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Review

The influence of long-term treatment with psychotropic drugs on cytochrome P450: the involvement of different mechanisms

Pages 203-217 | Published online: 16 Aug 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Ewa Bromek & Władysława Anna Daniel. (2021) The regulation of liver cytochrome P450 expression and activity by the brain serotonergic system in different experimental models. Expert Opinion on Drug Metabolism & Toxicology 17:4, pages 413-424.
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Wojciech Kuban & Władysława Anna Daniel. (2021) Cytochrome P450 expression and regulation in the brain. Drug Metabolism Reviews 53:1, pages 1-29.
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Steven L Dubovsky. (2015) The usefulness of genotyping cytochrome P450 enzymes in the treatment of depression. Expert Opinion on Drug Metabolism & Toxicology 11:3, pages 369-379.
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Jacek Wójcikowski & Władysława Anna Daniel. (2009) The brain dopaminergic system as an important center regulating liver cytochrome P450 in the rat. Expert Opinion on Drug Metabolism & Toxicology 5:6, pages 631-645.
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Articles from other publishers (30)

Joanna Jastrzębska & Władysława Anna Daniel. (2023) Cocaine-Induced Time-Dependent Alterations in Cytochrome P450 and Liver Function. International Journal of Molecular Sciences 24:2, pages 1632.
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Władysława A. Daniel, Ewa Bromek, Przemysław J. Danek & Anna Haduch. (2022) The mechanisms of interactions of psychotropic drugs with liver and brain cytochrome P450 and their significance for drug effect and drug-drug interactions. Biochemical Pharmacology 199, pages 115006.
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Przemysław J. Danek, Ewa Bromek, Anna Haduch & Władysława A. Daniel. (2021) Chronic treatment with asenapine affects cytochrome P450 2D (CYP2D) in rat brain and liver. Pharmacological aspects. Neurochemistry International 151, pages 105209.
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Karlijn Pellikaan, Yassine Ben Brahim, Anna G. W. Rosenberg, Kirsten Davidse, Christine Poitou, Muriel Coupaye, Anthony P. Goldstone, Charlotte Høybye, Tania P. Markovic, Graziano Grugni, Antonino Crinò, Assumpta Caixàs, Talia Eldar-Geva, Harry J. Hirsch, Varda Gross-Tsur, Merlin G. Butler, Jennifer L. Miller, Sjoerd A. A. van den Berg, Aart J. van der Lely & Laura C. G. de Graaff. (2021) Hypogonadism in Adult Males with Prader-Willi Syndrome—Clinical Recommendations Based on a Dutch Cohort Study, Review of the Literature and an International Expert Panel Discussion. Journal of Clinical Medicine 10:19, pages 4361.
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Przemysław J. Danek, Wojciech Kuban & Władysława A. Daniel. (2021) The Effect of Chronic Iloperidone Treatment on Cytochrome P450 Expression and Activity in the Rat Liver: Involvement of Neuroendocrine Mechanisms. International Journal of Molecular Sciences 22:16, pages 8447.
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Przemysław J. Danek, Agnieszka Basińska-Ziobroń, Jacek Wójcikowski & Władysława A. Daniel. (2020) Levomepromazine and clozapine induce the main human cytochrome P450 drug metabolizing enzyme CYP3A4. Pharmacological Reports 73:1, pages 303-308.
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Przemysław J. Danek, Jacek Wójcikowski & Władysława A. Daniel. (2020) Asenapine and iloperidone decrease the expression of major cytochrome P450 enzymes CYP1A2 and CYP3A4 in human hepatocytes. A significance for drug-drug interactions during combined therapy. Toxicology and Applied Pharmacology 406, pages 115239.
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Anna Haduch, Ewa Bromek, Marta Rysz, Renata Pukło, Mariusz Papp, Piotr Gruca, Magdalena Łasoń, Monika Niemczyk & Władysława A. Daniel. (2020) The effects of agomelatine and imipramine on liver cytochrome P450 during chronic mild stress (CMS) in the rat. Pharmacological Reports 72:5, pages 1271-1287.
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Jacek Wójcikowski, Przemysław J. Danek, Agnieszka Basińska-Ziobroń, Renata Pukło & Władysława A. Daniel. (2020) In vitro inhibition of human cytochrome P450 enzymes by the novel atypical antipsychotic drug asenapine: a prediction of possible drug–drug interactions. Pharmacological Reports 72:3, pages 612-621.
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Anna Haduch, Marta Rysz, Mariusz Papp & Władysława A. Daniel. (2018) The activity of brain and liver cytochrome P450 2D (CYP2D) is differently affected by antidepressants in the chronic mild stress (CMS) model of depression in the rat. Biochemical Pharmacology 156, pages 398-405.
