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Original Research

Acid-sensing ion channel 1a-mediated calcium influx regulates apoptosis of endplate chondrocytes in intervertebral discs

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Yingjun Guo, Yang Meng, Hao Liu, Beiyu Wang, Chen Ding, Xin Rong, Yi Yang & Ying Hong. (2019) Acid-sensing ion channels mediate the degeneration of intervertebral disc via various pathways—A systematic review. Channels 13:1, pages 367-373.
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Libo Jiang, Fenglai Yuan, Xiaofan Yin & Jian Dong. (2014) Responses and adaptations of intervertebral disc cells to microenvironmental stress: a possible central role of autophagy in the adaptive mechanism. Connective Tissue Research 55:5-6, pages 311-321.
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Articles from other publishers (57)

Zhangbin Luo, Ziyan Wei, Guangzhi Zhang, Haiwei Chen, Lei Li & Xuewen Kang. (2023) Achilles’ Heel—The Significance of Maintaining Microenvironmental Homeostasis in the Nucleus Pulposus for Intervertebral Discs. International Journal of Molecular Sciences 24:23, pages 16592.
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Zhenyu Zhang, Minnan Chen, Wenjing Zhan, Yuechun Chen, Tongtong Wang, Zhonghua Chen, Yifei Fu, Gang Zhao, Dong Mao, Jingjing Ruan & Feng-Lai Yuan. (2023) Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention. Cell Death Discovery 9:1.
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Rui Ran, Yi Wu & Hai-hong Zhang. (2023) Acid-sensing Ion Channels: Implications for Intervertebral Disc Degeneration. Current Pharmaceutical Biotechnology 24:11, pages 1343-1350.
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Xiaokun Zhao, Jinghong Yuan, Jingyu Jia, Jian Zhang, Jiahao Liu, Qi Chen, Tao Li, Zhiwen Wu, Hui Wu, Xinxin Miao, Tianlong Wu, Bin Li & Xigao Cheng. (2023) Role of non‑coding RNAs in cartilage endplate (Review). Experimental and Therapeutic Medicine 26:1.
Crossref
Ashish D. Diwan & James Melrose. (2022) Intervertebral disc degeneration and how it leads to low back pain. JOR SPINE 6:1.
Crossref
Ren-Peng Zhou, Hong-Yu Liang, Wei-Rong Hu, Jie Ding, Shu-Fang Li, Yong Chen, Ying-Jie Zhao, Chao Lu, Fei-Hu Chen & Wei Hu. (2023) Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases. Ageing Research Reviews 83, pages 101785.
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Zhuoyan Zai, Yayun Xu, Xuewen Qian, Zihan Li, Ziyao Ou, Tao Zhang, Longfei Wang, Yian Ling, Xiaoqing Peng, Yihao Zhang & Feihu Chen. (2022) Estrogen antagonizes ASIC1a-induced chondrocyte mitochondrial stress in rheumatoid arthritis. Journal of Translational Medicine 20:1.
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Jing Zhang, Wentao Zhang, Tianze Sun, Jinzuo Wang, Ying Li, Jing Liu & Zhonghai Li. (2022) The Influence of Intervertebral Disc Microenvironment on the Biological Behavior of Engrafted Mesenchymal Stem Cells. Stem Cells International 2022, pages 1-24.
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Clément Verkest, Miguel Salinas, Sylvie Diochot, Emmanuel Deval, Eric Lingueglia & Anne Baron. (2022) Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects. Toxins 14:10, pages 709.
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Jie Ding, Yong Chen, Ying-Jie Zhao, Fan Chen, Lei Dong, Hai-Lin Zhang, Wei-Rong Hu, Shu-Fang Li, Ren-Peng Zhou & Wei Hu. (2022) Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation. Biochemical Pharmacology 202, pages 115107.
