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Drug Evaluations

Dexmedetomidine: sedation, analgesia and beyond

, MD & , PharmD
Pages 619-627 | Published online: 18 May 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Huan He, Qichun Cui, Hengheng Chen, Xiao Huang, Shuai Wang, Tian Yu, Jinqiu Feng & Yun Shao. (2023) The Effect of Intranasal Dexmedetomidine on Emergence Delirium Prevention in Pediatric Ambulatory Dental Rehabilitation Under General Anesthesia: A Randomized Clinical Trial. Drug Design, Development and Therapy 17, pages 3563-3570.
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Silvia Bermejo, Begoña Covas, Teresa Silva-Costa-Gomes, Albert Sánchez-Font, Víctor Curull, Àlex Pérez-Ramos, Anna Mases & Lluís Gallart. (2022) Moderate sedation with dexmedetomidine–remifentanil is safer than deep sedation with propofol–remifentanil for endobronchial ultrasound while providing comparable quality: a randomized double-blind trial. Expert Review of Respiratory Medicine 16:11-12, pages 1237-1245.
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Doyeon Kim, Ji Seon Jeong, Huigyeong Park, Ki-Sun Sung, Soo Joo Choi, Mi Sook Gwak, Gaab Soo Kim, Tae Soo Hahm & Justin Sangwook Ko. (2019) Postoperative pain control after the use of dexmedetomidine and propofol to sedate patients undergoing ankle surgery under spinal anesthesia: a randomized controlled trial. Journal of Pain Research 12, pages 1479-1487.
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Emad Eldeen A. Ibrahim, Mokhtar M. Amer, Mohamed E. Abuelnaga & Wafaa I. Abd-Elaal. (2018) Dexmedetomidine infusion during caesarean section under general anaesthesia: Evaluation of maternal awareness using BIS, maternal and neonatal outcomes. Egyptian Journal of Anaesthesia 34:4, pages 145-150.
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Khaled Mohammed Maghawry, Ashraf El Sayed El-Agamy, Wael Ibrahim Tahir & Ayman F. Zein. (2015) Cerebral oxygen saturation monitoring during hypotensive anesthesia in shoulder arthroscopy: A comparative study between dexmedetomidine and esmolol. Egyptian Journal of Anaesthesia 31:1, pages 43-52.
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Articles from other publishers (112)

Alden S Jason, Gidean A Sundaram, Preethi J, Santhosh P Kumar & Murugesan Krishnan. (2023) Comparison of the Efficacy of Midazolam and Dexmedetomidine As Sedative Agents in Third Molar Surgery. Cureus.
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Xiao Liu, Bingchen Lang, Linan Zeng, Liang Huang, Shouming Chen, Zhi-Jun Jia, Guo Cheng, Qin Yu & Lingli Zhang. (2023) Comparison of the effects of ketamine via nebulization versus different pharmacological approaches in pediatric sedation: a systematic review and meta-analysis of randomized controlled trials. BMC Anesthesiology 23:1.
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Huayue Liu, Juan Zhang, Ke Peng, Xiaowen Meng, Xisheng Shan, Wenwen Huo, Hong Liu, Yishan Lei & Fuhai Ji. (2023) Protocol: dexmedetomidine on myocardial injury after noncardiac surgery—a multicenter, double-blind, controlled trial. Perioperative Medicine 12:1.
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MOHD MUSHEER KHAN, PRASHI SHARMA, SUSHIL KUMAR, VIVEK BADADA & SANJAY MELVILLE MASIH. (2023) COMPARATIVE STUDY OF BUPIVACAINE WITH DEXMEDETOMIDINE AND BUPIVACAINE ALONE IN SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK. Asian Journal of Pharmaceutical and Clinical Research, pages 193-197.
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Juan Guillen-Hernandez, Kay C. Kyllonen, Dmitry Tumin & Ricardo J. Rodriguez. (2023) The Use of Dexmedetomidine in Preterm Infants: A Single Academic Center Experience. The Journal of Pediatric Pharmacology and Therapeutics 28:7, pages 628-634.
