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Review

Role of efflux pumps and metabolising enzymes in drug delivery

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Pages 683-705 | Published online: 11 Aug 2005

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Kishore CholkarHoang M. TrinhAswani Dutt VadlapudiZhiying WangDhananjay PalAshim K. Mitra. (2015) Interaction Studies of Resolvin E1 Analog (RX-10045) with Efflux Transporters. Journal of Ocular Pharmacology and Therapeutics 31:4, pages 248-255.
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Shasha Rao, Angel Tan, Nicky Thomas & Clive A. Prestidge. (2014) Perspective and potential of oral lipid-based delivery to optimize pharmacological therapies against cardiovascular diseases. Journal of Controlled Release 193, pages 174-187.
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Ka Yaw Teo & Bumsoo Han. (2009) Freezing-Assisted Intracellular Drug Delivery to Multidrug Resistant Cancer Cells. Journal of Biomechanical Engineering 131:7.
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Sudharshan Hariharan, Sriram Gunda, Gyan P. Mishra, Dhananjay Pal & Ashim K. Mitra. (2008) Enhanced Corneal Absorption of Erythromycin by Modulating P-Glycoprotein and MRP Mediated Efflux with Corticosteroids. Pharmaceutical Research 26:5, pages 1270-1282.
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Christian Wischke & Steven P. Schwendeman. (2008) Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles. International Journal of Pharmaceutics 364:2, pages 298-327.
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L. Brown, O. Heyneke, D. Brown, J.P.H. van Wyk & J.H. Hamman. (2008) Impact of traditional medicinal plant extracts on antiretroviral drug absorption. Journal of Ethnopharmacology 119:3, pages 588-592.
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Ritesh Jain, Sheetal Agarwal, Nanda Kishore Mandava, Ye Sheng & Ashim K. Mitra. (2008) Interaction of dipeptide prodrugs of saquinavir with multidrug resistance protein-2 (MRP-2): Evasion of MRP-2 mediated efflux. International Journal of Pharmaceutics 362:1-2, pages 44-51.
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Ales Prokop & Jeffrey M. Davidson. (2008) Nanovehicular Intracellular Delivery Systems. Journal of Pharmaceutical Sciences 97:9, pages 3518-3590.
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Yaron Hassid, Erez Eyal, Raanan Margalit, Edna Furman-Haran & Hadassa Degani. (2008) Non-invasive imaging of barriers to drug delivery in tumors. Microvascular Research 76:2, pages 94-103.
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Jarkko Rautio, Hanna Kumpulainen, Tycho Heimbach, Reza Oliyai, Dooman Oh, Tomi Järvinen & Jouko Savolainen. (2008) Prodrugs: design and clinical applications. Nature Reviews Drug Discovery 7:3, pages 255-270.
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Sandrine Lemaire, Françoise Van Bambeke, Marie-Paule Mingeot-Leclercq & Paul M. Tulkens. (2007) Modulation of the Cellular Accumulation and Intracellular Activity of Daptomycin towards Phagocytized Staphylococcus aureus by the P-Glycoprotein (MDR1) Efflux Transporter in Human THP-1 Macrophages and Madin-Darby Canine Kidney Cells . Antimicrobial Agents and Chemotherapy 51:8, pages 2748-2757.
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Sheetal Agarwal, Dhananjay Pal & Ashim K. Mitra. (2007) Both P-gp and MRP2 mediate transport of Lopinavir, a protease inhibitor. International Journal of Pharmaceutics 339:1-2, pages 139-147.
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J.H. HammanP.H. DemanaE.I. Olivier. (2017) Targeting Receptors, Transporters and Site of Absorption to Improve Oral Drug Delivery. Drug Target Insights 2, pages 117739280700200.
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O Ammerpohl, A Trauzold, B Schniewind, U Griep, C Pilarsky, R Grutzmann, H-D Saeger, O Janssen, B Sipos, G Kloppel & H Kalthoff. (2006) Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells. British Journal of Cancer 96:1, pages 73-81.
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Lawrence S. Lee, Adriana S. A. Andrade & Charles Flexner. (2006) HIV/AIDS: Interactions between Natural Health Products and Antiretroviral Drugs: Pharmacokinetic and Pharmacodynamic Effects. Clinical Infectious Diseases 43:8, pages 1052-1059.
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Dhananjay Pal & Ashim K. Mitra. (2006) MDR- and CYP3A4-Mediated Drug–Drug Interactions. Journal of Neuroimmune Pharmacology 1:3, pages 323-339.
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