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Jun-Jie Wu, Zi-Li Sun, Si-Yu Liu, Zhong-Hua Chen, Zheng-Dong Yuan, Ming-Li Zou, Ying-Ying Teng, Yue-Yue Li, Dan-Yang Guo & Feng-Lai Yuan. (2022) The ASIC3-M-CSF-M2 macrophage-positive feedback loop modulates fibroblast-to-myofibroblast differentiation in skin fibrosis pathogenesis. Cell Death & Disease 13:6.
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Maite Esquijarosa Hechavarria & Seidu A. Richard. (2022) Edifying the Focal Factors Influencing Mesenchymal Stem Cells by the Microenvironment of Intervertebral Disc Degeneration in Low Back Pain. Pain Research and Management 2022, pages 1-12.
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Andy Sivils, Felix Yang, John Q. Wang & Xiang-Ping Chu. (2022) Acid-Sensing Ion Channel 2: Function and Modulation. Membranes 12:2, pages 113.
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Jingjing Tao, Zheng Lu, Jingwen Su, Xuewen Qian, Yihao Zhang, Yayun Xu, Sujing Song, Xiaoyu Hang, Xiaoqing Peng & Feihu Chen. (2021) ASIC1a promotes the proliferation of synovial fibroblasts via the ERK/MAPK pathway. Laboratory Investigation 101:10, pages 1353-1362.
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Jing-Wen Su, Shu-Fang Li, Jing-Jing Tao, Ya-Yun Xu, Ke Wang, Xue-Wen Qian, Ge Deng, Xiao-Qing Peng & Fei-Hu Chen. (2021) Estrogen protects against acidosis-mediated articular chondrocyte injury by promoting ASIC1a protein degradation. European Journal of Pharmacology 908, pages 174381.
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Jingyu Ding, Renjie Zhang, Huimin Li, Qiang Ji, Xiaomin Cheng, Rick Francis Thorne, Hubert Hondermarck, Xiaoying Liu & Cailiang Shen. (2021) ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration. Aging 13:7, pages 10703-10723.
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Xuewen Qian, Yihao Zhang, Jingjing Tao, Ruowen Niu, Sujing Song, Cong Wang, Xiaoqing Peng & Feihu Chen. (2021) Acidosis induces synovial fibroblasts to release vascular endothelial growth factor via acid-sensitive ion channel 1a. Laboratory Investigation 101:3, pages 280-291.
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Yanbin Zhang, Yiqiang Hu, Wentian Wang, Zijun Guo, Fan Yang, Xianyi Cai & Liming Xiong. (2021) Current Progress in the Endogenous Repair of Intervertebral Disk Degeneration Based on Progenitor Cells. Frontiers in Bioengineering and Biotechnology 8.
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Kangcheng Zhao, Ran An, Qian Xiang, Gaocai Li, Kun Wang, Yu Song, Zhiwei Liao, Shuai Li, Wenbin Hua, Xiaobo Feng, Xinghuo Wu, Yukun Zhang, Abhirup Das & Cao Yang. (2020) Acid‐sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration. Cell Proliferation 54:1.
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Danni Li, Fenghua Tao & Lin Jin. (2020) Mitochondrial Dysfunction in Intervertebral Disc Degeneration: From Pathogenesis to Therapeutic Target. Oxidative Medicine and Cellular Longevity 2020, pages 1-13.
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Sheng‐Qin Zu, Yu‐Bin Feng, Chuan‐Jun Zhu, Xiao‐Shan Wu, Ren‐Peng Zhou, Ge Li, Bei‐Bei Dai, Zhi‐Sen Wang, Ya‐Ya Xie, Yue Li, Jin‐Fang Ge & Fei‐Hu Chen. (2020) Acid‐sensing ion channel 1a mediates acid‐induced pyroptosis through calpain‐2/calcineurin pathway in rat articular chondrocytes. Cell Biology International 44:10, pages 2140-2152.
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Niloofar FarhangLara SilvermanRobby D. Bowles. (2020) Improving Cell Therapy Survival and Anabolism in Harsh Musculoskeletal Disease Environments. Tissue Engineering Part B: Reviews 26:4, pages 348-366.