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Marta Kot, Anna Haduch, Mariusz Papp & Władysława A. Daniel. (2017) The Effect of Chronic Treatment with Lurasidone on Rat Liver Cytochrome P450 Expression and Activity in the Chronic Mild Stress Model of Depression. Drug Metabolism and Disposition 45:12, pages 1336-1344.
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Steven L. Dubovsky. (2016) The Limitations of Genetic Testing in Psychiatry. Psychotherapy and Psychosomatics 85:3, pages 129-135.
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Marta Rysz, Ewa Bromek & Wſadysſawa A. Daniel. (2016) Activation of brain serotonergic system by repeated intracerebral administration of 5-hydroxytryptophan (5-HTP) decreases the expression and activity of liver cytochrome P450. Biochemical Pharmacology 99, pages 113-122.
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Steven L. Dubovsky & Amelia N. Dubovsky. (2015) The Role of Pharmacogenomics to Guide Treatment in Mood and Anxiety Disorders. Current Behavioral Neuroscience Reports 2:3, pages 154-164.
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Anna Haduch, Ewa Bromek, Marta Kot, Katarzyna Kamińska, Krystyna Gołembiowska & Wladyslawa A. Daniel. (2015) The cytochrome P450 2D-mediated formation of serotonin from 5-methoxytryptamine in the brain in vivo : a microdialysis study . Journal of Neurochemistry 133:1, pages 83-92.
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Jacek Wójcikowski, Agnieszka Basińska & Władysława A. Daniel. (2014) The cytochrome P450-catalyzed metabolism of levomepromazine: a phenothiazine neuroleptic with a wide spectrum of clinical application. Biochemical Pharmacology 90:2, pages 188-195.
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Ewa Bromek, Jacek Wójcikowski & Władysława A. Daniel. (2013) Involvement of the paraventricular (PVN) and arcuate (ARC) nuclei of the hypothalamus in the central noradrenergic regulation of liver cytochrome P450. Biochemical Pharmacology 86:11, pages 1614-1620.
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Anna Haduch, Ewa Bromek & Władysława A. Daniel. (2013) Role of brain cytochrome P450 (CYP2D) in the metabolism of monoaminergic neurotransmitters. Pharmacological Reports 65:6, pages 1519-1528.
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Jacek Wójcikowski, Anna Haduch & Władysława Anna Daniel. (2013) Effect of antidepressant drugs on cytochrome P450 2C11 (CYP2C11) in rat liver. Pharmacological Reports 65:5, pages 1247-1255.
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Katarzyna Kamińska, Krystyna Gołembiowska & Zofia Rogóż. (2013) Effect of risperidone on the fluoxetine-induced changes in extracellular dopamine, serotonin and noradrenaline in the rat frontal cortex. Pharmacological Reports 65:5, pages 1144-1151.
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Jessica L. Gören & Ashley Tewksbury. 2013. Polypharmacy in Psychiatry Practice, Volume I. Polypharmacy in Psychiatry Practice, Volume I 45 74 .
Marta Kot, Andrzej Pilc & Władysława A. Daniel. (2012) Simultaneous alterations of brain and plasma serotonin concentrations and liver cytochrome P450 in rats fed on a tryptophan-free diet. Pharmacological Research 66:4, pages 292-299.
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Anna Haduch, Jacek Wójcikowski & Władysława A. Daniel. (2011) Effect of neuroleptics on cytochrome P450 2C11 (CYP2C11) in rat liver. Pharmacological Reports 63:6, pages 1491-1499.
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Marta Kot & Władysława A. Daniel. (2011) Cytochrome P450 is regulated by noradrenergic and serotonergic systems. Pharmacological Research 64:4, pages 371-380.
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Anna Haduch, Ewa Bromek & Władysława A. Daniel. (2011) The effect of psychotropic drugs on cytochrome P450 2D (CYP2D) in rat brain. European Journal of Pharmacology 651:1-3, pages 51-58.
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Jacek Wójcikowski & Władysława A. Daniel. (2010) Influence of antidepressant drugs on chlorpromazine metabolism in human liver -an in vitro study. Pharmacological Reports 62:6, pages 1062-1069.
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Jacek Wójcikowski & Władysława A. Daniel. (2009) Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and caffeine metabolism – an in vitro study. Pharmacological Reports 61:5, pages 851-858.
Crossref
Jacek Wójcikowski, Krystyna Gołembiowska & Władysława Anna Daniel. (2008) Regulation of liver cytochrome P450 by activation of brain dopaminergic system: Physiological and pharmacological implications. Biochemical Pharmacology 76:2, pages 258-267.
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Marta Kot & Władysława A. Daniel. (2008) Relative contribution of rat cytochrome P450 isoforms to the metabolism of caffeine: The pathway and concentration dependence. Biochemical Pharmacology 75:7, pages 1538-1549.
Crossref
Julian Blagg. 2006. Annual Reports in Medicinal Chemistry Volume 41. Annual Reports in Medicinal Chemistry Volume 41 353 368 .

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