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Drug Evaluation

Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction

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Pages 283-293 | Published online: 16 Aug 2005

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Peng-fei Tang, Xiang Zheng, Xiao-xia Hu, Cheng-cheng Yang, Zhe Chen, Jian-chang Qian, Jian-ping Cai & Guo-xin Hu. (2020) Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism. Drug Design, Development and Therapy 14, pages 5129-5141.
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Hajime Tachikawa, Rei Nishiyama, Yoko Ichikawa-Kaji, Nozomi Uemura, Yasuhiro Takaku, Kiyoko Kishimoto, Yasushi Ono, Kuniaki Tayama, Toshinari Suzuki, Jin Suzuki & Takako Moriyasu. (2020) Structure elucidation of a PDE5 inhibitor detected as an illegal adulteration in a libido-boosting dietary supplement. Food Additives & Contaminants: Part A 37:12, pages 2023-2032.
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Gautam V Ramani & Myung H Park. (2010) Update on the clinical utility of sildenafil in the treatment of pulmonary arterial hypertension. Drug Design, Development and Therapy 4, pages 61-70.
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Stefan Ückert$suffix/text()$suffix/text(), Margit E Mayer, Christian G Stief & Udo Jonas. (2007) The future of the oral pharmacotherapy of male erectile dysfunction: things to come. Expert Opinion on Emerging Drugs 12:2, pages 219-228.
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Articles from other publishers (30)