Crossref
Su-Jing Song, Jing-Jing Tao, Shu-Fang Li, Xue-Wen Qian, Ruo-Wen Niu, Cong Wang, Yi-Hao Zhang, Yong Chen, Ke Wang, Fei Zhu, Chuan-Jun Zhu, Gang-Gang Ma, Yang-Yang, Xiao-Qing Peng, Ren-Peng Zhou & Fei-Hu Chen. (2020) 17β-estradiol attenuates rat articular chondrocyte injury by targeting ASIC1a-mediated apoptosis. Molecular and Cellular Endocrinology 505, pages 110742.
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Feng Cai, Xin Hong, Xiang Tang, Nai-Cheng Liu, Feng Wang, Lei Zhu, Xin-Hui Xie, Zhi-Yang Xie & Xiao-Tao Wu. (2019) ASIC1a activation induces calcium-dependent apoptosis of BMSCs under conditions that mimic the acidic microenvironment of the degenerated intervertebral disc. Bioscience Reports 39:11.
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Gianluca Vadalà, Luca Ambrosio, Fabrizio Russo, Rocco Papalia & Vincenzo Denaro. (2019) Interaction between Mesenchymal Stem Cells and Intervertebral Disc Microenvironment: From Cell Therapy to Tissue Engineering. Stem Cells International 2019, pages 1-15.
Crossref
Ching-Yu Lee, Tsung-Jen Huang, Meng-Huang Wu, Yen-Yao Li & Kuan-Der Lee. (2019) High Expression of Acid-Sensing Ion Channel 2 (ASIC2) in Bone Cells in Osteoporotic Vertebral Fractures. BioMed Research International 2019, pages 1-10.
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Feng‐Lai Yuan, Rui‐Sheng Xu, Jun‐Xing Ye, Ming‐Dong Zhao, Li‐Jun Ren & Xia Li. (2019) Apoptotic bodies from endplate chondrocytes enhance the oxidative stress‐induced mineralization by regulating PPi metabolism. Journal of Cellular and Molecular Medicine 23:5, pages 3665-3675.
Crossref
Nana Song, Zhihui Lu, Jian Zhang, Yiqin Shi, Yichun Ning, Jing Chen, Shi Jin, Bo Shen, Yi Fang, Jianzhou Zou, Jie Teng, Xiang-Ping Chu, Linlin Shen & Xiaoqiang Ding. (2019) Acid‐sensing ion channel 1a is involved in ischaemia/reperfusion induced kidney injury by increasing renal epithelia cell apoptosis. Journal of Cellular and Molecular Medicine 23:5, pages 3429-3440.
Crossref
A. Asmar, I. Semenov, R. KellyJrJr & M. Stacey. (2019) Abnormal response of costal chondrocytes to acidosis in patients with chest wall deformity. Experimental and Molecular Pathology 106, pages 27-33.
Crossref
Enrique Soto, Audrey Ortega-Ramírez & Rosario Vega. (2018) Protons as Messengers of Intercellular Communication in the Nervous System. Frontiers in Cellular Neuroscience 12.
Crossref
Yong Chen, Chuan-Jun Zhu, Fei Zhu, Bei-Bei Dai, Su-Jing Song, Zhi-Qiang Wang, Yu-Bin Feng, Jin-Fang Ge, Ren-Peng Zhou & Fei-Hu Chen. (2018) Necrostatin-1 ameliorates adjuvant arthritis rat articular chondrocyte injury via inhibiting ASIC1a-mediated necroptosis. Biochemical and Biophysical Research Communications 504:4, pages 843-850.
Crossref
Hisao Yamamura, Yoshiaki Suzuki & Yuji Imaizumi. (2018) Physiological and Pathological Functions of Cl<sup>−</sup> Channels in Chondrocytes. Biological and Pharmaceutical Bulletin 41:8, pages 1145-1151.
Crossref
Hua Zhou, Zhi Sen Wang, Xin Hua Liu & Fei Hu Chen. (2018) Novel amidrazone derivatives: Design, synthesis and activity evaluation. Bioorganic & Medicinal Chemistry 26:12, pages 3158-3165.