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Müge Yüce Yıldırım, Ayşe Ülgey, Gamze Talih, Hakkı Doğan & Işın Güneş. (2023) Evaluation of the Perioperative Effects of Dexmedetomidine and Midazolam-Ketamine Premedication in Strabismus Surgery. Journal of Pediatric Ophthalmology & Strabismus 60:6, pages 427-434.
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Anusha Kakarla, Laxman K Senapati, Asima Das, Mousumi Acharya, Sailaja Sukanya & Amit Pradhan. (2023) Intravenous Dexmedetomidine-Ketamine Versus Ketamine-Propofol for Procedural Sedation in Adults Undergoing Short Surgical Procedures: A Randomized Controlled Trial. Cureus.
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Junli Zhang, Jing Yin, Yuanyuan Li, Yu Zhang, Yaowu Bai & Hongyuan Yang. (2023) Effect of dexmedetomidine on preventing perioperative respiratory adverse events in children: A systematic review and meta‑analysis of randomized controlled trials. Experimental and Therapeutic Medicine 25:6.
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Kevin Baumgartner, Veronica Groff, Lauren H. Yaeger & Brian M. Fuller. (2022) The use of dexmedetomidine in the emergency department: A systematic review. Academic Emergency Medicine 30:3, pages 196-208.
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Yuzhi Fu, Qianqian Zhang, Yongxian Jiang & Bingchen Lang. (2023) A comparative evaluation of intranasal α2-adrenoceptor agonists and intranasal midazolam as premedication in pediatric sedation: A meta-analysis of randomized controlled trials. PLOS ONE 18:2, pages e0281751.
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Amit Chail, Madhubrata Ray, Ranveer Singh & Mayank Dhiman. (2023) Adjuvant dexmedetomidine in treatment of alcohol withdrawal delirium: Case series. Medical Journal of Dr. D.Y. Patil Vidyapeeth 16:7, pages 157.
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Zhihong Li, Qingwang Liu, Junchao Yao & Xiang Zhang. (2022) Effects of Supplemental Dexmedetomidine Anesthesia on Intracranial Aneurysm Patients Undergoing Intracranial Interventional Embolization. World Neurosurgery 168, pages e570-e577.
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Jun Lin, Chujun Wu, Dizhou Zhao, Xuhang Du, Wangzhi Zhang & Jieyu Fang. (2022) The Sedative Effects of Inhaled Nebulized Dexmedetomidine on Children: A Systematic Review and Meta-Analysis. Frontiers in Pediatrics 10.
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Georgia Efstathiou, Chrysanthi Batistaki, Eleftheria Soulioti, Loizos Roungeris & Paraskevi Matsota. (2022) Opioid-Free Anesthesia and Postoperative Cognitive Dysfunction After Minor Urological Surgery: A Case Series Study. Anesthesiology and Pain Medicine 12:1.
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BikramK Gupta, VanitaR Mhaske, VishalKrishna Pai & LD Mishra. (2022) A comparative study of sedo-analgesic effect of dexmedetomidine and dexmedetomidine with ketamine in postoperative mechanically ventilated patients. Journal of Anaesthesiology Clinical Pharmacology 38:1, pages 68.
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芹 赵. (2022) Comparison of Anesthetic Effects of Remazolam and Dexmetomidine in Hysteroscopic Surgery. Advances in Clinical Medicine 12:01, pages 25-29.
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Chenyu Jin, Xiang Lv, Yu Sun & Hong Jiang. (2021) Effect of continuous infusion of dexmedetomidine on blood loss in orthognathic surgery: a retrospective study. European Journal of Medical Research 26:1.
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Francisca Jerónimo Fonseca, Leonardo Ferreira, Ana Lídia Rouxinol-Dias & Joana Mourão. (2021) Effects of dexmedetomidine in non-operating room anesthesia in adults: a systematic review with meta-analysis. Brazilian Journal of Anesthesiology (English Edition).
