis and Drug Resistance. Breast Cancer Metastasis and Drug Resistance 311 334 .
Amar Desai, Yan Yan & Stanton L. Gerson. (2019) Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success. Stem Cells Translational Medicine 8:1, pages 75-81.
Crossref
Haseeb Zubair, Shafquat Azim, Aamir Ahmad, Mohammad Khan, Girijesh Patel, Seema Singh & Ajay Singh. (2017) Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch. Molecules 22:3, pages 395.
Crossref
Siying Zhou, Sijie Zhang, Hongyu Shen, Wei Chen, Hanzi Xu, Xiu Chen, Dawei Sun, Shanliang Zhong, Jianhua Zhao & Jinhai Tang. (2017) Curcumin inhibits cancer progression through regulating expression of microRNAs. Tumor Biology 39:2, pages 101042831769168.
Crossref
Sung Hoon ChoiSang Woo LeeMinseon OkKyung Sik KimSungsik KimSang Hoon Ahn. (2017) Gene Expression Profiling of Hepatocellular Carcinoma Derived Cancer Stem Like Cell under Hypoxia. Yonsei Medical Journal 58:5, pages 925.
Crossref
X Zhang, X Liu, J Luo, W Xiao, X Ye, M Chen, Y Li & G-J Zhang. (2016) Notch3 inhibits epithelial–mesenchymal transition by activating Kibra-mediated Hippo/YAP signaling in breast cancer epithelial cells. Oncogenesis 5:11, pages e269-e269.
Crossref
Amancio Carnero & Matilde Lleonart. (2016) The hypoxic microenvironment: A determinant of cancer stem cell evolution. BioEssays 38, pages S65-S74.
Crossref
Bee Luan Khoo, Prashant Kumar, Chwee Teck Lim & Jean Paul Thiery. 2016. Circulating Tumor Cells. Circulating Tumor Cells 139 182 .
Thamil Selvee Ramasamy, Ain Zubaidah Ayob, Hsu Hsu Lynn Myint, Sharmanee Thiagarajah & Farahnaz Amini. (2015) Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy. Cancer Cell International 15:1.
Crossref
Aamir Ahmad, Kevin Ginnebaugh, Yiwei Li, Subhash Padhye & Fazlul Sarkar. (2015) Molecular Targets of Naturopathy in Cancer Research: Bridge to Modern Medicine. Nutrients 7:1, pages 321-334.
Crossref
M Orciani, S Davis, G Appolloni, R Lazzarini, M Mattioli-Belmonte, R A Ricciuti, M Boscaro, R Di Primio & G Arnaldi. (2014) Isolation and characterization of progenitor mesenchymal cells in human pituitary tumors. Cancer Gene Therapy 22:1, pages 9-16.
Crossref
Katayoon Pakravan, Mohammad Amin Mahjoub, Babak Jahangiri & Sadegh Babashah. 2015. Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology. Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology 3 11 .
Ling Gao, Yijin Yang, Haiyan Xu, Ruqian Liu, Dechun Li, Han Hong, Mingde Qin & Yunliang Wang. (2014) miR-335 functions as a tumor suppressor in pancreatic cancer by targeting OCT4. Tumor Biology 35:8, pages 8309-8318.
Crossref
Yanyan Li & Tao Zhang. (2014) Targeting cancer stem cells by curcumin and clinical applications. Cancer Letters 346:2, pages 197-205.
Crossref
Atif A. Ahmed, Hamid Zia & Lars Wagner. (2014) Therapy resistance mechanisms in Ewing’s sarcoma family tumors. Cancer Chemotherapy and Pharmacology 73:4, pages 657-663.
Crossref
Shihori Tanabe. (2014) Role of mesenchymal stem cells in cell life and their signaling. World Journal of Stem Cells 6:1, pages 24.
Crossref
Bin Bao, Asfar S. Azmi, Aamir Ahmad, Yiwei Li, Sanjeev Banerjee, Dejuan Kong, Shadan Ali & Fazlul H. Sarkar. 2014. MicroRNAs: Key Regulators of Oncogenesis. MicroRNAs: Key Regulators of Oncogenesis 295 320 .
Bin Bao, Aamir Ahmad, Asfar S. Azmi, Shadan Ali & Fazlul H. Sarkar. (2013) Overview of Cancer Stem Cells (CSCs) and Mechanisms of Their Regulation: Implications for Cancer Therapy. Current Protocols in Pharmacology 61:1.
Crossref
Aamir Ahmad. (2013) Pathways to Breast Cancer Recurrence. ISRN Oncology 2013, pages 1-16.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.