Crossref
Ya-Ya Xie, Yue Li, Ren-peng Zhou, Bei-Bei Dai, Yue-jiao Qian, Xiao-shan Wu, Jin-fang Ge, Wei Hu & Fei-hu Chen. (2017) Effects of autophagy on acid-sensing ion channel 1a-mediated apoptosis in rat articular chondrocytes. Molecular and Cellular Biochemistry 443:1-2, pages 181-191.
Crossref
Ponarulselvam Sekar, Duen-Yi Huang, Shwu-Fen Chang & Wan-Wan Lin. (2018) Coordinate effects of P2X7 and extracellular acidification in microglial cells. Oncotarget 9:16, pages 12718-12731.
Crossref
Zhi-Yang XieLu ChenCong ZhangLei LiuFeng WangFeng CaiXiao-Hu WangRui ShiArjun SinkemaniHao-Min YuXin HongXiao-Tao Wu. (2018) Acid-Sensing Ion Channel 1a Regulates Fate of Rat Nucleus Pulposus Cells in Acid Stimulus Through Endoplasmic Reticulum Stress. BioResearch Open Access 7:1, pages 2-9.
Crossref
Ren-Peng Zhou, Wen-Lin Ni, Bei-Bei Dai, Xiao-Shan Wu, Zhi-Sen Wang, Ya-Ya Xie, Zhi-Qiang Wang, Wei-Jie Yang, Jin-Fang Ge, Wei Hu & Fei-Hu Chen. (2018) ASIC2a overexpression enhances the protective effect of PcTx1 and APETx2 against acidosis-induced articular chondrocyte apoptosis and cytotoxicity. Gene 642, pages 230-240.
Crossref
Ren-Peng Zhou, Bei-Bei Dai, Ya-Ya Xie, Xiao-Shan Wu, Zhi-Sen Wang, Yue Li, Zhi-Qiang Wang, Sheng-Qin Zu, Jin-Fang Ge & Fei-Hu Chen. (2018) Interleukin-1β and tumor necrosis factor-α augment acidosis-induced rat articular chondrocyte apoptosis via nuclear factor-kappaB-dependent upregulation of ASIC1a channel. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:1, pages 162-177.
Crossref
Beibei Dai, Fei Zhu, Yong Chen, Renpeng Zhou, Zhisen Wang, Yaya Xie, Xiaoshan Wu, Shengqin Zu, Ge Li, Jinfang Ge & Feihu Chen. (2017) ASIC1a Promotes Acid-Induced Autophagy in Rat Articular Chondrocytes through the AMPK/FoxO3a Pathway. International Journal of Molecular Sciences 18:10, pages 2125.
Crossref
X. Li, J.-X. Ye, M.-H. Xu, M.-D. Zhao & F.-L. Yuan. (2017) Evidence that activation of ASIC1a by acidosis increases osteoclast migration and adhesion by modulating integrin/Pyk2/Src signaling pathway. Osteoporosis International 28:7, pages 2221-2231.
Crossref
Jianjun LiuHui TaoHanbang WangFulong DongRenjie ZhangJie LiPeng GePeiwen SongHuaqing ZhangPeng XuXiaoying LiuCailiang Shen. (2017) Biological Behavior of Human Nucleus Pulposus Mesenchymal Stem Cells in Response to Changes in the Acidic Environment During Intervertebral Disc Degeneration. Stem Cells and Development 26:12, pages 901-911.
Crossref
Pu Wang & Zhan-You Wang. (2017) Metal ions influx is a double edged sword for the pathogenesis of Alzheimer’s disease. Ageing Research Reviews 35, pages 265-290.
Crossref
Audrey Ortega-Ramírez, Rosario Vega & Enrique Soto. (2017) Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation. Mediators of Inflammation 2017, pages 1-18.
Crossref
Shijing Jia & Kevin K. Kim. 2017. Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease. Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease 103 131 .