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Adam C. Adler, Anna Daszkowski, Joy C. Tan, Anna D. Poliner, Eric Z. Wei, Brian H. Nathanson & Arvind Chandrakantan. (2021) The Association of Dexmedetomidine on Perioperative Opioid Consumption in Children Undergoing Adenotonsillectomy With and Without Obstructive Sleep Apnea. Anesthesia & Analgesia 133:5, pages 1260-1268.
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Ji Yoon Kim, Kyu Nam Kim, Dong Won Kim, Hyun Jin Lim & Bong Soo Lee. (2021) Effects of dexmedetomidine sedation for magnetic resonance imaging in children: a systematic review and meta-analysis. Journal of Anesthesia 35:4, pages 525-535.
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Zaara Liaquat, Xiaoying Xu, Prince Last Mudenda Zilundu, Rao Fu & Lihua Zhou. (2021) The Current Role of Dexmedetomidine as Neuroprotective Agent: An Updated Review. Brain Sciences 11:7, pages 846.
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Bingchen Lang, Lingli Zhang, Wensheng Zhang, Yunzhu Lin, Yuzhi Fu & Shouming Chen. (2020) A comparative evaluation of dexmedetomidine and midazolam in pediatric sedation: A meta‐analysis of randomized controlled trials with trial sequential analysis. CNS Neuroscience & Therapeutics 26:8, pages 862-875.
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Qi‐hong Shen, Hui‐fang Li, Xu‐yan Zhou & Xiao‐zhong Yuan. (2020) Dexmedetomidine in the prevention of postoperative delirium in elderly patients following non‐cardiac surgery: A systematic review and meta‐analysis. Clinical and Experimental Pharmacology and Physiology 47:8, pages 1333-1341.
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Bingchen Lang, Lingli Zhang, Yunzhu Lin, Wensheng Zhang, Feng-shan Li & Shouming Chen. (2020) Comparison of effects and safety in providing controlled hypotension during surgery between dexmedetomidine and magnesium sulphate: A meta-analysis of randomized controlled trials. PLOS ONE 15:1, pages e0227410.
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Manoj Kamal, Deepa Agarwal, Geeta Singariya, Kamlesh Kumari, Bharat Paliwal & Shobha Ujwal. (2020) Effect of dexmedetomidine on attenuation of hemodynamic response to intubation, skin incision, and sternotomy in coronary artery bypass graft patients: A double-blind randomized control trial. Journal of Anaesthesiology Clinical Pharmacology 36:2, pages 255.
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Mohammed Khallaf, Ahmed Mostafa Thabet, Mahmoud Ali, Essam Sharkawy & Sherif Abdel-rehim. (2019) The effect of dexmedetomidine versus propofol in traumatic brain injury: evaluation of some hemodynamic and intracranial pressure changes. Egyptian Journal of Neurosurgery 34:1.
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Hala S. Abdel-Ghaffar, Amani H. Abdel-Wahab & Mohammed M. Roushdy. (2019) Oral trans-mucosal dexmedetomidine for controlling of emergence agitation in children undergoing tonsillectomy: a randomized controlled trial. Brazilian Journal of Anesthesiology (English Edition) 69:5, pages 469-476.
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Anam Amin Kazi, Aparna Amar Ruparel, Shreyas Rao, Akhil Bhalla & Amit Nagpal. (2019) COMPARATIVE STUDY OF IV DEXMEDETOMIDINE AND FENTANYL ON HEMODYNAMIC RESPONSE, SEDATION, ANALGESIA AND ANXIOLYSIS IN SURGERIES REQUIRING LOCAL ANAESTHESIA WITH INTRAVENOUS SEDATION. Journal of Evolution of Medical and Dental Sciences 8:11, pages 783-787.
