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Expert Opinion on Therapeutic Targets Volume 19, 2015 - Issue 4
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Editorial

The potential of targeting Ras proteins in lung cancer

Frank McCormickUniversity of California, Helen Diller Family Comprehensive Cancer Center, 1450 3rd St, Box 0128, San Francisco, CA 94158-9001, [email protected]
, PhD
Pages 451-454 | Published online: 06 Jan 2015

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Sherry S. Agabiti, Yilan Liang & Andrew J. Wiemer. (2016) Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation. Molecular Membrane Biology 33:1-2, pages 1-11.
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Articles from other publishers (14)

Metehan Ilter, Ramazan Kasmer, Farzaneh Jalalypour, Canan Atilgan, Ozan Topcu, Nihal Karakas & Ozge Sensoy. (2022) Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS. eLife 11.
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Leiming Dong, Yuanhui Mao, Aidong ZhouXiao-Min Liu, Jun ZhouJi WanShu-Bing Qian. (2021) Relaxed initiation pausing of ribosomes drives oncogenic translation. Science Advances 7:8.
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Ki‐Young Lee, Zhenhao Fang, Masahiro Enomoto, Genevieve Gasmi‐Seabrook, Le Zheng, Shohei Koide, Mitsuhiko Ikura & Christopher B. Marshall. (2020) Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement. Angewandte Chemie International Edition 59:27, pages 11037-11045.
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Ki‐Young Lee, Zhenhao Fang, Masahiro Enomoto, Genevieve Gasmi‐Seabrook, Le Zheng, Shohei Koide, Mitsuhiko Ikura & Christopher B. Marshall. (2020) Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement. Angewandte Chemie 132:27, pages 11130-11138.
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Duan Ni, Xinyi Li, Xinheng He, Hao Zhang, Jian Zhang & Shaoyong Lu. (2019) Drugging K-RasG12C through covalent inhibitors: Mission possible?. Pharmacology & Therapeutics 202, pages 1-17.
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Jong Woo Lee, Yu Zhang, Kyung Jin Eoh, Roshan Sharma, Miguel F. Sanmamed, Jenny Wu, Justin Choi, Hee Sun Park, Akiko Iwasaki, Edward Kaftan, Lieping Chen, Vali Papadimitrakopoulou, Roy S. Herbst & Ja Seok Koo. (2019) The Combination of MEK Inhibitor With Immunomodulatory Antibodies Targeting Programmed Death 1 and Programmed Death Ligand 1 Results in Prolonged Survival in Kras/p53-Driven Lung Cancer. Journal of Thoracic Oncology 14:6, pages 1046-1060.
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Ruth Nussinov, Chung-Jung Tsai & Hyunbum Jang. (2019) Oncogenic KRas mobility in the membrane and signaling response. Seminars in Cancer Biology 54, pages 109-113.
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Naoya Saito, Naoki Mine, Donald W. Kufe, Daniel D. Von Hoff & Takumi Kawabe. (2017) CBP501 inhibits EGF-dependent cell migration, invasion and epithelial-to-mesenchymal transition of non-small cell lung cancer cells by blocking KRas to calmodulin binding. Oncotarget 8:43, pages 74006-74018.
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Liang Chen, Wei Bing Leng, De Zhi Li, Hong Wei Xia, Min Ren, Qiu Lin Tang, Qi Yong Gong, Fa Bao Gao & Feng Bi. (2017) Noninvasive Imaging of Ras Activity by Monomolecular Biosensor Based on Split-Luciferase Complementary Assay. Scientific Reports 7:1.
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Ana J. Narvaez, Suzan Ber, Alex Crooks, Amy Emery, Bryn Hardwick, Estrella Guarino Almeida, David J. Huggins, David Perera, Meredith Roberts-Thomson, Roberta Azzarelli, Fiona E. Hood, Ian A. Prior, David W. Walker, Richard Boyce, Robert G. Boyle, Samuel P. Barker, Christopher J. Torrance, Grahame J. McKenzie & Ashok R. Venkitaraman. (2017) Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS. Cell Chemical Biology 24:8, pages 1017-1028.e7.
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Haiwei MouJill MooreSunil K. MaloniaYingxiang LiDeniz M. OzataSoren HoughChun-Qing SongJordan L. SmithAndrew FischerZhiping WengMichael R. Green & Wen Xue. (2017) Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis. Proceedings of the National Academy of Sciences 114:14, pages 3648-3653.
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Shaoyong Lu, Hyunbum Jang, Serena Muratcioglu, Attila Gursoy, Ozlem Keskin, Ruth Nussinov & Jian Zhang. (2016) Ras Conformational Ensembles, Allostery, and Signaling. Chemical Reviews 116:11, pages 6607-6665.
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Matthias Drosten & Mariano Barbacid. (2015) Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets. Journal of Molecular Medicine 94:2, pages 121-135.
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Shaoyong Lu, Hyunbum Jang, Shuo Gu, Jian Zhang & Ruth Nussinov. (2016) Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view. Chemical Society Reviews 45:18, pages 4929-4952.
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