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Targeting paraoxonase-1 in atherosclerosis

, PhD & , PhD
Pages 829-837 | Published online: 10 Apr 2013

Keep up to date with the latest research on this topic with citation updates for this article.

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Arda Atar, Asuman Gedikbasi, Erkan Sonmezay, Zeynep Kusku Kiraz, Semra Abbasoglu, Ali Ihsan Tasci & Volkan Tugcu. (2016) Serum paraoxonase-1 gene polymorphism and enzyme activity in patients with urolithiasis. Renal Failure 38:3, pages 378-382.
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Chiara Cristina Bortolasci, Heber Odebrecht Vargas, André Souza-Nogueira, Estefania Gastaldello Moreira, Sandra Odebrecht Vargas Nunes, Michael Berk, Seetal Dodd, Décio Sabbatini Barbosa & Michael Maes. (2014) Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity. Redox Report 19:6, pages 232-241.
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Hassan Ahmadvand, Maryam Ghasemi Dehnoo, Akram Dehghani, Shahrokh Bagheri & Rooh Angiz Cheraghi. (2014) Serum paraoxonase 1 status and its association with atherogenic indexes in gentamicin-induced nephrotoxicity in rats treated with coenzyme Q10. Renal Failure 36:3, pages 413-418.
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Teresita Menini & Alejandro Gugliucci. (2014) Paraoxonase 1 in neurological disorders. Redox Report 19:2, pages 49-58.
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Articles from other publishers (38)