Xiang-Tao Zheng, Zi-Heng Wu, Ye Wei, Ju-Ji Dai, Guan-Feng Yu, FengLai Yuan & Le-Chi Ye. (2016) Induction of autophagy by salidroside through the AMPK-mTOR pathway protects vascular endothelial cells from oxidative stress-induced apoptosis. Molecular and Cellular Biochemistry 425:1-2, pages 125-138.
Crossref
M. Zhu, S. Zhou, Z. Huang, J. Wen & H. Li. (2016) Ca 2+ -Dependent Endoplasmic Reticulum Stress Regulates Mechanical Stress?Mediated Cartilage Thinning . Journal of Dental Research 95:8, pages 889-896.
Crossref
Feng-Lai Yuan, Ming-Hui Xu, Xia Li, He Xinlong, Wei Fang & Jian Dong. (2016) The Roles of Acidosis in Osteoclast Biology. Frontiers in Physiology 7.
Crossref
Wenxiang Xiong, Yaru Liang, Xue Li, Guosong Liu & Zhao Wang. (2016) Erythrocyte intracellular Mg2+ concentration as an index of recognition and memory. Scientific Reports 6:1.
Crossref
FAN ZHANG, XUELING ZHAO, HONGXING SHEN & CAIGUO ZHANG. (2016) Molecular mechanisms of cell death in intervertebral disc degeneration (Review). International Journal of Molecular Medicine 37:6, pages 1439-1448.
Crossref
Yuepeng Jin, Yongyu Bai, Haizhen Ni, Li Qiang, Lechi Ye, Yunfeng Shan & Mengtao Zhou. (2016) Activation of autophagy through calcium‐dependent AMPK / mTOR and PKC θ pathway causes activation of rat hepatic stellate cells under hypoxic stress . FEBS Letters 590:5, pages 672-682.
Crossref
Ren-Peng Zhou, Xiao-Shan Wu, Zhi-Sen Wang, Ya-Ya Xie, Jin-Fang Ge & Fei-Hu Chen. (2016) Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative Diseases. Aging and disease 7:4, pages 491.
Crossref
Feng-Lai Yuan, Ming-Dong Zhao, Dong-Lin Jiang, Cheng Jin, Hai-Fei Liu, Ming-Hui Xu, Wei Hu & Xia Li. (2015) Involvement of acid-sensing ion channel 1a in matrix metabolism of endplate chondrocytes under extracellular acidic conditions through NF-κB transcriptional activity. Cell Stress and Chaperones 21:1, pages 97-104.
Crossref
Renpeng Zhou, Xiaoshan Wu, Zhisen Wang, Jinfang Ge & Feihu Chen. (2015) Interleukin-6 enhances acid-induced apoptosis via upregulating acid-sensing ion channel 1a expression and function in rat articular chondrocytes. International Immunopharmacology 29:2, pages 748-760.
Crossref
Feng WangRui ShiFeng CaiYun-Tao WangXiao-Tao Wu. (2015) Stem Cell Approaches to Intervertebral Disc Regeneration: Obstacles from the Disc Microenvironment. Stem Cells and Development 24:21, pages 2479-2495.
Crossref
Junga Lee, Mikyung Lee, Sunghyun Hong, Ji Young Kim, Hyuna Park, Minsuk Oh, Hyuk In Yang, Dong-woo Kang, Jihye Park, Dong-Il Kim, Sanghee Chu, Jiwon Lee, Hyuk Hur, Nam Kyu Kim & Justin Y. Jeon. (2015) Association between physical fitness, quality of life, and depression in stage II–III colorectal cancer survivors. Supportive Care in Cancer 23:9, pages 2569-2577.
Crossref
Anne Baron & Eric Lingueglia. (2015) Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives. Neuropharmacology 94, pages 19-35.
Crossref
Feng-Lai Yuan, Ming-Dong Zhao, Li-Bo Jiang, Hui-Ren Wang, Lu Cao, Xiao-Gang Zhou, Xi-Lei Li & Jian Dong. (2014) Molecular Actions of Ovarian Cancer G Protein-Coupled Receptor 1 Caused by Extracellular Acidification in Bone. International Journal of Molecular Sciences 15:12, pages 22365-22373.
Crossref

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