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Expert Opinion on Drug Delivery Volume 11, 2014 - Issue 2
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Properties, characteristics and applications of microbubbles for sonothrombolysis

Marie de Saint VictorUniversity of Oxford, Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, Oxford OX3 7DQ, UK+44(0)1865 617 747; [email protected]
,
Calum CrakeUniversity of Oxford, Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, Oxford OX3 7DQ, UK+44(0)1865 617 747; [email protected]
,
Constantin-C CoussiosUniversity of Oxford, Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, Oxford OX3 7DQ, UK+44(0)1865 617 747; [email protected]
&
Eleanor StrideUniversity of Oxford, Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, Oxford OX3 7DQ, UK+44(0)1865 617 747; [email protected]
Pages 187-209 | Published online: 09 Jan 2014

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Ni Fang, Jia Liu, Jingxin Hou, Yixin Zhong, Ying Luo, Liu Hu, Wenli Zhang, Junrui Wang, Jie Xu, Jun Zhou, Yu Zhang, Haitao Ran & Dajing Guo. (2022) Magnet-Guided Bionic System with LIFU Responsiveness and Natural Thrombus Tropism for Enhanced Thrombus-Targeting Ability. International Journal of Nanomedicine 17, pages 2019-2039.
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Hongyin Ma, Zhenmin Jiang, Jiayun Xu, Junqiu Liu & Zhen-Ni Guo. (2021) Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke. Drug Delivery 28:1, pages 357-371.
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Shan Liu, Xiaozhou Feng, Rong Jin & Guohong Li. (2018) Tissue plasminogen activator-based nanothrombolysis for ischemic stroke. Expert Opinion on Drug Delivery 15:2, pages 173-184.
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Xiangyang Xie, Wen Lin, Hui Liu, Jianping Deng, Ying Chen, Hong Liu, Xudong Fu & Yang Yang. (2016) Ultrasound-responsive nanobubbles contained with peptide–camptothecin conjugates for targeted drug delivery. Drug Delivery 23:8, pages 2756-2764.
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Wen Lin, Xiangyang Xie, Jianping Deng, Hui Liu, Ying Chen, Xudong Fu, Hong Liu & Yang Yang. (2016) Cell-penetrating peptide-doxorubicin conjugate loaded NGR-modified nanobubbles for ultrasound triggered drug delivery. Journal of Drug Targeting 24:2, pages 134-146.
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Roman A. Barmin, MirJavad Moosavifar, Anshuman Dasgupta, Andreas Herrmann, Fabian Kiessling, Roger M. Pallares & Twan Lammers. (2023) Polymeric materials for ultrasound imaging and therapy. Chemical Science 14:43, pages 11941-11954.
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Xinkang Hu, Bo Zhang, Chundu Wu, Xiaohong Xu, Mingming Xue & Xiaoyong Zheng. (2023) Numerical Simulation and Structural Optimization of Swirl Flow Micro-Nano Bubble Generator. Coatings 13:8, pages 1468.
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Jiang Li, Yuan Zhang, Chenghong Zou, Yuexin Chen, Yongjian Li & Haosheng Chen. (2022) Binding properties of flowing fibrin-targeted microbubbles evaluated with a thrombus-embedded microchannel. Lab on a Chip 22:12, pages 2292-2298.
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Xin-Bin Nie, Yong Wang, Xiong Ran, Ji-Chuan Wu, Ran Wei & Wei-Cheng Yan. (2022) Preparation of Nanoparticle-Loaded Microbubbles via an Electrohydrodynamic Atomization Process. Applied Sciences 12:7, pages 3621.
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Farheen Fatima Qizilbash, Muhammad Usama Ashhar, Ameeduzzafar Zafar, Zufika Qamar, Annu, Javed Ali, Sanjula Baboota, Mohammed M. Ghoneim, Sultan Alshehri & Asgar Ali. (2022) Thymoquinone-Enriched Naringenin-Loaded Nanostructured Lipid Carrier for Brain Delivery via Nasal Route: In Vitro Prospect and In Vivo Therapeutic Efficacy for the Treatment of Depression. Pharmaceutics 14:3, pages 656.
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Zenghui Liang, Huafang Chen, Xuehao Gong, Binbin Shi, Lili Lin, Fangyi Tao, Qilong Wu, Mingling Fang, Hui Li, Cuitao Lu, Helin Xu, Yingzheng Zhao & Bin Chen. (2022) Ultrasound-Induced Destruction of Nitric Oxide–Loaded Microbubbles in the Treatment of Thrombus and Ischemia–Reperfusion Injury. Frontiers in Pharmacology 12.
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Wenxiong Cao, Yuan Liu, Pan Ran, Jie He, Shuang Xie, Jie Weng & Xiaohong Li. (2021) Ultrasound-Propelled Janus Rod-Shaped Micromotors for Site-Specific Sonodynamic Thrombolysis. ACS Applied Materials & Interfaces 13:49, pages 58411-58421.
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Asma Akbar, Nagavalli Pillalamarri, Sriya Jonnakuti & Mujib Ullah. (2021) Artificial intelligence and guidance of medicine in the bubble. Cell & Bioscience 11:1.
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Ping Wei, Erik Jan Cornel & Jianzhong Du. (2021) Ultrasound-responsive polymer-based drug delivery systems. Drug Delivery and Translational Research 11:4, pages 1323-1339.