Vadim Z. Lankin, Alla K. Tikhaze, Valeria Y. Kosach & Galina G. Konovalova. (2023) Adsorption of Acylhydroperoxy-Derivatives of Phospholipids from Biomembranes by Blood Plasma Lipoproteins. Biochemistry (Moscow) 88:5, pages 698-703.
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Mustafa Oguzhan Kaya, Tuna Demirci, Oguzhan Ozdemir, Umit Calisir, Fatih Sonmez & Mustafa Arslan. (2023) Synthesis, inhibition effects, molecular docking and theoretical studies as Paraoxonase 1 (PON1) inhibitors of novel 1,4-dihydropyridine substituted sulfonamide derivatives. Medicinal Chemistry Research 32:5, pages 841-855.
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Jun Watanabe, Kazuhiko Kotani & Alejandro Gugliucci. (2023) Paraoxonase 1 and Chronic Kidney Disease: A Meta-Analysis. Journal of Clinical Medicine 12:3, pages 1199.
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Mohit Vijay Rojekar, Kaushalraj Sunil Dandegonker & Swati Ghanghurde. 2023. Acetylcholine - Recent Advances and New Perspectives [Working Title]. Acetylcholine - Recent Advances and New Perspectives [Working Title].
Richa Tyagi, Bhupesh Vaidya & Shyam Sunder Sharma. (2022) Crosstalk between neurological, cardiovascular, and lifestyle disorders: insulin and lipoproteins in the lead role. Pharmacological Reports 74:5, pages 790-817.
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Lin Zhang, Yu Pan, Yunfei Xu, Wenli Zhang, Wenjie Ma, Yassein M. Ibrahim, Gebremeskel Mamu Werid, He Zhang, Changyou Xia, Ping Wei, Hongyan Chen & Yue Wang. (2022) Paraoxonase-1 Facilitates PRRSV Replication by Interacting with Viral Nonstructural Protein-9 and Inhibiting Type I Interferon Pathway. Viruses 14:6, pages 1203.
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Björn Fagerberg & Lars Barregard. (2021) Review of cadmium exposure and smoking‐independent effects on atherosclerotic cardiovascular disease in the general population. Journal of Internal Medicine 290:6, pages 1153-1179.
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Pamela Munguía-Realpozo, Claudia Mendoza-Pinto, Mario García-Carrasco, Roberto Berra-Romani, Cristina Sierra-Benito, Socorro Méndez-Martínez & Ricard Cervera. (2021) The impact of antimalarial agents on traditional and non-traditional subclinical atherosclerosis biomarkers in systemic lupus erythematosus: A systematic review and meta-analysis. Autoimmunity Reviews 20:9, pages 102887.
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Kazuhiko Kotani, Jun Watanabe, Kouichi Miura & Alejandro Gugliucci. (2021) Paraoxonase 1 and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis. Molecules 26:8, pages 2323.
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Abdelouahed KhalilTamas FulopHicham Berrougui. (2021) Role of Paraoxonase1 in the Regulation of High-Density Lipoprotein Functionality and in Cardiovascular Protection. Antioxidants & Redox Signaling 34:3, pages 191-200.
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Júlia Carmona-Maurici, Elena Cuello, David Ricart-Jané, Antonio Miñarro, Jorge Juan Olsina Kissler, Juan Antonio Baena-Fustegueras, Julia Peinado-Onsurbe & Eva Pardina. (2020) Effect of bariatric surgery in the evolution of oxidative stress depending on the presence of atheroma in patients with morbid obesity. Surgery for Obesity and Related Diseases 16:9, pages 1258-1265.
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Omar M. E. Abdel-Salam, Amany A. Sleem, Marawan Abd El Baset Mohamed Sayed, Eman R. Youness & Nermeen Shaffie. (2020) Capsaicin Exerts Anti-convulsant and Neuroprotective Effects in Pentylenetetrazole-Induced Seizures. Neurochemical Research 45:5, pages 1045-1061.
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Omar M. E. Abdel-Salam, Amany A. Sleem, Marawan Abd El Baset Mohamed Sayed, Eman R. Youness & Nermeen Shaffie. (2019) Methylene blue protects against pentylenetetrazole-induced seizures, oxidative stress, and neuronal injury. Comparative Clinical Pathology 29:2, pages 341-354.
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Nevin Karakus, Fazilet Duygu, Umut Say Coskun, Ayfer Atay & Serbulent Yigit. (2020) Influence of PON1 gene polymorphisms (rs662 and rs854560) on the chronicity of HBV infection. Meta Gene 23, pages 100618.
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Hasseri Halim, Decha Pinkaew, Preedakorn Chunhacha, Patuma Sinthujaroen, Perumal Thiagarajan & Ken Fujise. (2019) Ticagrelor induces paraoxonase-1 (PON1) and better protects hypercholesterolemic mice against atherosclerosis compared to clopidogrel. PLOS ONE 14:6, pages e0218934.
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Nevin Karakus, Serbulent Yigit, Fazilet Duygu, Sener Barut, Aydin Rustemoglu & Nursah Basol. (2019) Effects of Paraoxonase-1 variants on course of severity and mortality of Crimean-Congo hemorrhagic fever. Gene 687, pages 188-192.
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Bharti Mackness & Mike Mackness. (2019) Unexpectedly higher diazoxon hydrolysis by serum paraoxonase-1 in coronary heart disease. Clinical Biochemistry 65, pages 21-23.
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Fátima E. Murillo González, Néstor Ponce-RuÍz, Aurora E. Rojas-GarcÍa, Yael Y. Bernal-Hernández, Mike Mackness, Jaime Ponce-Gallegos, Guillermo Cardoso-Saldaña, Esteban Jorge-Galarza, Margarita Torres-Tamayo & Irma Martha Medina-Díaz. (2019) PON1 concentration and high-density lipoprotein characteristics as cardiovascular biomarkers. Archives of Medical Science – Atherosclerotic Diseases 4:1, pages 47-54.