Dariusz Pajka, Urszula Lelek-Borkowska & Krzysztof K. Zborowski. (2022) Theoretical study on the origins of sildenafil tautomers’ relative stability. Zeitschrift für Physikalische Chemie 236:11-12, pages 1627-1638.
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Mohammadsadegh Hamzehnejadi, Marziye Ranjbar Tavakoli, Ardavan Abiri, Ali Ghasempour, Mohammad Amin Langarizadeh & Hamid Forootanfar. (2022) A Review on Phosphodiesterase-5 Inhibitors as a Topical Therapy for Erectile Dysfunction. Sexual Medicine Reviews 10:3, pages 376-391.
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Juanhong Zhang & Rong Wang. (2022) Changes in CYP3A4 Enzyme Expression and Biochemical Markers Under Acute Hypoxia Affect the Pharmacokinetics of Sildenafil. Frontiers in Physiology 13.
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Amira M AboYoussef, Marwa M Khalaf, Marina N Malak & Mohamed A Hamzawy. (2021) Repurposing of sildenafil as antitumour; induction of cyclic guanosine monophosphate/protein kinase G pathway, caspase-dependent apoptosis and pivotal reduction of Nuclear factor kappa light chain enhancer of activated B cells in lung cancer. Journal of Pharmacy and Pharmacology 73:8, pages 1080-1091.
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Andreas Ouranidis, Anastasia Tsiaxerli, Elisavet Vardaka, Catherine K. Markopoulou, Constantinos K. Zacharis, Ioannis Nicolaou, Dimitris Hatzichristou, Anna-Bettina Haidich, Nikolaos Kostomitsopoulos & Kyriakos Kachrimanis. (2021) Sildenafil 4.0—Integrated Synthetic Chemistry, Formulation and Analytical Strategies Effecting Immense Therapeutic and Societal Impact in the Fourth Industrial Era. Pharmaceuticals 14:4, pages 365.
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Mohammed MehannaSouraya DomiatiHania Nakkash ChmaisseAhmed El Mallah. (2020) Analgesia additive interaction between tadalafil and morphine in an experimental animal model. Canadian Journal of Physiology and Pharmacology 98:11, pages 771-776.
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Ishmael M. Inocencio, Graeme R. Polglase, Ilias Nitsos, Suzanne L. Miller & Beth J. Allison. (2020) Maternal sildenafil impairs the cardiovascular adaptations to chronic hypoxaemia in fetal sheep. The Journal of Physiology 598:19, pages 4405-4419.
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G. Kaur, D. Utreja, N. Jain & N. K. Dhillon. (2020) Synthesis and Evaluation of Pyrazole Derivatives as Potent Antinemic Agents. Russian Journal of Organic Chemistry 56:1, pages 113-118.
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Michele Albuquerque Jales de Carvalho, Adriano Chaves-Filho, Alana Gomes de Souza, Camila Nayane de Carvalho Lima, Klistenes Alves de Lima, Emiliano Ricardo Rios Vasconcelos, Mariana Lima Feitosa, João Victor Souza Oliveira, Denia Alves Albuquerque de Souza, Danielle S. Macedo, Francisca Cléa Florenço de Souza & Marta Maria de França Fonteles. (2019) Proconvulsant effects of sildenafil citrate on pilocarpine-induced seizures: Involvement of cholinergic, nitrergic and pro-oxidant mechanisms. Brain Research Bulletin 149, pages 60-74.
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Ishmael M. InocencioGraeme R. PolglaseSuzanne L. MillerArvind SehgalAmy SutherlandJamie MihelakisAnqi LiBeth J. Allison. (2019) Effects of Maternal Sildenafil Treatment on Vascular Function in Growth-Restricted Fetal Sheep. Arteriosclerosis, Thrombosis, and Vascular Biology 39:4, pages 731-740.
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Mikkel Fode, Christian Fuglesang S. Jensen & Peter Busch Østergren. (2019) Sildenafil in postprostatectomy erectile dysfunction (perspective). International Journal of Impotence Research 31:2, pages 61-64.
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Hye-In Choi, Bo-Mi Kang, Jeehee Jang, Sungjoo Tommy Hwang & Ohsang Kwon. (2018) Novel effect of sildenafil on hair growth. Biochemical and Biophysical Research Communications 505:3, pages 685-691.
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Andrew W. Brown. 2018. 55 107 .
Carmen W. Dessauer, Val J. Watts, Rennolds S. Ostrom, Marco Conti, Stefan Dove & Roland Seifert. (2017) International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacological Reviews 69:2, pages 93-139.
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Anne Loesche, Jana Wiese, Sven Sommerwerk, Vivienne Simon, Wolfgang Brandt & René Csuk. (2017) Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases. European Journal of Medicinal Chemistry 125, pages 430-434.
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Shufeng Zhou. 2016. Cytochrome P450 2D6. Cytochrome P450 2D6 139 288 .
Hamza Al-Hroub, Bayan Alkhawaja, Eman Alkhawaja & Tawfiq Arafat. (2016) Sensitive and rapid HPLC-UV method with back-extraction step for the determination of sildenafil in human plasma. Journal of Chromatography B 1009-1010, pages 1-6.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 783 800 .
Miles Houslay. (2015) Hypertension linked to PDE3A activation. Nature Genetics 47:6, pages 562-563.
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H. Matsushita, M. Matsuzaki, X.-J. Han, T.-I. Nishiki, I. Ohmori, H. Michiue, H. Matsui & K. Tomizawa. (2012) Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation. Neuroscience 200, pages 13-18.
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K.-E. Andersson. (2011) Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction. Pharmacological Reviews 63:4, pages 811-859.
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Matthew A. Movsesian & Rakesh C. Kukreja. 2011. Phosphodiesterases as Drug Targets. Phosphodiesterases as Drug Targets 237 249 .
Bertil B. FredholmSharron H. Francis, Konjeti R. Sekhar, Hengming Ke & Jackie D. Corbin. 2011. Methylxanthines. Methylxanthines 93 133 .
Wendy Ky NgYishai RosenblattGerald B BrockDavid B O'gormanBing Siang Gan. (2010) Phosphodiesterase Inhibitors in Vascular Ischemia: A Case Report and Review of Their Use in Ischemic Conditions. Canadian Journal of Plastic Surgery 18:1, pages 5-9.
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Fabrice Vandeput, Judith Krall, Ramzi Ockaili, Fadi N. Salloum, Vincent Florio, Jackie D. Corbin, Sharron H. Francis, Rakesh C. Kukreja & Matthew A. Movsesian. (2009) cGMP-Hydrolytic Activity and Its Inhibition by Sildenafil in Normal and Failing Human and Mouse Myocardium. Journal of Pharmacology and Experimental Therapeutics 330:3, pages 884-891.
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A.J. Becker, S. Ückert & C.G. Stief. (2008) Grundlagen der Phosphodiesterase-5- (PDE5-)InhibitorenThe basics of phosphodiesterase type 5 (PDE5) inhibition in urology. Der Urologe 47:12, pages 1582-1587.
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Ana L. Cavalcanti, Vicente R. Bagnoli, Ângela M. Fonseca, Roberto A. Pastore, Eduardo B. Cardoso, Jucilene S Paixão, José M. SoaresJr.Jr., Fabrício Saad & Edmund C. Baracat. (2008) Effect of sildenafil on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction. International Journal of Gynecology & Obstetrics 102:2, pages 115-119.
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K S Murthy. (2008) Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1. British Journal of Pharmacology 153:6, pages 1214-1224.
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R Duffin, C A Shaw & A G Rossi. (2008) Sildenafil reduces alcohol-induced gastric damage: just say ‘NO’. British Journal of Pharmacology 153:4, pages 623-624.
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David M FenigAndrew McCullough. (2007) Sildenafil in the treatment of erectile dysfunction. Aging Health 3:3, pages 295-303.
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