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João Manoel Silva-Jr, Henrique T Katayama, Fernando A M Nogueira, Tatiane B Moura, Thiago L Alves & Barbara W de Oliveira. (2019) Comparison of dexmedetomidine and benzodiazepine for intraoperative sedation in elderly patients: a randomized clinical trial. Regional Anesthesia & Pain Medicine 44:3, pages 319-324.
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Ran Liu, Xianke Li & Xiangdong Zhang. (2018) Dexmedetomidine protects high-glucose induced apoptosis in human retinal pigment epithelial cells through inhibition on p75(NTR). Biomedicine & Pharmacotherapy 106, pages 466-471.
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Xiaobao Zhang, Fang Yan, Jiying Feng, Haitao Qian, Zhi Cheng, Qianqian Yang, Yong Wu, Zhibin Zhao, Aimin Li & Hang Xiao. (2018) Dexmedetomidine inhibits inflammatory reaction in the hippocampus of septic rats by suppressing NF-κB pathway. PLOS ONE 13:5, pages e0196897.
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Mi Zhou, Qiang Wang, Qiong Zhang, Yifei Liu, Leyun Zhan & Aihua Shu. (2018) Application of pre-injection of dexmedetomidine of different doses in pediatric intravenous general anesthesia without tracheal intubation. Experimental and Therapeutic Medicine.
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Seyed Mojtaba Moosavi, Kiran Shekar, John F. Fraser, Maree T. Smith & Sussan Ghassabian. (2018) An improved liquid chromatography tandem mass spectrometry (LC–MS/MS) method for quantification of dexmedetomidine concentrations in samples of human plasma. Journal of Chromatography B 1073, pages 118-122.
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Ye Tu & Feng Gao. (2017) Dexmedetomidine-based monitored conscious sedation combined local anesthesia for levator resection in a 10-year-old child with Marcus Gunn jaw-winking synkinesis. Medicine 96:51, pages e9369.
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Jong Hun Jun, Kyu Nam Kim, Ji Yoon Kim & Shin Me Song. (2017) The effects of intranasal dexmedetomidine premedication in children: a systematic review and meta-analysisLes effets d’une prémédication intranasale de dexmédétomidine chez l’enfant : revue systématique et méta-analyse. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 64:9, pages 947-961.
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Ke Peng, Yun Qiu, Jian Li, Zhao‑Cai Zhang & Fu‑Hai Ji. (2017) Dexmedetomidine attenuates hypoxia/reoxygenation injury in primary neonatal rat cardiomyocytes. Experimental and Therapeutic Medicine.
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Cinara Andreolio, Jefferson Pedro Piva, Elisa Baldasso, Roberta Ferlini & Rafaela Piccoli. (2016) Prolonged infusion of dexmedetomidine in critically-ill children. Indian Pediatrics 53:11, pages 987-989.
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Wanying Pan, Lin Lin, Nan Zhang, Fuli Yuan, Xiaoxiao Hua, Yueting Wang & Liqiu Mo. (2015) Neuroprotective Effects of Dexmedetomidine Against Hypoxia-Induced Nervous System Injury are Related to Inhibition of NF-κB/COX-2 Pathways. Cellular and Molecular Neurobiology 36:7, pages 1179-1188.
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Wei Zhang, Jia-Qiang Zhang, Fan-Min Meng & Fu-Shan Xue. (2016) Dexmedetomidine protects against lung ischemia–reperfusion injury by the PI3K/Akt/HIF-1α signaling pathway. Journal of Anesthesia 30:5, pages 826-833.
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Somchai Amornyotin. (2016) Dexmedetomidine in gastrointestinal endoscopic procedures. World Journal of Anesthesiology 5:1, pages 1.
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Li-Hong Zhao, Zhong-Hua Shi, Ning-Ning Yin & Jian-Xin Zhou. (2013) Use of dexmedetomidine for prophylactic analgesia and sedation in delayed extubation patients after craniotomy: a study protocol and statistical analysis plan for a randomized controlled trial. Trials 14:1.
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