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Ali Jangjou, Amir Hossein Meisami, Kazem Jamali, Mohammad Hadi Niakan, Milad Abbasi, Mostafa Shafiee, Majid Salehi, Ahmad Hosseinzadeh, Ali Mohammad Amani & Ahmad Vaez. (2021) The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication. Journal of Biomedical Science 28:1.
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Shuting Ren, Ruoyan Si, Pengfei Sun, Tieqiao Wu, Aozhi Dai, Lina Chen, Wenbao Zhao, Tuo Han, Xin Zhang & Zhonglin Chai. (2021) Ultrasound combined with microbubbles enhances the renoprotective effects of methylprednisolone in rats with adriamycin-induced nephropathy. European Journal of Pharmaceutical Sciences 159, pages 105714.
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Xuemei Gao, Dajing Guo, Xiang Mao, Xuefeng Shan, Xuemei He & Chaoqun Yu. (2021) Perfluoropentane-filled chitosan poly-acrylic acid nanobubbles with high stability for long-term ultrasound imaging in vivo . Nanoscale 13:10, pages 5333-5343.
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Jiayuan Zhong, Yili Sun, Yuan Han, Xiaoqiang Chen, Hairui Li, Yusheng Ma, Yanxian Lai, Guoquan Wei, Xiang He, Mengsha Li, Wangjun Liao, Yulin Liao, Shiping Cao & Jianping Bin. (2021) Hydrogen sulfide‐loaded microbubbles combined with ultrasound mediate thrombolysis and simultaneously mitigate ischemia‐reperfusion injury in a rat hindlimb model. Journal of Thrombosis and Haemostasis 19:3, pages 738-752.
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Robert T. Kleven, Kunal B. Karani, Nicole Hilvert, Samantha M. Ford, Karla P. Mercado-Shekhar, John M. Racadio, Marepalli B. Rao, Todd A. Abruzzo & Christy K. Holland. (2021) Accelerated sonothrombolysis with Definity in a xenographic porcine cerebral thromboembolism model. Scientific Reports 11:1.
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Hui-Min Shi, Jing Hu, Cheng-Hui Wang, Fei-Long Feng & Run-Yang Mo. (2021) Vibrational behavior of coated microbubble in finite tube under magneto-acoustic composite field. Acta Physica Sinica 70:21, pages 214303.
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Jovana Janjic, Malin K Larsson & Anna Bjällmark. (2020) In-vitro sonothrombolysis using thick-shelled polymer microbubbles - a comparison with thin-shelled microbubbles. Cardiovascular Ultrasound 18:1.
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James H. Bezer, Hasan Koruk, Christopher J. Rowlands & James J. Choi. (2020) Elastic Deformation of Soft Tissue-Mimicking Materials Using a Single Microbubble and Acoustic Radiation Force. Ultrasound in Medicine & Biology 46:12, pages 3327-3338.
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Ruchira Raychaudhuri, Santoshi Naik, Ajjappla B. Shreya, Neha Kandpal, Abhijeet Pandey, Guruprasad Kalthur & Srinivas Mutalik. (2020) Pullulan based stimuli responsive and sub cellular targeted nanoplatforms for biomedical application: Synthesis, nanoformulations and toxicological perspective. International Journal of Biological Macromolecules 161, pages 1189-1205.
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Christopher D. Malone, David T. Fetzer, Wayne L. Monsky, Malak Itani, Vincent M. Mellnick, Philip A. Velez, William D. Middleton, Michalakis A. Averkiou & Raja S. Ramaswamy. (2020) Contrast-enhanced US for the Interventional Radiologist: Current and Emerging Applications. RadioGraphics 40:2, pages 562-588.
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Siyuan Zhang, Tianqi Xu, Zhiwei Cui, Wen Shi, Shan Wu, Yujin Zong, Gang Niu, Xijing He & Mingxi Wan. (2019) Time and Frequency Characteristics of Cavitation Activity Enhanced by Flowing Phase-Shift Nanodroplets and Lipid-Shelled Microbubbles During Focused Ultrasound Exposures. Ultrasound in Medicine & Biology 45:8, pages 2118-2132.
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Ting Huang, Ni Li & Jianqing Gao. (2019) Recent strategies on targeted delivery of thrombolytics. Asian Journal of Pharmaceutical Sciences 14:3, pages 233-247.
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Zhouqing Chen, Tao Xue, Huachen Huang, Jiayi Xu, Sandhya Shankar, Hao Yu & Zhong Wang. (2019) Efficacy and safety of sonothombolysis versus non-sonothombolysis in patients with acute ischemic stroke: A meta-analysis of randomized controlled trials. PLOS ONE 14:1, pages e0210516.
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Peng-Fei Sun, Tian Tian, Li-Na Chen, Rong-Guo Fu, Shan-Shan Xu, Hong Ai, Bing Wang, Jian Zhang, Ruo-Yan Si, Zhonglin Chai, Mark E. Cooper & Shu-Ting Ren. (2018) Ultrasound Combined with Microbubbles Enhances the Effects of Methylprednisolone in Lipopolysaccharide-Induced Human Mesangial Cells. Journal of Pharmacology and Experimental Therapeutics 365:3, pages 476-484.
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