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Editorial

Gastrointestinal safety of paracetamol: is there any cause for concern?

Pages 269-272 | Published online: 23 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Anna Marinopoulou, Vassilis Karageorgiou, Dimitris Petridis & Stylianos N. Raphaelides. (2021) Physical properties of starch-paracetamol molecular inclusion complexes produced by the spray drying process on an industrial scale. Drying Technology 39:12, pages 1950-1967.
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Nicholas Moore & James M Scheiman. (2018) Gastrointestinal safety and tolerability of oral non-aspirin over-the-counter analgesics. Postgraduate Medicine 130:2, pages 188-199.
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Vittorio Iorno, Laura Landi, Raffaella Di Pasquale, Stefano Cicenia & Vincenzo Moschini. (2013) Comparison of intravenous ketorolac with or without paracetamol in postoperative pain control following ambulatory surgery. Current Medical Research and Opinion 29:12, pages 1685-1690.
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Articles from other publishers (16)

Saleh Y Alabbas, Rabina Giri, Iulia Oancea, Julie Davies, Veronika Schreibner, Timothy H Florin & Jakob Begun. (2023) Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. Journal of Gastroenterology and Hepatology 38:4, pages 609-618.
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Nikhil Bangale, Suhas Erande, K Shyam Sundar & Ahmed Mohiuddin. (2023) Deciphering optimal management options for headache. IP Indian Journal of Neurosciences 8:4, pages 234-237.
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Hosny Abd El Fadil, Amany Behairy, Lamiaa L. M. Ebraheim, Yasmina M. Abd-Elhakim & Heba Hussein Fathy. (2023) The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats. Environmental Science and Pollution Research 30:14, pages 41682-41699.
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Junguo Zhou, Sandra De Jonghe, Ellen E. Codd, Sandy Weiner, David Gallacher, Paul Stahle, Michael F. Kelley, Edwin K. Kuffner, Christopher M. Flores & Gary E. Eichenbaum. (2023) Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses. Regulatory Toxicology and Pharmacology, pages 105334.
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Thi Ngoc Mai Nguyen, Sha Sha, Li‐Ju Chen, Bernd Holleczek, Hermann Brenner & Ben Schöttker. (2022) Strongly increased risk of gastric and duodenal ulcers among new users of low‐dose aspirin: results from two large cohorts with new‐user design. Alimentary Pharmacology & Therapeutics 56:2, pages 251-262.
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Iwona Popiolek & Grzegorz Porebski. 2022. Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics. Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics 309 317 .
Joseph Tsemeugne, Pamela Kemda Nangmo, Pierre Mkounga, Jean De Dieu Tamokou, Iréne Chinda Kengne, Giles Edwards, Emmanuel Fondjo Sopbué & Augustin Ephrem Nkengfack. (2021) Synthesis, characteristic fragmentation patterns, and antibacterial activity of new azo compounds from the coupling reaction of diazobenzothiazole ions and acetaminophen. Heterocyclic Communications 27:1, pages 79-89.
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Grzegorz W. Przybyła, Konrad A. Szychowski & Jan Gmiński. (2020) Paracetamol – An old drug with new mechanisms of action. Clinical and Experimental Pharmacology and Physiology 48:1, pages 3-19.
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Razia Abdool Gafaar Khammissa, Raoul Ballyram, Jeanine Fourie, Michael Bouckaert, Johan Lemmer & Liviu Feller. (2020) Selected pathobiological features and principles of pharmacological pain management. Journal of International Medical Research 48:5, pages 030006052090365.
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Yoichi Ishitsuka, Yuki Kondo & Daisuke Kadowaki. (2020) Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug?. Biological and Pharmaceutical Bulletin 43:2, pages 195-206.
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Guillermo Prada-Ramallal, Bahi Takkouche & Adolfo Figueiras. (2019) Bias in pharmacoepidemiologic studies using secondary health care databases: a scoping review. BMC Medical Research Methodology 19:1.
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Rania El-Shaheny, Takeshi Fuchigami, Sakura Yoshida, Mohamed O. Radwan & Morio Nakayama. (2019) Complementary HPLC, in silico toxicity, and molecular docking studies for investigation of the potential influences of gastric acidity and nitrite content on paracetamol safety. Microchemical Journal 150, pages 104107.
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J. C. McCrae, E. E. Morrison, I. M. MacIntyre, J. W. Dear & D. J. Webb. (2018) Long-term adverse effects of paracetamol - a review. British Journal of Clinical Pharmacology 84:10, pages 2218-2230.
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Erlangga Yusuf. (2016) Pharmacologic and Non-Pharmacologic Treatment of Osteoarthritis. Current Treatment Options in Rheumatology 2:2, pages 111-125.
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Burkhard Hinz, Olga Cheremina & Kay Brune. (2007) Acetaminophen (paracetamol) is a selective cyclooxygenase‐2 inhibitor in man. The FASEB Journal 22:2, pages 383-390.
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C. Jane Nikles, Michael Yelland, Chris Del Mar & David Wilkinson. (2005) The Role of Paracetamol in Chronic Pain: An Evidence-Based Approach. American Journal of Therapeutics 12:1, pages 80-91.
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