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Behrouz Baghaiee, Pouran Karimi, Khadije Ebrahimi, Saeed Dabagh Nikoo kheslat, Mohammad Hossein Sadeghi Zali, Amir Mohammad Daneshian Moghaddam & Mohammad Sadaghian. (2018) Effects of a 12-week aerobic exercise on markers of hypertension in men. Journal of Cardiovascular and Thoracic Research 10:3, pages 162-168.
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Vladimir Kuburovic, Jelena Vekic, Aleksandra Zeljkovic, Alain Carrie, Jelena Kotur-Stevuljevic, Dragana Bojanin, Jovan Kosutic, Vesna Spasojevic-Kalimanovska, Milica Miljkovic, Nina Kuburovic & Philippe Couvert. (2017) The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report. Clinical Biochemistry 50:18, pages 1323-1325.
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Ewa A. Ogłodek. (2017) The role of PON-1, GR, IL-18, and OxLDL in depression with and without posttraumatic stress disorder. Pharmacological Reports 69:5, pages 837-845.
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Renata Assis, Carlos Arcaro, Vânia Gutierres, Juliana Oliveira, Paulo Costa, Amanda Baviera & Iguatemy Brunetti. (2017) Combined Effects of Curcumin and Lycopene or Bixin in Yoghurt on Inhibition of LDL Oxidation and Increases in HDL and Paraoxonase Levels in Streptozotocin-Diabetic Rats. International Journal of Molecular Sciences 18:4, pages 332.
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Ulrich FörstermannNing XiaHuige Li. (2017) Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis. Circulation Research 120:4, pages 713-735.
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Bing Wang, Rui-Ning Yang, Yue-Rong Zhu, Ji-Cheng Xing, Xiao-Wei Lou, Yu-Jie He, Qi-Long Ding, Ming-Yue Zhang & Hong Qiu. (2017) Involvement of xanthine oxidase and paraoxonase 1 in the process of oxidative stress in nonalcoholic fatty liver disease. Molecular Medicine Reports 15:1, pages 387-395.
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Alejandro Gugliucci. 2017. The HDL Handbook. The HDL Handbook 187 208 .
Petri Kresanov, Tommi Vasankari, Markku Ahotupa, Jari Kaikkonen, Nina Hutri-Kähönen, Markus Juonala, Mika Kähönen, Terho Lehtimäki, Jorma Viikari & Olli T. Raitakari. (2015) Paraoxonase-1 and oxidized lipoprotein lipids. The Cardiovascular Risk in Young Finns Study. Atherosclerosis 241:2, pages 502-506.
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Srinivasa T. Reddy. 2015. Atherosclerosis. Atherosclerosis 257 265 .
Alejandro Gugliucci & Teresita Menini. (2015) Paraoxonase 1 and HDL maturation. Clinica Chimica Acta 439, pages 5-13.
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Tuba Esatbeyoglu, Anika E. Wagner, Rouhollah Motafakkerazad, Yu Nakajima, Seiichi Matsugo & Gerald Rimbach. (2014) Free radical scavenging and antioxidant activity of betanin: Electron spin resonance spectroscopy studies and studies in cultured cells. Food and Chemical Toxicology 73, pages 119-126.
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Huige Li, Sven Horke & Ulrich Förstermann. (2014) Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis 237:1, pages 208-219.
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Edit Bodolay, Zoltan Prohászka, Gyorgy Paragh, Istvan Csipő, Gabor Nagy, Renata Laczik, Nora Demeter, Eva Zöld, Britt Nakken, Gyula Szegedi & Peter Szodoray. (2014) Increased levels of anti-heat-shock protein 60 (anti-Hsp60) indicate endothelial dysfunction, atherosclerosis and cardiovascular diseases in patients with mixed connective tissue disease. Immunologic Research 60:1, pages 50-59.
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Glòria Lozano-Mena, Marta Sánchez-González, M. Juan & Joana Planas. (2014) Maslinic Acid, a Natural Phytoalexin-Type Triterpene from Olives — A Promising Nutraceutical?. Molecules 19:8, pages 11538-11559.
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Chiara Cristina Bortolasci, Heber Odebrecht Vargas, André Souza-Nogueira, Décio Sabbatini Barbosa, Estefania Gastaldello Moreira, Sandra Odebrecht Vargas Nunes, Michael Berk, Seetal Dodd & Michael Maes. (2014) Lowered plasma paraoxonase (PON)1 activity is a trait marker of major depression and PON1 Q192R gene polymorphism–smoking interactions differentially predict the odds of major depression and bipolar disorder. Journal of Affective Disorders 159, pages 23-30.
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Alejandro Gugliucci, Eriko Kinugasa, Hiroaki Ogata, Russell Caccavello & Satoshi Kimura. (2014) Activation of paraoxonase 1 after hemodialysis is associated with HDL remodeling and its increase in the HDL2 fraction and VLDL. Clinica Chimica Acta 430, pages 9-14.
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Sibel Taş, Emre Sarandöl & Melahat Dirican. (2014) Vitamin B6 Supplementation Improves Oxidative Stress and Enhances Serum Paraoxonase/Arylesterase Activities in Streptozotocin-Induced Diabetic Rats. The Scientific World Journal 2014, pages 1-7.
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Asokan Devarajan, Diana Shih & Srinivasa T. Reddy. 2014. Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics. Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics 33 41 .

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